{"id":"https://openalex.org/W2943839432","doi":"https://doi.org/10.1158/1538-7445.am2012-3348","title":"Abstract 3348: Pax8-PPAR\u03b4 fusion protein activates \u03b2-catenin/TCF pathways","display_name":"Abstract 3348: Pax8-PPAR\u03b4 fusion protein activates \u03b2-catenin/TCF pathways","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2943839432","doi":"https://doi.org/10.1158/1538-7445.am2012-3348","mag":"2943839432"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-3348","doi":"https://doi.org/10.1158/1538-7445.am2012-3348","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3348","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071042537","display_name":"Dang L. Vu-Phan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dang L. Vu-Phan","raw_affiliation_strings":["1University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101525462","display_name":"Jingcheng Yu","orcid":"https://orcid.org/0000-0003-0222-5046","observed_orcids":["https://orcid.org/0000-0003-0222-5046"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingcheng Yu","raw_affiliation_strings":["1University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088948001","display_name":"Ronald J. Koenig","orcid":"https://orcid.org/0000-0003-0021-4976","observed_orcids":["https://orcid.org/0000-0003-0021-4976"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald J. Koenig","raw_affiliation_strings":["1University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max S. Wicha","raw_affiliation_strings":["1University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"3348","last_page":"3348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4235999882221222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/beta-catenin-tcf-signaling","display_name":"beta-catenin/TCF signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ppardelta-agonist","display_name":"PPAR\u03b4 agonist","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6589999794960022},{"id":"https://openalex.org/keywords/anchorage-independent-colony-formation","display_name":"anchorage-independent colony formation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/single-cell-sorting","display_name":"single-cell sorting","score":0.6079999804496765},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.574999988079071},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.503000020980835},{"id":"https://openalex.org/keywords/fusion-oncogenes","display_name":"fusion oncogenes","score":0.4650000035762787},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7345373630523682},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6484807133674622},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6252070665359497},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.6061647534370422},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5561705231666565},{"id":"https://openalex.org/C124224327","wikidata":"https://www.wikidata.org/wiki/Q21120164","display_name":"PAX8","level":4,"score":0.4910242557525635},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39550256729125977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12323972582817078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11947834491729736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08422321081161499},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07664623856544495},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-3348","doi":"https://doi.org/10.1158/1538-7445.am2012-3348","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3348","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389311134","https://openalex.org/W2054531656","https://openalex.org/W1523746131","https://openalex.org/W2016682658","https://openalex.org/W2096015981","https://openalex.org/W2106625264","https://openalex.org/W2149567093","https://openalex.org/W2139993696","https://openalex.org/W2477731438","https://openalex.org/W2567691285"],"abstract_inverted_index":{"Abstract":[0],"Pax8-PPAR\u03b4":[1],"Fusion":[2],"Protein":[3],"(PPFP)":[4],"occurs":[5],"in":[6,15,37,148,237],"\u223c35%":[7],"of":[8,13,46,73,123,259,271,297,302],"follicular":[9],"thyroid":[10,19,59,136],"carcinomas.":[11],"Expression":[12],"PPFP":[14,41,56,113,134,238,277],"the":[16,25,27,44,121,143,149,218,234,242,257,284,298,303],"non-transformed":[17],"rat":[18],"cell":[20,60,84,115,130,152,286],"line":[21],"PCCL3":[22,58],"conferred":[23],"on":[24,279],"cells":[26,47,76,89,106,126,137,141,158,178,188,198,268,274],"ability":[28],"to":[29,34,80,92,128,161,246,282],"invade":[30],"through":[31],"matrigel":[32],"and":[33,55,77,107,169,275],"form":[35],"colonies":[36],"anchorage":[38,194],"independent":[39,195],"conditions.":[40],"also":[42],"increased":[43,233],"percentage":[45,122],"that":[48,265,276],"have":[49,269],"activated":[50],"\u03b2-catenin/TCF.":[51],"We":[52,68],"transfected":[53,83],"control":[54,129,223],"expressing":[57,114,135,239],"lines":[61,116],"with":[62,97,226,253],"two":[63],"different":[64],"\u03b2-catenin/TCF-GFP":[65],"reporter":[66],"systems.":[67],"then":[69],"sorted":[70],"a":[71,93,98],"population":[72,96,236,281],"GFP":[74,87,102,108,124,132,186,200,205],"positive":[75,88,125,133,187,206],"expanded":[78],"them":[79],"obtain":[81],"100%":[82],"lines.":[85,131,153],"These":[86,262],"gave":[90,159],"rise":[91,160],"new":[94],"heterogenous":[95,162],"stable":[99],"equilibrium":[100],"between":[101],"positive,":[103],"\u03b2-catenin/TCF":[104,110,155,167,176,235,249,266],"active":[105,156,168,250,267],"negative,":[109],"inactive":[111,177],"cells.":[112,171,224,240,251],"contained":[117],"more":[118,211],"than":[119,199,213],"twice":[120,190],"compared":[127],"were":[138,189,208,244],"enriched":[139,192],"for":[140,193,306],"exhibiting":[142],"transformed":[144],"phenotypes":[145],"previously":[146],"observed":[147],"unsorted,":[150],"untransfected":[151],"Sorted":[154],"single":[157],"clonal":[163],"populations":[164,173,183,247],"containing":[165,248],"both":[166],"negative":[170,201,214],"Clonal":[172,182],"derived":[174,184],"from":[175,185],"remained":[179],"purely":[180],"negative.":[181],"as":[191,222],"colony":[196],"forming":[197],"clones.":[202],"More":[203],"strikingly,":[204],"clones":[207],"5-10":[209],"times":[210],"invasive":[212,220],"clones,":[215],"which":[216],"exhibited":[217],"same":[219],"potential":[221],"Treatment":[225],"PPAR\u03b4":[227,254,260],"full":[228],"or":[229],"partial":[230],"agonists":[231],"further":[232],"Again,":[241],"effects":[243,258],"confined":[245],"Co-treatment":[252],"antagonists":[255],"reversed":[256],"agonists.":[261],"data":[263],"suggest":[264],"properties":[270],"cancer":[272],"stem":[273,285],"acts":[278],"this":[280],"expand":[283],"like":[287],"fraction.":[288],"Citation":[289],"Format:":[290],"{Authors}.":[291],"{Abstract":[292],"title}":[293],"[abstract].":[294],"In:":[295],"Proceedings":[296],"103rd":[299],"Annual":[300],"Meeting":[301],"American":[304],"Association":[305],"Cancer":[307,318],"Research;":[308],"2012":[309],"Mar":[310],"31-Apr":[311],"4;":[312],"Chicago,":[313],"IL.":[314],"Philadelphia":[315],"(PA):":[316],"AACR;":[317],"Res":[319],"2012;72(8":[320],"Suppl):Abstract":[321],"nr":[322],"3348.":[323],"doi:1538-7445.AM2012-3348":[324]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-05-16T00:00:00"}