{"id":"https://openalex.org/W2942932145","doi":"https://doi.org/10.1002/lary.28051","title":"Esophageal pepsin and proton pump synthesis in barrett's esophagus and esophageal adenocarcinoma","display_name":"Esophageal pepsin and proton pump synthesis in barrett's esophagus and esophageal adenocarcinoma","publication_year":2019,"publication_date":"2019-05-02","ids":{"openalex":"https://openalex.org/W2942932145","doi":"https://doi.org/10.1002/lary.28051","mag":"2942932145","pmid":"https://pubmed.ncbi.nlm.nih.gov/31046139"},"language":"en","primary_location":{"id":"doi:10.1002/lary.28051","doi":"https://doi.org/10.1002/lary.28051","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.28051","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078117282","display_name":"Tina L. Samuels","orcid":"https://orcid.org/0000-0002-7045-357X","observed_orcids":["https://orcid.org/0000-0002-7045-357X"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina L. Samuels","raw_affiliation_strings":["Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":"https://orcid.org/0000-0002-7045-357X","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062190777","display_name":"Kenneth W. Altman","orcid":"https://orcid.org/0000-0002-6290-3331","observed_orcids":["https://orcid.org/0000-0002-6290-3331"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth W. Altman","raw_affiliation_strings":["Department of Otolaryngology\u2013Head and Neck Surgery Baylor College of Medicine Houston Texas U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-6290-3331","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology\u2013Head and Neck Surgery Baylor College of Medicine Houston Texas U.S.A","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028058665","display_name":"Jon Charles Gould","orcid":"https://orcid.org/0000-0002-7038-6995","observed_orcids":["https://orcid.org/0000-0002-7038-6995"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon C. Gould","raw_affiliation_strings":["Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060722989","display_name":"Tammy Lyn Kindel","orcid":"https://orcid.org/0000-0001-7489-7189","observed_orcids":["https://orcid.org/0000-0001-7489-7189"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy Kindel","raw_affiliation_strings":["Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055823318","display_name":"Matthew E. Bosler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Bosler","raw_affiliation_strings":["Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060424549","display_name":"Alexander Craig Mackinnon","orcid":"https://orcid.org/0000-0002-2036-8529","observed_orcids":["https://orcid.org/0000-0002-2036-8529"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander MacKinnon","raw_affiliation_strings":["Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014534264","display_name":"Catherine E. Hagen","orcid":"https://orcid.org/0000-0002-1867-4957","observed_orcids":["https://orcid.org/0000-0002-1867-4957"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine E. Hagen","raw_affiliation_strings":["Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022032922","display_name":"Nikki Johnston","orcid":"https://orcid.org/0000-0003-4750-7637","observed_orcids":["https://orcid.org/0000-0003-4750-7637"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nikki Johnston","raw_affiliation_strings":["Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin","Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022032922"],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":2.6245,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.89334797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"129","issue":"12","first_page":"2687","last_page":"2695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pepsin","display_name":"pepsin","score":0.890999972820282},{"id":"https://openalex.org/keywords/proton-pump","display_name":"proton pump","score":0.8529999852180481},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/esophageal-metaplasia","display_name":"esophageal metaplasia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pepsinogen","display_name":"pepsinogen","score":0.7649999856948853},{"id":"https://openalex.org/keywords/esophageal-carcinogenesis","display_name":"esophageal carcinogenesis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/nonacid-reflux","display_name":"non-acid reflux","score":0.6679999828338623},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8320000171661377},{"id":"https://openalex.org/keywords/keratin-8","display_name":"keratin 8","score":0.6399999856948853},{"id":"https://openalex.org/keywords/keratin-10","display_name":"keratin 10","score":0.972000002861023},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.824999988079071},{"id":"https://openalex.org/keywords/acid-suppression","display_name":"acid suppression","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C16311235","wikidata":"https://www.wikidata.org/wiki/Q190265","display_name":"Pepsin","level":3,"score":0.9153359532356262},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.7668673396110535},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.6256328821182251},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6058807969093323},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.5325697064399719},{"id":"https://openalex.org/C2776497702","wikidata":"https://www.wikidata.org/wiki/Q872095","display_name":"Intestinal metaplasia","level":3,"score":0.4620110094547272},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.45710429549217224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4568943977355957},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42293310165405273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41608282923698425},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38019585609436035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3738041818141937},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.37069424986839294},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34572476148605347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18049153685569763},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15646666288375854},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0888414978981018}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017494","descriptor_name":"Proton Pumps","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017494","descriptor_name":"Proton Pumps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/lary.28051","doi":"https://doi.org/10.1002/lary.28051","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.28051","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},{"id":"pmid:31046139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31046139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310914","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W163038743","https://openalex.org/W1636180446","https://openalex.org/W1877062132","https://openalex.org/W1910791907","https://openalex.org/W1966130491","https://openalex.org/W1974846209","https://openalex.org/W1976757422","https://openalex.org/W1983632544","https://openalex.org/W1994379635","https://openalex.org/W2009282713","https://openalex.org/W2014640407","https://openalex.org/W2022640628","https://openalex.org/W2024274322","https://openalex.org/W2028609150","https://openalex.org/W2047421149","https://openalex.org/W2049031369","https://openalex.org/W2051056165","https://openalex.org/W2058995938","https://openalex.org/W2059142153","https://openalex.org/W2062492497","https://openalex.org/W2062498121","https://openalex.org/W2065707224","https://openalex.org/W2080284730","https://openalex.org/W2091320039","https://openalex.org/W2096162308","https://openalex.org/W2099999179","https://openalex.org/W2101631890","https://openalex.org/W2102911345","https://openalex.org/W2105425218","https://openalex.org/W2107114880","https://openalex.org/W2110751875","https://openalex.org/W2117981040","https://openalex.org/W2125543848","https://openalex.org/W2126327372","https://openalex.org/W2130591858","https://openalex.org/W2130669614","https://openalex.org/W2130699826","https://openalex.org/W2145310134","https://openalex.org/W2146926950","https://openalex.org/W2151405464","https://openalex.org/W2162222673","https://openalex.org/W2163170023","https://openalex.org/W2231156824","https://openalex.org/W2292401026","https://openalex.org/W2314540303","https://openalex.org/W2499434158","https://openalex.org/W2533329365","https://openalex.org/W2570454533","https://openalex.org/W2591333306","https://openalex.org/W2742585641","https://openalex.org/W2793430244","https://openalex.org/W4298904855","https://openalex.org/W4386637289"],"related_works":["https://openalex.org/W1877062132","https://openalex.org/W4221097993","https://openalex.org/W2333129556","https://openalex.org/W107220436","https://openalex.org/W2125543848","https://openalex.org/W2009716330","https://openalex.org/W2090016006","https://openalex.org/W2011581345","https://openalex.org/W2075955172","https://openalex.org/W2185544520"],"abstract_inverted_index":{"OBJECTIVES/HYPOTHESIS:":[0],"Gastroesophageal":[1],"reflux":[2,38,90,103,187],"disease":[3],"and":[4,51,91,97,122,138,147,165,174,188,206,211,213,228,233,247],"associated":[5],"metaplasia":[6],"of":[7,23,33,120,134,198,226,239],"the":[8,31,49,61,261],"esophagus":[9,11],"(Barrett's":[10],"[BE])":[12],"are":[13],"primary":[14],"risk":[15],"factors":[16],"for":[17,67,254],"esophageal":[18,56,62,77,98,154,200,216],"adenocarcinoma":[19],"(EAC).":[20],"Widespread":[21],"use":[22],"acid":[24],"suppression":[25],"medications":[26],"has":[27,52],"failed":[28],"to":[29],"stem":[30],"rise":[32],"EAC,":[34,96],"suggesting":[35],"that":[36],"nonacid":[37],"may":[39],"underlie":[40],"its":[41],"pathophysiology.":[42],"Pepsin":[43,86],"is":[44,235],"a":[45,252],"tumor":[46],"promoter":[47],"in":[48,55,75,89,152,171,180,202,231,242,248,256,260],"larynx":[50],"been":[53],"implicated":[54],"carcinogenesis.":[57],"Herein,":[58],"specimens":[59],"from":[60],"cancer":[63,92,99],"spectrum":[64],"were":[65,73,169],"tested":[66],"pepsin":[68,112,121,135,159,192,227,255],"presence.":[69],"Pepsin-induced":[70],"carcinogenic":[71,258],"changes":[72,259],"assayed":[74,88,114,126],"an":[76],"cell":[78,105],"culture":[79],"model.":[80],"STUDY":[81],"DESIGN:":[82],"Laboratory":[83],"analysis.":[84],"METHODS:":[85],"was":[87,113,125,141],"free":[93],"esophagi,":[94,245],"BE,":[95],"lacking":[100],"association":[101],"with":[102,158],"(squamous":[104],"carcinoma":[106],"[SCC]).":[107],"Refluxed":[108],"or":[109,160,186],"locally":[110],"synthesized":[111],"by":[115],"Western":[116],"blot.":[117],"Local":[118,224],"synthesis":[119,225],"proton":[123,166,229],"pumps":[124,230],"via":[127,143],"reverse":[128],"transcription-polymerase":[129],"chain":[130,150],"reaction.":[131],"The":[132],"effect":[133],"on":[136],"BE":[137,172,205,232],"EAC":[139,175,207,234],"markers":[140,208],"investigated":[142],"enzyme-linked":[144],"immunosorbent":[145],"assay":[146],"quantitative":[148],"polymerase":[149],"reaction":[151],"human":[153,199],"epithelial":[155],"cells":[156,201],"treated":[157],"control":[161],"diluent.":[162],"RESULTS:":[163],"Pepsinogen":[164],"pump":[167],"mRNA":[168],"observed":[170],"(3/5)":[173],"(4/4)":[176],"samples,":[177],"but":[178],"not":[179,236],"normal":[181,215,243],"adjacent":[182],"specimens,":[183],"SCC":[184],"(0/2),":[185],"cancer-free":[189],"esophagi.":[190],"Chronic":[191],"treatment":[193],"(0.1-1":[194],"mg/mL,":[195],"4":[196],"weeks)":[197],"vitro":[203,249],"induced":[204],"interleukin":[209],"8":[210],"KRT8":[212],"depleted":[214],"marker":[217],"KRT10":[218],"(P":[219],"<":[220],".05)":[221],"expression.":[222],"CONCLUSIONS:":[223],"uncommon.":[237],"Absence":[238],"these":[240],"molecules":[241],"(noncancer)":[244],"SCC,":[246],"data":[250],"support":[251],"role":[253],"reflux-attributed":[257],"esophagus.":[262],"LEVEL":[263],"OF":[264],"EVIDENCE:":[265],"NA":[266],"Laryngoscope,":[267],"129:2687-2695,":[268],"2019.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-09T00:00:00"}
