{"id":"https://openalex.org/W2943774115","doi":null,"title":"Long-Term Effects of Juvenile NMDAr or DAr Antagonism on Adolescent Reward-Related Neurobehavioral Outcomes","display_name":"Long-Term Effects of Juvenile NMDAr or DAr Antagonism on Adolescent Reward-Related Neurobehavioral Outcomes","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2943774115","mag":"2943774115"},"language":"en","primary_location":{"id":"mag:2943774115","doi":null,"is_oa":false,"landing_page_url":"https://curve.carleton.ca/system/files/etd/896e81e0-a774-419f-9237-e52ea2cf0274/etd_pdf/17ae87af62e96ebf0881677dd452e6a9/goheen-longtermeffectsofjuvenilenmdarordarantagonism.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037833022","display_name":"Kristin Goheen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katherine Frances Goheen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037833022"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04038473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor-antagonism","display_name":"NMDA receptor antagonism","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dopamine-receptor-antagonism","display_name":"dopamine receptor antagonism","score":0.953000009059906},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.8339999914169312},{"id":"https://openalex.org/keywords/flupenthixol","display_name":"flupenthixol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/operant-conditioning","display_name":"operant conditioning","score":0.8149999976158142},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.718999981880188},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.7160000205039978},{"id":"https://openalex.org/keywords/spine-density","display_name":"spine density","score":0.6629999876022339},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.7820000052452087},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9440000057220459},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/critical-period","display_name":"critical period","score":0.5690000057220459},{"id":"https://openalex.org/keywords/spatial-performance","display_name":"spatial performance","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.7609222531318665},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6598849296569824},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6252879500389099},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5849897861480713},{"id":"https://openalex.org/C2777836312","wikidata":"https://www.wikidata.org/wiki/Q4386371","display_name":"Dizocilpine","level":4,"score":0.5454713106155396},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.4686015844345093},{"id":"https://openalex.org/C2778258207","wikidata":"https://www.wikidata.org/wiki/Q600203","display_name":"Dopamine agonist","level":4,"score":0.441321462392807},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.43384185433387756},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.43381983041763306},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.427891343832016},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4245492219924927},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37371379137039185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32902592420578003},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28572899103164673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26313430070877075},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10785022377967834}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2943774115","doi":null,"is_oa":false,"landing_page_url":"https://curve.carleton.ca/system/files/etd/896e81e0-a774-419f-9237-e52ea2cf0274/etd_pdf/17ae87af62e96ebf0881677dd452e6a9/goheen-longtermeffectsofjuvenilenmdarordarantagonism.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":203,"referenced_works":["https://openalex.org/W53896497","https://openalex.org/W162223338","https://openalex.org/W264724675","https://openalex.org/W904184522","https://openalex.org/W1481125086","https://openalex.org/W1485072543","https://openalex.org/W1504292391","https://openalex.org/W1538762724","https://openalex.org/W1546941611","https://openalex.org/W1557933310","https://openalex.org/W1607644643","https://openalex.org/W1617042306","https://openalex.org/W1647678806","https://openalex.org/W1652403437","https://openalex.org/W1690644297","https://openalex.org/W1831515958","https://openalex.org/W1880531314","https://openalex.org/W1897169513","https://openalex.org/W1910298002","https://openalex.org/W1914381346","https://openalex.org/W1963868046","https://openalex.org/W1965270259","https://openalex.org/W1968024448","https://openalex.org/W1968146372","https://openalex.org/W1968950270","https://openalex.org/W1969134234","https://openalex.org/W1969212890","https://openalex.org/W1970580463","https://openalex.org/W1971612884","https://openalex.org/W1971999279","https://openalex.org/W1976063610","https://openalex.org/W1976503128","https://openalex.org/W1978674818","https://openalex.org/W1978726402","https://openalex.org/W1978748886","https://openalex.org/W1980938183","https://openalex.org/W1981077446","https://openalex.org/W1981091199","https://openalex.org/W1982864908","https://openalex.org/W1983348906","https://openalex.org/W1983721187","https://openalex.org/W1984679265","https://openalex.org/W1985053181","https://openalex.org/W1986092185","https://openalex.org/W1986714849","https://openalex.org/W1989637315","https://openalex.org/W1989839225","https://openalex.org/W1992991774","https://openalex.org/W1993643880","https://openalex.org/W1995056605","https://openalex.org/W1995079626","https://openalex.org/W1995484013","https://openalex.org/W1998461664","https://openalex.org/W1998703804","https://openalex.org/W2001570842","https://openalex.org/W2002265975","https://openalex.org/W2003248744","https://openalex.org/W2003289804","https://openalex.org/W2003289842","https://openalex.org/W2004284922","https://openalex.org/W2006977548","https://openalex.org/W2007760226","https://openalex.org/W2008865872","https://openalex.org/W2008930892","https://openalex.org/W2009570830","https://openalex.org/W2009798253","https://openalex.org/W2010408327","https://openalex.org/W2010845511","https://openalex.org/W2012253806","https://openalex.org/W2013366988","https://openalex.org/W2013622904","https://openalex.org/W2014415095","https://openalex.org/W2014803723","https://openalex.org/W2016036141","https://openalex.org/W2016465405","https://openalex.org/W2016995432","https://openalex.org/W2019645577","https://openalex.org/W2020625714","https://openalex.org/W2021782736","https://openalex.org/W2022219194","https://openalex.org/W2022233762","https://openalex.org/W2022402243","https://openalex.org/W2023574451","https://openalex.org/W2024749533","https://openalex.org/W2025240330","https://openalex.org/W2025495736","https://openalex.org/W2026609620","https://openalex.org/W2031334446","https://openalex.org/W2031348804","https://openalex.org/W2031739172","https://openalex.org/W2032747448","https://openalex.org/W2033975383","https://openalex.org/W2034533563","https://openalex.org/W2035590629","https://openalex.org/W2036209909","https://openalex.org/W2037305376","https://openalex.org/W2038825302","https://openalex.org/W2040297259","https://openalex.org/W2041483782","https://openalex.org/W2043401071","https://openalex.org/W2043493551","https://openalex.org/W2043866252","https://openalex.org/W2045654866","https://openalex.org/W2046928615","https://openalex.org/W2046929321","https://openalex.org/W2048123433","https://openalex.org/W2049547155","https://openalex.org/W2049750414","https://openalex.org/W2050077524","https://openalex.org/W2053717786","https://openalex.org/W2054528757","https://openalex.org/W2054965221","https://openalex.org/W2055354313","https://openalex.org/W2055523610","https://openalex.org/W2057605801","https://openalex.org/W2058865607","https://openalex.org/W2059148040","https://openalex.org/W2063971950","https://openalex.org/W2064865336","https://openalex.org/W2065160260","https://openalex.org/W2065169750","https://openalex.org/W2066881127","https://openalex.org/W2067415178","https://openalex.org/W2069663343","https://openalex.org/W2070022690","https://openalex.org/W2071656982","https://openalex.org/W2072060777","https://openalex.org/W2073595900","https://openalex.org/W2074235051","https://openalex.org/W2075604288","https://openalex.org/W2076112470","https://openalex.org/W2078167209","https://openalex.org/W2080827032","https://openalex.org/W2081304551","https://openalex.org/W2081631042","https://openalex.org/W2083738090","https://openalex.org/W2084273284","https://openalex.org/W2084331785","https://openalex.org/W2084596811","https://openalex.org/W2085064222","https://openalex.org/W2085287004","https://openalex.org/W2085293745","https://openalex.org/W2086137351","https://openalex.org/W2086789511","https://openalex.org/W2087157604","https://openalex.org/W2089123987","https://openalex.org/W2089413793","https://openalex.org/W2089771119","https://openalex.org/W2092191486","https://openalex.org/W2093984961","https://openalex.org/W2094075491","https://openalex.org/W2094126290","https://openalex.org/W2100750550","https://openalex.org/W2103903531","https://openalex.org/W2105506304","https://openalex.org/W2110925924","https://openalex.org/W2111990860","https://openalex.org/W2113313450","https://openalex.org/W2115271248","https://openalex.org/W2115602937","https://openalex.org/W2116635659","https://openalex.org/W2117726420","https://openalex.org/W2117770051","https://openalex.org/W2119102767","https://openalex.org/W2124064773","https://openalex.org/W2127087784","https://openalex.org/W2127190848","https://openalex.org/W2130784302","https://openalex.org/W2133292118","https://openalex.org/W2134330719","https://openalex.org/W2136748963","https://openalex.org/W2146521940","https://openalex.org/W2147122909","https://openalex.org/W2147359625","https://openalex.org/W2147639837","https://openalex.org/W2149904207","https://openalex.org/W2157844171","https://openalex.org/W2161321963","https://openalex.org/W2163113436","https://openalex.org/W2163773342","https://openalex.org/W2165386990","https://openalex.org/W2167021628","https://openalex.org/W2167126500","https://openalex.org/W2179259141","https://openalex.org/W2203324782","https://openalex.org/W2217542595","https://openalex.org/W2278727961","https://openalex.org/W2307353306","https://openalex.org/W2323625784","https://openalex.org/W2341498450","https://openalex.org/W2412834711","https://openalex.org/W2415689892","https://openalex.org/W2435236715","https://openalex.org/W2460746537","https://openalex.org/W2460802970","https://openalex.org/W2472440942","https://openalex.org/W2509123191","https://openalex.org/W2528267729","https://openalex.org/W2587736741","https://openalex.org/W2607024291","https://openalex.org/W2612675639","https://openalex.org/W4214891130","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W3012411291","https://openalex.org/W2112234785","https://openalex.org/W1966619262","https://openalex.org/W2513740192","https://openalex.org/W4251058547","https://openalex.org/W2464801958","https://openalex.org/W2149926159","https://openalex.org/W2337842076","https://openalex.org/W1980157080","https://openalex.org/W4380154009"],"abstract_inverted_index":{"Previous":[0],"research":[1],"from":[2,39],"our":[3],"laboratory":[4],"found":[5,124],"a":[6],"critical":[7],"period":[8],"of":[9,22,53],"development":[10],"between":[11,125],"postnatal":[12],"day":[13],"(P)18-P24":[14],"in":[15,44,82,112,115],"which":[16,107],"synaptogenesis":[17],"occurs":[18],"with":[19,28,109],"the":[20,29,35,57,72,83,116,126],"emergence":[21],"spatial":[23],"performance.":[24],"Subjects":[25],"were":[26,42,55,76,88,123],"treated":[27],"dopamine":[30],"receptor":[31,98],"antagonist,":[32,37],"flupenthixol":[33,101,134],"or":[34,93,120],"NMDAr":[36],"MK-801":[38,128,143],"P18-P24":[40],"and":[41,85,130,138],"tested":[43],"an":[45,91,110],"operant":[46,136],"conditioning":[47],"procedure":[48],"during":[49,105],"adolescence.":[50],"Another":[51],"group":[52,129],"subjects":[54],"given":[56],"same":[58],"drugs":[59],"prior":[60],"to":[61,65,78,96],"each":[62],"acquisition":[63,137],"session":[64],"test":[66],"immediate":[67],"effects.":[68],"Spine":[69],"densities":[70],"for":[71],"early":[73,127],"treatment":[74],"groups":[75],"quantified":[77,89],"measure":[79,97],"structural":[80,121],"changes":[81],"NAc":[84],"c-Fos":[86],"labeling":[87],"after":[90],"DA":[92],"NMDA":[94],"agonist":[95],"desensitization.":[99],"Early":[100],"increased":[102,144],"locomotor":[103,139],"activity":[104],"acquisition,":[106],"corresponded":[108],"increase":[111],"DAr":[113],"sensitization":[114],"NAc.":[117],"No":[118],"behavioural":[119],"differences":[122],"saline":[131],"control.":[132],"Late":[133],"decreased":[135],"activity,":[140],"while":[141],"late":[142],"both.":[145]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2019-05-09T00:00:00"}
