{"id":"https://openalex.org/W2943849032","doi":"https://doi.org/10.1093/nar/gkz344","title":"c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer","display_name":"c-MYC empowers transcription and productive splicing of the oncogenic splicing factor Sam68 in cancer","publication_year":2019,"publication_date":"2019-04-24","ids":{"openalex":"https://openalex.org/W2943849032","doi":"https://doi.org/10.1093/nar/gkz344","mag":"2943849032","pmid":"https://pubmed.ncbi.nlm.nih.gov/31066450","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614821"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkz344","doi":"https://doi.org/10.1093/nar/gkz344","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz344","pdf_url":"https://academic.oup.com/nar/article-pdf/47/12/6160/28917037/gkz344.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/47/12/6160/28917037/gkz344.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086430166","display_name":"Cinzia Caggiano","orcid":"https://orcid.org/0000-0002-2381-1848","observed_orcids":["https://orcid.org/0000-0002-2381-1848"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Caggiano","raw_affiliation_strings":["Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061164548","display_name":"Marco Pieraccioli","orcid":"https://orcid.org/0000-0003-3995-535X","observed_orcids":["https://orcid.org/0000-0003-3995-535X"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Pieraccioli","raw_affiliation_strings":["Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034779699","display_name":"Valentina Panzeri","orcid":"https://orcid.org/0000-0002-8930-7222","observed_orcids":["https://orcid.org/0000-0002-8930-7222"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Panzeri","raw_affiliation_strings":["Department of Science medical/chirurgic and translational medicine, University of Rome Sapienza,00189 Rome, Italy","Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science medical/chirurgic and translational medicine, University of Rome Sapienza,00189 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020418933","display_name":"Claudio Sette","orcid":"https://orcid.org/0000-0003-2864-8266","observed_orcids":["https://orcid.org/0000-0003-2864-8266"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudio Sette","raw_affiliation_strings":["Institute of Human Anatomy and Cell Biology, Catholic University of the Sacred Hearth, 00168\u00a0Rome, Italy","Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Anatomy and Cell Biology, Catholic University of the Sacred Hearth, 00168\u00a0Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058431645","display_name":"Pamela Bielli","orcid":"https://orcid.org/0000-0003-3347-8345","observed_orcids":["https://orcid.org/0000-0003-3347-8345"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pamela Bielli","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133\u00a0Rome, Italy","Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3347-8345","affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133\u00a0Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Laboratory of Neuroembryology, IRCCS Fondazione Santa Lucia, 00143\u00a0Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020418933","https://openalex.org/A5058431645"],"corresponding_institution_ids":["https://openalex.org/I103320735","https://openalex.org/I116067653","https://openalex.org/I4210150112"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.9045,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.86541156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"47","issue":"12","first_page":"6160","last_page":"6171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sam68","display_name":"Sam68","score":0.9300000071525574},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/splicing","display_name":"splicing","score":0.5299999713897705},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.5590000152587891},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mitogens","display_name":"mitogens","score":0.9580000042915344},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9391368627548218},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7795103788375854},{"id":"https://openalex.org/C73758832","wikidata":"https://www.wikidata.org/wiki/Q7578564","display_name":"Splicing factor","level":5,"score":0.6432257890701294},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6383911371231079},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6039571762084961},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5279135704040527},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4605720341205597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4074374735355377},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3878578841686249},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3493671119213104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32994747161865234},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.2652789056301117},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12458187341690063},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034541","descriptor_name":"Heterogeneous-Nuclear Ribonucleoprotein Group F-H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061805","descriptor_name":"Transcription Elongation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/nar/gkz344","doi":"https://doi.org/10.1093/nar/gkz344","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz344","pdf_url":"https://academic.oup.com/nar/article-pdf/47/12/6160/28917037/gkz344.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5588816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614821","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6614821","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6614821","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:31066450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31066450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1337925","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1337925","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1337925/1/Caggiano_c-MYC-empowers-transcription_2019.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:art.torvergata.it:2108/231873","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/231873","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publicatt.unicatt.it:10807/136128","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10807/136128","pdf_url":null,"source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkz344","doi":"https://doi.org/10.1093/nar/gkz344","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkz344","pdf_url":"https://academic.oup.com/nar/article-pdf/47/12/6160/28917037/gkz344.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1630142887","display_name":null,"funder_award_id":"RF-2016-02363460.","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2372857201","display_name":null,"funder_award_id":"GR-2011-02348423","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G5486568802","display_name":null,"funder_award_id":"IG18790","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943849032.pdf","grobid_xml":"https://content.openalex.org/works/W2943849032.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1263857580","https://openalex.org/W1520966126","https://openalex.org/W1553178519","https://openalex.org/W1883773314","https://openalex.org/W1966559042","https://openalex.org/W1971993554","https://openalex.org/W1973861733","https://openalex.org/W1977846477","https://openalex.org/W1998566859","https://openalex.org/W1999343166","https://openalex.org/W2001327335","https://openalex.org/W2004071564","https://openalex.org/W2016762377","https://openalex.org/W2021536610","https://openalex.org/W2026506733","https://openalex.org/W2027701384","https://openalex.org/W2048255587","https://openalex.org/W2051604556","https://openalex.org/W2056138285","https://openalex.org/W2061657172","https://openalex.org/W2062348957","https://openalex.org/W2072954540","https://openalex.org/W2074097219","https://openalex.org/W2075555151","https://openalex.org/W2081141657","https://openalex.org/W2089601677","https://openalex.org/W2098010370","https://openalex.org/W2105037453","https://openalex.org/W2107633226","https://openalex.org/W2109732750","https://openalex.org/W2113623044","https://openalex.org/W2115803553","https://openalex.org/W2120600865","https://openalex.org/W2122358139","https://openalex.org/W2129214044","https://openalex.org/W2130191776","https://openalex.org/W2135229538","https://openalex.org/W2135798683","https://openalex.org/W2140073418","https://openalex.org/W2152566759","https://openalex.org/W2157936723","https://openalex.org/W2163939306","https://openalex.org/W2167212154","https://openalex.org/W2340151486","https://openalex.org/W2515668871","https://openalex.org/W2549890733","https://openalex.org/W2570618306","https://openalex.org/W2588930356","https://openalex.org/W2604710533","https://openalex.org/W2617241572","https://openalex.org/W2804202174","https://openalex.org/W2902200003"],"related_works":["https://openalex.org/W1973861733","https://openalex.org/W1534005970","https://openalex.org/W7096443934","https://openalex.org/W2015945652","https://openalex.org/W2163939306","https://openalex.org/W2072954540","https://openalex.org/W1996871750","https://openalex.org/W2278288743","https://openalex.org/W2096967258","https://openalex.org/W6922819728"],"abstract_inverted_index":{"The":[0],"splicing":[1,85,127],"factor":[2,54],"Sam68":[3,47,61,65,79,89,104,129],"is":[4,105],"upregulated":[5],"in":[6,22,28,69,138],"many":[7],"human":[8],"cancers,":[9],"including":[10],"prostate":[11],"cancer":[12],"(PCa)":[13],"where":[14],"it":[15],"promotes":[16],"cell":[17],"proliferation":[18],"and":[19,50,66,76,126],"survival.":[20],"Nevertheless,":[21],"spite":[23],"of":[24,45,60,64,86,103,110,124,128],"its":[25,33],"frequent":[26],"upregulation":[27],"cancer,":[29],"the":[30,42,46,51,78,87,93,98,107],"mechanism(s)":[31],"underlying":[32],"expression":[34,102],"are":[35],"largely":[36],"unknown.":[37],"Herein,":[38],"bioinformatics":[39],"analyses":[40],"identified":[41],"promoter":[43],"region":[44],"gene":[48],"(KHDRBS1)":[49],"proto-oncogenic":[52],"transcription":[53,125],"c-MYC":[55,67,72,82],"as":[56,114],"a":[57,135],"key":[58,136],"regulator":[59],"expression.":[62],"Upregulation":[63],"correlate":[68],"PCa":[70,139],"patients.":[71],"directly":[73],"binds":[74],"to":[75],"activates":[77],"promoter.":[80],"Furthermore,":[81],"affects":[83],"productive":[84],"nascent":[88],"transcript":[90],"by":[91,130],"modulating":[92],"transcriptional":[94],"elongation":[95],"rate":[96],"within":[97],"gene.":[99],"Importantly,":[100],"c-MYC-dependent":[101],"under":[106],"tight":[108],"control":[109],"external":[111],"cues,":[112],"such":[113],"androgens":[115],"and/or":[116],"mitogens.":[117],"These":[118],"findings":[119],"uncover":[120],"an":[121],"unexpected":[122],"coordination":[123],"c-MYC,":[131],"which":[132],"may":[133],"represent":[134],"step":[137],"tumorigenesis.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-05-16T00:00:00"}