{"id":"https://openalex.org/W2944155703","doi":"https://doi.org/10.1158/1538-7445.sabcs18-es8-1","title":"Abstract ES8-1: Windows of susceptibility across the lifecourse and breast cancer","display_name":"Abstract ES8-1: Windows of susceptibility across the lifecourse and breast cancer","publication_year":2019,"publication_date":"2019-02-15","ids":{"openalex":"https://openalex.org/W2944155703","doi":"https://doi.org/10.1158/1538-7445.sabcs18-es8-1","mag":"2944155703"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-es8-1","doi":"https://doi.org/10.1158/1538-7445.sabcs18-es8-1","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-es8-1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031698839","display_name":"Lawrence H. Kushi","orcid":"https://orcid.org/0000-0001-9136-1175","observed_orcids":["https://orcid.org/0000-0001-9136-1175"]},"institutions":[{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L Kushi","raw_affiliation_strings":["Kaiser Permanente Northern California, Oakland, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Northern California, Oakland, CA","institution_ids":["https://openalex.org/I4405284138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031698839"],"corresponding_institution_ids":["https://openalex.org/I4405284138"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"4_Supplement","first_page":"ES8","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/windows-of-susceptibility","display_name":"windows of susceptibility","score":0.9860000014305115},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9409999847412109},{"id":"https://openalex.org/keywords/life-course-epidemiology","display_name":"life course epidemiology","score":0.6349999904632568},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8289999961853027},{"id":"https://openalex.org/keywords/puberty-onset","display_name":"puberty onset","score":0.7689999938011169},{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.9139999747276306},{"id":"https://openalex.org/keywords/body-size","display_name":"body size","score":0.8270000219345093},{"id":"https://openalex.org/keywords/timing-of-exposure","display_name":"exposure timing","score":0.6050000190734863},{"id":"https://openalex.org/keywords/breast-cancer-prevention","display_name":"breast cancer prevention","score":0.734000027179718},{"id":"https://openalex.org/keywords/atomic-bomb-survivors","display_name":"atomic bomb survivors","score":0.5699999928474426},{"id":"https://openalex.org/keywords/radiation-exposure","display_name":"radiation exposure","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.849802553653717},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5820654034614563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5556681156158447},{"id":"https://openalex.org/C1691868","wikidata":"https://www.wikidata.org/wiki/Q1811049","display_name":"Life course approach","level":2,"score":0.484953910112381},{"id":"https://openalex.org/C2776880931","wikidata":"https://www.wikidata.org/wiki/Q6745783","display_name":"Breast development","level":3,"score":0.484785258769989},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4238091707229614},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4019869565963745},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3959766924381256},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3834622800350189},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.36124569177627563},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.33242619037628174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2941187620162964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18601852655410767},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1796865463256836},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16729092597961426},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.1437320113182068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-es8-1","doi":"https://doi.org/10.1158/1538-7445.sabcs18-es8-1","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-es8-1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2969786335","https://openalex.org/W2030919502","https://openalex.org/W2233693381","https://openalex.org/W2315793238","https://openalex.org/W3198622716","https://openalex.org/W2485385051","https://openalex.org/W2406483258","https://openalex.org/W4254034232","https://openalex.org/W1969340782","https://openalex.org/W2207576476"],"abstract_inverted_index":{"Abstract":[0],"With":[1],"increasing":[2],"knowledge":[3],"regarding":[4],"the":[5,11,37,48,78,104,118,133,137,152,164,166,171,179,183,195,255,300,320,332,345,354],"role":[6,197],"of":[7,13,25,27,50,57,80,106,120,128,154,161,198,225,260,285,302,304,310,319,329,334,342,353],"various":[8],"factors":[9,52,158,205,267,278],"in":[10,53,71,96,99,112,134,201,306,331],"development":[12],"breast":[14,58,85,121,209,234,264,286,312,335,348],"cancer,":[15],"a":[16,41,257],"concept":[17,30,61],"that":[18,24,32,77,109,117,206,218,229,241,263,283,292],"has":[19,74,114],"attracted":[20],"substantial":[21],"attention":[22],"is":[23,62,88,289],"windows":[26,127,303],"susceptibility.":[28],"This":[29,60,314],"suggests":[31],"there":[33],"are":[34,110],"periods":[35,253],"over":[36,254],"lifecourse":[38,346],"during":[39,126,132,163],"which":[40],"woman":[42],"may":[43,123,207,268],"be":[44,124],"particularly":[45],"vulnerable":[46],"to":[47,149,193,275,294,298],"influence":[49,208],"modifiable":[51],"determining":[54],"long-term":[55,308],"risk":[56,87,119,266,277,288],"cancer.":[59,313,336],"not":[63],"new;":[64],"for":[65,174,214],"example,":[66,215],"among":[67],"atomic":[68],"bomb":[69],"survivors":[70],"Japan,":[72],"it":[73],"been":[75],"observed":[76],"effect":[79],"radiation":[81],"exposure":[82],"on":[83,221,223,231,233,272],"subsequent":[84],"cancer":[86,122,210,265,287,349],"substantially":[89],"higher":[90],"if":[91],"women":[92],"were":[93],"exposed":[94],"earlier":[95],"life":[97,204],"than":[98],"their":[100],"later":[101],"years.":[102],"However,":[103],"impact":[105],"hormonally-active":[107,199],"agents":[108,200],"ubiquitous":[111],"environment":[113],"raised":[115],"concern":[116],"altered":[125],"susceptibility,":[129],"such":[130],"as":[131],"utero":[135],"period,":[136],"pubertal":[138],"transition,":[139],"or":[140,246],"between":[141],"puberty":[142],"and":[143,156,170,182,190,227,291,323,347],"first":[144],"full-term":[145],"pregnancy.":[146],"In":[147,236],"order":[148],"better":[150],"understand":[151],"interplay":[153],"environmental":[155],"lifestyle":[157],"with":[159,238],"timing":[160],"exposures":[162,274],"lifecourse,":[165,256],"National":[167,172],"Cancer":[168,181,359,370],"Institute":[169,173],"Environmental":[175],"Health":[176],"Sciences":[177],"established":[178],"Breast":[180,358],"Environment":[184],"Research":[185],"Program,":[186],"including":[187],"both":[188],"laboratory":[189],"epidemiologic":[191,216],"studies":[192,217,240],"investigate":[194],"potential":[196],"altering":[202],"early":[203],"risk.":[211],"These":[212,280],"include,":[213],"have":[219,242],"focused":[220],"impacts":[222,232],"age-at-onset":[224],"puberty,":[226],"others":[228],"focus":[230],"density.":[235],"conjunction":[237],"other":[239,247],"examined":[243],"body":[244,259],"size":[245],"metabolic":[248],"parameters":[249],"measured":[250],"at":[251],"different":[252],"growing":[258,327],"literature":[261],"indicates":[262],"operate":[269],"differently":[270],"depending":[271],"when":[273],"these":[276],"occur.":[279],"observations":[281],"indicate":[282],"establishment":[284],"complex,":[290],"approaches":[293],"prevention":[295],"likely":[296],"need":[297],"recognize":[299],"importance":[301],"susceptibility":[305,343],"influencing":[307],"likelihood":[309],"developing":[311],"presentation":[315],"will":[316],"review":[317],"some":[318],"key":[321],"concepts":[322],"findings":[324],"underlying":[325],"this":[326],"area":[328],"interest":[330],"epidemiology":[333],"Citation":[337],"Format:":[338],"Kushi":[339],"L.":[340],"Windows":[341],"across":[344],"[abstract].":[350],"In:":[351],"Proceedings":[352],"2018":[355,361],"San":[356,364],"Antonio":[357],"Symposium;":[360],"Dec":[362],"4-8;":[363],"Antonio,":[365],"TX.":[366],"Philadelphia":[367],"(PA):":[368],"AACR;":[369],"Res":[371],"2019;79(4":[372],"Suppl):Abstract":[373],"nr":[374],"ES8-1.":[375]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2019-05-16T00:00:00"}