{"id":"https://openalex.org/W2942880644","doi":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","title":"Abstract 61: Amifostine Prophylaxis in Irradiated Breast Reconstruction: A Study of Oncologic Safety","display_name":"Abstract 61: Amifostine Prophylaxis in Irradiated Breast Reconstruction: A Study of Oncologic Safety","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2942880644","doi":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","mag":"2942880644"},"language":"en","primary_location":{"id":"doi:10.1097/01.gox.0000558335.49983.a8","doi":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003898248","display_name":"Alexandra O. Luby","orcid":"https://orcid.org/0000-0002-5847-1492","observed_orcids":["https://orcid.org/0000-0002-5847-1492"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra O. Luby","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075065118","display_name":"Chitra Subramanian","orcid":"https://orcid.org/0000-0003-1871-2834","observed_orcids":["https://orcid.org/0000-0003-1871-2834"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chitra Subramanian","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007678593","display_name":"Lauren K. Buchman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren K. Buchman","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022702039","display_name":"Jeremy V. Lynn","orcid":"https://orcid.org/0000-0001-7107-3635","observed_orcids":["https://orcid.org/0000-0001-7107-3635"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy V. Lynn","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025759132","display_name":"Kevin M. Urlaub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Urlaub","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109893680","display_name":"Noah S. Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah S. Nelson","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050327233","display_name":"Alexis Donneys","orcid":"https://orcid.org/0000-0001-8690-0971","observed_orcids":["https://orcid.org/0000-0001-8690-0971"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Donneys","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057675169","display_name":"Mark Steven Cohen","orcid":"https://orcid.org/0000-0002-2517-0757","observed_orcids":["https://orcid.org/0000-0002-2517-0757"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Cohen","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036135458","display_name":"Steven R. Buchman","orcid":"https://orcid.org/0000-0001-9742-558X","observed_orcids":["https://orcid.org/0000-0001-9742-558X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Buchman","raw_affiliation_strings":["University of Michigan, Ann Arbor, MI, USA","This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":2195,"currency":"USD","value_usd":2195},"apc_paid":{"value":2195,"currency":"USD","value_usd":2195},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4S","first_page":"43","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amifostine","display_name":"amifostine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-reconstruction","display_name":"breast reconstruction","score":0.7350000143051147},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.6990000009536743},{"id":"https://openalex.org/keywords/radiation-induced-cell-death","display_name":"radiation-induced cell death","score":0.6759999990463257},{"id":"https://openalex.org/keywords/wr-1065","display_name":"WR-1065","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oncologic-safety","display_name":"oncological safety","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mda-mb-468-cells","display_name":"MDA-MB-468","score":0.9940000176429749},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.6769999861717224},{"id":"https://openalex.org/keywords/radiotherapy-complications","display_name":"radiotherapy complications","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2779387952","wikidata":"https://www.wikidata.org/wiki/Q251698","display_name":"Amifostine","level":3,"score":0.9139844179153442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8968120813369751},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7389819025993347},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6009350419044495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5108701586723328},{"id":"https://openalex.org/C2781001896","wikidata":"https://www.wikidata.org/wiki/Q994507","display_name":"Breast reconstruction","level":4,"score":0.4845108389854431},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46995070576667786},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.45044106245040894},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.42488664388656616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38381069898605347},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35624563694000244}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/01.gox.0000558335.49983.a8","doi":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6504458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6504458","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plast Reconstr Surg Glob Open","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:85dcb063a4de44bfa455abeb726c0f49","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/85dcb063a4de44bfa455abeb726c0f49","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plastic and Reconstructive Surgery, Global Open, Vol 7, Iss 4S, Pp 43-44 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/01.gox.0000558335.49983.a8","doi":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.gox.0000558335.49983.a8","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2996652855","https://openalex.org/W1489037272","https://openalex.org/W2275745337","https://openalex.org/W2893861607","https://openalex.org/W2328625710","https://openalex.org/W124699378","https://openalex.org/W2139831711","https://openalex.org/W2316520032","https://openalex.org/W2102595128","https://openalex.org/W1764487123"],"abstract_inverted_index":{"PURPOSE:":[0],"Oncologic":[1],"surgical":[2],"planning":[3],"has":[4,60,104,152],"become":[5],"increasingly":[6],"collaborative":[7],"in":[8,53,109,129,140,157,185,235,453,468],"recent":[9],"years,":[10],"as":[11,263,390,400,447],"breast":[12,39,57,161,183,193,203,410,457],"surgeons":[13,16],"and":[14,27,64,71,145,176,198,200,222,226,229,272,290,314,352,357,368],"plastic":[15],"partner":[17],"to":[18,131,154,169,216,249,252,309,332,420,464],"deliver":[19],"the":[20,110,135,141,158,171,186,242,394,437,454],"most":[21],"optimal":[22],"results":[23,433],"from":[24,47,127,413,425],"both":[25,350],"oncologic":[26,136,172,438],"aesthetic":[28],"perspectives.":[29],"Radiation":[30],"therapy":[31],"(XRT)":[32],"is":[33,76,92,117,148,461],"a":[34,96,254,266,277,345,448],"highly":[35,449],"effective":[36,450],"component":[37],"of":[38,86,94,138,143,160,165,174,188,220,245,257,280,397,440,456],"cancer":[40,125,147,184,194,377,411,428],"treatment":[41,387],"algorithms;":[42],"however,":[43,102],"patients":[44],"often":[45],"suffer":[46],"associated":[48],"pernicious":[49],"side":[50],"effects":[51,66],"resulting":[52],"delayed":[54],"or":[55,283],"compromised":[56],"reconstruction.":[58],"XRT":[59,128,221,286,330],"profoundly":[61],"destructive":[62],"short":[63],"long-term":[65],"on":[67,180],"skin,":[68],"soft":[69],"tissue,":[70],"surrounding":[72],"vasculature.":[73],"Thus,":[74],"there":[75],"an":[77,81],"extraordinary":[78],"need":[79],"for":[80,115],"effective,":[82],"yet":[83,153],"safe":[84],"method":[85],"radiation":[87],"injury":[88],"prophylaxis.":[89],"Amifostine":[90,175,404],"(AMF)":[91],"one":[93,201],"only":[95,435],"few":[97],"FDA":[98],"approved":[99],"prophylactic":[100,386,451],"radio-protectants,":[101],"it":[103,151,336,343],"not":[105,338,375,406,434],"been":[106],"widely":[107],"adopted":[108],"clinical":[111],"setting.":[112],"One":[113],"reason":[114],"this":[116,166,445],"lingering":[118],"uncertainty":[119],"over":[120],"whether":[121],"AMF":[122,139],"potentially":[123],"protects":[124],"cells":[126,228,232,269,292,359,381,392,412,424,429],"addition":[130],"healthy":[132,202,325,340,423],"cells.":[133,402],"While":[134,335],"safety":[137,173,439],"setting":[142,159,187,455],"head":[144],"neck":[146],"well":[149],"studied,":[150],"be":[155],"investigated":[156],"cancer.":[162,458],"The":[163],"purpose":[164],"study":[167,213,416],"was":[168,214,247,287,302,307],"evaluate":[170],"determine":[177],"its":[178,418],"effect":[179,348],"triple":[181,408],"negative":[182,409],"XRT.":[189,298,414],"METHODS:":[190],"Two":[191,304],"ER-/PR-/Her2-":[192],"cell":[195,204,300,327,341,364,378,398],"lines,":[196],"MDA-MB-231":[197,225,358],"MDA-MB-468,":[199],"line,":[205],"Female":[206],"Fibroblasts":[207],"(FF),":[208],"were":[209,233,270,293,317],"investigated.":[210],"A":[211],"standardization":[212],"performed":[215,308],"identify":[217,444],"appropriate":[218],"doses":[219],"WR-1065.":[223],"25,000":[224],"MDA-MB-468":[227,356],"50,000":[230],"FF":[231,326],"seeded":[234],"24-well":[236],"plates.":[237],"After":[238],"24":[239],"hours,":[240],"WR-1065,":[241,389],"active":[243],"metabolite":[244],"AMF,":[246],"added":[248],"experimental":[250],"wells":[251,261],"achieve":[253],"final":[255],"concentration":[256],"0.25":[258],"mM.":[259],"Untreated":[260],"functioned":[262],"controls.":[264,334],"Following":[265],"20-minute":[267],"exposure,":[268],"washed":[271],"media":[273],"replaced.":[274],"Immediately":[275],"thereafter,":[276],"single":[278],"dose":[279],"0,":[281],"10,":[282],"20":[284,353,369],"Gy":[285],"administered.":[288],"Live":[289],"dead":[291],"quantified":[294],"48":[295],"hours":[296],"after":[297,329],"Percent":[299],"death":[301,328,365,399],"calculated.":[303],"sample":[305],"t-test":[306],"compare":[310],"values":[311],"between":[312],"groups":[313],"two-tail":[315],"p-values":[316],"determined.":[318],"RESULTS:":[319],"Treatment":[320],"with":[321,362,372,388],"WR-1065":[322,373],"significantly":[323],"reduced":[324],"compared":[331],"untreated":[333,401],"does":[337,405],"eliminate":[339],"death,":[342],"demonstrated":[344,417],"significant":[346],"radio-protective":[347],"at":[349,366],"10":[351,367],"Gy.":[354,370],"Both":[355],"exhibited":[360],"radio-sensitivity":[361,384],"substantial":[363],"Pretreatment":[371],"did":[374],"demonstrate":[376],"protection.":[379],"Cancer":[380],"retained":[382],"their":[383],"despite":[385],"pretreated":[391],"achieved":[393],"same":[395],"degree":[396],"CONCLUSIONS:":[403],"protect":[407,422],"This":[415],"proficiency":[419],"selectively":[421],"XRT,":[426],"while":[427],"remained":[430],"radiosensitive.":[431],"These":[432],"support":[436],"Amifostine,":[441],"but":[442],"also":[443],"drug":[446],"radio-protectant":[452],"Further":[459],"investigation":[460],"now":[462],"warranted":[463],"validate":[465],"these":[466],"findings":[467],"vivo.":[469]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-05-09T00:00:00"}
