{"id":"https://openalex.org/W2943417746","doi":null,"title":"Development of the porous bone scaffold utilizing 3-dimensional CAD and solid freeform fabrication method","display_name":"Development of the porous bone scaffold utilizing 3-dimensional CAD and solid freeform fabrication method","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2943417746","mag":"2943417746"},"language":"en","primary_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/133472","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133472","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133472","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133472","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031528447","display_name":"\uae40\uc815\uc131","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\uae40\uc815\uc131","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031528447"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10783","display_name":"Additive Manufacturing and 3D Printing Technologies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porous-bone-scaffolds","display_name":"porous bone scaffolds","score":0.9369999766349792},{"id":"https://openalex.org/keywords/additive-manufacturing","display_name":"additive manufacturing","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bone-graft-substitutes","display_name":"bone graft substitutes","score":0.6740000247955322},{"id":"https://openalex.org/keywords/3d-cad","display_name":"3D CAD","score":0.6050000190734863},{"id":"https://openalex.org/keywords/pore-size-control","display_name":"pore size control","score":0.7390000224113464},{"id":"https://openalex.org/keywords/porosity","display_name":"porosity","score":0.5640000104904175},{"id":"https://openalex.org/keywords/compressive-strength","display_name":"compressive strength","score":0.8629999756813049},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.8899999856948853},{"id":"https://openalex.org/keywords/osteoconductivity","display_name":"osteoconductivity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/histomorphometry","display_name":"histomorphometry","score":0.7900000214576721},{"id":"https://openalex.org/keywords/interfacial-bond-strength","display_name":"interfacial strength","score":0.949999988079071},{"id":"https://openalex.org/keywords/hydroxyapatite-scaffolds","display_name":"hydroxyapatite scaffolds","score":0.7009999752044678},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.671999990940094},{"id":"https://openalex.org/keywords/bone-histomorphometry","display_name":"bone histomorphometry","score":0.49799999594688416},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.7180172204971313},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.7063971757888794},{"id":"https://openalex.org/C194789388","wikidata":"https://www.wikidata.org/wiki/Q17855283","display_name":"CAD","level":2,"score":0.6987959146499634},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5637863278388977},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.4754635691642761},{"id":"https://openalex.org/C199639397","wikidata":"https://www.wikidata.org/wiki/Q1788588","display_name":"Engineering drawing","level":1,"score":0.37963801622390747},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.352273166179657},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3500737249851227},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.20119988918304443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10947391390800476},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/133472","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133472","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133472","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2943417746","doi":null,"is_oa":false,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/133472/1/T011714.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/133472","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133472","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/133472","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943417746.pdf","grobid_xml":"https://content.openalex.org/works/W2943417746.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W122585317","https://openalex.org/W149636168","https://openalex.org/W203494167","https://openalex.org/W1499165638","https://openalex.org/W1524201876","https://openalex.org/W1553742473","https://openalex.org/W1559012262","https://openalex.org/W1601817977","https://openalex.org/W1622143753","https://openalex.org/W1902067154","https://openalex.org/W1945113591","https://openalex.org/W1959891668","https://openalex.org/W1964484523","https://openalex.org/W1968590981","https://openalex.org/W1971337798","https://openalex.org/W1971339046","https://openalex.org/W1971599056","https://openalex.org/W1972211130","https://openalex.org/W1974823397","https://openalex.org/W1974844401","https://openalex.org/W1975587522","https://openalex.org/W1979658598","https://openalex.org/W1980075417","https://openalex.org/W1980329646","https://openalex.org/W1986150311","https://openalex.org/W1998550080","https://openalex.org/W2002896651","https://openalex.org/W2003488635","https://openalex.org/W2003527087","https://openalex.org/W2004450834","https://openalex.org/W2004747114","https://openalex.org/W2010361875","https://openalex.org/W2010621406","https://openalex.org/W2011582230","https://openalex.org/W2012025608","https://openalex.org/W2017150999","https://openalex.org/W2017899903","https://openalex.org/W2023894506","https://openalex.org/W2026975571","https://openalex.org/W2029523901","https://openalex.org/W2030108579","https://openalex.org/W2030663143","https://openalex.org/W2031789487","https://openalex.org/W2034123520","https://openalex.org/W2034325001","https://openalex.org/W2034569148","https://openalex.org/W2035494112","https://openalex.org/W2038860414","https://openalex.org/W2040157816","https://openalex.org/W2041897038","https://openalex.org/W2045961538","https://openalex.org/W2046232956","https://openalex.org/W2048098748","https://openalex.org/W2048468796","https://openalex.org/W2050904814","https://openalex.org/W2052677241","https://openalex.org/W2055965667","https://openalex.org/W2058721292","https://openalex.org/W2060293764","https://openalex.org/W2060786071","https://openalex.org/W2060944528","https://openalex.org/W2063202895","https://openalex.org/W2063514102","https://openalex.org/W2065795757","https://openalex.org/W2068855229","https://openalex.org/W2071046468","https://openalex.org/W2075328483","https://openalex.org/W2075543804","https://openalex.org/W2078126231","https://openalex.org/W2082135472","https://openalex.org/W2089318972","https://openalex.org/W2090180975","https://openalex.org/W2091086527","https://openalex.org/W2095507523","https://openalex.org/W2096820646","https://openalex.org/W2103378167","https://openalex.org/W2106279840","https://openalex.org/W2113042424","https://openalex.org/W2118782903","https://openalex.org/W2119178479","https://openalex.org/W2126587152","https://openalex.org/W2127524214","https://openalex.org/W2127610623","https://openalex.org/W2139076385","https://openalex.org/W2142057495","https://openalex.org/W2144964774","https://openalex.org/W2148009863","https://openalex.org/W2155124369","https://openalex.org/W2159210886","https://openalex.org/W2162538987","https://openalex.org/W2168557841","https://openalex.org/W2199338994","https://openalex.org/W2252170449","https://openalex.org/W2329742995","https://openalex.org/W2477817573","https://openalex.org/W2488433791","https://openalex.org/W2897555650","https://openalex.org/W4234361284","https://openalex.org/W4295850198"],"related_works":["https://openalex.org/W3124250431","https://openalex.org/W2805550203","https://openalex.org/W2526219300","https://openalex.org/W2525859945","https://openalex.org/W2793906368","https://openalex.org/W2522809874","https://openalex.org/W2332637155","https://openalex.org/W2521174712","https://openalex.org/W7018699559","https://openalex.org/W2892296359"],"abstract_inverted_index":{"The":[0,23,234,248,369],"number":[1],"of":[2,11,17,73,95,141,159,169,241,256,283,293,327,367,380,383,392,405,416,422,464,471,483,498],"bone-graft":[3],"surgery":[4,485],"is":[5,109,263,388],"rising":[6],"rapidly":[7],"with":[8,33,92,138,163,467],"the":[9,12,15,20,38,70,74,93,103,114,121,135,153,157,160,170,195,199,208,214,218,229,239,245,319,343,346,354,365,410,414,417,423,432,449,462,492],"growth":[10,150],"interest":[13],"in":[14,80,89,222,225,342,420,502],"quality":[16],"life":[18],"and":[19,30,59,77,102,143,176,198,217,224,244,259,291,332,339,349,359,440,442,446,454,496],"population":[21],"recently.":[22],"grafting":[24],"bone":[25,39,46,75,117,122,136,149,155,242,434,465,472,479],"should":[26],"have":[27,309,409],"proper":[28],"pores":[29,255],"mechanical":[31,312],"strength":[32,282,351],"a":[34,51,55,60,131,177],"shape":[35,439],"adjusting":[36],"to":[37,111,119,129,134,413,430,443,475,491],"defect":[40,123],"area.At":[41],"present,":[42],"commercially":[43],"available":[44],"porous":[45,116,433],"substitutes":[47],"are":[48],"manufactured":[49],"by":[50,173,183,202,269,275,286,296,316,325,357,451],"sacrificial":[52],"template":[53],"method,":[54],"direct":[56],"foaming":[57],"method":[58,63,204],"polymer":[61,297],"replication":[62,298],"(PRM).":[64],"But":[65],"current":[66],"manufacturing":[67],"methods":[68],"provide":[69],"simplest":[71],"form":[72],"scaffold":[76,137,231,284,294],"also":[78],"limited":[79],"that":[81,274,292,305,315,391,403],"it":[82,108],"cannot":[83],"easily":[84],"control":[85],"pore":[86,438],"size.":[87],"However,":[88],"recent":[90],"years":[91],"development":[94],"medical":[96],"imaging":[97],"technology,":[98],"computer-aided":[99],"design":[100,172],"(CAD)":[101],"solid":[104],"freeform":[105],"fabrication":[106,307],"(SFF),":[107],"possible":[110],"accurately":[112],"produce":[113],"synthetic":[115],"scaffolds":[118,191,267,355,419,435,450],"fit":[120],"shape.":[124],"Therefore,":[125,457],"this":[126,427,458],"study":[127,428],"aimed":[128],"propose":[130],"new":[132],"approach":[133],"various":[139,171],"kinds":[140],"external":[142],"internal":[144,164],"structure,":[145],"which":[146],"could":[147,308,460],"existing":[148],"factor":[151],"as":[152],"optimal":[154,161],"scaffold.For":[156],"suggestion":[158],"structure":[162],"pores,":[165],"an":[166],"engineering":[167],"review":[168],"3D":[174,250],"CAD":[175],"comparison":[178],"between":[179],"their":[180],"structural":[181],"characteristics":[182],"finite":[184],"element":[185],"analysis":[186,348],"(FEA)":[187],"were":[188,192,232,361],"conducted.":[189],"SFF":[190,230,270,287,306,358,384,406],"fabricated":[193,268,285,295,356],"using":[194],"suggested":[196,249],"model":[197,251],"one":[200],"produced":[201],"commercialized":[203],"was":[205,236,288,299,303,323,335,429],"prepared":[206],"for":[207,213,364],"biomechanical":[209],"stability":[210],"comparison.":[211],"And":[212,345],"cell-compatibility":[215],"assessment":[216,366],"biological":[219,453,476],"safety":[220,322,445],"evaluation,":[221],"vitro":[223],"vivo":[226],"test":[227],"on":[228,353,372,448],"proceeded.":[233],"efficacy":[235,447],"confirmed":[237,304,324],"from":[238],"aspect":[240],"histomorphometry":[243],"interfacial":[246,350],"strength.":[247],"has":[252],"interconnected":[253],"cubic":[254],"500":[257],"\ufffd\ub7fe":[258],"its":[260],"calculated":[261],"porosity":[262],"25%.":[264],"Whereas":[265],"HA":[266],"showed":[271,374],"connective":[272],"macropores,":[273],"PRM":[276,317,360,393],"formed":[277],"closed":[278],"pores.":[279],"Average":[280],"compressive":[281],"14.6":[289],"\ufffd\ub816,":[290],"3.56":[300],"\ufffd\ub816.":[301],"It":[302,401],"relatively":[310],"higher":[311,389],"property":[313],"than":[314,390],"at":[318],"same":[320],"porosity.Biocompatibility":[321],"tests":[326],"cytotoxicity,":[328],"hemolysis,":[329],"irritation,":[330],"sensitization":[331],"implantation.":[333],"There":[334],"no":[336,375,481,489],"abnormal":[337],"response":[338],"potential":[340],"hazard":[341],"tests.":[344,456],"histological":[347,370],"evaluation":[352],"carried":[362],"out":[363],"efficacy.":[368],"results":[371,412],"osteoconductivity":[373],"significant":[376],"difference.":[377],"An":[378],"average":[379],"maximum":[381],"load":[382,500],"type":[385,394,407],"(169":[386],"N)":[387,396],"(153":[395],"without":[397],"any":[398],"statistical":[399],"significance.":[400],"means":[402],"implantation":[404,455],"would":[408],"effective":[411],"level":[415],"conventional":[418],"terms":[421],"osteoconduction.":[424],"In":[425],"summary,":[426],"implement":[431],"freely":[436],"controlling":[437],"size,":[441],"verify":[444],"biomechanical,":[452],"research":[459],"promote":[461],"feasibility":[463],"substitute":[466],"following":[468],"feature:":[469],"regeneration":[470],"tissue":[473],"suitable":[474],"environment":[477],"like":[478,486],"grafts,":[480],"need":[482],"extra":[484],"synthesis":[487],"material,":[488],"limit":[490],"amount":[493],"or":[494],"shape,":[495],"endurance":[497],"physiological":[499],"occurring":[501],"operating":[503],"area.":[504]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-05-09T00:00:00"}