{"id":"https://openalex.org/W2943225619","doi":"https://doi.org/10.7326/m19-1013","title":"Mortality Risk in Older Adults: What the Nose Knows","display_name":"Mortality Risk in Older Adults: What the Nose Knows","publication_year":2019,"publication_date":"2019-04-30","ids":{"openalex":"https://openalex.org/W2943225619","doi":"https://doi.org/10.7326/m19-1013","mag":"2943225619","pmid":"https://pubmed.ncbi.nlm.nih.gov/31035295"},"language":"en","primary_location":{"id":"doi:10.7326/m19-1013","doi":"https://doi.org/10.7326/m19-1013","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m19-1013","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075841791","display_name":"Vidyulata J. Kamath","orcid":"https://orcid.org/0000-0001-7711-3597","observed_orcids":["https://orcid.org/0000-0001-7711-3597"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidyulata Kamath","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Baltimore, Maryland (V.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Baltimore, Maryland (V.K.)","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083477380","display_name":"Bruce A. Leff","orcid":"https://orcid.org/0000-0003-1714-7458","observed_orcids":["https://orcid.org/0000-0003-1714-7458"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Leff","raw_affiliation_strings":["The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Johns Hopkins School of Nursing, Baltimore, Maryland (B.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Johns Hopkins School of Nursing, Baltimore, Maryland (B.L.)","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"170","issue":"10","first_page":"722","last_page":"723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olfactory-dysfunction","display_name":"olfactory dysfunction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anosmia","display_name":"anosmia","score":0.5799999833106995},{"id":"https://openalex.org/keywords/mortality-risk","display_name":"mortality risk","score":0.8870000243186951},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9890000224113464},{"id":"https://openalex.org/keywords/odor-identification","display_name":"odor identification","score":0.703000009059906},{"id":"https://openalex.org/keywords/olfactory-nerve","display_name":"olfactory nerve","score":0.5809999704360962},{"id":"https://openalex.org/keywords/appetite","display_name":"appetite","score":0.3149999976158142},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.6340000033378601},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.5669999718666077},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.5926663875579834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5771937370300293},{"id":"https://openalex.org/C163214680","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfaction","level":2,"score":0.5272811055183411},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3436232805252075},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27145832777023315}],"mesh":[{"descriptor_ui":"D009666","descriptor_name":"Nose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057187","descriptor_name":"Independent Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7326/m19-1013","doi":"https://doi.org/10.7326/m19-1013","is_oa":false,"landing_page_url":"https://doi.org/10.7326/m19-1013","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:31035295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31035295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2010082386","https://openalex.org/W2056118681","https://openalex.org/W2117696888","https://openalex.org/W2139295438","https://openalex.org/W2140625462","https://openalex.org/W2156297351","https://openalex.org/W2291289268","https://openalex.org/W2564825033","https://openalex.org/W2598034755","https://openalex.org/W2617879515","https://openalex.org/W2942707571","https://openalex.org/W4245621102","https://openalex.org/W4247626895"],"related_works":["https://openalex.org/W3006695261","https://openalex.org/W4410231322","https://openalex.org/W7097022928","https://openalex.org/W4306734217","https://openalex.org/W2139295438","https://openalex.org/W2056118681","https://openalex.org/W2345111102","https://openalex.org/W3161511522","https://openalex.org/W7095633341","https://openalex.org/W2117696888"],"abstract_inverted_index":{"Editorials21":[0],"May":[1,641,659],"2019Mortality":[2],"Risk":[3],"in":[4,83,177,203,230,266,331,390,423,453],"Older":[5,600],"Adults:":[6],"What":[7],"the":[8,72,140,149,267],"Nose":[9],"KnowsVidyulata":[10],"Kamath,":[11,17,512],"PhD":[12],"and":[13,28,45,55,76,85,93,98,105,108,117,133,151,175,227,263,327,365,420,449,469,495,566,596,630],"Bruce":[14,29],"Leff,":[15,30],"MDVidyulata":[16],"PhDThe":[18],"Johns":[19,32,38,46,473,482,488,496,519,546,568],"Hopkins":[20,33,39,47,474,483,489,497,520,547,569],"University":[21,34,475,484,521,548,570],"School":[22,35,41,48,476,485,491,498,522,549,571],"of":[23,36,42,49,89,95,298,329,385,451,457,477,486,492,499,515,523,542,550,563,572,636,638,669],"Medicine,":[24,37,478,487,524,551,573],"Baltimore,":[25,51,479,501,531,558,577],"Maryland":[26,52,480,502],"(V.K.)":[27],"MDThe":[31],"Bloomberg":[40,490],"Public":[43,493],"Health,":[44,494],"Nursing,":[50,500],"(B.L.)Author,":[53],"Article,":[54,468],"Disclosure":[56,470],"Informationhttps://doi.org/10.7326/M19-1013":[57],"SectionsAboutFull":[58],"TextPDF":[59],"ToolsAdd":[60],"to":[61,125,148,155,161],"favoritesDownload":[62],"CitationsTrack":[63],"CitationsPermissions":[64],"ShareFacebookTwitterLinkedInRedditEmail":[65],"The":[66,87,136,222,472,518,545],"human":[67],"olfactory":[68,137,225],"system":[69],"is":[70,139,145,153],"among":[71,367],"oldest":[73],"limbic":[74],"structures":[75],"has":[77],"a":[78,454],"critical":[79],"yet":[80],"underappreciated":[81],"role":[82],"health":[84],"behavior.":[86,119],"sense":[88],"smell":[90],"facilitates":[91],"detection":[92],"identification":[94,174,261],"spoiled":[96],"food":[97],"volatile":[99],"environmental":[100],"hazards,":[101],"influences":[102],"healthy":[103],"grooming":[104],"personal":[106],"hygiene,":[107],"affects":[109],"nutritional":[110],"status":[111],"through":[112],"its":[113],"impact":[114],"on":[115,585],"appetite":[116],"feeding":[118],"Olfactory":[120,198,260,415],"regions":[121,128],"have":[122],"reciprocal":[123],"connections":[124],"key":[126],"brain":[127],"that":[129,144,159],"subserve":[130],"memory,":[131],"emotion,":[132],"satiety":[134],"signaling.":[135],"nerve":[138,143,388],"only":[141],"cranial":[142,387],"directly":[146],"exposed":[147],"environment,":[150],"it":[152],"vulnerable":[154],"disruption":[156],"by":[157,666],"conditions":[158],"contribute":[160],"mortality,":[162],"including":[163],"medical":[164],"illness,":[165],"...References1.":[166],"Wilson":[167],"RS,":[168],"Yu":[169],"L,":[170],"Bennett":[171],"DA.":[172],"Odor":[173],"mortality":[176,202,229,265,295,330,366],"old":[178],"age.":[179],"Chem":[180],"Senses.":[181],"2011;36:63-7.":[182],"[PMID:":[183,209,241,272,306,342,397,429,462],"20923931]":[184],"doi:10.1093/chemse/bjq098":[185],"CrossrefMedlineGoogle":[186,212,244,275,309,345,399,432,465],"Scholar2.":[187],"Pinto":[188,315,351,610],"JM,":[189,352],"Wroblewski":[190],"KE,":[191],"Kern":[192],"DW,":[193],"Schumm":[194],"LP,":[195],"McClintock":[196],"MK.":[197],"dysfunction":[199],"predicts":[200,294],"5-year":[201],"older":[204,231,332,369,458],"adults.":[205,232,333,370,459],"PLoS":[206],"One.":[207],"2014;9:e107541.":[208],"25271633]":[210],"doi:10.1371/journal.pone.0107541":[211],"Scholar3.":[213],"Gopinath":[214],"B,":[215,348],"Sue":[216],"CM,":[217],"Kifley":[218],"A,":[219,257,285,443],"Mitchell":[220],"P.":[221],"association":[223],"between":[224,362],"impairment":[226],"total":[228],"J":[233,301,334],"Gerontol":[234,335],"A":[235,336,371],"Biol":[236,337],"Sci":[237,338],"Med":[238,339],"Sci.":[239,340],"2012;67:204-9.":[240],"22080501]":[242],"doi:10.1093/gerona/glr165":[243],"Scholar4.":[245],"Devanand":[246,401],"DP,":[247,402],"Lee":[248,403],"S,":[249,280,282,404,445],"Manly":[250,405],"J,":[251,406],"Andrews":[252,407],"H,":[253,408,439],"Schupf":[254,409],"N,":[255,410],"Masurkar":[256],"et":[258,290,323,359,413,446],"al.":[259,291,324,360,414,447],"deficits":[262,416],"increased":[264],"community.":[268,426],"Ann":[269,374],"Neurol.":[270],"2015;78:401-11.":[271],"26031760]":[273],"doi:10.1002/ana.24447":[274],"Scholar5.":[276],"Ekstr\u00f6m":[277],"I,":[278],"Sj\u00f6lund":[279],"Nordin":[281,283],"Adolfsson":[284,286],"R,":[287,320],"Nilsson":[288],"LG,":[289],"Smell":[292],"loss":[293,651],"risk":[296,328,450],"regardless":[297],"dementia":[299,422,452],"conversion.":[300],"Am":[302],"Geriatr":[303],"Soc.":[304],"2017;65:1238-43.":[305],"28326534]":[307],"doi:10.1111/jgs.14770":[308],"Scholar6.":[310],"Schubert":[311],"CR,":[312],"Fischer":[313],"ME,":[314],"AA,":[316],"Klein":[317,319],"BEK,":[318],"Tweed":[321],"TS,":[322],"Sensory":[325],"impairments":[326],"2017;72:710-5.":[341],"26946102]":[343],"doi:10.1093/gerona/glw036":[344],"Scholar7.":[346],"Liu":[347,603],"Luo":[349,606],"Z,":[350],"Shiroma":[353,614],"EJ,":[354],"Tranah":[355,618],"GJ,":[356],"Wirdefeldt":[357,621],"K,":[358,435,441],"Relationship":[361],"poor":[363],"olfaction":[364],"community-dwelling":[368],"cohort":[372,456],"study.":[373],"Intern":[375],"Med.":[376],"2019;170:673-81.":[377],"doi:10.7326/M18-0775":[378],"LinkGoogle":[379],"Scholar8.":[380],"Waldton":[381],"S.":[382],"Clinical":[383],"observations":[384],"impaired":[386],"function":[389],"senile":[391],"dementia.":[392],"Acta":[393],"Psychiatr":[394],"Scand.":[395],"1974;50:539-47.":[396],"4460686]":[398],"Scholar9.":[400],"Doty":[411],"RL,":[412],"predict":[417],"cognitive":[418],"decline":[419],"Alzheimer":[421],"an":[424],"urban":[425],"Neurology.":[427,460],"2015;84:182-9.":[428],"25471394]":[430],"doi:10.1212/WNL.0000000000001132":[431],"Scholar10.":[433],"Yaffe":[434],"Freimer":[436],"D,":[437],"Chen":[438,632],"Asao":[440],"Rosso":[442],"Rubin":[444],"Olfaction":[448,595],"biracial":[455],"2017;88:456-62.":[461],"28039314]":[463],"doi:10.1212/WNL.0000000000003558":[464],"Scholar":[466],"Author,":[467],"InformationAffiliations:":[471],"(V.K.)The":[481],"(B.L.)Disclosures:":[503],"Disclosures":[504],"can":[505],"be":[506],"viewed":[507],"at":[508,583],"www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-1013.Corresponding":[509],"Author:":[510],"Vidyulata":[511],"PhD,":[513],"Division":[514,541,562],"Medical":[516,543],"Psychology,":[517,544],"600":[525,552],"North":[526,553],"Wolfe":[527,554],"Street,":[528,555],"Meyer":[529,556],"218,":[530,557],"MD":[532,559,578],"21287;":[533],"e-mail,":[534],"[email":[535],"protected]edu.Current":[536],"Author":[537],"Addresses:":[538],"Dr.":[539],"Kamath:":[540],"21287.Dr.":[560],"Leff:":[561],"Geriatric":[564],"Medicine":[565],"Gerontology,":[567],"5200":[574],"Eastern":[575],"Avenue,":[576],"21224.This":[579],"article":[580],"was":[581],"published":[582],"Annals.org":[584],"30":[586,653],"April":[587,654],"2019.":[588],"PreviousarticleNextarticle":[589],"Advertisement":[590],"FiguresReferencesRelatedDetailsSee":[591],"AlsoRelationship":[592],"Between":[593],"Poor":[594],"Mortality":[597],"Among":[598],"Community-Dwelling":[599],"Adults":[601],"Bojing":[602],",":[604,607,611,615,619,622,625,629],"Zhehui":[605],"Jayant":[608],"M.":[609],"Eric":[612],"J.":[613,617],"Gregory":[616],"Karin":[620],"Fang":[623,624],"Tamara":[626],"B.":[627],"Harris":[628],"Honglei":[631],"Metrics":[633],"Cited":[634],"byPhysiology":[635],"AgingPhysiology":[637],"Aging":[639],"21":[640,658],"2019Volume":[642],"170,":[643],"Issue":[644,656],"10Page:":[645],"722-723KeywordsAgingCohort":[646],"studiesDementiaElderlyLongitudinal":[647],"studiesMortalityNeurodegenerative":[648],"diseasesParkinson":[649],"diseaseSmellWeight":[650],"ePublished:":[652],"2019":[655,660,665],"Published:":[657],"Copyright":[661],"&":[662],"PermissionsCopyright":[663],"\u00a9":[664],"American":[667],"College":[668],"Physicians.":[670],"All":[671],"Rights":[672],"Reserved.PDF":[673],"downloadLoading":[674],"...":[675]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-09T00:00:00"}