{"id":"https://openalex.org/W2943976937","doi":"https://doi.org/10.2147/idr.s193712","title":"Simulating moxalactam dosage for extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae using blood antimicrobial surveillance network data","display_name":"Simulating moxalactam dosage for extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae using blood antimicrobial surveillance network data","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2943976937","doi":"https://doi.org/10.2147/idr.s193712","mag":"2943976937","pmid":"https://pubmed.ncbi.nlm.nih.gov/31190908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6522843"},"language":"en","primary_location":{"id":"doi:10.2147/idr.s193712","doi":"https://doi.org/10.2147/idr.s193712","is_oa":true,"landing_page_url":"https://doi.org/10.2147/idr.s193712","pdf_url":"https://www.dovepress.com/getfile.php?fileID=49722","source":{"id":"https://openalex.org/S2765028195","display_name":"Infection and Drug Resistance","issn_l":"1178-6973","issn":["1178-6973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Drug Resistance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=49722","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085789193","display_name":"Chen Huang","orcid":"https://orcid.org/0000-0002-7092-7587","observed_orcids":["https://orcid.org/0000-0002-7092-7587","https://orcid.org/0000-0002-2072-7237","https://orcid.org/0000-0002-1840-5765"]},"institutions":[{"id":"https://openalex.org/I4210113377","display_name":"Ningbo Medical Center Lihuili Hospital","ror":"https://ror.org/030zcqn97","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113377"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Huang","raw_affiliation_strings":["Department of Respiratory Medicine, Lihuili Hospital, Ningbo Medical Center, Ningbo, People's Republic of China","State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Lihuili Hospital, Ningbo Medical Center, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I4210113377"]},{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002541045","display_name":"Qingyi Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyi Shi","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049425878","display_name":"Beiwen Zheng","orcid":"https://orcid.org/0000-0002-7690-372X","observed_orcids":["https://orcid.org/0000-0002-7690-372X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Beiwen Zheng","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-7690-372X","affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081516887","display_name":"Jinru Ji","orcid":"https://orcid.org/0000-0003-1579-2250","observed_orcids":["https://orcid.org/0000-0003-1579-2250"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinru Ji","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100654611","display_name":"Chaoqun Ying","orcid":"https://orcid.org/0000-0001-8599-3838","observed_orcids":["https://orcid.org/0000-0001-8599-3838"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoqun Ying","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061926020","display_name":"Yu Xiao","orcid":"https://orcid.org/0000-0003-2711-5070","observed_orcids":["https://orcid.org/0000-0003-2711-5070"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Yu","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460897","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0003-1450-6320","observed_orcids":["https://orcid.org/0000-0003-1450-6320"]},"institutions":[{"id":"https://openalex.org/I4210113377","display_name":"Ningbo Medical Center Lihuili Hospital","ror":"https://ror.org/030zcqn97","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113377"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":["Department of Respiratory Medicine, Lihuili Hospital, Ningbo Medical Center, Ningbo, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Lihuili Hospital, Ningbo Medical Center, Ningbo, People's Republic of China","institution_ids":["https://openalex.org/I4210113377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058306932","display_name":"Yonghong Xiao","orcid":"https://orcid.org/0000-0003-4845-5904","observed_orcids":["https://orcid.org/0000-0003-4845-5904"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yonghong Xiao","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058306932"],"corresponding_institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.1423,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.45257089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"Volume 12","issue":null,"first_page":"1199","last_page":"1208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moxalactam","display_name":"moxalactam","score":0.9810000061988831},{"id":"https://openalex.org/keywords/extended-spectrum-beta-lactamase","display_name":"extended-spectrum beta-lactamase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/esbl-producing-enterobacterales","display_name":"ESBL-producing Enterobacteriaceae","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cefepime","display_name":"cefepime","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.6890000104904175},{"id":"https://openalex.org/keywords/probability-of-target-attainment","display_name":"probability of target attainment","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cumulative-fraction-of-response","display_name":"cumulative fraction of response","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bloodstream-infection","display_name":"bloodstream infection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9179999828338623},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6959999799728394},{"id":"https://openalex.org/keywords/empirical-antibiotic-therapy","display_name":"empirical antibiotic therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2909971615","wikidata":"https://www.wikidata.org/wiki/Q3827439","display_name":"Moxalactam","level":4,"score":0.9254850149154663},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.7098860144615173},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6681714653968811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42222708463668823},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4166371822357178},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.2922026515007019},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2639217972755432},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2599602937698364},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.2267797589302063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21680042147636414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08704996109008789},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04436236619949341}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/idr.s193712","doi":"https://doi.org/10.2147/idr.s193712","is_oa":true,"landing_page_url":"https://doi.org/10.2147/idr.s193712","pdf_url":"https://www.dovepress.com/getfile.php?fileID=49722","source":{"id":"https://openalex.org/S2765028195","display_name":"Infection and Drug Resistance","issn_l":"1178-6973","issn":["1178-6973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Drug Resistance","raw_type":"journal-article"},{"id":"pmid:31190908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31190908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and drug resistance","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6522843","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6522843/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Drug Resist","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c670e5a21cf4468ca1ced5ed75ba04c7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c670e5a21cf4468ca1ced5ed75ba04c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Infection and Drug Resistance, Vol Volume 12, Pp 1199-1208 (2019)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/45692","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/simulating-moxalactam-dosage-for-extended-spectrum-beta-lactamase-prod-peer-reviewed-article-IDR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/idr.s193712","doi":"https://doi.org/10.2147/idr.s193712","is_oa":true,"landing_page_url":"https://doi.org/10.2147/idr.s193712","pdf_url":"https://www.dovepress.com/getfile.php?fileID=49722","source":{"id":"https://openalex.org/S2765028195","display_name":"Infection and Drug Resistance","issn_l":"1178-6973","issn":["1178-6973"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Drug Resistance","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F8142712028","display_name":"Key Research and Development Program of Zhejiang Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943976937.pdf","grobid_xml":"https://content.openalex.org/works/W2943976937.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W26641785","https://openalex.org/W63539545","https://openalex.org/W142136126","https://openalex.org/W1501112436","https://openalex.org/W1920090046","https://openalex.org/W1945945803","https://openalex.org/W1965050284","https://openalex.org/W1976697622","https://openalex.org/W1982202966","https://openalex.org/W1982462000","https://openalex.org/W1984775780","https://openalex.org/W1991276906","https://openalex.org/W1996438898","https://openalex.org/W1999247986","https://openalex.org/W2003127722","https://openalex.org/W2024331651","https://openalex.org/W2039118393","https://openalex.org/W2057226149","https://openalex.org/W2076322253","https://openalex.org/W2078550933","https://openalex.org/W2081491728","https://openalex.org/W2089051496","https://openalex.org/W2100783429","https://openalex.org/W2111368630","https://openalex.org/W2127308195","https://openalex.org/W2129029644","https://openalex.org/W2130820946","https://openalex.org/W2133118972","https://openalex.org/W2134906113","https://openalex.org/W2135733750","https://openalex.org/W2136501331","https://openalex.org/W2149523226","https://openalex.org/W2151135031","https://openalex.org/W2153495421","https://openalex.org/W2155512096","https://openalex.org/W2170605303","https://openalex.org/W2305526013","https://openalex.org/W2440614447","https://openalex.org/W2465656423","https://openalex.org/W2468793326","https://openalex.org/W2515879167","https://openalex.org/W2562116146","https://openalex.org/W2783531990","https://openalex.org/W2795654288","https://openalex.org/W2945792041","https://openalex.org/W2977022834","https://openalex.org/W4233044260"],"related_works":["https://openalex.org/W2783531990","https://openalex.org/W1604012476","https://openalex.org/W142136126","https://openalex.org/W2374718248","https://openalex.org/W2382595742","https://openalex.org/W6990920409","https://openalex.org/W4391109665","https://openalex.org/W2011810147","https://openalex.org/W4301502099","https://openalex.org/W2156903764"],"abstract_inverted_index":{"Objectives:":[0],"Monte":[1,262],"Carlo":[2,263],"simulation":[3],"(MCS)":[4],"was":[5,39],"used":[6,250],"to":[7,143,218,252],"evaluate":[8],"optimal":[9],"dosage":[10],"for":[11,116,169,193,208,226,232],"cefepime":[12,271],"(FEP),":[13],"moxalactam":[14],"(MOX),":[15],"and":[16,44,52,66,72,94,100,119,125,133,139,153,179,195,204,220],"cefperazone/sulbactam":[17],"(CFZ/SBT)":[18],"against":[19,121,147,186,200],"extended-spectrum":[20,267],"\u03b2-lactamase":[21],"(ESBL)":[22],"producers":[23,46,212],"isolated":[24,106],"from":[25,61,107,213],"the":[26],"Blood":[27],"Bacterial":[28],"Resistant":[29],"Investigation":[30],"Collaborative":[31],"System.":[32],"Methods":[33],":":[34],"Minimum":[35],"inhibitory":[36],"concentration":[37],"(MIC)":[38],"tested":[40],"by":[41,49,83,256],"agar":[42],"dilution,":[43],"ESBL":[45,158,211],"were":[47,59,81,105,128,197,215,223],"identified":[48],"modified":[50],"Clinical":[51],"Laboratory":[53],"Standards":[54],"Institute":[55],"tests.":[56],"Pharmacokinetic":[57],"parameters":[58],"derived":[60],"data":[62],"on":[63],"healthy":[64],"individuals,":[65],"probability":[67],"of":[68,75,88],"target":[69],"attainment":[70],"(PTA)":[71],"cumulative":[73],"fraction":[74],"response":[76],"(CFR)":[77],"%fT":[78],">MIC":[79],"values":[80,115,222],"estimated":[82],"MCS.":[84],"Results:":[85],"A":[86],"total":[87],"2032":[89],"Escherichia":[90],"coli":[91,124,189,259],"(875":[92],"ESBL-producing)":[93,98],"Klebsiella":[95],"pneumoniae":[96,127],"(157":[97],"strains,":[99,104],"371":[101],"other":[102],"Enterobacteriaceae":[103,202,265],"patients":[108],"with":[109,149],"bloodstream":[110],"infections":[111],"(BSIs).":[112],"MIC":[113],"90":[114],"FEP,":[117],"MOX,":[118,219],"CFZ/SBT":[120,140,163,231,247],"ESBL-producing":[122,187,257],"E.":[123,188,258],"K.":[126],"64/64":[129],"mg/L,":[130,132,135,155],"2/32":[131],"64/128":[134],"respectively.":[136,156],"Conventional":[137],"MOX":[138,170,196,227,242],"doses":[141],"failed":[142],"reach":[144],"90%":[145,185],"PTA":[146,221],"isolates":[148],"MICs":[150],"\u22658":[151],"mg/L":[152],"\u22654":[154],"Against":[157],"producers,":[159],"neither":[160],"FEP":[161,194,229,245],"nor":[162],"achieved":[164],"\u226590%":[165],"CFR,":[166],"while":[167],"CFRs":[168,192,207],"(1":[171],"g":[172,176,181],"iv":[173,177,182],"q6h,":[174],"2":[175,180],"q12h,":[178],"q8h)":[183],"exceeded":[184],".":[190],"Simulated":[191],"similar":[198],"(>90%)":[199],"non-ESBL-producing":[201],",":[203,266],"higher":[205,225],"than":[206,228],"CFZ/SBT.":[209],"Conclusion:":[210],"BSIs":[214,254],"highly":[216],"susceptible":[217],"generally":[224],"or":[230,246],"conventional":[233],"dosing":[234],"regimens.":[235],"This":[236],"large":[237],"MCS":[238],"analysis":[239],"shows":[240],"that":[241],"but":[243],"not":[244],"can":[248],"be":[249],"empirically":[251],"treat":[253],"caused":[255],"strains.":[260],"Keywords:":[261],"simulation,":[264],"\u03b2-lactamase,":[268],"moxalactam,":[269],"cefperazone/sulbactam,":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-16T00:00:00"}
