{"id":"https://openalex.org/W2942969918","doi":"https://doi.org/10.21608/ejhm.2019.30966","title":"Effect of Buspirone on the Histological and Immunohistochemical Alterations on Pancreas of Fetuses in Pregnant Rats","display_name":"Effect of Buspirone on the Histological and Immunohistochemical Alterations on Pancreas of Fetuses in Pregnant Rats","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2942969918","doi":"https://doi.org/10.21608/ejhm.2019.30966","mag":"2942969918"},"language":"en","primary_location":{"id":"doi:10.21608/ejhm.2019.30966","doi":"https://doi.org/10.21608/ejhm.2019.30966","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejhm.2019.30966","pdf_url":"https://ejhm.journals.ekb.eg/article_30966_4506fd18cd95f79c06932c9ff73856e0.pdf","source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ejhm.journals.ekb.eg/article_30966_4506fd18cd95f79c06932c9ff73856e0.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036813447","display_name":"Nahla H. El-shaer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Nahla H. El-Shaer","raw_affiliation_strings":["Zoology Department, Faculty of Science, Zagazig University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Zagazig University, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049029188","display_name":"Asmaa M. Abd El-Azez","orcid":"https://orcid.org/0000-0003-4293-8446","observed_orcids":["https://orcid.org/0000-0003-4293-8446"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Asmaa M. Abd El-Azez","raw_affiliation_strings":["Zoology Department, Faculty of Science, Al-Azhar University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Al-Azhar University, Egypt","institution_ids":["https://openalex.org/I184834183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036813447"],"corresponding_institution_ids":["https://openalex.org/I192398990"],"apc_list":null,"apc_paid":null,"fwci":0.2368,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55678932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"75","issue":"3","first_page":"2481","last_page":"2491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.3086000084877014,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buspirone","display_name":"buspirone","score":1.0},{"id":"https://openalex.org/keywords/prenatal-drug-exposure","display_name":"prenatal drug exposure","score":0.7540000081062317},{"id":"https://openalex.org/keywords/fetal-pancreas","display_name":"fetal pancreas","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pancreatic-histopathology","display_name":"pancreatic histopathology","score":0.8220000267028809},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C2777287423","wikidata":"https://www.wikidata.org/wiki/Q412194","display_name":"Buspirone","level":4,"score":0.9053090810775757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8506424427032471},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.7322320342063904},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.587828516960144},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.44414329528808594},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.44402697682380676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41659682989120483},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.34424859285354614},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3440468907356262},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3254123330116272},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.063871830701828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05724024772644043},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.04946708679199219},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21608/ejhm.2019.30966","doi":"https://doi.org/10.21608/ejhm.2019.30966","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejhm.2019.30966","pdf_url":"https://ejhm.journals.ekb.eg/article_30966_4506fd18cd95f79c06932c9ff73856e0.pdf","source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21608/ejhm.2019.30966","doi":"https://doi.org/10.21608/ejhm.2019.30966","is_oa":true,"landing_page_url":"https://doi.org/10.21608/ejhm.2019.30966","pdf_url":"https://ejhm.journals.ekb.eg/article_30966_4506fd18cd95f79c06932c9ff73856e0.pdf","source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942969918.pdf","grobid_xml":"https://content.openalex.org/works/W2942969918.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W431215260","https://openalex.org/W1545745337","https://openalex.org/W1560644015","https://openalex.org/W1583514966","https://openalex.org/W1979926597","https://openalex.org/W1992458142","https://openalex.org/W2018015335","https://openalex.org/W2041611624","https://openalex.org/W2066404322","https://openalex.org/W2069266192","https://openalex.org/W2110756701","https://openalex.org/W2161024131","https://openalex.org/W2163107093","https://openalex.org/W2181430872","https://openalex.org/W2333104098","https://openalex.org/W2884997988","https://openalex.org/W3005563669","https://openalex.org/W4249907955","https://openalex.org/W4414041363"],"related_works":["https://openalex.org/W1984669348","https://openalex.org/W2397830406","https://openalex.org/W1996912214","https://openalex.org/W2046375634","https://openalex.org/W2041269450","https://openalex.org/W2107304850","https://openalex.org/W2034531855","https://openalex.org/W2063828562","https://openalex.org/W2313881390","https://openalex.org/W2004317605"],"abstract_inverted_index":{"Aim":[0],"of":[1,13,21,43,48,51,102,109,128,147,165,173,182,205,216,246],"the":[2,11,41,46,52,119,124,137,157,161,214,225,236,257],"work:":[3],"Buspar":[4,22],"drug(buspirone)":[5],"is":[6],"an":[7,30],"antianxiety":[8],"agent":[9],"for":[10,115,153,189,195],"treatment":[12],"anxiety,":[14],"and":[15,58,184,192,198,231,253],"there":[16],"are":[17],"no":[18],"adequate":[19],"studies":[20,194],"in":[23,79,213,224,233,235,250,256],"pregnant":[24,77,87,96,132,171,206],"women":[25],"which":[26,176],"made":[27],"this":[28],"issue":[29],"exciting":[31],"research":[32],"area;":[33],"so":[34],"that":[35,244],"our":[36],"aim":[37],"was":[38],"to":[39,123,160],"study":[40,242],"effects":[42],"buspirone":[44,103,141,209,247],"on":[45],"structure":[47],"pancreatic":[49,196,237,259],"tissue":[50],"maternally":[53,228],"treated":[54,135,229],"rat":[55],"fetuses.":[56],"Material":[57],"methods:":[59],"Buspirone":[60],"hydrochloride":[61,104,142],"tablets":[62],"were":[63,71,98,134,168,186,221],"obtained":[64],"from":[65,118,156,170],"Beecham,":[66],"Haram,":[67],"Giza,":[68],"Egypt.":[69],"Animals":[70],"divided":[72],"into":[73],"three":[74],"groups":[75,175],"(Ten":[76],"rats":[78,88,97,133,172,207],"each":[80],"group).":[81],"Group":[82,94,130],"I:":[83],"(The":[84],"control":[85],"group)":[86],"administrated":[89],"orally":[90],"distilled":[91],"water":[92],"only;":[93],"II:":[95],"given":[99],"oral":[100],"dosages":[101],"at":[105,143,178],"a":[106,144],"dose":[107,145,227],"level":[108,146],"0.27":[110],"mg/":[111,149],"100g":[112,150],"b.w./day,":[113],"daily":[114],"15":[116,154],"days":[117,155],"6":[120,158],"th":[121,126,159,163,180],"day":[122,127,152,164,181],"20":[125,162,179],"gestation;":[129],"III:":[131],"with":[136,140,208],"same":[138],"manner":[139],"0.41":[148],"b.w./":[151],"gestation.":[166],"Samples":[167],"taken":[169],"all":[174],"sacrificed":[177],"gestation":[183],"fetuses":[185],"picked":[187],"out":[188],"histological,":[190],"histochemical":[191],"immunohistochemical":[193,254],"anti-insulin":[197],"caspase-3":[199],"monoclonal":[200],"antibody":[201],"markers.":[202],"Results:":[203],"Treatment":[204],"showed":[210,243],"histopathological":[211],"alterations":[212,220],"pancreas":[215],"their":[217],"fetuses;":[218],"these":[219],"well":[222],"marked":[223],"high":[226],"fetuses,":[230],"resulted":[232],"deformity":[234,255],"tissues.":[238,260],"Conclusion:":[239],"The":[240],"present":[241],"administration":[245],"may":[248],"result":[249],"several":[251],"histological":[252],"fetal":[258]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}