{"id":"https://openalex.org/W2943589024","doi":"https://doi.org/10.2147/dddt.s192681","title":"Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3\u03b2/\u03b2-catenin pathway in colorectal cancer cells","display_name":"Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3\u03b2/\u03b2-catenin pathway in colorectal cancer cells","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2943589024","doi":"https://doi.org/10.2147/dddt.s192681","mag":"2943589024","pmid":"https://pubmed.ncbi.nlm.nih.gov/31118579","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6503305"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s192681","doi":"https://doi.org/10.2147/dddt.s192681","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s192681","pdf_url":"https://www.dovepress.com/getfile.php?fileID=49496","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=49496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100663089","display_name":"Yanxi Li","orcid":"https://orcid.org/0000-0002-2640-2978","observed_orcids":["https://orcid.org/0000-0002-2640-2978"]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanxi Li","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065628118","display_name":"Xiaoxue Qin","orcid":"https://orcid.org/0009-0003-4308-2958","observed_orcids":["https://orcid.org/0009-0003-4308-2958"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxue Qin","raw_affiliation_strings":["Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053048092","display_name":"Penglei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Penglei Li","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Zhang","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881084","display_name":"Tao Lin","orcid":"https://orcid.org/0000-0003-1849-1656","observed_orcids":["https://orcid.org/0000-0003-1849-1656"]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Lin","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113899010","display_name":"Ziwei Miao","orcid":"https://orcid.org/0000-0003-4369-9395","observed_orcids":["https://orcid.org/0000-0003-4369-9395"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziwei Miao","raw_affiliation_strings":["Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100524126","display_name":"Siping Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Siping Ma","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100524126"],"corresponding_institution_ids":["https://openalex.org/I4210161255"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":4.8658,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.96044103,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"Volume 13","issue":null,"first_page":"1449","last_page":"1460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.35670000314712524,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isobavachalcone","display_name":"isobavachalcone","score":1.0},{"id":"https://openalex.org/keywords/psoralea-corylifolia","display_name":"Psoralea corylifolia","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.847000002861023},{"id":"https://openalex.org/keywords/akt-gsk3beta-beta-catenin-signaling","display_name":"AKT/GSK3\u03b2/\u03b2-catenin signaling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9079999923706055},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5260000228881836},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8230000138282776},{"id":"https://openalex.org/keywords/bax-bcl-2-ratio","display_name":"Bax/Bcl-2 ratio","score":0.8119999766349792},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9290000200271606},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2779855038","wikidata":"https://www.wikidata.org/wiki/Q15530962","display_name":"Psoralea corylifolia","level":3,"score":0.6745204925537109},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6389217376708984},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6192583441734314},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.551782488822937},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.532010555267334},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.5291764140129089},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5253968834877014},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.47191813588142395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4614701271057129},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.45332542061805725},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44693148136138916},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.4274328947067261},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3880614638328552},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3351185619831085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3296456038951874},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.28987616300582886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2644450068473816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19288033246994019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17862585186958313},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D029907","descriptor_name":"Psoralea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/dddt.s192681","doi":"https://doi.org/10.2147/dddt.s192681","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s192681","pdf_url":"https://www.dovepress.com/getfile.php?fileID=49496","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5500271","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6503305","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6503305","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6503305","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmid:31118579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31118579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4113516f5cd047e49b512cfe2d18d52c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4113516f5cd047e49b512cfe2d18d52c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol Volume 13, Pp 1449-1460 (2019)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/45479","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/isobavachalcone-isolated-from-psoralea-corylifolia-inhibits-cell-proli-peer-reviewed-article-DDDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s192681","doi":"https://doi.org/10.2147/dddt.s192681","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s192681","pdf_url":"https://www.dovepress.com/getfile.php?fileID=49496","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943589024.pdf","grobid_xml":"https://content.openalex.org/works/W2943589024.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1468825335","https://openalex.org/W1964617786","https://openalex.org/W2008757142","https://openalex.org/W2012071567","https://openalex.org/W2013372525","https://openalex.org/W2024215200","https://openalex.org/W2027604198","https://openalex.org/W2030593583","https://openalex.org/W2038683465","https://openalex.org/W2045563337","https://openalex.org/W2058043554","https://openalex.org/W2058706076","https://openalex.org/W2074806331","https://openalex.org/W2078172545","https://openalex.org/W2103789431","https://openalex.org/W2125245877","https://openalex.org/W2125988618","https://openalex.org/W2140366256","https://openalex.org/W2144385726","https://openalex.org/W2147297736","https://openalex.org/W2158021558","https://openalex.org/W2184433486","https://openalex.org/W2272984102","https://openalex.org/W2581171415","https://openalex.org/W2727266038","https://openalex.org/W2742620638","https://openalex.org/W2768237001","https://openalex.org/W2781695784","https://openalex.org/W2805213012","https://openalex.org/W2806824289","https://openalex.org/W2837712885","https://openalex.org/W2865704681","https://openalex.org/W2883391967","https://openalex.org/W2889646458","https://openalex.org/W2891141728","https://openalex.org/W2891811374","https://openalex.org/W4254884815","https://openalex.org/W7099931410"],"related_works":["https://openalex.org/W4399326111","https://openalex.org/W2030593583","https://openalex.org/W2184433486","https://openalex.org/W4315776736","https://openalex.org/W2994434820","https://openalex.org/W2727266038","https://openalex.org/W1983472990","https://openalex.org/W4226371099","https://openalex.org/W2897066638","https://openalex.org/W2778724367"],"abstract_inverted_index":{"Background:":[0],"Colorectal":[1],"cancer":[2,9],"(CRC)":[3],"is":[4,57],"a":[5,12,47,269],"common":[6],"form":[7],"of":[8,23,44,68,77,95,121,141,154,159,173,183,194,205,208,218,255,266,276],"associated":[10,232],"with":[11,92,107,233],"high":[13],"mortality":[14],"rate":[15],"and":[16,71,75,86,104,125,138,148,176,188,202,213,250],"poor":[17],"prognosis.":[18],"Given":[19],"the":[20,41,51,126,167,181,184,189,197,200,237,256,264,274],"limited":[21],"efficacy":[22],"current":[24],"therapies":[25],"for":[26,273],"CRC,":[27,234],"interest":[28],"in":[29,59,63,65,146,166,180,259],"novel":[30,270],"therapeutic":[31,271],"agents":[32],"isolated":[33,49],"from":[34,50,157,196],"natural":[35],"sources":[36],"has":[37,229],"increased.":[38],"We":[39],"studied":[40],"anticancer":[42],"properties":[43],"isobavachalcone":[45],"(IBC),":[46],"flavonoid":[48],"herb":[52],"Psoralea":[53],"corylifolia":[54],",":[55],"which":[56,228],"used":[58,117],"traditional":[60],"Chinese":[61],"medicine,":[62],"an":[64],"vitro":[66],"model":[67],"CRC.":[69,260,277],"Materials":[70],"methods:":[72],"Cell":[73,83],"viability":[74],"growth":[76],"CRC":[78,143],"cells":[79],"were":[80],"determined":[81],"by":[82,101,163,235],"Counting":[84],"Kit-8":[85],"colony":[87,139],"formation":[88,140],"assays":[89],"following":[90],"treatment":[91,275],"varying":[93],"concentrations":[94],"IBC,":[96],"respectively.":[97],"Apoptosis":[98],"was":[99,116],"examined":[100],"4\u2032,6-diamidino-2-phenylindole":[102],"staining":[103],"flow":[105,169],"cytometry":[106,170],"Annexin":[108],"V/propidium":[109],"iodide":[110],"double":[111],"staining.":[112],"Western":[113,215],"blot":[114,216],"analysis":[115,217],"to":[118,199],"analyze":[119],"expression":[120,204],"apoptosis-associated":[122],"protein":[123,186,191],"pathway":[124,220,258],"AKT/GSK-3\u03b2/\u03b2-catenin":[127,257],"signaling":[128,219,239,286],"pathway.":[129,240],"Results:":[130],"Initial":[131],"experiments":[132],"showed":[133],"that":[134,223,245],"IBC":[135,155,224,246,267],"inhibited":[136,247],"proliferation":[137,249],"human":[142],"cell":[144,248],"lines":[145],"dose-":[147],"time-dependent":[149],"manners.":[150],"The":[151],"antiproliferative":[152],"effect":[153],"resulted":[156],"induction":[158],"apoptosis,":[160,282],"as":[161,268],"evidenced":[162],"morphological":[164],"changes":[165,179],"nucleus,":[168],"analysis,":[171],"upregulation":[172],"cleaved":[174,177],"caspase-3":[175],"PARP,":[178],"ratio":[182],"anti-apoptotic":[185],"Bcl-2":[187],"pro-apoptotic":[190],"Bax,":[192],"translocation":[193],"Bax":[195],"cytosol":[198],"mitochondria,":[201],"decreased":[203],"two":[206],"inhibitors":[207],"apoptosis":[209,252],"family":[210],"proteins,":[211],"XIAP,":[212],"survivin.":[214],"proteins":[221],"demonstrated":[222,244],"downregulated":[225],"Wnt/\u03b2-catenin":[226],"signaling,":[227],"previously":[230],"been":[231],"inhibiting":[236],"AKT/GSK-3\u03b2":[238],"Conclusion:":[241],"This":[242],"study":[243],"induced":[251],"through":[253],"inhibition":[254],"These":[261],"results":[262],"suggest":[263],"potential":[265],"agent":[272],"Keywords:":[278],"colorectal":[279],"cancer,":[280],"isobavachalcone,":[281],"AKT,":[283],"GSK-3\u03b2,":[284],"\u03b2-catenin":[285]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-05-09T00:00:00"}