{"id":"https://openalex.org/W2943950583","doi":"https://doi.org/10.29219/fnr.v63.3410","title":"VMP35 MNC, a novel iron-free supplement, enhances cytoprotection against anemia in human subjects: a novel hypothesis","display_name":"VMP35 MNC, a novel iron-free supplement, enhances cytoprotection against anemia in human subjects: a novel hypothesis","publication_year":2019,"publication_date":"2019-05-09","ids":{"openalex":"https://openalex.org/W2943950583","doi":"https://doi.org/10.29219/fnr.v63.3410","mag":"2943950583","pmid":"https://pubmed.ncbi.nlm.nih.gov/31105509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6510707"},"language":"en","primary_location":{"id":"doi:10.29219/fnr.v63.3410","doi":"https://doi.org/10.29219/fnr.v63.3410","is_oa":true,"landing_page_url":"https://doi.org/10.29219/fnr.v63.3410","pdf_url":null,"source":{"id":"https://openalex.org/S199424200","display_name":"Food & Nutrition Research","issn_l":"1654-661X","issn":["1654-661X","1654-6628"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317151","host_organization_name":"Swedish Nutrition Foundation","host_organization_lineage":["https://openalex.org/P4310317151"],"host_organization_lineage_names":["Swedish Nutrition Foundation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & Nutrition Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.29219/fnr.v63.3410","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073231921","display_name":"Jean-Ronel Corbier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Ronel Corbier","raw_affiliation_strings":["Brain Restoration Clinic, A Division of Integra Wellness Center, Indian Land, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Restoration Clinic, A Division of Integra Wellness Center, Indian Land, SC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110292054","display_name":"Bernard William Downs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard William Downs","raw_affiliation_strings":["Victory Nutrition International, Inc., Department of R&D, Lederach, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victory Nutrition International, Inc., Department of R&D, Lederach, PA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103975098","display_name":"Steve W. Kushner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Kushner","raw_affiliation_strings":["ALM R&D, Oldsmar, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALM R&D, Oldsmar, FL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050496635","display_name":"Ted Aloisio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149081","display_name":"Acuitas Therapeutics (Canada)","ror":"https://ror.org/04eaec870","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210149081"]},{"id":"https://openalex.org/I4405267304","display_name":"Veristat, LLC (United States)","ror":"https://ror.org/023qnpq80","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267304"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ted Aloisio","raw_affiliation_strings":["Veritas Health Inc., Woodbridge, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veritas Health Inc., Woodbridge, ON, Canada","institution_ids":["https://openalex.org/I4210149081","https://openalex.org/I4405267304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019498762","display_name":"Debasis Bagchi","orcid":"https://orcid.org/0000-0001-9478-6427","observed_orcids":["https://orcid.org/0000-0001-9478-6427"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debasis Bagchi","raw_affiliation_strings":["Department of Pharmacological & Pharmaceutical Sciences, University of Houston college of Pharmacy, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological & Pharmaceutical Sciences, University of Houston college of Pharmacy, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025047849","display_name":"Manashi Bagchi","orcid":"https://orcid.org/0000-0002-1527-6419","observed_orcids":["https://orcid.org/0000-0002-1527-6419"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Manashi Bagchi","raw_affiliation_strings":["Dr. Herbs LLC, R&D, Concord, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Herbs LLC, R&D, Concord, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025047849"],"corresponding_institution_ids":[],"apc_list":{"value":1950,"currency":"EUR","value_usd":2103},"apc_paid":{"value":1950,"currency":"EUR","value_usd":2103},"fwci":1.5699,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.83161892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"63","issue":"0","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.8059999942779541},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.6050000190734863},{"id":"https://openalex.org/keywords/hemochromatosis","display_name":"hemochromatosis","score":0.871999979019165},{"id":"https://openalex.org/keywords/hemorheology","display_name":"hemorheology","score":0.6899999976158142},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.7509999871253967},{"id":"https://openalex.org/keywords/histidine","display_name":"histidine","score":0.6179999709129333},{"id":"https://openalex.org/keywords/nutraceutical-supplement","display_name":"nutraceutical supplement","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.7623062133789062},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5763668417930603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49142515659332275},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35070517659187317},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34799832105636597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3229506015777588},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24480915069580078},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.11730113625526428}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.29219/fnr.v63.3410","doi":"https://doi.org/10.29219/fnr.v63.3410","is_oa":true,"landing_page_url":"https://doi.org/10.29219/fnr.v63.3410","pdf_url":null,"source":{"id":"https://openalex.org/S199424200","display_name":"Food & Nutrition Research","issn_l":"1654-661X","issn":["1654-661X","1654-6628"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317151","host_organization_name":"Swedish Nutrition Foundation","host_organization_lineage":["https://openalex.org/P4310317151"],"host_organization_lineage_names":["Swedish Nutrition Foundation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & Nutrition Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6510707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6510707","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Nutr Res","raw_type":"Text"},{"id":"pmid:31105509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31105509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & nutrition research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cbb816ebe1584f97a776a4e39826d26e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cbb816ebe1584f97a776a4e39826d26e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food & Nutrition Research, Vol 63, Iss 0, Pp 1-10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.29219/fnr.v63.3410","doi":"https://doi.org/10.29219/fnr.v63.3410","is_oa":true,"landing_page_url":"https://doi.org/10.29219/fnr.v63.3410","pdf_url":null,"source":{"id":"https://openalex.org/S199424200","display_name":"Food & Nutrition Research","issn_l":"1654-661X","issn":["1654-661X","1654-6628"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317151","host_organization_name":"Swedish Nutrition Foundation","host_organization_lineage":["https://openalex.org/P4310317151"],"host_organization_lineage_names":["Swedish Nutrition Foundation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food & Nutrition Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W56635258","https://openalex.org/W1510835874","https://openalex.org/W1547764162","https://openalex.org/W1549872517","https://openalex.org/W1576551594","https://openalex.org/W1588378362","https://openalex.org/W1966792207","https://openalex.org/W1969021588","https://openalex.org/W2000031904","https://openalex.org/W2010015133","https://openalex.org/W2014865621","https://openalex.org/W2024589065","https://openalex.org/W2035675177","https://openalex.org/W2054975571","https://openalex.org/W2063145992","https://openalex.org/W2092787133","https://openalex.org/W2108837029","https://openalex.org/W2114266222","https://openalex.org/W2115312495","https://openalex.org/W2121273614","https://openalex.org/W2123200029","https://openalex.org/W2124571377","https://openalex.org/W2140319435","https://openalex.org/W2173906027","https://openalex.org/W2316618576","https://openalex.org/W2330912863","https://openalex.org/W2358153020","https://openalex.org/W2398156854","https://openalex.org/W2419237011","https://openalex.org/W2563186820","https://openalex.org/W2610785983","https://openalex.org/W2746106229","https://openalex.org/W2768169449","https://openalex.org/W2900713076","https://openalex.org/W2913038357","https://openalex.org/W3048856955","https://openalex.org/W4299414395"],"related_works":["https://openalex.org/W3029918273","https://openalex.org/W2949071371","https://openalex.org/W3017306404","https://openalex.org/W3011115596","https://openalex.org/W3159527982","https://openalex.org/W4210523958","https://openalex.org/W2612433813","https://openalex.org/W2411086952","https://openalex.org/W2150368236","https://openalex.org/W3108998641"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,95],"American":[2],"Society":[3],"of":[4,36,51,82,98,109,124,131,143,158,208,214,236,281,289],"Hematology":[5],"reported":[6,41],"that":[7,42],"according":[8],"to":[9,63,138,168,176,204,332],"the":[10,20,33,48,122,165,206,274,301,334],"National":[11],"Heart,":[12],"Lung,":[13],"and":[14,70,73,111,155,210,283,311],"Blood":[15],"Institute":[16],"(NHLBI)":[17],"anemia":[18,45,77,99,102],"is":[19,47,60,100,106,150],"most":[21],"common":[22],"blood":[23,90,144,159,213,246,255,309],"disorder,":[24],"which":[25,53,84,105,291],"affects":[26,54],"more":[27],"than":[28],"3":[29],"million":[30],"Americans,":[31],"while":[32],"Global":[34],"Burden":[35],"Disease":[37],"2016":[38],"(GBD":[39],"2016)":[40],"iron":[43,149],"deficiency":[44],"(IDA)":[46],"leading":[49],"cause":[50],"anemia,":[52],"1.93":[55],"billion":[56],"people":[57],"worldwide.":[58],"Anemia":[59],"intricately":[61],"linked":[62],"chronic":[64,66,101,112],"inflammation,":[65],"kidney":[67],"disease,":[68],"gastrointestinal":[69],"gynecological":[71],"malignancies,":[72],"autoimmune":[74],"disorders.":[75],"Hemorrhagic":[76],"results":[78],"in":[79,88,134,191,244,273,308,330],"substantial":[80],"loss":[81],"blood,":[83,275],"causes":[85],"significant":[86],"alterations":[87],"all":[89],"parameters,":[91],"including":[92,276],"reduced":[93],"iron.":[94],"other":[96,162],"type":[97],"syndrome":[103],"(CAS),":[104],"a":[107,128,140,219,234],"constellation":[108],"disorders":[110],"inflammatory":[113],"events":[114,264,323],"caused":[115,270],"by":[116],"an":[117],"increasing":[118],"anaerobic/acidic":[119],"environment":[120],"(promoting":[121],"growth":[123],"anaerobic":[125],"organisms),":[126],"inducing":[127],"defensive":[129],"expenditure":[130],"alkalinizing":[132],"buffers":[133],"hemoglobin":[135],"(i.e.":[136],"histidine),":[137],"prevent":[139],"dangerous":[141],"lowering":[142],"pH.":[145],"In":[146],"this":[147],"process,":[148],"cleaved":[151],"from":[152,248],"heme":[153],"groups":[154],"transferred":[156],"out":[157],"circulation":[160],"into":[161],"organs,":[163],"like":[164],"liver,":[166],"appearing":[167],"be":[169],"IDA,":[170],"where":[171],"excessive":[172],"accumulation":[173],"can":[174,305],"lead":[175],"hemochromatosis,":[177],"also":[178],"known":[179],"as":[180],"'iron":[181],"overload":[182],"anemia'.":[183],"DESIGN:":[184],"A":[185],"pilot":[186],"clinical":[187],"study":[188],"was":[189],"conducted":[190],"38":[192,249],"subjects":[193,250,315],"(men":[194],"=":[195,198,201],"10;":[196],"women":[197],"28;":[199],"age":[200],"22-82":[202],"years)":[203],"evaluate":[205],"rate":[207],"absorption":[209],"effects":[211],"on":[212],"VMP35":[215,230,269,304],"multi-nutrient":[216],"complex":[217],"(MNC),":[218],"non-iron":[220,302],"containing":[221,303],"liquid":[222],"nutraceutical":[223],"supplement.":[224],"Subjects":[225],"consumed":[226],"either":[227],"placebo":[228],"or":[229,239],"(30":[231],"mL)":[232],"over":[233],"period":[235],"0,":[237],"5,":[238],"30":[240,297],"min.":[241,298],"METHODS:":[242],"Changes":[243],"peripheral":[245],"smears":[247],"were":[251,265,292,324],"observed":[252],"using":[253],"live":[254],"cell":[256],"imaging":[257],"(LBCI)":[258],"with":[259,317],"phase":[260],"contrast":[261],"microscopy.":[262],"Adverse":[263],"rigorously":[266],"monitored.":[267],"RESULTS:":[268],"positive":[271],"changes":[272,285],"morphological,":[277],"hematological":[278],"(including":[279],"restoration":[280],"hemoglobin),":[282],"rheological":[284],"following":[286],"5":[287],"min":[288],"administration,":[290],"sustained":[293],"for":[294,314],"at":[295],"least":[296],"CONCLUSION:":[299],"Overall,":[300],"induce":[306],"improvements":[307],"properties":[310],"potential":[312],"benefits":[313],"even":[316],"compromised":[318],"digestive":[319],"systems.":[320],"No":[321],"adverse":[322],"reported.":[325],"Further":[326],"research":[327],"studies":[328],"are":[329],"progress":[331],"explore":[333],"mechanistic":[335],"insight.":[336]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-16T00:00:00"}