{"id":"https://openalex.org/W2942565595","doi":null,"title":"An Evidence-Based Look at Misconceptions in the Treatment of Patients with IBS-D.","display_name":"An Evidence-Based Look at Misconceptions in the Treatment of Patients with IBS-D.","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2942565595","mag":"2942565595","pmid":"https://pubmed.ncbi.nlm.nih.gov/24872792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034490"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3009343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034490","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034490","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086017036","display_name":"Brian E. Lacy","orcid":"https://orcid.org/0000-0003-4121-7970","observed_orcids":["https://orcid.org/0000-0003-4121-7970","https://orcid.org/0000-0002-2778-0786"]},"institutions":[{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian E Lacy","raw_affiliation_strings":["Professor of Medicine Geisel School of Medicine at Dartmouth Chief of Gastroenterology and Hepatology Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine Geisel School of Medicine at Dartmouth Chief of Gastroenterology and Hepatology Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire","institution_ids":["https://openalex.org/I1289422878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027136649","display_name":"William D. Chey","orcid":"https://orcid.org/0000-0002-4584-4026","observed_orcids":["https://orcid.org/0000-0002-4584-4026"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D Chey","raw_affiliation_strings":["Professor of Medicine Division of Gastroenterology Director, GI Physiology Laboratory and Michigan Bowel Control Program University of Michigan Health System Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine Division of Gastroenterology Director, GI Physiology Laboratory and Michigan Bowel Control Program University of Michigan Health System Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048152931","display_name":"Lin Chang","orcid":"https://orcid.org/0000-0001-6800-2967","observed_orcids":["https://orcid.org/0000-0001-6800-2967"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Chang","raw_affiliation_strings":["Professor of Medicine Division of Digestive Diseases Department of Medicine The David Geffen School of Medicine University of California, Los Angeles Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Medicine Division of Digestive Diseases Department of Medicine The David Geffen School of Medicine University of California, Los Angeles Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7751,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.84218713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"11 Suppl 5","first_page":"1","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome-with-diarrhea","display_name":"irritable bowel syndrome with diarrhea","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alosetron","display_name":"alosetron","score":0.9909999966621399},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ischemic-colitis","display_name":"ischemic colitis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6230000257492065},{"id":"https://openalex.org/keywords/risk-management-plan","display_name":"risk management plan","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fecal-incontinence","display_name":"fecal incontinence","score":0.8619999885559082},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9240000247955322},{"id":"https://openalex.org/keywords/functional-gastrointestinal-disorders","display_name":"functional gastrointestinal disorders","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9706712365150452},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8067350387573242},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.7014507055282593},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.6280311942100525},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6159809231758118},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5829747319221497},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5254035592079163},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5054874420166016},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4654475152492523},{"id":"https://openalex.org/C108797546","wikidata":"https://www.wikidata.org/wiki/Q204015","display_name":"Defecation","level":2,"score":0.44282686710357666},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43956056237220764},{"id":"https://openalex.org/C2777043163","wikidata":"https://www.wikidata.org/wiki/Q1532338","display_name":"Ischemic colitis","level":3,"score":0.4299778938293457},{"id":"https://openalex.org/C2781093762","wikidata":"https://www.wikidata.org/wiki/Q6695342","display_name":"Lubiprostone","level":4,"score":0.4280160069465637},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41542911529541016},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3256361484527588},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.2535072863101959},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.24266979098320007},{"id":"https://openalex.org/C3017955636","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Chronic constipation","level":3,"score":0.09251922369003296},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3009343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034490","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24872792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24872792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology & hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4034490","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4034490/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterol Hepatol (N Y)","raw_type":"Text"},{"id":"mag:2942565595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24872792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3009343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4034490","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W7585096","https://openalex.org/W66355024","https://openalex.org/W165675192","https://openalex.org/W1172541955","https://openalex.org/W1606920119","https://openalex.org/W1768851900","https://openalex.org/W1873048077","https://openalex.org/W1986215651","https://openalex.org/W1994154508","https://openalex.org/W1998159103","https://openalex.org/W2001290314","https://openalex.org/W2002324192","https://openalex.org/W2007655479","https://openalex.org/W2008019573","https://openalex.org/W2010638665","https://openalex.org/W2010780461","https://openalex.org/W2011454419","https://openalex.org/W2012442346","https://openalex.org/W2012842548","https://openalex.org/W2018343808","https://openalex.org/W2020004427","https://openalex.org/W2033600566","https://openalex.org/W2035889417","https://openalex.org/W2042335480","https://openalex.org/W2043222610","https://openalex.org/W2053593613","https://openalex.org/W2056827810","https://openalex.org/W2063653508","https://openalex.org/W2064201279","https://openalex.org/W2064441871","https://openalex.org/W2067430156","https://openalex.org/W2068598506","https://openalex.org/W2085538087","https://openalex.org/W2087399526","https://openalex.org/W2087547193","https://openalex.org/W2090377492","https://openalex.org/W2103771013","https://openalex.org/W2112959079","https://openalex.org/W2114792198","https://openalex.org/W2121184314","https://openalex.org/W2125423663","https://openalex.org/W2127837438","https://openalex.org/W2128908882","https://openalex.org/W2134117303","https://openalex.org/W2141397074","https://openalex.org/W2146355677","https://openalex.org/W2149216059","https://openalex.org/W2159407687","https://openalex.org/W2300162814"],"related_works":["https://openalex.org/W2052341274","https://openalex.org/W4399248314","https://openalex.org/W2462094204","https://openalex.org/W2800741817","https://openalex.org/W2017274600","https://openalex.org/W2063330271","https://openalex.org/W2012492954","https://openalex.org/W2006312240","https://openalex.org/W2005523188","https://openalex.org/W1972403965"],"abstract_inverted_index":{"Irritable":[0],"bowel":[1],"syndrome":[2],"(IBS)":[3],"is":[4,88],"the":[5,21,61,95,136,160,194],"most":[6],"common":[7],"functional":[8],"gastrointestinal":[9,167],"disorder":[10],"and":[11,30,42,52,98,171,177,202,215],"affects":[12],"up":[13],"to":[14,16,74,83,112],"12%":[15],"15%":[17],"of":[18,40,64,77,124,138,173,179,190,199,204],"adults":[19],"in":[20,119,122,154,184],"United":[22],"States,":[23],"with":[24,45,104,129,131],"a":[25,89,139,188],"higher":[26],"prevalence":[27],"among":[28],"women":[29,103],"those":[31],"younger":[32],"than":[33],"50":[34],"years.":[35],"IBS":[36,65,107,120],"adversely":[37],"impacts":[38],"quality":[39,172],"life":[41],"medical":[43],"expenditures,":[44],"significant":[46,68,152],"costs":[47],"arising":[48],"from":[49,80],"healthcare":[50],"visits":[51],"reduced":[53],"workplace":[54],"productivity.":[55],"Recent":[56],"studies":[57],"have":[58,181,212],"shown":[59],"that":[60,69,108,208],"adverse":[62,78],"effects":[63],"are":[66,72],"so":[67],"many":[70],"patients":[71,125,148],"willing":[73],"accept":[75],"risks":[76],"events":[79],"effective":[81],"treatment":[82],"gain":[84],"symptom":[85],"relief.":[86],"Alosetron":[87,115],"5-HT3":[90],"receptor":[91],"antagonist":[92],"approved":[93],"by":[94],"US":[96],"Food":[97],"Drug":[99],"Administration":[100],"(FDA)":[101],"for":[102],"severe":[105],"diarrhea-predominant":[106],"has":[109],"not":[110],"responded":[111],"traditional":[113],"therapies.":[114],"yields":[116],"overall":[117],"improvements":[118,153],"symptoms":[121],"51%":[123],"vs":[126],"36%":[127],"treated":[128],"placebo,":[130],"efficacy":[132],"continuing":[133],"undiminished":[134],"over":[135],"course":[137],"48-week":[140],"randomized,":[141],"controlled":[142],"trial.":[143],"In":[144],"real-world":[145],"clinical":[146,157],"practice,":[147],"receiving":[149],"alosetron":[150,191],"had":[151],"multiple":[155],"IBS-related":[156],"parameters,":[158],"including":[159],"new":[161],"FDA":[162],"IBS-diarrhea":[163],"composite":[164],"endpoint,":[165],"lower":[166],"symptoms,":[168],"fecal":[169],"incontinence,":[170],"life.":[174],"Ischemic":[175],"colitis":[176,201],"complications":[178,203],"constipation":[180,205],"been":[182],"rare":[183],"occurrence.":[185],"After":[186],"nearly":[187],"decade":[189],"use":[192],"under":[193],"risk":[195],"management":[196],"plan,":[197],"adjudication":[198],"ischemic":[200],"cases":[206],"indicate":[207],"their":[209],"incidence":[210],"rates":[211],"remained":[213],"low":[214],"stable.":[216]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-09T00:00:00"}
