{"id":"https://openalex.org/W2943787231","doi":"https://doi.org/10.3390/toxics7020026","title":"The Associations between Immunological Reactivity to the Haptenation of Unconjugated Bisphenol A to Albumin and Protein Disulfide Isomerase with Alpha-Synuclein Antibodies","display_name":"The Associations between Immunological Reactivity to the Haptenation of Unconjugated Bisphenol A to Albumin and Protein Disulfide Isomerase with Alpha-Synuclein Antibodies","publication_year":2019,"publication_date":"2019-05-06","ids":{"openalex":"https://openalex.org/W2943787231","doi":"https://doi.org/10.3390/toxics7020026","mag":"2943787231","pmid":"https://pubmed.ncbi.nlm.nih.gov/31064082","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6630361"},"language":"en","primary_location":{"id":"doi:10.3390/toxics7020026","doi":"https://doi.org/10.3390/toxics7020026","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/toxics7020026","pdf_url":"https://www.mdpi.com/2305-6304/7/2/26/pdf?version=1557130509","source":{"id":"https://openalex.org/S2738661068","display_name":"Toxics","issn_l":"2305-6304","issn":["2305-6304"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2305-6304/7/2/26/pdf?version=1557130509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058904258","display_name":"Datis Kharrazian","orcid":"https://orcid.org/0000-0001-7985-476X","observed_orcids":["https://orcid.org/0000-0001-7985-476X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Datis Kharrazian","raw_affiliation_strings":["Department of Preventive Medicine, Loma Linda University School of Medicine, 24785 Stewart Street, Loma Linda, CA 92354, USA","Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA","TRANSCEND Research Laboratory, Department of Neurology, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA"],"raw_orcid":"https://orcid.org/0000-0001-7985-476X","affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Loma Linda University School of Medicine, 24785 Stewart Street, Loma Linda, CA 92354, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"TRANSCEND Research Laboratory, Department of Neurology, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074539208","display_name":"Martha R. Herbert","orcid":"https://orcid.org/0000-0002-3775-5488","observed_orcids":["https://orcid.org/0000-0002-3775-5488"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Herbert","raw_affiliation_strings":["Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA","TRANSCEND Research Laboratory, Department of Neurology, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"TRANSCEND Research Laboratory, Department of Neurology, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017537703","display_name":"Aristo Vojdani","orcid":"https://orcid.org/0000-0003-2925-9334","observed_orcids":["https://orcid.org/0000-0003-2925-9334"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210124820","display_name":"Immunosciences Lab (United States)","ror":"https://ror.org/030gh7x86","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124820"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aristo Vojdani","raw_affiliation_strings":["Department of Preventive Medicine, Loma Linda University School of Medicine, 24785 Stewart Street, Loma Linda, CA 92354, USA","Immunosciences Lab., Inc., 822 S. Robertson Boulevard, Suite 312, Los Angeles, CA 90035, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Loma Linda University School of Medicine, 24785 Stewart Street, Loma Linda, CA 92354, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Immunosciences Lab., Inc., 822 S. Robertson Boulevard, Suite 312, Los Angeles, CA 90035, USA","institution_ids":["https://openalex.org/I4210124820"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058904258"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I26347476","https://openalex.org/I4210087915"],"apc_list":{"value":1000,"currency":"CHF","value_usd":1013},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1013},"fwci":0.4982,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.62177881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"2","first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.24070000648498535,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.9660000205039978},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/protein-disulfide-isomerase","display_name":"protein disulfide isomerase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7289999723434448},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.9020000100135803},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.7099999785423279},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.8184887170791626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7002686262130737},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.6585761904716492},{"id":"https://openalex.org/C5098756","wikidata":"https://www.wikidata.org/wiki/Q1641611","display_name":"Protein disulfide-isomerase","level":3,"score":0.6394577026367188},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.5770634412765503},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4587661623954773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45171383023262024},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4254201352596283},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3203498125076294},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31774789094924927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1876794695854187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17303600907325745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1428597867488861},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.12334075570106506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09795266389846802},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/toxics7020026","doi":"https://doi.org/10.3390/toxics7020026","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/toxics7020026","pdf_url":"https://www.mdpi.com/2305-6304/7/2/26/pdf?version=1557130509","source":{"id":"https://openalex.org/S2738661068","display_name":"Toxics","issn_l":"2305-6304","issn":["2305-6304"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5646600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6630361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31064082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31064082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6630361","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6630361/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b9780bef9eb343d3a11425a7050b2e51","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b9780bef9eb343d3a11425a7050b2e51","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxics, Vol 7, Iss 2, p 26 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/toxics7020026","doi":"https://doi.org/10.3390/toxics7020026","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/toxics7020026","pdf_url":"https://www.mdpi.com/2305-6304/7/2/26/pdf?version=1557130509","source":{"id":"https://openalex.org/S2738661068","display_name":"Toxics","issn_l":"2305-6304","issn":["2305-6304"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943787231.pdf","grobid_xml":"https://content.openalex.org/works/W2943787231.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1540839441","https://openalex.org/W1579132652","https://openalex.org/W1606001397","https://openalex.org/W1970864084","https://openalex.org/W1991663668","https://openalex.org/W2001712775","https://openalex.org/W2009214097","https://openalex.org/W2021696080","https://openalex.org/W2041444194","https://openalex.org/W2067753015","https://openalex.org/W2082907050","https://openalex.org/W2102577321","https://openalex.org/W2118790362","https://openalex.org/W2127567198","https://openalex.org/W2162830803","https://openalex.org/W2164627569","https://openalex.org/W2165339984","https://openalex.org/W2170550655","https://openalex.org/W2172071810","https://openalex.org/W2258458588","https://openalex.org/W2345979337","https://openalex.org/W2508534590","https://openalex.org/W2510621258","https://openalex.org/W2519843859","https://openalex.org/W2521063020","https://openalex.org/W2549535102","https://openalex.org/W2562788054","https://openalex.org/W2754056008","https://openalex.org/W2754143932"],"related_works":["https://openalex.org/W2519843859","https://openalex.org/W3035614161","https://openalex.org/W3190440911","https://openalex.org/W2754143932","https://openalex.org/W2894856023","https://openalex.org/W1579132652","https://openalex.org/W1600451809","https://openalex.org/W2019420266","https://openalex.org/W2916083029","https://openalex.org/W2921523577"],"abstract_inverted_index":{"Patients":[0],"with":[1],"Parkinson\u2019s":[2],"disease":[3],"(PD)":[4],"have":[5,15,25],"increased":[6,40],"susceptibility":[7],"to":[8,20,32,36,45,47,62,75,86,109,116,140,148,199],"bisphenol":[9],"A":[10],"(BPA)":[11],"exposure":[12],"since":[13],"they":[14],"an":[16],"impaired":[17],"biotransformation":[18],"capacity":[19],"metabolize":[21],"BPA.":[22],"PD":[23],"subjects":[24],"reduced":[26],"levels":[27,164,181],"of":[28,69,81,105,144,157,165,182],"conjugated":[29],"BPA":[30,38,44,60,114],"compared":[31],"controls.":[33],"Reduced":[34],"ability":[35,80],"conjugate":[37],"provides":[39],"opportunity":[41],"for":[42,177,205],"unconjugated":[43,59,113,166],"bind":[46],"albumin":[48,119],"in":[49,154],"human":[50,117],"serum":[51,118],"and":[52,78,122,125,132,151,174,195,202],"protein":[53,73,76,85],"disulfide":[54],"isomerase":[55],"on":[56],"neurons.":[57],"Once":[58,91],"binds":[61],"proteins,":[63],"it":[64],"changes":[65],"the":[66,70,79,82,96,142,155],"allosteric":[67],"structure":[68],"newly":[71,83],"configured":[72,84],"leading":[74],"misfolding":[77],"act":[87],"as":[88],"a":[89],"neoantigen.":[90],"this":[92],"neoantigen":[93],"is":[94],"formed,":[95],"immune":[97],"system":[98],"produces":[99],"antibodies":[100,121,124,131,147,153,168,171,184,198,204],"against":[101],"it.":[102],"The":[103],"goal":[104],"our":[106],"research":[107],"was":[108,138],"investigate":[110],"associations":[111,194],"between":[112,126,197],"bound":[115],"(BPA\u2013HSA)":[120],"alpha-synuclein":[123,133,145,183,207],"Protein":[127],"Disulfide":[128],"Isomerase":[129],"(PDI)":[130],"antibodies.":[134,208],"Enzyme\u2013linked":[135],"immunosorbent":[136],"assay":[137],"used":[139],"determine":[141],"occurrences":[143],"antibodies,":[146],"BPA\u2013HSA":[149,167,200],"adducts,":[150],"PDI":[152,170,203],"sera":[156],"blood":[158],"donors.":[159],"Subjects":[160],"that":[161,190],"exhibited":[162],"high":[163,180],"or":[169],"had":[172],"correlations":[173],"substantial":[175],"risk":[176],"also":[178],"exhibiting":[179],"(p":[185],"<":[186],"0.0001).":[187],"We":[188],"conclude":[189],"there":[191],"are":[192],"significant":[193],"risks":[196],"adducts":[201],"developing":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-09T00:00:00"}