{"id":"https://openalex.org/W2944174704","doi":"https://doi.org/10.1038/s41598-019-43542-7","title":"Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone","display_name":"Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone","publication_year":2019,"publication_date":"2019-05-10","ids":{"openalex":"https://openalex.org/W2944174704","doi":"https://doi.org/10.1038/s41598-019-43542-7","mag":"2944174704","pmid":"https://pubmed.ncbi.nlm.nih.gov/31076574","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6510799"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-43542-7","doi":"https://doi.org/10.1038/s41598-019-43542-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-43542-7","pdf_url":"https://www.nature.com/articles/s41598-019-43542-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-43542-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042640158","display_name":"Mustafa \u00dcnal","orcid":"https://orcid.org/0000-0002-9518-8952","observed_orcids":["https://orcid.org/0000-0002-9518-8952"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mustafa Unal","raw_affiliation_strings":["Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","Department of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37212, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030048263","display_name":"Sasidhar Uppuganti","orcid":"https://orcid.org/0000-0002-0656-2122","observed_orcids":["https://orcid.org/0000-0002-0656-2122"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasidhar Uppuganti","raw_affiliation_strings":["Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","Department of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069949475","display_name":"Selin Timur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selin Timur","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023756240","display_name":"Anita M. Mahadevan-Jansen","orcid":"https://orcid.org/0000-0002-0491-3769","observed_orcids":["https://orcid.org/0000-0002-0491-3769"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Mahadevan-Jansen","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37212, USA","Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37212, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37212, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078624568","display_name":"Ozan Akku\u015f","orcid":"https://orcid.org/0000-0003-3523-3421","observed_orcids":["https://orcid.org/0000-0003-3523-3421"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ozan Akkus","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA","Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA","Department of Orthopaedics, Case Western Reserve University, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Orthopaedics, Case Western Reserve University, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017780140","display_name":"Jeffry Stephen Nyman","orcid":"https://orcid.org/0000-0001-7403-7605","observed_orcids":["https://orcid.org/0000-0001-7403-7605"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffry S. Nyman","raw_affiliation_strings":["Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. jeffry.s.nyman@vanderbilt.edu","Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37212, USA. jeffry.s.nyman@vanderbilt.edu","Department of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. jeffry.s.nyman@vanderbilt.edu","Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37212, USA. jeffry.s.nyman@vanderbilt.edu","Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA"],"raw_orcid":"https://orcid.org/0000-0001-7403-7605","affiliations":[{"raw_affiliation_string":"Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. jeffry.s.nyman@vanderbilt.edu","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37212, USA. jeffry.s.nyman@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery & Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. jeffry.s.nyman@vanderbilt.edu","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37212, USA. jeffry.s.nyman@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017780140"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":3.9912,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.94986385,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"7195","last_page":"7195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.049800001084804535,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11212","display_name":"Cultural Heritage Materials Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1204","display_name":"Archeology"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raman-spectroscopy","display_name":"Raman spectroscopy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cortical-bone","display_name":"cortical bone","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fracture-toughness","display_name":"fracture toughness","score":0.8930000066757202},{"id":"https://openalex.org/keywords/amide-i-band","display_name":"amide I band","score":0.9390000104904175},{"id":"https://openalex.org/keywords/second-derivative-analysis","display_name":"second derivative analysis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/fiberoptic-probe","display_name":"optical fiber probe","score":0.6449999809265137},{"id":"https://openalex.org/keywords/micro-raman-spectroscopy","display_name":"micro-Raman spectroscopy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/j-integral","display_name":"J-integral","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fracture-resistance","display_name":"fracture resistance","score":0.6639999747276306},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fracture-risk-assessment","display_name":"fracture risk assessment","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.8735371828079224},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5177299380302429},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.5028738379478455},{"id":"https://openalex.org/C97549433","wikidata":"https://www.wikidata.org/wiki/Q911969","display_name":"Fracture toughness","level":2,"score":0.4598345160484314},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.4458412528038025},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.42532968521118164},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.416599839925766},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.39252033829689026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3277042508125305},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1846063733100891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17146536707878113},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1553460657596588},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1445775032043457},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12868168950080872},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.08141937851905823},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071538","descriptor_name":"Cortical Bone","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-019-43542-7","doi":"https://doi.org/10.1038/s41598-019-43542-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-43542-7","pdf_url":"https://www.nature.com/articles/s41598-019-43542-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6510799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6510799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31076574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31076574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-43542-7","doi":"https://doi.org/10.1038/s41598-019-43542-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-43542-7","pdf_url":"https://www.nature.com/articles/s41598-019-43542-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3649672275","display_name":null,"funder_award_id":"1I01BX001018","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G3720808619","display_name":null,"funder_award_id":"I01 BX001018","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3978841215","display_name":null,"funder_award_id":"AR063157","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5056867431","display_name":null,"funder_award_id":"BX001018","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5275133757","display_name":null,"funder_award_id":"1I01BX001018","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5722371116","display_name":"Advancing Raman spectroscopy toward the clinical assessment of bone quality","funder_award_id":"R21AR073133","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6074681096","display_name":null,"funder_award_id":"AR063157","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G610952283","display_name":null,"funder_award_id":"I01 BX004297","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G7557251021","display_name":null,"funder_award_id":"AR073133","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000920906","display_name":"Roles of Collagen and Water in the Fracture Resistance of Bone","funder_award_id":"R01AR063157","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2944174704.pdf","grobid_xml":"https://content.openalex.org/works/W2944174704.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1896856921","https://openalex.org/W1956233601","https://openalex.org/W1963966569","https://openalex.org/W1965020770","https://openalex.org/W1965505631","https://openalex.org/W1966907599","https://openalex.org/W1967872439","https://openalex.org/W1979255076","https://openalex.org/W1979563615","https://openalex.org/W1982467614","https://openalex.org/W1986379188","https://openalex.org/W1993612260","https://openalex.org/W1999941851","https://openalex.org/W2000772498","https://openalex.org/W2001235125","https://openalex.org/W2005601953","https://openalex.org/W2006905874","https://openalex.org/W2019121872","https://openalex.org/W2024585892","https://openalex.org/W2024608325","https://openalex.org/W2026911387","https://openalex.org/W2031269108","https://openalex.org/W2031838608","https://openalex.org/W2035532578","https://openalex.org/W2042591533","https://openalex.org/W2043957334","https://openalex.org/W2058564535","https://openalex.org/W2062972212","https://openalex.org/W2077455087","https://openalex.org/W2085322355","https://openalex.org/W2102719653","https://openalex.org/W2107478685","https://openalex.org/W2113583319","https://openalex.org/W2115007414","https://openalex.org/W2116742964","https://openalex.org/W2120488989","https://openalex.org/W2130720048","https://openalex.org/W2137438672","https://openalex.org/W2140678804","https://openalex.org/W2144137222","https://openalex.org/W2150778544","https://openalex.org/W2154094465","https://openalex.org/W2159775719","https://openalex.org/W2162212747","https://openalex.org/W2171183137","https://openalex.org/W2212630919","https://openalex.org/W2298650860","https://openalex.org/W2306142233","https://openalex.org/W2416894330","https://openalex.org/W2423109914","https://openalex.org/W2491708948","https://openalex.org/W2539013856","https://openalex.org/W2604116598","https://openalex.org/W2625546516","https://openalex.org/W2735926161","https://openalex.org/W2791897953","https://openalex.org/W2794264295","https://openalex.org/W2796086776","https://openalex.org/W2805471295","https://openalex.org/W2898347735"],"related_works":["https://openalex.org/W2625546516","https://openalex.org/W3131034908","https://openalex.org/W4413290563","https://openalex.org/W4392718015","https://openalex.org/W2035532578","https://openalex.org/W4413161230","https://openalex.org/W4321378361","https://openalex.org/W2473403255","https://openalex.org/W1989015819","https://openalex.org/W2060158072"],"abstract_inverted_index":{"Abstract":[0],"Developing":[1],"clinical":[2],"tools":[3],"that":[4],"assess":[5],"bone":[6,34,178],"matrix":[7,227],"quality":[8],"could":[9],"improve":[10],"the":[11,140,188,232,239,244],"assessment":[12,233],"of":[13,187,216,234,237],"a":[14],"person\u2019s":[15],"fracture":[16,50,121,130,235],"risk.":[17],"To":[18],"determine":[19],"whether":[20,45],"Raman":[21,29,41,104],"spectroscopy":[22],"(RS)":[23],"has":[24],"such":[25],"potential,":[26],"we":[27],"acquired":[28,135],"spectra":[30,133],"from":[31,58,114],"human":[32],"cortical":[33],"using":[35],"microscope-":[36],"and":[37,43,49,95,129,160,176,184,198],"fiber":[38],"optic":[39],"probe-based":[40],"systems":[42],"tested":[44],"correlations":[46,126],"between":[47,127],"RS":[48,128],"toughness":[51,131],"properties":[52,228],"were":[53,124,134,213],"statistically":[54],"significant.":[55],"Calculated":[56],"directly":[57],"intensities":[59],"at":[60],"wavenumbers":[61],"identified":[62],"by":[63,103,136],"second":[64],"derivative":[65],"analysis,":[66],"Amide":[67,245],"I":[68,71,77,141,171,194,204,208,246],"sub-peak":[69,145],"ratio":[70,146],"1670":[72,78,109,142,172,195,209],"/I":[73,79,143,173,196,210],"1640":[74,144,197,211],",":[75,81],"not":[76,118],"1690":[80,111],"was":[82],"negatively":[83,148],"correlated":[84,149],"with":[85,120,150],"K":[86,151,191],"init":[87,152,192],"(N":[88,153],"=":[89,93,99,154,158,164,220],"58;":[90],"R":[91,156],"2":[92,98,157,163,219],"32.4%)":[94],"J-integral":[96,161,217],"(R":[97,162],"47.4%)":[100],"when":[101,132],"assessed":[102],"micro-spectroscopy.":[105],"Area":[106],"ratios":[107],"(A":[108],"/A":[110],")":[112],"determined":[113],"sub-band":[115],"fitting":[116],"did":[117],"correlate":[119],"toughness.":[122],"There":[123],"fewer":[125],"probe":[137],"RS.":[138],"Nonetheless,":[139],"again":[147],"56;":[155],"25.6%)":[159],"39.0%).":[165],"In":[166],"best-fit":[167],"general":[168],"linear":[169],"models,":[170],"1640,":[174],"age,":[175],"volumetric":[177],"mineral":[179],"density":[180],"explained":[181],"50.2%":[182],"(microscope)":[183,205],"49.4%":[185],"(probe)":[186,212],"variance":[189],"in":[190],".":[193],"v":[199],"1":[200],"PO":[201],"4":[202],"/Amide":[203],"or":[206,222],"just":[207],"negative":[214],"predictors":[215],"(adjusted-R":[218],"54.9%":[221],"37.9%,":[223],"respectively).":[224],"While":[225],"Raman-derived":[226],"appear":[229],"useful":[230],"to":[231,242,249],"resistance":[236],"bone,":[238],"acquisition":[240],"strategy":[241],"resolve":[243],"band":[247],"needs":[248],"be":[250],"identified.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-16T00:00:00"}