{"id":"https://openalex.org/W2943466816","doi":null,"title":"Developing Droplet Based 3D Cell Culture Methods to Enable Investigations of the Chemical Tumor Microenvironment","display_name":"Developing Droplet Based 3D Cell Culture Methods to Enable Investigations of the Chemical Tumor Microenvironment","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2943466816","mag":"2943466816"},"language":"en","primary_location":{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1198","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/186","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1198&context=biom_etds","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1198&context=biom_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084868739","display_name":"De Lora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De Lora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000494634","display_name":"A Jacqueline","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Jacqueline","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cancer-cell-spheroids","display_name":"cancer cell spheroids","score":0.6380000114440918},{"id":"https://openalex.org/keywords/droplet-generator","display_name":"droplet generator","score":0.625},{"id":"https://openalex.org/keywords/3d-spheroids","display_name":"multicellular spheroids","score":0.8399999737739563},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.531000018119812},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5059999823570251},{"id":"https://openalex.org/keywords/biochemical-gradients","display_name":"biochemical gradients","score":0.38999998569488525},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6213544607162476},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4234049320220947},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4076511561870575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39983314275741577},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.347456693649292},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3275882601737976},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32741057872772217},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32289600372314453},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3098796606063843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2976391911506653},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22293365001678467},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19036775827407837},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.17150872945785522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13481006026268005}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1198","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/186","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1198&context=biom_etds","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},{"id":"mag:2943466816","doi":null,"is_oa":false,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/186/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalrepository.unm.edu:biom_etds-1198","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/biom_etds/186","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1198&context=biom_etds","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Sciences ETDs","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943466816.pdf","grobid_xml":"https://content.openalex.org/works/W2943466816.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1965975485","https://openalex.org/W2010251891","https://openalex.org/W2018439279","https://openalex.org/W2018671779","https://openalex.org/W2053387982","https://openalex.org/W2056876853","https://openalex.org/W2064616746","https://openalex.org/W2094214288","https://openalex.org/W2159902988","https://openalex.org/W2332155194","https://openalex.org/W2520107693","https://openalex.org/W2605245846","https://openalex.org/W2805761162"],"related_works":["https://openalex.org/W2622516502","https://openalex.org/W2751974637","https://openalex.org/W2131887259","https://openalex.org/W7011526542","https://openalex.org/W2519361252","https://openalex.org/W6992781309","https://openalex.org/W7055908283","https://openalex.org/W4392294466","https://openalex.org/W7065190818","https://openalex.org/W6941030925"],"abstract_inverted_index":{"Adaptation":[0],"of":[1,19,36,79,157,162,165,181,202,219,228,233],"cancer":[2,45,70,106,119],"cells":[3,107,209,220,245],"to":[4,32,66,104,149,154,170],"changes":[5],"in":[6,10,48,59,108,222,246],"the":[7,34,40,68,77,102,178,200,226],"biochemical":[8,37],"microenvironment":[9],"an":[11],"expanding":[12],"tumor":[13,22],"mass":[14],"is":[15,30,51],"a":[16,163,239],"crucial":[17],"aspect":[18],"malignant":[20],"progression,":[21],"metabolism,":[23],"and":[24,39,57,73,94,112,118,130,141,199,224,230,238],"drug":[25],"efficacy.":[26],"In":[27],"vitro,":[28],"it":[29],"challenging":[31],"mimic":[33],"evolution":[35],"gradients":[38],"cellular":[41],"heterogeneity":[42],"that":[43,54,96],"characterizes":[44],"tissues":[46],"found":[47],"vivo.":[49],"It":[50],"well":[52],"accepted":[53],"more":[55,113],"realistic":[56,114],"controllable":[58],"vitro":[60],"3D":[61,115,214],"model":[62],"systems":[63],"are":[64,84],"required":[65],"improve":[67,75],"overall":[69],"research":[71],"paradigm":[72],"thus":[74],"on":[76,196],"translation":[78],"results,":[80],"but":[81],"multidisciplinary":[82],"approaches":[83,93],"needed":[85],"for":[86,110,132,160,185,207,242],"these":[87,145,212],"advances.":[88],"This":[89],"work":[90],"develops":[91],"such":[92],"demonstrates":[95,177],"new":[97,213,240],"droplet-based":[98,133],"cell-encapsulation":[99],"techniques":[100],"have":[101,127],"ability":[103],"encapsulate":[105],"droplets":[109,159,184,188],"standardized":[111],"cell":[116,134,166],"culture":[117],"biology":[120],"applications.":[121],"Three":[122],"individual":[123],"droplet":[124],"generating":[125],"platforms":[126],"been":[128],"designed":[129],"optimized":[131],"encapsulation.":[135],"Each":[136],"has":[137],"its":[138],"own":[139],"advancements":[140],"challenges.":[142],"Together,":[143],"however,":[144],"technologies":[146],"accomplish":[147],"medium":[148],"high-throughput":[150],"generation":[151,180,201,227],"(10":[152],"droplets/second":[153],"25,000":[155],"droplets/second)":[156],"biomaterial":[158],"encapsulation":[161],"range":[164],"occupancies":[167],"(5":[168],"cells/droplet":[169],"400":[171],"cells/droplet).":[172],"The":[173],"data":[174],"presented":[175],"also":[176],"controlled":[179],"cell-sized":[182],"small":[183],"biomolecule":[186],"compartmentalization,":[187],"with":[189],"diameters":[190],"ranging":[191],"between":[192],"100-400":[193],"\u03bcm":[194],"depending":[195],"device":[197],"parameters,":[198],"instant":[203],"spheroids.":[204],"Standardized":[205],"assays":[206,218],"analyzing":[208],"grown":[210,221],"within":[211],"environments":[215],"include":[216],"proliferation":[217],"mono-":[223],"co-cultures,":[225],"large":[229],"uniform":[231],"populations":[232],"scaffold":[234],"supported":[235],"multicellular":[236],"spheroids,":[237],"system":[241],"culturing":[243],"encapsulated":[244],"altered":[247],"environmental":[248],"conditions.":[249]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-05-09T00:00:00"}