{"id":"https://openalex.org/W2942777031","doi":null,"title":"The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis","display_name":"The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2942777031","mag":"2942777031"},"language":"en","primary_location":{"id":"mag:2942777031","doi":null,"is_oa":false,"landing_page_url":"http://irep.iium.edu.my/64805/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057063075","display_name":"Akma Azmiera Akman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akma Azmiera Akman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088853119","display_name":"Ain Aisyah Talib","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ain Aisyah Talib","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052080640","display_name":"Azirah Md Yusof","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azirah Md Yusof","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005324951","display_name":"Kamarul Ariffin Khalid","orcid":"https://orcid.org/0000-0002-2044-6902","observed_orcids":["https://orcid.org/0000-0002-2044-6902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamarul Ariffin Khalid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2044-6902","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019295532","display_name":"Nurul Asyiqin Yusof","orcid":"https://orcid.org/0000-0002-8848-1405","observed_orcids":["https://orcid.org/0000-0002-8848-1405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nurul Asyiqin Yusof","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080461737","display_name":"Radiah Abdul Ghani","orcid":"https://orcid.org/0000-0002-9528-5568","observed_orcids":["https://orcid.org/0000-0002-9528-5568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radiah Abdul Ghani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031958037","display_name":"Asmah Hanim Hamdan","orcid":"https://orcid.org/0000-0002-5115-7839","observed_orcids":["https://orcid.org/0000-0002-5115-7839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asmah Hanim Hamdan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5115-7839","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077081730","display_name":"Zaitunnatakhin Zamli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zaitunnatakhin Zamli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tibia","display_name":"tibia","score":0.8019999861717224},{"id":"https://openalex.org/keywords/subchondral-bone","display_name":"subchondral bone","score":0.8930000066757202},{"id":"https://openalex.org/keywords/bone-formation-rate","display_name":"bone formation rate","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mineral-apposition-rate","display_name":"mineral apposition rate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/histomorphometry","display_name":"histomorphometry","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dunkin-hartley-guinea-pig","display_name":"Dunkin-Hartley guinea pig","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8076275587081909},{"id":"https://openalex.org/C2909674915","wikidata":"https://www.wikidata.org/wiki/Q1851434","display_name":"Bone histomorphometry","level":4,"score":0.7059327363967896},{"id":"https://openalex.org/C117866178","wikidata":"https://www.wikidata.org/wiki/Q321056","display_name":"Apposition","level":2,"score":0.7039988040924072},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.68414306640625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.633594274520874},{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.5641484260559082},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5233972668647766},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.44094786047935486},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42007049918174744},{"id":"https://openalex.org/C3018268312","wikidata":"https://www.wikidata.org/wiki/Q2671642","display_name":"Trabecular bone","level":3,"score":0.386024534702301},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3723418414592743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27856528759002686},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.2138587236404419},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2942777031","doi":null,"is_oa":false,"landing_page_url":"http://irep.iium.edu.my/64805/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2921403721","https://openalex.org/W2134380578","https://openalex.org/W1636707632","https://openalex.org/W2518096851","https://openalex.org/W2028255010","https://openalex.org/W2088699366","https://openalex.org/W2046055951","https://openalex.org/W2082382846","https://openalex.org/W1515304645","https://openalex.org/W2065308678"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2,17],"a":[3],"common":[4],"degenerative":[5],"joint":[6],"disease":[7],"among":[8],"elderly":[9],"population.":[10],"Previous":[11],"studies":[12,29],"have":[13],"shown":[14],"that":[15,130,206],"OA":[16,124,197],"associated":[18],"with":[19,73,82],"the":[20,32,38,44,50,117,131,139,146,162,178,181,193,207,211],"subchondral":[21],"bone":[22,34,59],"remodelling.":[23],"However,":[25,160],"none":[26],"of":[27,41,63,76,85,107,119,145,158,184,214],"these":[28,166],"focuses":[30],"on":[31],"trabecular":[33],"(Tb)":[35],"remodelling":[36,121],"in":[37,138,177],"epiphyseal":[39],"region":[40],"tibia.":[42],"Hence,":[43],"present":[45],"study":[46],"aims":[47],"to":[48,94,115],"determine":[49],"mineral":[51],"apposition":[52],"rate":[53,61],"(MAR),":[54],"mineralising":[55],"surface":[56],"(MS)":[57],"and":[58,70,90,104,110,122,134,151,155,174,195],"formation":[60],"(BFR)":[62],"Tb":[64,120,208],"Dunkin":[65],"Hartley":[66],"(DH)":[67],"guinea":[68],"pigs,":[69],"its":[71],"association":[72],"microscopic":[74,123,196],"score":[75],"OA.":[77,215],"The":[78,96,127],"DH":[79],"was":[80,190],"administered":[81],"20":[83,103,156],"mg/kg":[84],"calcein":[86],"dye":[87],"at":[88,101,161],"9":[89],"2":[91],"days":[92],"prior":[93],"euthanasia.":[95],"tibia":[97,147],"were":[98,113,136,168],"then":[99],"collected":[100],"10,":[102],"30":[105],"weeks":[106,157],"age.":[108,159],"Histomorphometry":[109],"histopathology":[111],"analyses":[112],"conducted":[114],"quantify":[116],"parameters":[118,167],"score,":[125],"respectively.":[126],"data":[128],"showed":[129],"MAR,":[132],"MS":[133],"BFR":[135,194],"higher":[137],"medial":[140,179],"side":[141,183],"(versus":[142],"lateral":[143,182],"side)":[144],"(p":[148,171],"\u2264":[149,172,203],"0.05),":[150,173],"increased":[152],"between":[153,192],"10":[154],"final":[163],"time":[164],"point,":[165],"significantly":[169],"decreased":[170],"became":[175],"lower":[176],"than":[180],"Tb.":[185],"A":[186],"strong":[187],"negative":[188],"correlation":[189],"observed":[191],"scores":[198],"(r":[199],"=":[200],"-1.0,":[201],"p":[202],"0.01),":[204],"suggesting":[205],"loss":[209],"dominates":[210],"late":[212],"stage":[213]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2019-05-09T00:00:00"}
