{"id":"https://openalex.org/W2943112186","doi":"https://doi.org/10.1039/c9nr00943d","title":"Nanoscale distribution of TLR4 on primary human macrophages stimulated with LPS and ATI","display_name":"Nanoscale distribution of TLR4 on primary human macrophages stimulated with LPS and ATI","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2943112186","doi":"https://doi.org/10.1039/c9nr00943d","mag":"2943112186","pmid":"https://pubmed.ncbi.nlm.nih.gov/31066732"},"language":"en","primary_location":{"id":"doi:10.1039/c9nr00943d","doi":"https://doi.org/10.1039/c9nr00943d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c9nr00943d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2019/nr/c9nr00943d","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2019/nr/c9nr00943d","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078826627","display_name":"J Neumann","orcid":"https://orcid.org/0000-0003-1435-8129","observed_orcids":["https://orcid.org/0000-0003-1435-8129"]},"institutions":[{"id":"https://openalex.org/I4210113422","display_name":"Max Planck Institute for Chemistry","ror":"https://ror.org/02f5b7n18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210113422"]},{"id":"https://openalex.org/I4210165538","display_name":"Institute of Molecular Biology","ror":"https://ror.org/05kxtq558","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165538"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Neumann","raw_affiliation_strings":["55128 Mainz","Germany","Institute of Molecular Biology","Max Planck Institute for Chemistry","Multiphase Chemistry Department","Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany","Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1435-8129","affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Chemistry","institution_ids":["https://openalex.org/I4210113422"]},{"raw_affiliation_string":"Multiphase Chemistry Department","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210165538"]},{"raw_affiliation_string":"Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210113422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004357895","display_name":"Kira Ziegler","orcid":"https://orcid.org/0000-0003-1368-9487","observed_orcids":["https://orcid.org/0000-0003-1368-9487"]},"institutions":[{"id":"https://openalex.org/I4210113422","display_name":"Max Planck Institute for Chemistry","ror":"https://ror.org/02f5b7n18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210113422"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kira Ziegler","raw_affiliation_strings":["55128 Mainz","Germany","Max Planck Institute for Chemistry","Multiphase Chemistry Department","Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1368-9487","affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Chemistry","institution_ids":["https://openalex.org/I4210113422"]},{"raw_affiliation_string":"Multiphase Chemistry Department","institution_ids":[]},{"raw_affiliation_string":"Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210113422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011438361","display_name":"M\u00e1rton Gell\u00e9ri","orcid":"https://orcid.org/0000-0003-2145-838X","observed_orcids":["https://orcid.org/0000-0003-2145-838X"]},"institutions":[{"id":"https://openalex.org/I4210165538","display_name":"Institute of Molecular Biology","ror":"https://ror.org/05kxtq558","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165538"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M\u00e1rton Gell\u00e9ri","raw_affiliation_strings":["55128 Mainz","Germany","Institute of Molecular Biology","Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210165538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057353442","display_name":"Janine Fr\u00f6hlich\u2010Nowoisky","orcid":"https://orcid.org/0000-0002-1278-0054","observed_orcids":["https://orcid.org/0000-0002-1278-0054"]},"institutions":[{"id":"https://openalex.org/I4210113422","display_name":"Max Planck Institute for Chemistry","ror":"https://ror.org/02f5b7n18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210113422"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janine Fr\u00f6hlich-Nowoisky","raw_affiliation_strings":["55128 Mainz","Germany","Max Planck Institute for Chemistry","Multiphase Chemistry Department","Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1278-0054","affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Chemistry","institution_ids":["https://openalex.org/I4210113422"]},{"raw_affiliation_string":"Multiphase Chemistry Department","institution_ids":[]},{"raw_affiliation_string":"Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210113422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016021122","display_name":"Fobang Liu","orcid":"https://orcid.org/0000-0002-9914-165X","observed_orcids":["https://orcid.org/0000-0002-9914-165X"]},"institutions":[{"id":"https://openalex.org/I4210113422","display_name":"Max Planck Institute for Chemistry","ror":"https://ror.org/02f5b7n18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210113422"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fobang Liu","raw_affiliation_strings":["55128 Mainz","Germany","Max Planck Institute for Chemistry","Multiphase Chemistry Department","Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Chemistry","institution_ids":["https://openalex.org/I4210113422"]},{"raw_affiliation_string":"Multiphase Chemistry Department","institution_ids":[]},{"raw_affiliation_string":"Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210113422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013745387","display_name":"Iris Bellinghausen","orcid":"https://orcid.org/0000-0001-7281-0844","observed_orcids":["https://orcid.org/0000-0001-7281-0844"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Iris Bellinghausen","raw_affiliation_strings":["55131 Mainz","Department of Dermatology","Germany","University Medical Center of the Johannes Gutenberg University","Department of Dermatology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7281-0844","affiliations":[{"raw_affiliation_string":"55131 Mainz","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"University Medical Center of the Johannes Gutenberg University","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Department of Dermatology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006504627","display_name":"Detlef Schuppan","orcid":"https://orcid.org/0000-0002-4972-1293","observed_orcids":["https://orcid.org/0000-0002-4972-1293"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Detlef Schuppan","raw_affiliation_strings":["55131 Mainz","Division of Gastroenterology","Germany","Institute of Translational Immunology","University Medical Center of the Johannes Gutenberg University","Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA"],"raw_orcid":"https://orcid.org/0000-0002-4972-1293","affiliations":[{"raw_affiliation_string":"55131 Mainz","institution_ids":[]},{"raw_affiliation_string":"Division of Gastroenterology","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Translational Immunology","institution_ids":[]},{"raw_affiliation_string":"University Medical Center of the Johannes Gutenberg University","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]},{"raw_affiliation_string":"Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026493064","display_name":"Udo Jochen Birk","orcid":"https://orcid.org/0000-0001-6313-7475","observed_orcids":["https://orcid.org/0000-0001-6313-7475"]},"institutions":[{"id":"https://openalex.org/I4210165538","display_name":"Institute of Molecular Biology","ror":"https://ror.org/05kxtq558","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165538"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Udo Birk","raw_affiliation_strings":["55128 Mainz","Germany","Institute of Molecular Biology","Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6313-7475","affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210165538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057359066","display_name":"Ulrich P\u00f6schl","orcid":"https://orcid.org/0000-0003-1412-3557","observed_orcids":["https://orcid.org/0000-0003-1412-3557"]},"institutions":[{"id":"https://openalex.org/I4210113422","display_name":"Max Planck Institute for Chemistry","ror":"https://ror.org/02f5b7n18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210113422"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich P\u00f6schl","raw_affiliation_strings":["55128 Mainz","Germany","Max Planck Institute for Chemistry","Multiphase Chemistry Department","Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1412-3557","affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Chemistry","institution_ids":["https://openalex.org/I4210113422"]},{"raw_affiliation_string":"Multiphase Chemistry Department","institution_ids":[]},{"raw_affiliation_string":"Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210113422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058586071","display_name":"Christoph G. Cremer","orcid":"https://orcid.org/0000-0002-2090-6905","observed_orcids":["https://orcid.org/0000-0002-2090-6905","https://orcid.org/0000-0002-1830-9589"]},"institutions":[{"id":"https://openalex.org/I4210113422","display_name":"Max Planck Institute for Chemistry","ror":"https://ror.org/02f5b7n18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210113422"]},{"id":"https://openalex.org/I4210165538","display_name":"Institute of Molecular Biology","ror":"https://ror.org/05kxtq558","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165538"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Cremer","raw_affiliation_strings":["55128 Mainz","Germany","Institute of Molecular Biology","Max Planck Institute for Chemistry","Multiphase Chemistry Department","Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany","Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2090-6905","affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Chemistry","institution_ids":["https://openalex.org/I4210113422"]},{"raw_affiliation_string":"Multiphase Chemistry Department","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210165538"]},{"raw_affiliation_string":"Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210113422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034561426","display_name":"Kurt Lucas","orcid":"https://orcid.org/0000-0001-8267-7397","observed_orcids":["https://orcid.org/0000-0001-8267-7397"]},"institutions":[{"id":"https://openalex.org/I4210113422","display_name":"Max Planck Institute for Chemistry","ror":"https://ror.org/02f5b7n18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210113422"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kurt Lucas","raw_affiliation_strings":["55128 Mainz","Germany","Max Planck Institute for Chemistry","Multiphase Chemistry Department","Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8267-7397","affiliations":[{"raw_affiliation_string":"55128 Mainz","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Chemistry","institution_ids":["https://openalex.org/I4210113422"]},{"raw_affiliation_string":"Multiphase Chemistry Department","institution_ids":[]},{"raw_affiliation_string":"Multiphase Chemistry Department, Max Planck Institute for Chemistry, Hahn-Meitner-Weg 1, 55128 Mainz, Germany","institution_ids":["https://openalex.org/I4210113422"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5034561426"],"corresponding_institution_ids":["https://openalex.org/I4210113422"],"apc_list":null,"apc_paid":null,"fwci":0.9791,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.71261515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"19","first_page":"9769","last_page":"9779"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9710000157356262},{"id":"https://openalex.org/keywords/receptor-clustering","display_name":"receptor clustering","score":0.8569999933242798},{"id":"https://openalex.org/keywords/membrane-distribution","display_name":"membrane distribution","score":0.722000002861023},{"id":"https://openalex.org/keywords/single-molecule-localization-microscopy","display_name":"single-molecule localization microscopy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gluten","display_name":"gluten","score":0.4860000014305115},{"id":"https://openalex.org/keywords/signaling-platforms","display_name":"signaling platforms","score":0.671999990940094},{"id":"https://openalex.org/keywords/donor-variability","display_name":"donor variability","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.6885999441146851},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6748432517051697},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.6742668747901917},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3917554020881653},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36853861808776855},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3676961064338684},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33598098158836365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20336833596229553},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13842719793319702},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08385524153709412},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014361","descriptor_name":"Trypsin Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/c9nr00943d","doi":"https://doi.org/10.1039/c9nr00943d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c9nr00943d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2019/nr/c9nr00943d","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},{"id":"pmid:31066732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31066732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"Journal Article"},{"id":"pmh:oai:pure.mpg.de:item_3080828","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0003-EC5A-F","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nanoscale","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1039/c9nr00943d","doi":"https://doi.org/10.1039/c9nr00943d","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c9nr00943d","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2019/nr/c9nr00943d","source":{"id":"https://openalex.org/S23181512","display_name":"Nanoscale","issn_l":"2040-3364","issn":["2040-3364","2040-3372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanoscale","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1259633684","display_name":null,"funder_award_id":"BE 4504/3-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1638155935","display_name":null,"funder_award_id":"DFG Schu646/17-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3273196857","display_name":"Spinning Disk Confocal Microscope","funder_award_id":"402386039","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4349347763","display_name":null,"funder_award_id":"DFG Schu 646/20-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322301","display_name":"Johannes Gutenberg-Universit\u00e4t Mainz","ror":"https://ror.org/023b0x485"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943112186.pdf","grobid_xml":"https://content.openalex.org/works/W2943112186.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1494412155","https://openalex.org/W1893408494","https://openalex.org/W1967041495","https://openalex.org/W1969175670","https://openalex.org/W1992858116","https://openalex.org/W1995484660","https://openalex.org/W1997904982","https://openalex.org/W2001750397","https://openalex.org/W2006134319","https://openalex.org/W2015258075","https://openalex.org/W2021810362","https://openalex.org/W2023746601","https://openalex.org/W2032829494","https://openalex.org/W2033023829","https://openalex.org/W2043891370","https://openalex.org/W2049197565","https://openalex.org/W2054455698","https://openalex.org/W2062409614","https://openalex.org/W2064435741","https://openalex.org/W2064565544","https://openalex.org/W2068098140","https://openalex.org/W2068365384","https://openalex.org/W2073382731","https://openalex.org/W2075119852","https://openalex.org/W2078565488","https://openalex.org/W2086501301","https://openalex.org/W2086525281","https://openalex.org/W2091102092","https://openalex.org/W2101336703","https://openalex.org/W2105731567","https://openalex.org/W2106316394","https://openalex.org/W2111428445","https://openalex.org/W2115737236","https://openalex.org/W2118659568","https://openalex.org/W2121131635","https://openalex.org/W2121642161","https://openalex.org/W2123925424","https://openalex.org/W2127934565","https://openalex.org/W2138294176","https://openalex.org/W2139234780","https://openalex.org/W2140546870","https://openalex.org/W2149241780","https://openalex.org/W2157246740","https://openalex.org/W2158603948","https://openalex.org/W2160805000","https://openalex.org/W2165410977","https://openalex.org/W2421881253","https://openalex.org/W2521170301","https://openalex.org/W2554087588","https://openalex.org/W2561900357","https://openalex.org/W2582719690","https://openalex.org/W2601510549","https://openalex.org/W2726258137","https://openalex.org/W2763840905","https://openalex.org/W2765381479","https://openalex.org/W2766275264","https://openalex.org/W2793440851","https://openalex.org/W2795316578","https://openalex.org/W2903919837","https://openalex.org/W2914070748"],"related_works":["https://openalex.org/W2952800838","https://openalex.org/W2100788479","https://openalex.org/W2358311350","https://openalex.org/W2906613938","https://openalex.org/W4409415427","https://openalex.org/W2112175334","https://openalex.org/W1830583197","https://openalex.org/W2892324900","https://openalex.org/W2999878510","https://openalex.org/W1992632078"],"abstract_inverted_index":{"Toll-like":[0],"receptor":[1,213],"4":[2],"(TLR4)":[3],"plays":[4],"a":[5,198,221],"crucial":[6],"role":[7,219],"in":[8,94,107,117,134,204],"the":[9,57,64,70,81,89,110,135,145,157,190],"recognition":[10],"of":[11,59,67,83,92,112,137,142,167,174,193,201],"invading":[12],"pathogens.":[13],"Upon":[14],"activation":[15,203],"by":[16,36],"lipopolysaccharides":[17],"(LPS),":[18],"TLR4":[19,32,68,93,113,202,212],"is":[20],"recruited":[21],"into":[22],"specific":[23],"membrane":[24,65,90,146,191],"domains":[25],"and":[26,53,85,140,149,186,215],"dimerizes.":[27],"In":[28,76],"addition":[29],"to":[30,125],"LPS,":[31],"can":[33],"be":[34],"stimulated":[35],"wheat":[37],"amylase-trypsin":[38],"inhibitors":[39],"(ATI).":[40],"ATI":[41,60,86,150,185],"are":[42,115],"proteins":[43],"associated":[44],"with":[45,120],"gluten":[46],"containing":[47],"grains,":[48],"whose":[49],"ingestion":[50],"promotes":[51],"intestinal":[52],"extraintestinal":[54],"inflammation.":[55],"However,":[56],"effect":[58,82],"vs.":[61],"LPS":[62,84,148,187],"on":[63,88,128,144,189],"distribution":[66,91,192],"at":[69],"nanoscale":[71],"has":[72],"not":[73],"been":[74],"analyzed.":[75],"this":[77],"study,":[78],"we":[79,130,160],"investigated":[80],"stimulation":[87,188],"primary":[95,205],"human":[96,158,206],"macrophages":[97,109],"using":[98],"single":[99],"molecule":[100],"localization":[101],"microscopy":[102],"(SMLM).":[103],"We":[104],"found":[105,131,161],"that":[106],"unstimulated":[108],"majority":[111],"molecules":[114,139],"located":[116],"clusters,":[118],"but":[119,181],"donor-dependent":[121,180],"variations":[122,133],"from":[123],"\u223c51%":[124],"\u223c75%.":[126],"Depending":[127],"pre-clustering,":[129],"pronounced":[132],"fraction":[136],"clustered":[138],"density":[141],"clusters":[143],"upon":[147],"stimulation.":[151],"Although":[152],"clustering":[153,214],"differed":[154],"greatly":[155],"among":[156],"donors,":[159,172],"an":[162],"almost":[163],"constant":[164],"cluster":[165],"diameter":[166],"\u223c44":[168],"nm":[169],"for":[170],"all":[171],"independent":[173],"treatment.":[175],"Together,":[176],"our":[177,209],"results":[178],"show":[179],"comparable":[182],"effects":[183],"between":[184],"TLR4.":[194],"This":[195],"may":[196],"indicate":[197],"general":[199],"mechanism":[200],"macrophages.":[207],"Furthermore,":[208],"methodology":[210],"visualizes":[211],"underlines":[216],"its":[217],"functional":[218],"as":[220],"signaling":[222],"platform.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-05-09T00:00:00"}