{"id":"https://openalex.org/W2943704635","doi":null,"title":"Analiza autofagije u stani\u010dnoj liniji Neuro 2a s CRISPR/Cas9 posredovanom delecijom optineurina","display_name":"Analiza autofagije u stani\u010dnoj liniji Neuro 2a s CRISPR/Cas9 posredovanom delecijom optineurina","publication_year":2018,"publication_date":"2018-09-26","ids":{"openalex":"https://openalex.org/W2943704635","mag":"2943704635"},"language":"hr","primary_location":{"id":"mag:2943704635","doi":null,"is_oa":false,"landing_page_url":"https://repository.biotech.uniri.hr/islandora/object/biotechri:238","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108742598","display_name":"Nikolina Prtenja\u010da","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nikolina Prtenja\u010da","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108742598"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optineurin","display_name":"optineurin","score":0.984000027179718},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neuro-2a-cells","display_name":"N2a cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/basal-autophagy","display_name":"basal autophagy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/starvation-induced-autophagy","display_name":"starvation-induced autophagy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.7250000238418579},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.7760000228881836},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9139999747276306},{"id":"https://openalex.org/keywords/autophagy-adaptors","display_name":"autophagy adaptors","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2777801377","wikidata":"https://www.wikidata.org/wiki/Q18035056","display_name":"Optineurin","level":4,"score":0.996369481086731},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9582386612892151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6934630274772644},{"id":"https://openalex.org/C2780042272","wikidata":"https://www.wikidata.org/wiki/Q27548992","display_name":"ATG8","level":4,"score":0.492239385843277},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.42077741026878357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38251936435699463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3361565172672272},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1789853274822235},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.13080549240112305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11781403422355652}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2943704635","doi":null,"is_oa":false,"landing_page_url":"https://repository.biotech.uniri.hr/islandora/object/biotechri:238","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2771547364","https://openalex.org/W4409527051","https://openalex.org/W4412602549","https://openalex.org/W745428933","https://openalex.org/W1985484942","https://openalex.org/W2801531148","https://openalex.org/W4413934938","https://openalex.org/W2051362437","https://openalex.org/W2608367614","https://openalex.org/W4210666473"],"abstract_inverted_index":{"Autophagy":[0],"is":[1,14,58,86,90,140,226],"a":[2,15,46,91,98,154,196,228,247],"eukaryotic":[3],"cellular":[4,11,20],"process":[5,25],"that":[6,18,60,138,169,183,207,224,233,244,260],"removes":[7],"unnecessary":[8],"and":[9,26,38,106,117,162,232,251,256,259,272],"toxic":[10],"content.":[12],"Optineurin":[13,89],"ubiquitin-binding":[16],"protein":[17,40,43,274],"binds":[19],"content":[21],"in":[22,63,81,100,115,126,164,192,213,218,236,249,276],"the":[23,75,111,188,214,267,273],"autophagy":[24,35,93,145,158,177,201,230,237,258,271],"allows":[27],"its":[28,261],"lysosomal":[29],"degradation.":[30],"Lack":[31],"of":[32,48,72,78,113,157,176,185,190,199,254,266,269],"optineurin":[33,61,84,114,128,139,165,170,186,211,225,245],"causes":[34,268],"related":[36],"disorders":[37],"possible":[39],"aggregation.":[41],"Since":[42],"aggregates":[44],"are":[45],"hallmark":[47],"neurodegenerative":[49,277],"diseases":[50],"such":[51,103],"as":[52,104],"amyotrophic":[53],"lateral":[54],"sclerosis":[55],"(ALS),":[56],"it":[57,234],"suggested":[59],"mutations":[62,85],"ALS":[64,79],"patients":[65,82],"lead":[66],"to":[67,70],"disease":[68],"due":[69],"loss":[71],"autophagy.":[73],"However,":[74,179],"exact":[76],"mechanism":[77],"pathogenesis":[80],"with":[83],"not":[87,141,227],"known.":[88],"multifunctional":[92],"adaptor,":[94],"but":[95,151],"also":[96],"has":[97,246],"role":[99,112,248],"other":[101,239],"processes":[102],"inflammation":[105],"vesicle":[107],"trafficking.\r\n":[108],"To":[109],"investigate":[110],"basal":[116,200,219,255],"induced":[118,257],"autophagy,":[119,220],"we":[120,180,205],"used":[121],"Neuro":[122],"2a":[123],"cell":[124],"line":[125],"which":[127,221],"gene":[129],"was":[130,153,209],"deleted":[131],"by":[132,146],"CRISPR/Cas9":[133],"method.":[134],"We":[135],"have":[136,181],"shown":[137,182],"necessary":[142],"for":[143],"inducing":[144,250],"starvation":[147],"or":[148],"IFN-\u03b2":[149],"stimulation,":[150],"there":[152,208],"mild":[155],"accumulation":[156,189],"markers":[159],"p62,":[160],"LC3-II":[161,191],"autophagosomes":[163],"knockout":[166],"cells,":[167,194],"suggesting":[168,195],"deficiency":[171,262],"can":[172],"cause":[173],"partial":[174,197],"block":[175,198],"flow.":[178,202],"lack":[184],"caused":[187],"non-stimulated":[193],"In":[203],"addition,":[204],"noticed":[206],"no":[210],"depletion":[212],"wild":[215],"type":[216],"cells":[217],"potentially":[222],"suggests":[223],"selective":[229],"adaptor":[231],"participates":[235],"through":[238],"mechanisms.":[240],"Our":[241],"results":[242],"suggest":[243],"proper":[252],"functioning":[253],"could":[263],"be":[264],"one":[265],"disrupted":[270],"aggregation":[275],"diseases.":[278]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-09T00:00:00"}
