{"id":"https://openalex.org/W2943323697","doi":"https://doi.org/10.1080/1061186x.2019.1605519","title":"SIRT1: a potential tumour biomarker and therapeutic target","display_name":"SIRT1: a potential tumour biomarker and therapeutic target","publication_year":2019,"publication_date":"2019-05-06","ids":{"openalex":"https://openalex.org/W2943323697","doi":"https://doi.org/10.1080/1061186x.2019.1605519","mag":"2943323697","pmid":"https://pubmed.ncbi.nlm.nih.gov/31056963"},"language":"en","primary_location":{"id":"doi:10.1080/1061186x.2019.1605519","doi":"https://doi.org/10.1080/1061186x.2019.1605519","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1061186x.2019.1605519","pdf_url":null,"source":{"id":"https://openalex.org/S100629371","display_name":"Journal of drug targeting","issn_l":"1026-7158","issn":["1026-7158","1029-2330","1061-186X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Targeting","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101777179","display_name":"Bin Zhao","orcid":"https://orcid.org/0000-0003-4533-7101","observed_orcids":["https://orcid.org/0000-0003-4533-7101"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Zhao","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354010","display_name":"Xin Li","orcid":"https://orcid.org/0000-0003-0661-6212","observed_orcids":["https://orcid.org/0000-0003-0661-6212","https://orcid.org/0009-0007-9054-0201","https://orcid.org/0009-0008-3056-9659"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Li","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100753310","display_name":"Liangfu Zhou","orcid":"https://orcid.org/0000-0002-0675-7720","observed_orcids":["https://orcid.org/0000-0002-0675-7720"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangfu Zhou","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423409","display_name":"Ye Wang","orcid":"https://orcid.org/0009-0004-0722-8021","observed_orcids":["https://orcid.org/0009-0004-0722-8021","https://orcid.org/0000-0001-5779-1294"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Wang","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Life Science, Northwestern Polytechnical University, Xi\u2019an, China;","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078166119","display_name":"Peng Shang","orcid":"https://orcid.org/0000-0001-5418-6240","observed_orcids":["https://orcid.org/0000-0001-5418-6240"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Shang","raw_affiliation_strings":["Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;"],"raw_orcid":"https://orcid.org/0000-0001-5418-6240","affiliations":[{"raw_affiliation_string":"Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"Research & Development Institute of\u00a0Northwestern Polytechnical University in Shenzhen, Shenzhen, China;","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078166119"],"corresponding_institution_ids":["https://openalex.org/I17145004"],"apc_list":null,"apc_paid":null,"fwci":0.3833,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.36458333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"10","first_page":"1046","last_page":"1052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":1.0},{"id":"https://openalex.org/keywords/tumour-biomarkers","display_name":"tumour biomarkers","score":0.9750000238418579},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nad-dependent-deacetylase","display_name":"NAD+-dependent deacetylase","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.819649875164032},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6586698889732361},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46758580207824707},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4132886826992035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4066569209098816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3897186815738678},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3418751358985901},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1612495481967926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1067800521850586}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/1061186x.2019.1605519","doi":"https://doi.org/10.1080/1061186x.2019.1605519","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1061186x.2019.1605519","pdf_url":null,"source":{"id":"https://openalex.org/S100629371","display_name":"Journal of drug targeting","issn_l":"1026-7158","issn":["1026-7158","1029-2330","1061-186X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Targeting","raw_type":"journal-article"},{"id":"pmid:31056963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31056963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drug targeting","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W177186481","https://openalex.org/W574462879","https://openalex.org/W1190494591","https://openalex.org/W1583054722","https://openalex.org/W1585195307","https://openalex.org/W1722289295","https://openalex.org/W1951075546","https://openalex.org/W1965513606","https://openalex.org/W1966912731","https://openalex.org/W1971565911","https://openalex.org/W1974113113","https://openalex.org/W1981281388","https://openalex.org/W1984073962","https://openalex.org/W1984371096","https://openalex.org/W1985211115","https://openalex.org/W1985308585","https://openalex.org/W1987065605","https://openalex.org/W1988085908","https://openalex.org/W1991746961","https://openalex.org/W1997145913","https://openalex.org/W2001686534","https://openalex.org/W2002418205","https://openalex.org/W2004173211","https://openalex.org/W2010338855","https://openalex.org/W2014316879","https://openalex.org/W2022631487","https://openalex.org/W2024492396","https://openalex.org/W2024786674","https://openalex.org/W2030898588","https://openalex.org/W2034629671","https://openalex.org/W2034896461","https://openalex.org/W2037331644","https://openalex.org/W2038129428","https://openalex.org/W2041497080","https://openalex.org/W2043661576","https://openalex.org/W2045029750","https://openalex.org/W2054829361","https://openalex.org/W2054850873","https://openalex.org/W2055519118","https://openalex.org/W2056501544","https://openalex.org/W2066605494","https://openalex.org/W2068753140","https://openalex.org/W2071418897","https://openalex.org/W2071754840","https://openalex.org/W2086201463","https://openalex.org/W2089890578","https://openalex.org/W2093026971","https://openalex.org/W2096417401","https://openalex.org/W2100044165","https://openalex.org/W2101345691","https://openalex.org/W2101690600","https://openalex.org/W2103420582","https://openalex.org/W2106039024","https://openalex.org/W2110197462","https://openalex.org/W2118964113","https://openalex.org/W2123356446","https://openalex.org/W2129131491","https://openalex.org/W2129222266","https://openalex.org/W2140625809","https://openalex.org/W2150805233","https://openalex.org/W2154202727","https://openalex.org/W2155837574","https://openalex.org/W2156531035","https://openalex.org/W2158153532","https://openalex.org/W2161483027","https://openalex.org/W2161817637","https://openalex.org/W2163435127","https://openalex.org/W2163588562","https://openalex.org/W2163832486","https://openalex.org/W2165368743","https://openalex.org/W2171207571","https://openalex.org/W2312634587","https://openalex.org/W2328603548","https://openalex.org/W2340669800","https://openalex.org/W2386879760","https://openalex.org/W2477417872","https://openalex.org/W2483760101","https://openalex.org/W2541358760","https://openalex.org/W2543110461","https://openalex.org/W2545308352","https://openalex.org/W2551037394","https://openalex.org/W2568724142","https://openalex.org/W2582897574","https://openalex.org/W2592035771","https://openalex.org/W2604757237","https://openalex.org/W2613415919","https://openalex.org/W2614493867","https://openalex.org/W2735875576","https://openalex.org/W2735916077","https://openalex.org/W2743291675","https://openalex.org/W2753468713","https://openalex.org/W2772086055","https://openalex.org/W2890638020","https://openalex.org/W2910815001","https://openalex.org/W7098997929"],"related_works":["https://openalex.org/W1989236302","https://openalex.org/W2063370132","https://openalex.org/W2120526866","https://openalex.org/W3032879706","https://openalex.org/W2890638020","https://openalex.org/W2010336485","https://openalex.org/W177186481","https://openalex.org/W2344049925","https://openalex.org/W2077117930","https://openalex.org/W2114382827"],"abstract_inverted_index":{"SIRT1,":[0],"which":[1],"is":[2,32],"highly":[3,33],"homologous":[4],"to":[5,55],"yeast":[6],"silent":[7],"information":[8],"regulator":[9],"2,":[10],"has":[11,53,71],"recently":[12],"garnered":[13],"tremendous":[14],"attention":[15],"because":[16],"of":[17,39,49,81,90],"its":[18,60],"various":[19],"regulatory":[20],"effects":[21],"in":[22,35,51,83],"several":[23],"pathological":[24],"conditions.":[25],"Numerous":[26],"studies":[27],"have":[28],"found":[29],"that":[30],"SIRT1":[31,50,82,91],"expressed":[34],"a":[36,63,93],"broad":[37],"range":[38],"tumours":[40,70],"compared":[41],"with":[42],"the":[43,47,79,87],"paracancerous":[44],"tissue.":[45],"However,":[46],"role":[48],"malignancies":[52],"yet":[54],"be":[56],"systematically":[57],"elucidated,":[58],"and":[59,85],"use":[61,89],"as":[62,92],"promising":[64,94],"biomarker":[65,96],"or":[66,97],"therapeutic":[67,98],"target":[68],"for":[69],"not":[72],"been":[73],"well-reported.":[74],"Herein,":[75],"we":[76],"focus":[77],"on":[78],"roles":[80],"cancers":[84],"summarise":[86],"potential":[88],"tumour":[95],"target.":[99]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-05-09T00:00:00"}
