{"id":"https://openalex.org/W2942669148","doi":"https://doi.org/10.1016/j.bbcan.2019.04.004","title":"Exosomes in cancer development, metastasis, and immunity","display_name":"Exosomes in cancer development, metastasis, and immunity","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2942669148","doi":"https://doi.org/10.1016/j.bbcan.2019.04.004","mag":"2942669148","pmid":"https://pubmed.ncbi.nlm.nih.gov/31047959","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6542596"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbcan.2019.04.004","doi":"https://doi.org/10.1016/j.bbcan.2019.04.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbcan.2019.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S4210180990","display_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","issn_l":"0304-419X","issn":["0304-419X","1879-2561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6542596","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040450464","display_name":"Dihua Yu","orcid":"https://orcid.org/0000-0001-6231-9381","observed_orcids":["https://orcid.org/0000-0001-6231-9381"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dihua Yu","raw_affiliation_strings":["Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: dyu@mdanderson.org","Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: dyu@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040450464"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":6.6634,"has_fulltext":false,"cited_by_count":967,"citation_normalized_percentile":{"value":0.98604778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"1871","issue":"2","first_page":"455","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.828000009059906},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.9629999995231628},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9497069120407104},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7056055665016174},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.6942546963691711},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.51450514793396},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5115069150924683},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5056793689727783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5040377974510193},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43511682748794556},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42421677708625793},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4189353287220001},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4024471640586853},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38359326124191284},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3371328115463257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2996424734592438},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.23508012294769287},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10833552479743958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06661438941955566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06628334522247314}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bbcan.2019.04.004","doi":"https://doi.org/10.1016/j.bbcan.2019.04.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbcan.2019.04.004","pdf_url":null,"source":{"id":"https://openalex.org/S4210180990","display_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","issn_l":"0304-419X","issn":["0304-419X","1879-2561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","raw_type":"journal-article"},{"id":"pmid:31047959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31047959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta. Reviews on cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6542596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6542596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochim Biophys Acta Rev Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6542596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6542596","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochim Biophys Acta Rev Cancer","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1964240783","display_name":"Inhibition of brain metastasis by blocking MAPK12 driver kinase functions","funder_award_id":"R01CA208213","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5957642917","display_name":"Co-targeting PDAC tumor cells and the microenvironment to succeed in EGFR/ErbB2-targeted therapy","funder_award_id":"R21CA223102","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7404567932","display_name":"Target p70S6K for Chemodietary Prevention/Early Intervention of ER- Breast Cancer","funder_award_id":"R01CA184836","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8837382729","display_name":"Stromal activation in the progression of high ErbB2/1433zeta DCIS to IBC","funder_award_id":"R01CA112567","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":180,"referenced_works":["https://openalex.org/W224880912","https://openalex.org/W1499993276","https://openalex.org/W1500925570","https://openalex.org/W1502784604","https://openalex.org/W1511964634","https://openalex.org/W1520425169","https://openalex.org/W1522977578","https://openalex.org/W1534453667","https://openalex.org/W1542448731","https://openalex.org/W1571387405","https://openalex.org/W1574663134","https://openalex.org/W1600015917","https://openalex.org/W1601681275","https://openalex.org/W1658801485","https://openalex.org/W1830346366","https://openalex.org/W1866826175","https://openalex.org/W1894510512","https://openalex.org/W1898690520","https://openalex.org/W1950118853","https://openalex.org/W1964232997","https://openalex.org/W1965913620","https://openalex.org/W1969123951","https://openalex.org/W1969628829","https://openalex.org/W1973449430","https://openalex.org/W1974608177","https://openalex.org/W1974954833","https://openalex.org/W1975355918","https://openalex.org/W1975859224","https://openalex.org/W1976196055","https://openalex.org/W1977560532","https://openalex.org/W1978724459","https://openalex.org/W1979624912","https://openalex.org/W1979751563","https://openalex.org/W1980354353","https://openalex.org/W1981820123","https://openalex.org/W1983275829","https://openalex.org/W1986321004","https://openalex.org/W1987019376","https://openalex.org/W1993528700","https://openalex.org/W1995827114","https://openalex.org/W1998336649","https://openalex.org/W2001149149","https://openalex.org/W2001525415","https://openalex.org/W2002811765","https://openalex.org/W2003388948","https://openalex.org/W2005993715","https://openalex.org/W2009649000","https://openalex.org/W2015222608","https://openalex.org/W2015279451","https://openalex.org/W2018106032","https://openalex.org/W2021637137","https://openalex.org/W2022956911","https://openalex.org/W2024745748","https://openalex.org/W2025199750","https://openalex.org/W2025813658","https://openalex.org/W2028445515","https://openalex.org/W2030701238","https://openalex.org/W2033612573","https://openalex.org/W2036073789","https://openalex.org/W2038236600","https://openalex.org/W2040140079","https://openalex.org/W2048883725","https://openalex.org/W2049169655","https://openalex.org/W2051761998","https://openalex.org/W2054077259","https://openalex.org/W2055298098","https://openalex.org/W2055313665","https://openalex.org/W2056048178","https://openalex.org/W2058404073","https://openalex.org/W2063480251","https://openalex.org/W2066234893","https://openalex.org/W2066432115","https://openalex.org/W2066788401","https://openalex.org/W2067871959","https://openalex.org/W2071132994","https://openalex.org/W2071134774","https://openalex.org/W2073985854","https://openalex.org/W2077773656","https://openalex.org/W2080143331","https://openalex.org/W2080879611","https://openalex.org/W2085462535","https://openalex.org/W2091984900","https://openalex.org/W2098259366","https://openalex.org/W2100772466","https://openalex.org/W2102135956","https://openalex.org/W2104824311","https://openalex.org/W2106175063","https://openalex.org/W2107705644","https://openalex.org/W2108375854","https://openalex.org/W2109564400","https://openalex.org/W2110576880","https://openalex.org/W2110847485","https://openalex.org/W2111855289","https://openalex.org/W2114032563","https://openalex.org/W2116489432","https://openalex.org/W2119764013","https://openalex.org/W2121354606","https://openalex.org/W2126210405","https://openalex.org/W2138011817","https://openalex.org/W2140690761","https://openalex.org/W2140910902","https://openalex.org/W2141003137","https://openalex.org/W2142755954","https://openalex.org/W2143729276","https://openalex.org/W2143839116","https://openalex.org/W2145625720","https://openalex.org/W2150309717","https://openalex.org/W2151079805","https://openalex.org/W2151917704","https://openalex.org/W2151940597","https://openalex.org/W2152503181","https://openalex.org/W2153840858","https://openalex.org/W2155366992","https://openalex.org/W2159175710","https://openalex.org/W2160202949","https://openalex.org/W2166053801","https://openalex.org/W2166595775","https://openalex.org/W2169465106","https://openalex.org/W2169491358","https://openalex.org/W2171264103","https://openalex.org/W2207291742","https://openalex.org/W2274058631","https://openalex.org/W2290775492","https://openalex.org/W2316242722","https://openalex.org/W2323795628","https://openalex.org/W2340580991","https://openalex.org/W2342038157","https://openalex.org/W2482783327","https://openalex.org/W2485668101","https://openalex.org/W2527247503","https://openalex.org/W2542701142","https://openalex.org/W2551331593","https://openalex.org/W2557658326","https://openalex.org/W2567639438","https://openalex.org/W2577697770","https://openalex.org/W2579136823","https://openalex.org/W2582660163","https://openalex.org/W2588757737","https://openalex.org/W2589546201","https://openalex.org/W2592995008","https://openalex.org/W2605377619","https://openalex.org/W2605526871","https://openalex.org/W2607481912","https://openalex.org/W2608932173","https://openalex.org/W2614787430","https://openalex.org/W2615498501","https://openalex.org/W2624616322","https://openalex.org/W2735060541","https://openalex.org/W2738173133","https://openalex.org/W2743022421","https://openalex.org/W2765148841","https://openalex.org/W2767133324","https://openalex.org/W2772391116","https://openalex.org/W2774491730","https://openalex.org/W2787963369","https://openalex.org/W2788994265","https://openalex.org/W2790701366","https://openalex.org/W2791742323","https://openalex.org/W2792578813","https://openalex.org/W2793992337","https://openalex.org/W2796318327","https://openalex.org/W2800494230","https://openalex.org/W2800838685","https://openalex.org/W2801177534","https://openalex.org/W2803834684","https://openalex.org/W2803997637","https://openalex.org/W2804801760","https://openalex.org/W2804840825","https://openalex.org/W2805601712","https://openalex.org/W2806738650","https://openalex.org/W2808930783","https://openalex.org/W2809724091","https://openalex.org/W2810664676","https://openalex.org/W2827119614","https://openalex.org/W2858674133","https://openalex.org/W2883884612","https://openalex.org/W2887249435","https://openalex.org/W4230882199","https://openalex.org/W4251639919","https://openalex.org/W6682640898"],"related_works":["https://openalex.org/W2935463419","https://openalex.org/W2807828500","https://openalex.org/W4405593059","https://openalex.org/W2770151606","https://openalex.org/W2625902221","https://openalex.org/W2794281274","https://openalex.org/W4367182113","https://openalex.org/W4303195457","https://openalex.org/W2987234948","https://openalex.org/W4416067828"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":76},{"year":2025,"cited_by_count":147},{"year":2024,"cited_by_count":224},{"year":2023,"cited_by_count":224},{"year":2022,"cited_by_count":172},{"year":2021,"cited_by_count":86},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-09T00:00:00"}