{"id":"https://openalex.org/W2944145603","doi":"https://doi.org/10.1021/acs.analchem.9b00374","title":"Analysis of Conjugated Fatty Acid Isomers by the Patern\u00f2-B\u00fcchi Reaction and Trapped Ion Mobility Mass Spectrometry","display_name":"Analysis of Conjugated Fatty Acid Isomers by the Patern\u00f2-B\u00fcchi Reaction and Trapped Ion Mobility Mass Spectrometry","publication_year":2019,"publication_date":"2019-05-10","ids":{"openalex":"https://openalex.org/W2944145603","doi":"https://doi.org/10.1021/acs.analchem.9b00374","mag":"2944145603","pmid":"https://pubmed.ncbi.nlm.nih.gov/31074607"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.9b00374","doi":"https://doi.org/10.1021/acs.analchem.9b00374","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.9b00374","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022419886","display_name":"Xiaobo Xie","orcid":"https://orcid.org/0000-0001-9315-5543","observed_orcids":["https://orcid.org/0000-0001-9315-5543"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Xie","raw_affiliation_strings":["MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062534695","display_name":"Yu Xia","orcid":"https://orcid.org/0000-0001-8694-9900","observed_orcids":["https://orcid.org/0000-0001-8694-9900"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Xia","raw_affiliation_strings":["MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China"],"raw_orcid":"https://orcid.org/0000-0001-8694-9900","affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062534695"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.1904,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.93771784,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"91","issue":"11","first_page":"7173","last_page":"7180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conjugated-fatty-acids","display_name":"conjugated fatty acids","score":0.9580000042915344},{"id":"https://openalex.org/keywords/conjugated-linoleic-acid","display_name":"conjugated linoleic acid","score":0.9769999980926514},{"id":"https://openalex.org/keywords/paterno-buchi-reaction","display_name":"Patern\u00f2-B\u00fcchi reaction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/trapped-ion-mobility-spectrometry","display_name":"trapped ion mobility spectrometry","score":0.921999990940094},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.7620000243186951},{"id":"https://openalex.org/keywords/double-bond-location","display_name":"double bond location","score":0.5009999871253967},{"id":"https://openalex.org/keywords/cis-trans-isomerization","display_name":"cis-trans isomerization","score":0.6600000262260437},{"id":"https://openalex.org/keywords/regioselectivity","display_name":"regioselectivity","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.980820894241333},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6686818599700928},{"id":"https://openalex.org/C15213710","wikidata":"https://www.wikidata.org/wiki/Q904207","display_name":"Ion-mobility spectrometry","level":3,"score":0.6169103384017944},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.5595157146453857},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.49962806701660156},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.48855337500572205},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.42944058775901794},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3342428207397461},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32764625549316406},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.09149473905563354}],"mesh":[{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044243","descriptor_name":"Linoleic Acids, Conjugated","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.9b00374","doi":"https://doi.org/10.1021/acs.analchem.9b00374","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.9b00374","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:31074607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31074607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1831686664","display_name":null,"funder_award_id":"2162100-3","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3911007315","display_name":null,"funder_award_id":"21722506","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1490646316","https://openalex.org/W1840351579","https://openalex.org/W1938198361","https://openalex.org/W1966820675","https://openalex.org/W1983753556","https://openalex.org/W1984078906","https://openalex.org/W1986698362","https://openalex.org/W1991837742","https://openalex.org/W1992209802","https://openalex.org/W2001241024","https://openalex.org/W2011785272","https://openalex.org/W2021489803","https://openalex.org/W2026029711","https://openalex.org/W2030662645","https://openalex.org/W2036033244","https://openalex.org/W2045950965","https://openalex.org/W2053239212","https://openalex.org/W2054091689","https://openalex.org/W2058906815","https://openalex.org/W2059273799","https://openalex.org/W2059479765","https://openalex.org/W2077570595","https://openalex.org/W2088546850","https://openalex.org/W2138299029","https://openalex.org/W2147753992","https://openalex.org/W2223347777","https://openalex.org/W2287611448","https://openalex.org/W2330550673","https://openalex.org/W2336803069","https://openalex.org/W2507869595","https://openalex.org/W2559816299","https://openalex.org/W2572119288","https://openalex.org/W2610210647","https://openalex.org/W2624683179","https://openalex.org/W2626266454","https://openalex.org/W2738452797","https://openalex.org/W2761019098","https://openalex.org/W2767187738","https://openalex.org/W2767822344","https://openalex.org/W2795771483","https://openalex.org/W2801759026","https://openalex.org/W2883609331","https://openalex.org/W2884365761","https://openalex.org/W2894398213","https://openalex.org/W2908586978","https://openalex.org/W6609177861"],"related_works":["https://openalex.org/W1969631276","https://openalex.org/W4399770894","https://openalex.org/W7220868853","https://openalex.org/W2074214080","https://openalex.org/W1983666048","https://openalex.org/W4391139465","https://openalex.org/W2166995695","https://openalex.org/W4387844526","https://openalex.org/W2085918487","https://openalex.org/W2122104414"],"abstract_inverted_index":{"Fatty":[0],"acids":[1,12],"containing":[2],"conjugated":[3,10,29,124],"carbon-carbon":[4],"double":[5],"bonds":[6],"(C\u2550Cs),":[7],"such":[8],"as":[9],"linoleic":[11],"(CLAs),":[13],"attract":[14],"growing":[15],"research":[16],"interest":[17],"due":[18],"to":[19,64,114,123,171],"their":[20],"bioactivities":[21],"against":[22],"diabetes,":[23],"cancer,":[24],"and":[25,52,68,91,133,204],"atherosclerosis.":[26],"Analysis":[27],"of":[28,43,54,71,81,110,135,145,147,158,177,181],"fatty":[30],"acid":[31],"(CFA)":[32],"is":[33,112,169],"challenging":[34],"for":[35,87,102,164],"existing":[36],"analytical":[37],"techniques":[38],"because":[39],"it":[40],"requires":[41],"determination":[42],"geometry":[44,157],"(cis":[45],"(":[46,50],"Z)":[47,208],"vs":[48],"trans":[49],"E))":[51],"location":[53,104],"individual":[55,136],"C\u2550C.":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"developed":[61],"a":[62,215],"method":[63,77],"achieve":[65],"confident,":[66],"fast,":[67],"quantitative":[69],"analysis":[70],"CFA":[72,111],"isomers":[73,138,176],"from":[74,126],"mixtures.":[75],"This":[76],"combines":[78],"the":[79,92,107,156,185,190],"strength":[80],"trapped":[82],"ion":[83],"mobility":[84],"spectrometry":[85,100],"(TIMS)":[86],"fast":[88],"isomer":[89],"separation":[90],"Patern\u00f2-B\u00fcchi":[93],"(PB)":[94],"reaction":[95,109],"followed":[96],"by":[97],"tandem":[98],"mass":[99],"(MS/MS)":[101],"C\u2550C":[103,141,166,174,182],"determination.":[105],"Notably,":[106],"PB":[108,186],"regioselective":[113],"terminal":[115],"C\u2550Cs,":[116],"thus":[117],"forming":[118],"diagnostic":[119],"fragment":[120,129],"ions":[121,130],"unique":[122],"C\u2550Cs":[125],"PB-MS/MS.":[127],"These":[128],"facilitate":[131],"identification":[132,146],"quantitation":[134],"CLA":[137,195,197,205,217],"differing":[139],"in":[140,214],"locations,":[142],"affording":[143],"limit":[144],"1":[148],"nM.":[149],"Given":[150],"that":[151],"PB-MS/MS":[152,191],"alone":[153],"cannot":[154],"identify":[155],"C\u2550C,":[159],"TIMS":[160,168],"has":[161],"been":[162],"employed":[163],"characterizing":[165],"geometry.":[167],"capable":[170],"separate":[172],"various":[173],"geometric":[175],"CLAs,":[178],"allowing":[179],"visualization":[180],"isomerization":[183],"during":[184],"reaction.":[187],"By":[188],"coupling":[189],"with":[192],"TIMS,":[193],"two":[194],"isomers,":[196],"18:2(9":[198],"Z,11":[199],"E)":[200],"(46.9":[201],"\u00b1":[202,210],"1.1%)":[203],"18:2(10":[206],"E,12":[207],"(53.1":[209],"1.1%),":[211],"are":[212],"quantified":[213],"commercial":[216],"supplement.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-16T00:00:00"}