{"id":"https://openalex.org/W2942835007","doi":"https://doi.org/10.1186/s13046-019-1183-2","title":"Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growth","display_name":"Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growth","publication_year":2019,"publication_date":"2019-05-03","ids":{"openalex":"https://openalex.org/W2942835007","doi":"https://doi.org/10.1186/s13046-019-1183-2","mag":"2942835007","pmid":"https://pubmed.ncbi.nlm.nih.gov/31053152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6500071"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-019-1183-2","doi":"https://doi.org/10.1186/s13046-019-1183-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-019-1183-2","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-019-1183-2","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-019-1183-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101405797","display_name":"Kang Yang","orcid":"https://orcid.org/0000-0001-9435-4202","observed_orcids":["https://orcid.org/0000-0001-9435-4202"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Yang","raw_affiliation_strings":["Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063848653","display_name":"Wei Guo","orcid":"https://orcid.org/0000-0002-2029-5462","observed_orcids":["https://orcid.org/0000-0002-2029-5462"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Guo","raw_affiliation_strings":["Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China. bonetumorr@163.com","Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China. bonetumorr@163.com","Musculoskeletal Tumor Center, Peking University People\u2019s Hospital, No.11 Xizhimen South Street, Beijing, 100044, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China. bonetumorr@163.com","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China. bonetumorr@163.com","institution_ids":["https://openalex.org/I4210124809"]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People\u2019s Hospital, No.11 Xizhimen South Street, Beijing, 100044, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101415424","display_name":"Tingting Ren","orcid":"https://orcid.org/0000-0002-6226-6504","observed_orcids":["https://orcid.org/0000-0002-6226-6504"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Ren","raw_affiliation_strings":["Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101854539","display_name":"Yi Huang","orcid":"https://orcid.org/0000-0002-5607-1989","observed_orcids":["https://orcid.org/0000-0002-5607-1989"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Huang","raw_affiliation_strings":["Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Han","raw_affiliation_strings":["Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108046749","display_name":"Hongliang Zhang","orcid":"https://orcid.org/0000-0001-9205-5559","observed_orcids":["https://orcid.org/0000-0001-9205-5559","https://orcid.org/0000-0002-4184-896X"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongliang Zhang","raw_affiliation_strings":["Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107932600","display_name":"Jie Zhang","orcid":"https://orcid.org/0009-0001-3283-9420","observed_orcids":["https://orcid.org/0009-0001-3283-9420"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063848653"],"corresponding_institution_ids":["https://openalex.org/I4210124809"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":3.3107,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.92336822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"38","issue":"1","first_page":"185","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmga2","display_name":"HMGA2","score":1.0},{"id":"https://openalex.org/keywords/malignant-peripheral-nerve-sheath-tumor","display_name":"malignant peripheral nerve sheath tumor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/msi2","display_name":"MSI2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9810000061988831},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7927824258804321},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6570627689361572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5967588424682617},{"id":"https://openalex.org/C2529059","wikidata":"https://www.wikidata.org/wiki/Q20771632","display_name":"HMGA2","level":4,"score":0.5365666747093201},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5229421854019165},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4753703474998474},{"id":"https://openalex.org/C2777831590","wikidata":"https://www.wikidata.org/wiki/Q1418735","display_name":"Neurofibroma","level":3,"score":0.4698822796344757},{"id":"https://openalex.org/C2778173781","wikidata":"https://www.wikidata.org/wiki/Q654485","display_name":"Malignant peripheral nerve sheath tumor","level":3,"score":0.447797030210495},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.4461134076118469},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3682013750076294},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.23878881335258484},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.1513344943523407},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.15059944987297058},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.14552521705627441},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13660970330238342},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12347817420959473},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08141139149665833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06885498762130737},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000071186","descriptor_name":"Beclin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012583","descriptor_name":"Schwann Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018319","descriptor_name":"Neurofibrosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018319","descriptor_name":"Neurofibrosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025542","descriptor_name":"Neurofibromin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025743","descriptor_name":"HMGA2 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D025743","descriptor_name":"HMGA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13046-019-1183-2","doi":"https://doi.org/10.1186/s13046-019-1183-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-019-1183-2","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-019-1183-2","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:31053152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31053152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6500071","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6500071/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:74df29e90aa645f589a9aceea0f23749","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/74df29e90aa645f589a9aceea0f23749","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-18 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13046-019-1183-2","doi":"https://doi.org/10.1186/s13046-019-1183-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-019-1183-2","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-019-1183-2","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8183621132","display_name":null,"funder_award_id":"81572633","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309575","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320326234","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942835007.pdf","grobid_xml":"https://content.openalex.org/works/W2942835007.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1852828105","https://openalex.org/W1882985910","https://openalex.org/W1965124005","https://openalex.org/W1972400878","https://openalex.org/W1976009942","https://openalex.org/W1996539839","https://openalex.org/W2001141591","https://openalex.org/W2020231002","https://openalex.org/W2029221495","https://openalex.org/W2051554622","https://openalex.org/W2055697275","https://openalex.org/W2065484467","https://openalex.org/W2070604281","https://openalex.org/W2072478579","https://openalex.org/W2088202919","https://openalex.org/W2094659333","https://openalex.org/W2109436606","https://openalex.org/W2120420804","https://openalex.org/W2121651129","https://openalex.org/W2136274459","https://openalex.org/W2147874293","https://openalex.org/W2148043102","https://openalex.org/W2148606273","https://openalex.org/W2154151857","https://openalex.org/W2155201542","https://openalex.org/W2192807450","https://openalex.org/W2314069811","https://openalex.org/W2418418689","https://openalex.org/W2472956705","https://openalex.org/W2489474474","https://openalex.org/W2584218507","https://openalex.org/W2587513172","https://openalex.org/W2607960337","https://openalex.org/W2615238397","https://openalex.org/W2616605534","https://openalex.org/W2616864589","https://openalex.org/W2766427540","https://openalex.org/W2791338205","https://openalex.org/W2801232303","https://openalex.org/W2805521969","https://openalex.org/W2808491310","https://openalex.org/W2886452822","https://openalex.org/W4241629386"],"related_works":["https://openalex.org/W6940147180","https://openalex.org/W6921078379","https://openalex.org/W4293829994","https://openalex.org/W7125593083","https://openalex.org/W4366742716","https://openalex.org/W2245201144","https://openalex.org/W7010204433","https://openalex.org/W2327736215","https://openalex.org/W2107040596","https://openalex.org/W7099920688"],"abstract_inverted_index":{"BACKGROUND:":[0],"Malignant":[1],"peripheral":[2],"nerve":[3],"sheath":[4],"tumours":[5],"(MPNSTs)":[6],"are":[7],"sarcomas":[8],"of":[9,35],"Schwann":[10],"cell":[11,170,181,191,227],"lineage":[12],"origin":[13],"that":[14,164,197],"occur":[15],"sporadically":[16],"or":[17],"in":[18,42,60,90,94,97,117,120,123,172,175,213],"association":[19],"with":[20,149,218],"the":[21,33,47,201],"inherited":[22],"syndrome,":[23],"neurofibromatosis":[24],"type":[25],"1":[26,153],"(NF1).":[27],"This":[28],"study":[29],"aimed":[30],"to":[31,56,86,109,179,237],"examine":[32],"function":[34],"High":[36,144],"mobility":[37],"group":[38],"protein":[39],"A2":[40],"(HMGA2)":[41],"NF1":[43,91,118,126,168,239],"MPNST":[44,61,92,127,137,155,169,240],"progression":[45],"and":[46,62,70,80,96,103,115,122,139,174,184,194,206,211,220],"underlying":[48],"molecular":[49],"mechanism.":[50],"METHODS:":[51],"Immunohistochemistry":[52],"(IHC)":[53],"was":[54],"used":[55,108],"detect":[57,110],"HMGA2":[58,88,131,145,159,165,186,198,230],"expression":[59,146],"neurofibroma":[63,140],"patient":[64,142],"samples.":[65,143],"Cell":[66],"Cycle":[67],"Kit-8":[68],"(CCK-8)":[69],"5-ethynyl-20-deoxyuridine":[71],"(EdU)":[72],"assays,":[73],"terminal":[74],"deoxynucleotidyl":[75],"transferase-mediated":[76],"nick":[77],"end":[78],"labelling,":[79],"transmission":[81],"electron":[82],"microscopy":[83],"were":[84,107],"performed":[85],"reveal":[87],"functions":[89],"cells":[93,156],"vitro":[95,121,173],"vivo.":[98,124,176],"Chromatin":[99],"immunoprecipitation":[100],"sequencing":[101,105],"(ChIP-Seq)":[102],"RNA":[104],"(RNA-Seq)":[106],"HMGA2-modulated":[111],"genes":[112],"regulating":[113],"autophagy":[114,210,233],"growth":[116,171,212],"MPNSTs":[119],"RESULTS:":[125],"samples":[128],"exhibit":[129],"higher":[130],"positivity":[132],"rates":[133],"(13/16)":[134],"than":[135],"sporadic":[136],"(16/41)":[138],"(0/7)":[141],"is":[147],"correlated":[148],"poor":[150],"prognosis.":[151],"Neurofibromin":[152],"(NF1)-deficient":[154],"display":[157],"elevated":[158],"expression.":[160],"Functional":[161],"experiments":[162],"revealed":[163,196],"knockdown":[166,187,231],"inhibits":[167,188,223],"In":[177],"addition":[178],"promoting":[180],"cycle":[182],"arrest":[183],"apoptosis,":[185],"autophagy,":[189,224],"favouring":[190],"death.":[192],"RNA-Seq":[193],"ChIP-Seq":[195],"directly":[199],"activates":[200],"Musashi-2":[202],"(MSI2)":[203],"promoter":[204],"region,":[205],"MSI2":[207,216],"overexpression":[208],"reverses":[209],"shHMGA2-transfected":[214],"cells.":[215],"interacts":[217],"Beclin1,":[219],"Beclin1":[221],"blockade":[222],"thereby":[225],"inhibiting":[226],"proliferation.":[228],"CONCLUSIONS:":[229],"regulates":[232],"via":[234],"MSI2-Beclin1":[235],"interactions":[236],"inhibit":[238],"growth,":[241],"revealing":[242],"potential":[243],"therapeutic":[244],"targets":[245],"for":[246],"these":[247],"untreatable":[248],"tumours.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-05-09T00:00:00"}
