{"id":"https://openalex.org/W2942532222","doi":"https://doi.org/10.48550/arxiv.1905.00334","title":"Homogeneous and Heterogeneous Response of Quorum-Sensing Bacteria in an Evolutionary Context","display_name":"Homogeneous and Heterogeneous Response of Quorum-Sensing Bacteria in an Evolutionary Context","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2942532222","doi":"https://doi.org/10.48550/arxiv.1905.00334","mag":"2942532222"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:1905.00334","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1905.00334","pdf_url":"https://arxiv.org/pdf/1905.00334","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1905.00334","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034666318","display_name":"Burkhard A. Hense","orcid":"https://orcid.org/0000-0001-5848-7227","observed_orcids":["https://orcid.org/0000-0001-5848-7227"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4405263983","display_name":"Institute of Computational Biology","ror":"https://ror.org/00kg2yq63","country_code":"DE","type":"education","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4405263983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hense, Burkhard A.","raw_affiliation_strings":["(deceased) Institute of Computational Biology , Helmholtz Zentrum M\u00fcnchen -German Research Center for Environmental Health , Ingolst\u00e4dter Landstr. 1 , D-85764 Neuherberg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(deceased) Institute of Computational Biology , Helmholtz Zentrum M\u00fcnchen -German Research Center for Environmental Health , Ingolst\u00e4dter Landstr. 1 , D-85764 Neuherberg , Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405263983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078293681","display_name":"Matthew McIntosh","orcid":"https://orcid.org/0000-0002-8212-8205","observed_orcids":["https://orcid.org/0000-0002-8212-8205"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"McIntosh, Matthew","raw_affiliation_strings":["Department of Microbiology and Molecular Biology , Univ. of Giessen , Heinrich-Buff-Ring 26-31 D-35392 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Biology , Univ. of Giessen , Heinrich-Buff-Ring 26-31 D-35392 , Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060996213","display_name":"Johannes M\u00fcller","orcid":"https://orcid.org/0000-0001-5892-8598","observed_orcids":["https://orcid.org/0000-0001-5892-8598"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00fcller, Johannes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011858015","display_name":"Mart\u00edn Schuster","orcid":"https://orcid.org/0000-0002-7674-0887","observed_orcids":["https://orcid.org/0000-0002-7674-0887"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4405263983","display_name":"Institute of Computational Biology","ror":"https://ror.org/00kg2yq63","country_code":"DE","type":"education","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4405263983"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Schuster, Martin","raw_affiliation_strings":["Department of Microbiology , Oregon State Univ. , Nash Hall 226 , Corvallis , OR 97331","Institute of Computational Biology , Helmholtz Zentrum M\u00fcnchen -German Research Center for Environmental Health , Ingolst\u00e4dter Landstr. 1 , D-85764 Neuherberg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology , Oregon State Univ. , Nash Hall 226 , Corvallis , OR 97331","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Institute of Computational Biology , Helmholtz Zentrum M\u00fcnchen -German Research Center for Environmental Health , Ingolst\u00e4dter Landstr. 1 , D-85764 Neuherberg , Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405263983"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.67330002784729,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.3167000114917755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bacterial-cooperation","display_name":"bacterial cooperation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/public-goods","display_name":"public goods","score":0.7879999876022339},{"id":"https://openalex.org/keywords/prisoner-s-dilemma","display_name":"prisoner's dilemma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/multilevel-selection","display_name":"multilevel selection","score":0.9399999976158142},{"id":"https://openalex.org/keywords/evolutionary-stability","display_name":"evolutionary stability","score":0.9279999732971191},{"id":"https://openalex.org/keywords/on-and-off-responses","display_name":"ON and OFF responses","score":0.699999988079071},{"id":"https://openalex.org/keywords/graded-response","display_name":"graded response","score":0.628000020980835},{"id":"https://openalex.org/keywords/cooperation-stability","display_name":"cooperation stability","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.7943771481513977},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6053594350814819},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5922753810882568},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4689725637435913},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4510393440723419},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4452044367790222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4339388310909271},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4285767078399658},{"id":"https://openalex.org/C175444787","wikidata":"https://www.wikidata.org/wiki/Q39072","display_name":"Microeconomics","level":1,"score":0.3900131285190582},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35889554023742676},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.312940388917923},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.27967995405197144},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2701954245567322},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2592470347881317},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22937434911727905},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.18455085158348083},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1659279465675354},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1152307391166687},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:arXiv.org:1905.00334","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1905.00334","pdf_url":"https://arxiv.org/pdf/1905.00334","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2942532222","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/pdf/1905.00334.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"doi:10.48550/arxiv.1905.00334","doi":"https://doi.org/10.48550/arxiv.1905.00334","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1905.00334","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1905.00334","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1905.00334","pdf_url":"https://arxiv.org/pdf/1905.00334","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4218643055","display_name":null,"funder_award_id":"MU2339/2-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5081055245","display_name":null,"funder_award_id":"SPP 1617","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5868870124","display_name":null,"funder_award_id":"Be 2121/6-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1479664019","https://openalex.org/W1507229922","https://openalex.org/W1814976688","https://openalex.org/W1822201252","https://openalex.org/W1938292773","https://openalex.org/W1980814579","https://openalex.org/W1991642577","https://openalex.org/W1994426944","https://openalex.org/W2004778468","https://openalex.org/W2007364207","https://openalex.org/W2023262956","https://openalex.org/W2024229255","https://openalex.org/W2029139718","https://openalex.org/W2032090023","https://openalex.org/W2032625637","https://openalex.org/W2033349024","https://openalex.org/W2036991131","https://openalex.org/W2044128702","https://openalex.org/W2046539688","https://openalex.org/W2050630722","https://openalex.org/W2052360631","https://openalex.org/W2071824069","https://openalex.org/W2073966355","https://openalex.org/W2075738310","https://openalex.org/W2080930023","https://openalex.org/W2084414402","https://openalex.org/W2085728653","https://openalex.org/W2088304654","https://openalex.org/W2090952227","https://openalex.org/W2093514941","https://openalex.org/W2094183398","https://openalex.org/W2098069022","https://openalex.org/W2099640515","https://openalex.org/W2105591146","https://openalex.org/W2106758768","https://openalex.org/W2118521369","https://openalex.org/W2120479418","https://openalex.org/W2120988439","https://openalex.org/W2124643913","https://openalex.org/W2126794261","https://openalex.org/W2130558864","https://openalex.org/W2131153966","https://openalex.org/W2135276973","https://openalex.org/W2142612324","https://openalex.org/W2143868963","https://openalex.org/W2146433021","https://openalex.org/W2151136700","https://openalex.org/W2157639208","https://openalex.org/W2171616025","https://openalex.org/W2175665218","https://openalex.org/W2219121760","https://openalex.org/W2229989463","https://openalex.org/W2343359885","https://openalex.org/W2575249633","https://openalex.org/W2914058264"],"related_works":["https://openalex.org/W2510668779","https://openalex.org/W4230744405","https://openalex.org/W2283773724","https://openalex.org/W2479671399","https://openalex.org/W2171616025","https://openalex.org/W7096383516","https://openalex.org/W4288447593","https://openalex.org/W3193994739","https://openalex.org/W2929183660","https://openalex.org/W2141647877"],"abstract_inverted_index":{"To":[0],"explain":[1],"the":[2,18,38,71,84,91,102,108,114,117,134,137,140,146,149,164,177,192],"stability":[3,78],"of":[4,10,20,54,70,76,86,93,107,116,136,148,163,195,206],"cooperation":[5],"is":[6,35,125,143,184],"a":[7,44,55,97,122,160,198,202,207],"central":[8],"task":[9],"evolutionary":[11,77],"theory.":[12],"We":[13,99],"investigate":[14],"this":[15],"question":[16],"in":[17,29,88,127],"case":[19],"quorum":[21],"sensing":[22],"(QS)":[23],"bacteria,":[24],"which":[25],"regulate":[26],"cooperative":[27],"traits":[28],"response":[30,124,142,205],"to":[31,200],"population":[32,110],"density.":[33],"Cooperation":[34],"modeled":[36],"by":[37,145],"prisoner's":[39],"dilemma,":[40],"where":[41],"individuals":[42,95,153],"produce":[43],"costly":[45],"public":[46],"good":[47],"(PG)":[48],"that":[49,101],"equally":[50],"benefits":[51],"all":[52],"members":[53],"community":[56],"divided":[57],"into":[58],"multiple,":[59],"distinct":[60,173],"patches":[61],"(multilevel":[62],"selection).":[63],"Cost":[64],"and":[65,121,190],"benefit":[66],"are":[67,159,179],"non-linear":[68],"functions":[69],"PG":[72,87,105,165],"production.":[73],"The":[74,181],"analysis":[75],"yields":[79],"an":[80],"optimization":[81],"problem":[82],"for":[83],"expression":[85],"dependency":[89],"on":[90,113],"number":[92],"QS":[94,109,141,152,196],"within":[96],"colony.":[98],"find":[100],"optimal":[103],"total":[104],"production":[106,166],"mainly":[111],"depends":[112],"shape":[115,147],"benefit.":[118],"A":[119],"graded":[120],"switch-like":[123],"possible,":[126],"accordance":[128],"with":[129,172,186],"earlier":[130],"results.":[131],"Interestingly,":[132],"at":[133],"level":[135],"individual":[138],"cell,":[139],"determined":[144],"costs.":[150],"All":[151],"respond":[154,170],"either":[155],"homogeneously":[156],"if":[157,176],"cost":[158],"convex":[161],"function":[162],"rate,":[167],"or":[168],"they":[169],"heterogeneously":[171],"ON/OFF":[174],"responses":[175],"costs":[178],"concave.":[180],"latter":[182],"finding":[183],"consistent":[185],"recent":[187],"experimental":[188],"findings,":[189],"contradicts":[191],"usual":[193],"interpretation":[194],"as":[197],"mechanism":[199],"establish":[201],"uniform,":[203],"synchronized":[204],"bacterial":[208],"population.":[209]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2019-05-09T00:00:00"}