{"id":"https://openalex.org/W294337075","doi":"https://doi.org/10.1021/acs.langmuir.5b00520","title":"Synergistic Effect of PEI and PDMAEMA on Transgene Expression in Vitro","display_name":"Synergistic Effect of PEI and PDMAEMA on Transgene Expression in Vitro","publication_year":2015,"publication_date":"2015-05-19","ids":{"openalex":"https://openalex.org/W294337075","doi":"https://doi.org/10.1021/acs.langmuir.5b00520","mag":"294337075","pmid":"https://pubmed.ncbi.nlm.nih.gov/25985827"},"language":"en","primary_location":{"id":"doi:10.1021/acs.langmuir.5b00520","doi":"https://doi.org/10.1021/acs.langmuir.5b00520","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.langmuir.5b00520","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059115053","display_name":"Chia\u2010Wen Lo","orcid":"https://orcid.org/0009-0000-8983-2804","observed_orcids":["https://orcid.org/0009-0000-8983-2804"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Wen Lo","raw_affiliation_strings":["Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103064336","display_name":"Wei\u2010Hao Liao","orcid":"https://orcid.org/0009-0000-0167-5470","observed_orcids":["https://orcid.org/0009-0000-0167-5470"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Hao Liao","raw_affiliation_strings":["Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046699614","display_name":"Chueh\u2010Hung Wu","orcid":"https://orcid.org/0000-0002-3979-3541","observed_orcids":["https://orcid.org/0000-0002-3979-3541"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chueh-Hung Wu","raw_affiliation_strings":["Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","Institute\rof Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Institute\rof Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057473499","display_name":"Jyun\u2010Lin Lee","orcid":"https://orcid.org/0000-0002-1904-3890","observed_orcids":["https://orcid.org/0000-0002-1904-3890"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jyun-Lin Lee","raw_affiliation_strings":["Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035922486","display_name":"Mingkuan Sun","orcid":"https://orcid.org/0000-0002-4511-5894","observed_orcids":["https://orcid.org/0000-0002-4511-5894"]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Kuan Sun","raw_affiliation_strings":["Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032407446","display_name":"Hui-Shan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151221077","display_name":"Chung Yuan Christian University","ror":"https://ror.org/02w8ws377","country_code":"TW","type":"education","lineage":["https://openalex.org/I151221077"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Shan Yang","raw_affiliation_strings":["R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong-Li, Taoyuan, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong-Li, Taoyuan, Taiwan, ROC","institution_ids":["https://openalex.org/I151221077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073049010","display_name":"Wei\u2010Bor Tsai","orcid":"https://orcid.org/0000-0002-2316-5751","observed_orcids":["https://orcid.org/0000-0002-2316-5751"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Bor Tsai","raw_affiliation_strings":["Department\rof Chemical Engineering, National Taiwan University, Taipei, Taiwan ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemical Engineering, National Taiwan University, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012321811","display_name":"Yung Chang","orcid":"https://orcid.org/0000-0003-1419-4478","observed_orcids":["https://orcid.org/0000-0003-1419-4478"]},"institutions":[{"id":"https://openalex.org/I151221077","display_name":"Chung Yuan Christian University","ror":"https://ror.org/02w8ws377","country_code":"TW","type":"education","lineage":["https://openalex.org/I151221077"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yung Chang","raw_affiliation_strings":["R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong-Li, Taoyuan, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong-Li, Taoyuan, Taiwan, ROC","institution_ids":["https://openalex.org/I151221077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053808528","display_name":"Wen\u2010Shiang Chen","orcid":"https://orcid.org/0000-0003-1488-5164","observed_orcids":["https://orcid.org/0000-0003-1488-5164"]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]},{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wen-Shiang Chen","raw_affiliation_strings":["Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","Division\rof Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan","Department#R#of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","Division#R#of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Division\rof Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan","institution_ids":["https://openalex.org/I165441096"]},{"raw_affiliation_string":"Department#R#of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan ROC","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Division#R#of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan","institution_ids":["https://openalex.org/I165441096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012321811","https://openalex.org/A5053808528"],"corresponding_institution_ids":["https://openalex.org/I151221077","https://openalex.org/I165441096","https://openalex.org/I16733864","https://openalex.org/I4210131804"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7411,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64819809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"31","issue":"22","first_page":"6130","last_page":"6136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyethylenimine","display_name":"polyethyleneimine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pdmaema","display_name":"PDMAEMA","score":0.8730000257492065},{"id":"https://openalex.org/keywords/polyplexes","display_name":"polyplexes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dna-delivery","display_name":"DNA delivery","score":0.7120000123977661},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.9309999942779541},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.8389999866485596},{"id":"https://openalex.org/keywords/polymer-blends","display_name":"polymer blends","score":0.3659999966621399},{"id":"https://openalex.org/keywords/dna-internalization","display_name":"DNA internalization","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2775925850","wikidata":"https://www.wikidata.org/wiki/Q418697","display_name":"Polyethylenimine","level":4,"score":0.9652007818222046},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7174116373062134},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6919022798538208},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5902340412139893},{"id":"https://openalex.org/C132050475","wikidata":"https://www.wikidata.org/wiki/Q736232","display_name":"Methacrylate","level":4,"score":0.5725990533828735},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4969694912433624},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48508015275001526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48088863492012024},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42634284496307373},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.421073317527771},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.327362060546875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27610117197036743},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.22611859440803528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21909642219543457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19656416773796082},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07158368825912476},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.06971251964569092}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009757","descriptor_name":"Nylons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009757","descriptor_name":"Nylons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011094","descriptor_name":"Polyethyleneimine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011094","descriptor_name":"Polyethyleneimine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.langmuir.5b00520","doi":"https://doi.org/10.1021/acs.langmuir.5b00520","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.langmuir.5b00520","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},{"id":"pmid:25985827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25985827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir : the ACS journal of surfaces and colloids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7018190148","display_name":null,"funder_award_id":"103-M2546","funder_id":"https://openalex.org/F4320323422","funder_display_name":"National Taiwan University Hospital"},{"id":"https://openalex.org/G7991526754","display_name":"Ultrasound Gene Therapy for Tendinopathy","funder_award_id":"MOST103-2314-B002-011-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G8857335908","display_name":null,"funder_award_id":"ME-103-PP-03","funder_id":"https://openalex.org/F4320322845","funder_display_name":"National Health Research Institutes"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"},{"id":"https://openalex.org/F4320323422","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1560355462","https://openalex.org/W1599588446","https://openalex.org/W1604428153","https://openalex.org/W1979146520","https://openalex.org/W1997002018","https://openalex.org/W1998266559","https://openalex.org/W2007328831","https://openalex.org/W2016232662","https://openalex.org/W2021140900","https://openalex.org/W2026808689","https://openalex.org/W2031632278","https://openalex.org/W2036732463","https://openalex.org/W2040101471","https://openalex.org/W2050432620","https://openalex.org/W2077850392","https://openalex.org/W2086731246","https://openalex.org/W2086848733","https://openalex.org/W2100751439","https://openalex.org/W2129982560","https://openalex.org/W2156733259","https://openalex.org/W2160355377","https://openalex.org/W2170542801","https://openalex.org/W2949870653"],"related_works":["https://openalex.org/W2751250499","https://openalex.org/W2043586030","https://openalex.org/W898153971","https://openalex.org/W1992273316","https://openalex.org/W2031050060","https://openalex.org/W2129569835","https://openalex.org/W2892393604","https://openalex.org/W1976949504","https://openalex.org/W1977922381","https://openalex.org/W2025471675"],"abstract_inverted_index":{"Polyethylenimine":[0],"(PEI)":[1],"and":[2,52,65,90,121],"poly(2-(dimethylamino)":[3],"ethyl":[4],"methacrylate)":[5],"(PDMAEMA)":[6],"have":[7],"both":[8,48],"been":[9,16],"used":[10],"for":[11,68],"DNA":[12,53,63,66],"delivery.":[13],"PDMAEMA":[14],"has":[15],"shown":[17],"to":[18,38,104,124],"exhibit":[19],"better":[20],"gene":[21,49],"transfection":[22,50],"efficiency":[23,51],"but":[24],"lower":[25],"expression":[26,54,67,127],"ability":[27],"than":[28],"PEI.":[29],"We":[30],"mixed":[31],"the":[32,41,69,106,113],"two":[33],"polymers":[34],"at":[35,72,92],"different":[36],"ratios":[37],"investigate":[39],"whether":[40],"resulting":[42],"\"dual\"":[43],"polyplex":[44],"(PEI/PDMAEMA/DNA)":[45],"could":[46],"enhance":[47],"ability.":[55],"Experimental":[56],"results":[57],"showed":[58],"a":[59,73,118],"significant":[60],"increase":[61],"in":[62,85],"internalization":[64],"PDMAEMA/PEI/DNA":[70,91,95],"polyplexes":[71,96],"ratio":[74],"of":[75],"1:3":[76],"or":[77],"1:9":[78],"(PDMAEMA:":[79],"PEI),":[80],"depending":[81],"on":[82],"cell":[83,100],"type,":[84],"comparison":[86],"with":[87,105],"PEI/DNA,":[88],"PDMAEMA/DNA,":[89],"other":[93],"ratios.":[94],"did":[97],"not":[98],"reduce":[99],"viability.":[101],"In":[102],"contrast":[103],"conventional":[107],"approach":[108,116],"using":[109],"covalently":[110],"modified":[111],"PEI,":[112],"proposed":[114],"\"combination\"":[115],"provided":[117],"more":[119],"convenient":[120],"effective":[122],"way":[123],"improve":[125],"transgene":[126],"efficiency.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}