{"id":"https://openalex.org/W2942765104","doi":null,"title":"Trial of Pazopanib in a Multiply Relapsed Osteosarcoma Patient","display_name":"Trial of Pazopanib in a Multiply Relapsed Osteosarcoma Patient","publication_year":2019,"publication_date":"2019-03-05","ids":{"openalex":"https://openalex.org/W2942765104","mag":"2942765104"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.hsc.unt.edu:rad-2594","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.hsc.unt.edu/rad/RAD19/Cancer/18","pdf_url":null,"source":{"id":"https://openalex.org/S4406922508","display_name":"Digital Commons @ UNT Health Science Center","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Appreciation Day","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013696290","display_name":"Kunal Elete","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elete, Kunal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003791140","display_name":"Karen H. Albritton","orcid":"https://orcid.org/0000-0002-4427-5634","observed_orcids":["https://orcid.org/0000-0002-4427-5634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albritton, Karen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064840856","display_name":"Lauren J. Akers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akers, Lauren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072440595","display_name":"Anish Ray","orcid":"https://orcid.org/0000-0002-6349-1869","observed_orcids":["https://orcid.org/0000-0002-6349-1869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ray, Anish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007695569","display_name":"Riyaz M. Basha","orcid":"https://orcid.org/0000-0002-4071-0993","observed_orcids":["https://orcid.org/0000-0002-4071-0993","https://orcid.org/0000-0002-6955-5448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Basha, Riyaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06329859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pazopanib","display_name":"pazopanib","score":0.9470000267028809},{"id":"https://openalex.org/keywords/relapsed-osteosarcoma","display_name":"relapsed osteosarcoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.6629999876022339},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6050000190734863},{"id":"https://openalex.org/keywords/expanded-access","display_name":"compassionate use","score":0.4659999907016754},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/pleural-tumors","display_name":"pleural neoplasms","score":0.6330000162124634},{"id":"https://openalex.org/keywords/disease-stability","display_name":"disease stability","score":0.41100001335144043},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.9493352174758911},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6851338744163513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.655287504196167},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4637157917022705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4407680332660675},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24447080492973328},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.18655312061309814},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.11726745963096619}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:digitalcommons.hsc.unt.edu:rad-2594","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.hsc.unt.edu/rad/RAD19/Cancer/18","pdf_url":null,"source":{"id":"https://openalex.org/S4406922508","display_name":"Digital Commons @ UNT Health Science Center","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Appreciation Day","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2903630948","https://openalex.org/W2889964457","https://openalex.org/W4205899024","https://openalex.org/W4214949429","https://openalex.org/W4416853879","https://openalex.org/W4411661569","https://openalex.org/W2998558444","https://openalex.org/W7120176681","https://openalex.org/W2890746729","https://openalex.org/W4379280776"],"abstract_inverted_index":{"Background:":[0],"Osteosarcomas":[1],"(OS)":[2],"are":[3],"typically":[4],"found":[5],"among":[6,328],"adolescents":[7],"and":[8,11,51,104,113,118,138,170,186,264,306],"young":[9],"adults":[10],"usually":[12],"affect":[13],"the":[14,18,150,221,333,336],"long":[15],"bones":[16],"around":[17],"knee.":[19],"The":[20],"current":[21],"treatment":[22,91,179,259,296],"options":[23],"for":[24,154,234],"relapsed":[25,210,277],"OS":[26],"include":[27],"surgery,":[28],"chemotherapy,":[29],"targeted":[30],"therapy,":[31],"or":[32,290],"some":[33],"combination":[34],"of":[35,40,48,87,110,124,168,174,195,202,256,314,335,348],"these":[36],"modalities.":[37],"Constitutive":[38],"activation":[39],"tyrosine":[41],"kinase":[42,78],"mediated":[43],"pathways":[44],"leading":[45],"to":[46,85,184,225,261,301,342],"up-regulation":[47],"cell":[49],"division":[50],"growth":[52],"have":[53,322],"been":[54],"implicated":[55],"in":[56,149,204,253,325],"OS.":[57],"This":[58],"study":[59,245],"identifies":[60],"a":[61,76,199,237,244,323,343],"patient":[62],"at":[63,287],"Cook":[64],"Children\u2019s":[65],"Medical":[66],"Center":[67],"(CCMC)":[68],"who,":[69],"upon":[70],"relapse,":[71],"was":[72,105,157],"treated":[73,106,158,249,281],"with":[74,90,100,107,128,136,146,159,165,250,276,282,330],"pazopanib,":[75,226],"multi-tyrosine":[77],"inhibitor,":[79],"on":[80],"compassionate":[81],"basis,":[82],"which":[83,155],"led":[84],"stability":[86],"disease,":[88],"along":[89,135],"related":[92],"toxicities.\\nCase":[93],"Information:":[94],"A":[95],"25-year-old":[96],"female":[97],"initially":[98],"presented":[99,127,145],"left":[101],"femur":[102],"osteosarcoma":[103,278],"chemotherapy":[108,137],"consisting":[109],"methotrexate,":[111],"doxorubicin":[112],"cisplatin":[114],"followed":[115],"by":[116,240,270],"amputation":[117],"neo-adjuvant":[119],"chemotherapy.":[120],"Following":[121],"6":[122],"years":[123],"remission,":[125],"she":[126,144,156,197,208],"two":[129,294],"lung":[130],"masses":[131],"that":[132,319],"were":[133,280,284],"resected":[134],"radiation.":[139],"After":[140],"almost":[141],"2.5":[142],"years,":[143],"progressive":[147],"tumor":[148,169,175],"right":[151],"pleural":[152],"base":[153],"pazopanib.":[160],"She":[161],"demonstrated":[162],"positive":[163,222,298],"response":[164,223,299],"stable":[166],"size":[167],"increased":[171],"homogeneity":[172],"(suggestive":[173],"necrosis)":[176],"but":[177,212],"ended":[178],"after":[180,217],"3":[181,274],"months":[182,216,289],"due":[183,260,300],"hypothyroidism":[185],"GI":[187],"toxicity,":[188],"namely":[189],"diarrhea.":[190],"Within":[191],"just":[192],"1":[193],"week":[194],"discontinuation,":[196],"had":[198],"concerning":[200],"increase":[201],"17%":[203],"her":[205],"lesion.":[206],"Thereafter,":[207],"has":[209,339],"multiply":[211],"remains":[213],"alive":[214,286],"18":[215],"discontinuing":[218,258],"pazopanib.\\nConclusion:":[219],"Despite":[220],"seen":[224],"it\u2019s":[227],"toxicity":[228],"profile":[229],"can":[230],"be":[231],"over":[232],"bearing":[233],"patients.":[235],"In":[236,266],"retrospective":[238],"analysis":[239],"Velho":[241],"et":[242,272],"al,":[243,273],"involving":[246],"113":[247],"patients":[248,275,329],"pazopanib":[251,283,320],"resulted":[252],"about":[254],"12%":[255],"those":[257,315],"fatigue,":[262],"diarrhea,":[263],"nausea/vomiting.":[265],"another":[267],"study,":[268],"described":[269],"Umeda":[271],"who":[279],"all":[285],"21":[288],"longer.":[291],"Of":[292],"those,":[293],"discontinued":[295],"despite":[297],"nausea/fatigue,":[302],"lymphopenia,":[303],"anemia,":[304],"hypothyroidism,":[305],"elevated":[307],"alkaline":[308],"phosphatase.":[309],"Our":[310],"experience":[311],"as":[312,316],"well":[313],"others":[317],"suggests":[318],"may":[321],"role":[324],"prolonging":[326],"survival":[327],"osteosarcoma,":[331],"however":[332],"extent":[334],"side":[337],"effects":[338],"clearly":[340],"contributed":[341],"lesser":[344],"than":[345],"optimal":[346],"length":[347],"treatment.":[349]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
