{"id":"https://openalex.org/W2943616694","doi":null,"title":"Topical Dexamethasone gamma-Cyclodextrin Nanoparticle Eye Drops increase Visual Acuity and decrease Macular Thickness in Diabetic Macular Edema","display_name":"Topical Dexamethasone gamma-Cyclodextrin Nanoparticle Eye Drops increase Visual Acuity and decrease Macular Thickness in Diabetic Macular Edema","publication_year":2015,"publication_date":"2015-06-11","ids":{"openalex":"https://openalex.org/W2943616694","mag":"2943616694"},"language":"en","primary_location":{"id":"mag:2943616694","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2332054","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074918314","display_name":"Akihiro Ohira","orcid":"https://orcid.org/0000-0002-1307-5592","observed_orcids":["https://orcid.org/0000-0002-1307-5592"]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Ohira","raw_affiliation_strings":["Ophthalmology, Shimane Univ Sch of Medicine, Izumo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1307-5592","affiliations":[{"raw_affiliation_string":"Ophthalmology, Shimane Univ Sch of Medicine, Izumo, Japan","institution_ids":["https://openalex.org/I169016828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032030497","display_name":"Katsunori Hara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunori Hara","raw_affiliation_strings":["Ophthalmology, Shimane Univ Sch of Medicine, Izumo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Shimane Univ Sch of Medicine, Izumo, Japan","institution_ids":["https://openalex.org/I169016828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068216380","display_name":"Gauti J\u00f3hannesson","orcid":"https://orcid.org/0000-0003-0218-4563","observed_orcids":["https://orcid.org/0000-0003-0218-4563"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gauti J\u00f3hannesson","raw_affiliation_strings":["Department of Clinical Science/Ophthalmology, Ume\u00e5 University, Ume\u00e5, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-0218-4563","affiliations":[{"raw_affiliation_string":"Department of Clinical Science/Ophthalmology, Ume\u00e5 University, Ume\u00e5, Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042536343","display_name":"Masaki Tanito","orcid":"https://orcid.org/0000-0001-6512-7203","observed_orcids":["https://orcid.org/0000-0001-6512-7203"]},"institutions":[{"id":"https://openalex.org/I169016828","display_name":"Shimane University","ror":"https://ror.org/01jaaym28","country_code":"JP","type":"education","lineage":["https://openalex.org/I169016828"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Tanito","raw_affiliation_strings":["Ophthalmology, Shimane Univ Sch of Medicine, Izumo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6512-7203","affiliations":[{"raw_affiliation_string":"Ophthalmology, Shimane Univ Sch of Medicine, Izumo, Japan","institution_ids":["https://openalex.org/I169016828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005050724","display_name":"Gudr\u00fan Marta \u00c1sgr\u00edmsd\u00f3ttir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159585","display_name":"Oculis (Iceland)","ror":"https://ror.org/0530w9m46","country_code":"IS","type":"company","lineage":["https://openalex.org/I4210159585"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Gudr\u00fan Marta \u00c1sgr\u00edmsd\u00f3ttir","raw_affiliation_strings":["Oculis ehf., Reykjavik, Iceland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oculis ehf., Reykjavik, Iceland","institution_ids":["https://openalex.org/I4210159585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018640108","display_name":"Sigr\u00fan H. Lund","orcid":"https://orcid.org/0000-0002-3806-2296","observed_orcids":["https://orcid.org/0000-0002-3806-2296"]},"institutions":[{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Sigr\u00fan H. Lund","raw_affiliation_strings":["Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland"],"raw_orcid":"https://orcid.org/0000-0002-3806-2296","affiliations":[{"raw_affiliation_string":"Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062520026","display_name":"\u00deorsteinn Loftsson","orcid":"https://orcid.org/0000-0002-9439-1553","observed_orcids":["https://orcid.org/0000-0002-9439-1553"]},"institutions":[{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"\u00deorsteinn Loftsson","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland"],"raw_orcid":"https://orcid.org/0000-0002-9439-1553","affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland","institution_ids":["https://openalex.org/I165368041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037180334","display_name":"Einar Stef\u00e1nsson","orcid":"https://orcid.org/0000-0002-8113-2958","observed_orcids":["https://orcid.org/0000-0002-8113-2958"]},"institutions":[{"id":"https://openalex.org/I165368041","display_name":"University of Iceland","ror":"https://ror.org/01db6h964","country_code":"IS","type":"education","lineage":["https://openalex.org/I165368041"]}],"countries":["IS"],"is_corresponding":false,"raw_author_name":"Einar Stef\u00e1nsson","raw_affiliation_strings":["Ophthalmology University of Iceland Reykjavik Iceland"],"raw_orcid":"https://orcid.org/0000-0002-8113-2958","affiliations":[{"raw_affiliation_string":"Ophthalmology University of Iceland Reykjavik Iceland","institution_ids":["https://openalex.org/I165368041"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41285495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"7","first_page":"2289","last_page":"2289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9300000071525574},{"id":"https://openalex.org/keywords/eye-drops","display_name":"eye drops","score":0.847000002861023},{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macular-thickness","display_name":"macular thickness","score":0.7519999742507935},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.996999979019165},{"id":"https://openalex.org/keywords/posterior-subtenon-injection","display_name":"posterior subtenon injection","score":0.9610000252723694},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2985127711","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic macular edema","level":4,"score":0.7768867015838623},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7686044573783875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7205709218978882},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.713361382484436},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6889627575874329},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.5813133120536804},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.2636449635028839},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2149970829486847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1192488968372345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08172076940536499}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2943616694","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2332054","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1892439708","https://openalex.org/W2034358901","https://openalex.org/W1886856767","https://openalex.org/W2751835832","https://openalex.org/W2949611464","https://openalex.org/W4312080396","https://openalex.org/W2597903313","https://openalex.org/W3012095197","https://openalex.org/W794953491","https://openalex.org/W2967911218"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"test":[2],"the":[3],"efficacy":[4],"and":[5,21],"safety":[6],"of":[7,27],"topical":[8],"1.5%":[9],"dexamethasone":[10],"\u03b3-cyclodextrin":[11],"nanoparticle":[12],"eye":[13],"drops":[14],"(dexNP)":[15],"for":[16],"diabetic":[17],"macular":[18],"edema":[19],"(DME)":[20],"compare":[22],"to":[23],"posterior":[24],"subtenon":[25],"injection":[26],"...":[29]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2019-05-09T00:00:00"}