{"id":"https://openalex.org/W2943095119","doi":"https://doi.org/10.1371/journal.ppat.1007730","title":"Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system","display_name":"Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system","publication_year":2019,"publication_date":"2019-05-02","ids":{"openalex":"https://openalex.org/W2943095119","doi":"https://doi.org/10.1371/journal.ppat.1007730","mag":"2943095119","pmid":"https://pubmed.ncbi.nlm.nih.gov/31048927","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6497286"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1007730","doi":"https://doi.org/10.1371/journal.ppat.1007730","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007730","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007730&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007730&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert E. Smith","orcid":"https://orcid.org/0000-0003-4948-7174","observed_orcids":["https://orcid.org/0000-0003-4948-7174"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert E. Smith","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":"https://orcid.org/0000-0003-4948-7174","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075242860","display_name":"Bart\u0142omiej Salamaga","orcid":"https://orcid.org/0000-0001-9157-5800","observed_orcids":["https://orcid.org/0000-0001-9157-5800"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bart\u0142omiej Salamaga","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":"https://orcid.org/0000-0001-9157-5800","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049202941","display_name":"Piotr T. Szkuta","orcid":"https://orcid.org/0000-0001-6757-2212","observed_orcids":["https://orcid.org/0000-0001-6757-2212"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Piotr Szkuta","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076136513","display_name":"Natalia H. Hajdamowicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalia Hajdamowicz","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021661829","display_name":"Tomasz K. Prajsnar","orcid":"https://orcid.org/0000-0001-6562-8630","observed_orcids":["https://orcid.org/0000-0001-6562-8630"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tomasz K. Prajsnar","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078351866","display_name":"Gregory S. Bulmer","orcid":"https://orcid.org/0000-0003-4794-2858","observed_orcids":["https://orcid.org/0000-0003-4794-2858"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gregory S. Bulmer","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":"https://orcid.org/0000-0003-4794-2858","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070408387","display_name":"Thierry Fontaine","orcid":"https://orcid.org/0000-0002-8184-789X","observed_orcids":["https://orcid.org/0000-0002-8184-789X"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Fontaine","raw_affiliation_strings":["Unit\u00e9 des Aspergillus, Institut Pasteur, Paris, France","Aspergillus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 des Aspergillus, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Aspergillus","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111387195","display_name":"J Ko\u0142odziejczyk","orcid":"https://orcid.org/0000-0002-2940-5445","observed_orcids":["https://orcid.org/0000-0002-2940-5445"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Justyna Ko\u0142odziejczyk","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001600625","display_name":"Jean\u2010Marie Herry","orcid":"https://orcid.org/0000-0001-8627-9994","observed_orcids":["https://orcid.org/0000-0001-8627-9994"]},"institutions":[{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I3017594750","display_name":"Microbiologie de l\u2019alimentation au service de la sant\u00e9","ror":"https://ror.org/0471cyx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Marie Herry","raw_affiliation_strings":["Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, Jouy en Josas, France","MICrobiologie de l'ALImentation au Service de la Sant\u00e9","Universit\u00e9 Paris Saclay (COmUE)"],"raw_orcid":"https://orcid.org/0000-0001-8627-9994","affiliations":[{"raw_affiliation_string":"Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, Jouy en Josas, France","institution_ids":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750"]},{"raw_affiliation_string":"MICrobiologie de l'ALImentation au Service de la Sant\u00e9","institution_ids":["https://openalex.org/I3017594750"]},{"raw_affiliation_string":"Universit\u00e9 Paris Saclay (COmUE)","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010273258","display_name":"Andrea M. Hounslow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrea M. Hounslow","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070853726","display_name":"Michael P. Williamson","orcid":"https://orcid.org/0000-0001-5572-1903","observed_orcids":["https://orcid.org/0000-0001-5572-1903"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mike P. Williamson","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":"https://orcid.org/0000-0001-5572-1903","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088660770","display_name":"Pascale Serror","orcid":"https://orcid.org/0000-0002-8446-9011","observed_orcids":["https://orcid.org/0000-0002-8446-9011"]},"institutions":[{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I3017594750","display_name":"Microbiologie de l\u2019alimentation au service de la sant\u00e9","ror":"https://ror.org/0471cyx86","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pascale Serror","raw_affiliation_strings":["Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, Jouy en Josas, France","MICrobiologie de l'ALImentation au Service de la Sant\u00e9","Universit\u00e9 Paris Saclay (COmUE)"],"raw_orcid":"https://orcid.org/0000-0002-8446-9011","affiliations":[{"raw_affiliation_string":"Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, Jouy en Josas, France","institution_ids":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750"]},{"raw_affiliation_string":"MICrobiologie de l'ALImentation au Service de la Sant\u00e9","institution_ids":["https://openalex.org/I3017594750"]},{"raw_affiliation_string":"Universit\u00e9 Paris Saclay (COmUE)","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103152628","display_name":"St\u00e9phane Mesnage","orcid":"https://orcid.org/0000-0003-1648-4890","observed_orcids":["https://orcid.org/0000-0003-1648-4890"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"St\u00e9phane Mesnage","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","Department of Molecular Biology and Biotechnology","University of Sheffield"],"raw_orcid":"https://orcid.org/0000-0003-1648-4890","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology","institution_ids":[]},{"raw_affiliation_string":"University of Sheffield","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5088660770","https://openalex.org/A5103152628"],"corresponding_institution_ids":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I3017594750","https://openalex.org/I91136226"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2350,"currency":"USD","value_usd":2350},"fwci":3.4455,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92961418,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"15","issue":"5","first_page":"e1007730","last_page":"e1007730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.46459999680519104,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.46459999680519104,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.3774000108242035,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.02019999921321869,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epa","display_name":"EPA","score":0.6230000257492065},{"id":"https://openalex.org/keywords/lysozyme-resistance","display_name":"lysozyme resistance","score":0.828000009059906},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7080000042915344},{"id":"https://openalex.org/keywords/phagocytosis-resistance","display_name":"phagocytosis resistance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cell-surface-charge","display_name":"cell surface charge","score":0.7200000286102295},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"innate immune system","score":0.5249999761581421},{"id":"https://openalex.org/keywords/zebrafish-infection-model","display_name":"zebrafish infection model","score":0.7839999794960022},{"id":"https://openalex.org/keywords/transposon-mutagenesis","display_name":"transposon mutagenesis","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6895753145217896},{"id":"https://openalex.org/C28693550","wikidata":"https://www.wikidata.org/wiki/Q7835335","display_name":"Transposon mutagenesis","level":5,"score":0.6617482900619507},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.642018735408783},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.618100106716156},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.606894850730896},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.5816922783851624},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.580242395401001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5053024888038635},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.4477505683898926},{"id":"https://openalex.org/C168707992","wikidata":"https://www.wikidata.org/wiki/Q15439223","display_name":"Colicin","level":4,"score":0.4332043528556824},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.43251416087150574},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.40909701585769653},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3860912024974823},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3772558569908142},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.28925269842147827},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2828083634376526},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.24835705757141113}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1007730","doi":"https://doi.org/10.1371/journal.ppat.1007730","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007730","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007730&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5494271","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6497286","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31048927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31048927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6497286","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6497286/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:eprints.whiterose.ac.uk:145856","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/145856/1/journal.ppat.1007730.pdf","pdf_url":"http://eprints.whiterose.ac.uk/145856/1/journal.ppat.1007730.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:HAL:hal-02628940v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02628940","pdf_url":"https://hal.inrae.fr/hal-02628940v1/file/2019-Smith_Plos%20Pathogens_1.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 2019, 15 (5), pp.e1007730. &#x27E8;10.1371/journal.ppat.1007730&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0e27ab749ed34e8c8bacb4ac182c42cb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0e27ab749ed34e8c8bacb4ac182c42cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 15, Iss 5, p e1007730 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8072024","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Decoration_of_the_enterococcal_polysaccharide_antigen_EPA_is_essential_for_virulence_cell_surface_charge_and_interaction_with_effectors_of_the_innate_immune_system/8072024","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1007730","doi":"https://doi.org/10.1371/journal.ppat.1007730","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007730","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007730&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2911649891","display_name":"A World-Leading National Network for NMR in the Physical and Life Science: Very-High Field Infrastructure at Sheffield","funder_award_id":"EP/S01358X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4033533736","display_name":"Upgrade to 600 MHz NMR spectrometer","funder_award_id":"BB/R000727/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4219199536","display_name":"Optimising Innate Host Defence to Combat Antimicrobial Resistance","funder_award_id":"MR/N02995X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6942171995","display_name":null,"funder_award_id":"BB/M011151/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7808321526","display_name":"Functional characterization of a novel peptidoglycan binding domain conserved in Gram-positive nosocomial pathogens","funder_award_id":"1802691","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8633396862","display_name":"White Rose Doctoral Training Partnership in Mechanistic Biology and its Strategic Application","funder_award_id":"BB/M011151/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320360","display_name":"University of Bristol","ror":"https://ror.org/0524sp257"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2943095119.pdf","grobid_xml":"https://content.openalex.org/works/W2943095119.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W593945491","https://openalex.org/W645508545","https://openalex.org/W1548162677","https://openalex.org/W1599380810","https://openalex.org/W1965892736","https://openalex.org/W1973437578","https://openalex.org/W1973523054","https://openalex.org/W1975604894","https://openalex.org/W1976666632","https://openalex.org/W1976667730","https://openalex.org/W1980987268","https://openalex.org/W1987006179","https://openalex.org/W1989354063","https://openalex.org/W1992601854","https://openalex.org/W1994411346","https://openalex.org/W2004753400","https://openalex.org/W2019275072","https://openalex.org/W2039048807","https://openalex.org/W2060913542","https://openalex.org/W2073685094","https://openalex.org/W2074198759","https://openalex.org/W2094223081","https://openalex.org/W2104371716","https://openalex.org/W2116463025","https://openalex.org/W2116859600","https://openalex.org/W2118058022","https://openalex.org/W2119638146","https://openalex.org/W2121857077","https://openalex.org/W2123113723","https://openalex.org/W2128778651","https://openalex.org/W2130815099","https://openalex.org/W2142586531","https://openalex.org/W2149837711","https://openalex.org/W2150825041","https://openalex.org/W2155052732","https://openalex.org/W2159440450","https://openalex.org/W2398608465","https://openalex.org/W2405525610","https://openalex.org/W2547593044","https://openalex.org/W2629313469","https://openalex.org/W2737712203","https://openalex.org/W2766957423"],"related_works":["https://openalex.org/W2900964536","https://openalex.org/W4295279689","https://openalex.org/W7204786156","https://openalex.org/W7223432894","https://openalex.org/W7099597676","https://openalex.org/W2073685094","https://openalex.org/W4400092950","https://openalex.org/W3017490302","https://openalex.org/W4402044389","https://openalex.org/W6980737547"],"abstract_inverted_index":{"Enterococcus":[0],"faecalis":[1,63,187],"is":[2,181],"an":[3,7,191],"opportunistic":[4],"pathogen":[5],"with":[6],"intrinsically":[8],"high":[9,22],"resistance":[10,25,64,151,166],"to":[11,43,57,65,78,97,115,128,150,167,184],"lysozyme,":[12],"a":[13,27,94,117],"key":[14],"effector":[15],"of":[16,24,30,53,81,108,137,162,176,194,197],"the":[17,46,73,79,87,99,109,135,159,174,177,195],"innate":[18],"immune":[19],"system.":[20],"This":[21],"level":[23],"requires":[26],"complex":[28],"network":[29],"transcriptional":[31],"regulators":[32],"and":[33,39,48,155,189],"several":[34,82],"genes":[35,60,113],"(oatA,":[36],"pgdA,":[37],"dltA":[38],"sigV)":[40],"acting":[41],"synergistically":[42],"inhibit":[44],"both":[45],"enzymatic":[47],"cationic":[49],"antimicrobial":[50],"peptide":[51],"activities":[52],"lysozyme.":[54,66],"We":[55],"sought":[56],"identify":[58],"novel":[59],"modulating":[61],"E.":[62,186],"Random":[67],"transposon":[68],"mutagenesis":[69],"carried":[70],"out":[71],"in":[72,93,158],"quadruple":[74],"oatA/pgdA/dltA/sigV":[75],"mutant":[76],"led":[77],"identification":[80],"independent":[83],"insertions":[84],"clustered":[85],"on":[86],"chromosome.":[88],"These":[89],"mutations":[90],"were":[91],"located":[92,106],"locus":[95,139],"referred":[96],"as":[98],"enterococcal":[100,202],"polysaccharide":[101],"antigen":[102],"(EPA)":[103],"variable":[104,123],"region":[105,124],"downstream":[107],"highly":[110],"conserved":[111],"epaA-epaR":[112],"proposed":[114,127],"encode":[116],"core":[118],"synthetic":[119],"machinery.":[120],"The":[121],"epa":[122],"was":[125],"previously":[126],"be":[129],"responsible":[130],"for":[131,201],"EPA":[132,147,178],"decorations,":[133],"but":[134],"role":[136,193],"this":[138,198],"remains":[140],"largely":[141],"unknown.":[142],"Here,":[143],"we":[144],"show":[145],"that":[146,173],"decoration":[148],"contributes":[149],"towards":[152],"charged":[153],"antimicrobials":[154],"underpins":[156],"virulence":[157],"zebrafish":[160],"model":[161],"infection":[163],"by":[164],"conferring":[165],"phagocytosis.":[168],"Collectively,":[169],"our":[170],"results":[171],"indicate":[172],"production":[175],"rhamnopolysaccharide":[179],"backbone":[180],"not":[182],"sufficient":[183],"promote":[185],"infections":[188],"reveal":[190],"essential":[192],"modification":[196],"surface":[199],"polymer":[200],"pathogenesis.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-09T00:00:00"}
