{"id":"https://openalex.org/W2943155462","doi":"https://doi.org/10.1016/j.phrs.2019.104256","title":"Pharmacological actions and therapeutic potentials of bilirubin in islet transplantation for the treatment of diabetes","display_name":"Pharmacological actions and therapeutic potentials of bilirubin in islet transplantation for the treatment of diabetes","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2943155462","doi":"https://doi.org/10.1016/j.phrs.2019.104256","mag":"2943155462","pmid":"https://pubmed.ncbi.nlm.nih.gov/31054312"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2019.104256","doi":"https://doi.org/10.1016/j.phrs.2019.104256","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2019.104256","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009368703","display_name":"Qing Yao","orcid":"https://orcid.org/0000-0003-0115-9075","observed_orcids":["https://orcid.org/0000-0003-0115-9075"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Yao","raw_affiliation_strings":["School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: yqpharm@163.com","School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":"https://orcid.org/0000-0003-0115-9075","affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: yqpharm@163.com","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101613961","display_name":"Xue Jiang","orcid":"https://orcid.org/0000-0002-2048-1767","observed_orcids":["https://orcid.org/0000-0002-2048-1767"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Jiang","raw_affiliation_strings":["School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084818765","display_name":"Longfa Kou","orcid":"https://orcid.org/0000-0001-8502-4279","observed_orcids":["https://orcid.org/0000-0001-8502-4279"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longfa Kou","raw_affiliation_strings":["The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029915552","display_name":"Adelaide T. Samuriwo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Adelaide T. Samuriwo","raw_affiliation_strings":["School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045648276","display_name":"Helin Xu","orcid":"https://orcid.org/0000-0001-5312-7820","observed_orcids":["https://orcid.org/0000-0001-5312-7820"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He-Lin Xu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100923596","display_name":"Ying\u2010Zheng Zhao","orcid":"https://orcid.org/0009-0007-6819-3231","observed_orcids":["https://orcid.org/0009-0007-6819-3231"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying-Zheng Zhao","raw_affiliation_strings":["School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: pharmtds@163.com","School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: pharmtds@163.com","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China","institution_ids":["https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009368703","https://openalex.org/A5100923596"],"corresponding_institution_ids":["https://openalex.org/I27781120"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":0.4179,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.39286371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"145","issue":null,"first_page":"104256","last_page":"104256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.28200000524520874,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":1.0},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":1.0},{"id":"https://openalex.org/keywords/islet-protection","display_name":"islet protection","score":0.6959999799728394},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9909999966621399},{"id":"https://openalex.org/keywords/immune-rejection","display_name":"immune rejection","score":0.7139999866485596},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pharmacological-mechanisms","display_name":"pharmacological mechanisms","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8251952528953552},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.767483651638031},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6075092554092407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6057826280593872},{"id":"https://openalex.org/C2777411314","wikidata":"https://www.wikidata.org/wiki/Q1664517","display_name":"Islet cell transplantation","level":4,"score":0.4707435071468353},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.4701680541038513},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.45093995332717896},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42284533381462097},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35872989892959595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3270622789859772},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2944730520248413}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2019.104256","doi":"https://doi.org/10.1016/j.phrs.2019.104256","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2019.104256","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:31054312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31054312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5171566406","display_name":null,"funder_award_id":"81571392","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G945262793","display_name":null,"funder_award_id":"81772316","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327809","display_name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1512758510","https://openalex.org/W1607264122","https://openalex.org/W1881100739","https://openalex.org/W1900670142","https://openalex.org/W1945667310","https://openalex.org/W1948770027","https://openalex.org/W1966582616","https://openalex.org/W1968972782","https://openalex.org/W1971637301","https://openalex.org/W1978288865","https://openalex.org/W1980303724","https://openalex.org/W1986319516","https://openalex.org/W1987777210","https://openalex.org/W1993077324","https://openalex.org/W1993122745","https://openalex.org/W1998411289","https://openalex.org/W2021443072","https://openalex.org/W2028874766","https://openalex.org/W2036499561","https://openalex.org/W2041724829","https://openalex.org/W2050761331","https://openalex.org/W2056410662","https://openalex.org/W2058293228","https://openalex.org/W2062573090","https://openalex.org/W2067757134","https://openalex.org/W2083957671","https://openalex.org/W2086751835","https://openalex.org/W2089100446","https://openalex.org/W2095002839","https://openalex.org/W2101841221","https://openalex.org/W2105731956","https://openalex.org/W2116345973","https://openalex.org/W2116461298","https://openalex.org/W2122025820","https://openalex.org/W2127798432","https://openalex.org/W2136127635","https://openalex.org/W2141749502","https://openalex.org/W2152189447","https://openalex.org/W2153934627","https://openalex.org/W2164519226","https://openalex.org/W2195434535","https://openalex.org/W2234396308","https://openalex.org/W2264698511","https://openalex.org/W2335950049","https://openalex.org/W2343128608","https://openalex.org/W2346987069","https://openalex.org/W2395179752","https://openalex.org/W2403445405","https://openalex.org/W2467585178","https://openalex.org/W2471039706","https://openalex.org/W2488374037","https://openalex.org/W2505003459","https://openalex.org/W2508196617","https://openalex.org/W2516954156","https://openalex.org/W2554650020","https://openalex.org/W2560734985","https://openalex.org/W2569544800","https://openalex.org/W2580021927","https://openalex.org/W2590470309","https://openalex.org/W2595371222","https://openalex.org/W2599064047","https://openalex.org/W2606390916","https://openalex.org/W2615579411","https://openalex.org/W2620106997","https://openalex.org/W2626072785","https://openalex.org/W2747754797","https://openalex.org/W2751737965","https://openalex.org/W2765817436","https://openalex.org/W2766975249","https://openalex.org/W2771706219","https://openalex.org/W2773213563","https://openalex.org/W2773289331","https://openalex.org/W2774426915","https://openalex.org/W2778303971","https://openalex.org/W2790518348","https://openalex.org/W2790566633","https://openalex.org/W2792586015","https://openalex.org/W2792888090","https://openalex.org/W2792971737","https://openalex.org/W2795272867","https://openalex.org/W2799570943","https://openalex.org/W2799776696","https://openalex.org/W2883398259","https://openalex.org/W2887308812","https://openalex.org/W2889921714","https://openalex.org/W2890787708","https://openalex.org/W6731859396","https://openalex.org/W6733979227","https://openalex.org/W6738499987","https://openalex.org/W6749103587"],"related_works":["https://openalex.org/W2966804350","https://openalex.org/W3036733618","https://openalex.org/W2999811204","https://openalex.org/W2472741975","https://openalex.org/W1968972782","https://openalex.org/W2086751835","https://openalex.org/W2143468368","https://openalex.org/W2111952445","https://openalex.org/W2778303971","https://openalex.org/W2606390916"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-09T00:00:00"}