{"id":"https://openalex.org/W2942392743","doi":"https://doi.org/10.1074/jbc.ra118.006814","title":"Bioinformatic and mutational studies of related toxin\u2013antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues","display_name":"Bioinformatic and mutational studies of related toxin\u2013antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues","publication_year":2019,"publication_date":"2019-04-24","ids":{"openalex":"https://openalex.org/W2942392743","doi":"https://doi.org/10.1074/jbc.ra118.006814","mag":"2942392743","pmid":"https://pubmed.ncbi.nlm.nih.gov/31018964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6556569"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.ra118.006814","doi":"https://doi.org/10.1074/jbc.ra118.006814","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.006814","pdf_url":"http://www.jbc.org/article/S0021925820351553/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820351553/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060681735","display_name":"Himani Tandon","orcid":"https://orcid.org/0000-0002-3469-8449","observed_orcids":["https://orcid.org/0000-0002-3469-8449"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himani Tandon","raw_affiliation_strings":["From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and","Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012"],"raw_orcid":"https://orcid.org/0000-0002-3469-8449","affiliations":[{"raw_affiliation_string":"From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101405778","display_name":"Arun Sharma","orcid":"https://orcid.org/0000-0002-4491-8732","observed_orcids":["https://orcid.org/0000-0002-4491-8732"]},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arun Sharma","raw_affiliation_strings":["the Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","institution_ids":["https://openalex.org/I2801880299"]},{"raw_affiliation_string":"Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034148219","display_name":"Saruchi Wadhwa","orcid":"https://orcid.org/0000-0001-7271-0421","observed_orcids":["https://orcid.org/0000-0001-7271-0421"]},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saruchi Wadhwa","raw_affiliation_strings":["the Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","institution_ids":["https://openalex.org/I2801880299"]},{"raw_affiliation_string":"Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082106691","display_name":"Raghavan Varadarajan","orcid":"https://orcid.org/0000-0002-0823-7577","observed_orcids":["https://orcid.org/0000-0002-0823-7577"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Raghavan Varadarajan","raw_affiliation_strings":["From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and","Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685858","display_name":"Ramandeep Singh","orcid":"https://orcid.org/0000-0003-2705-3826","observed_orcids":["https://orcid.org/0000-0003-2705-3826"]},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramandeep Singh","raw_affiliation_strings":["the Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India"],"raw_orcid":"https://orcid.org/0000-0003-2705-3826","affiliations":[{"raw_affiliation_string":"the Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","institution_ids":["https://openalex.org/I2801880299"]},{"raw_affiliation_string":"Tuberculosis Research Laboratory, Vaccine and Infectious Disease Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Milestone, P. O. Box 4, Faridabad, Haryana-121001, India","institution_ids":["https://openalex.org/I2801880299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076920718","display_name":"Narayanaswamy Srinivasan","orcid":"https://orcid.org/0000-0002-6566-6239","observed_orcids":["https://orcid.org/0000-0002-6566-6239"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narayanaswamy Srinivasan","raw_affiliation_strings":["From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and ns@iisc.ac.in","Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and ns@iisc.ac.in","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100695289","display_name":"Sankaran Sandhya","orcid":"https://orcid.org/0000-0003-0055-302X","observed_orcids":["https://orcid.org/0000-0003-0055-302X"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sankaran Sandhya","raw_affiliation_strings":["From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and sandhyas@iisc.ac.in","Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012"],"raw_orcid":"https://orcid.org/0000-0003-0055-302X","affiliations":[{"raw_affiliation_string":"From the Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012 and sandhyas@iisc.ac.in","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Molecular Biophysics Unit, Indian Institute of Science, Bangalore-560012","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076920718","https://openalex.org/A5100695289"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2917,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.87972028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"294","issue":"23","first_page":"9048","last_page":"9063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxin-antitoxin-systems","display_name":"toxin-antitoxin systems","score":0.9089999794960022},{"id":"https://openalex.org/keywords/type-ii-toxin-antitoxin-systems","display_name":"type II toxin-antitoxin systems","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/actinobacteria","display_name":"actinobacteria","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bacteriostatic-activity","display_name":"bacteriostatic activity","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C2778973234","wikidata":"https://www.wikidata.org/wiki/Q584135","display_name":"Antitoxin","level":3,"score":0.8856649398803711},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7445083260536194},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5691549777984619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5060786604881287},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5036346316337585},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.450151652097702},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4477708339691162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38495147228240967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12724238634109497},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075704","descriptor_name":"Toxin-Antitoxin Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000992","descriptor_name":"Antitoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000992","descriptor_name":"Antitoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.ra118.006814","doi":"https://doi.org/10.1074/jbc.ra118.006814","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.006814","pdf_url":"http://www.jbc.org/article/S0021925820351553/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:31018964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31018964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6556569","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6556569/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:eprints.iisc.ac.in:63128","doi":null,"is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/63128/13/142105_2_supp_318886_pqbb9j.xlsx","pdf_url":null,"source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.ra118.006814","doi":"https://doi.org/10.1074/jbc.ra118.006814","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra118.006814","pdf_url":"http://www.jbc.org/article/S0021925820351553/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942392743.pdf","grobid_xml":"https://content.openalex.org/works/W2942392743.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W805066248","https://openalex.org/W1560675666","https://openalex.org/W1604915411","https://openalex.org/W1803102843","https://openalex.org/W1963592098","https://openalex.org/W1963786669","https://openalex.org/W1965517743","https://openalex.org/W1984774221","https://openalex.org/W1985347638","https://openalex.org/W1986703858","https://openalex.org/W1990802442","https://openalex.org/W1996357994","https://openalex.org/W2003142446","https://openalex.org/W2005548636","https://openalex.org/W2008154822","https://openalex.org/W2013903508","https://openalex.org/W2015402183","https://openalex.org/W2017145164","https://openalex.org/W2023424516","https://openalex.org/W2023490488","https://openalex.org/W2031753305","https://openalex.org/W2042777786","https://openalex.org/W2045114886","https://openalex.org/W2047628885","https://openalex.org/W2051584259","https://openalex.org/W2065283382","https://openalex.org/W2073895233","https://openalex.org/W2090188358","https://openalex.org/W2090486365","https://openalex.org/W2091426267","https://openalex.org/W2094095960","https://openalex.org/W2096525273","https://openalex.org/W2097854076","https://openalex.org/W2103222799","https://openalex.org/W2106648157","https://openalex.org/W2110869427","https://openalex.org/W2114716642","https://openalex.org/W2115463917","https://openalex.org/W2126573196","https://openalex.org/W2130060890","https://openalex.org/W2133711117","https://openalex.org/W2140029549","https://openalex.org/W2142529984","https://openalex.org/W2144795887","https://openalex.org/W2149292210","https://openalex.org/W2151899778","https://openalex.org/W2152219892","https://openalex.org/W2153544371","https://openalex.org/W2154139219","https://openalex.org/W2158714788","https://openalex.org/W2158804744","https://openalex.org/W2158992333","https://openalex.org/W2163406805","https://openalex.org/W2164814134","https://openalex.org/W2167970541","https://openalex.org/W2168974130","https://openalex.org/W2170305714","https://openalex.org/W2224056471","https://openalex.org/W2336330109","https://openalex.org/W2429647350","https://openalex.org/W2431006159","https://openalex.org/W2511299360","https://openalex.org/W2513670426","https://openalex.org/W2516471498","https://openalex.org/W2550875942","https://openalex.org/W2570965848","https://openalex.org/W2588841384","https://openalex.org/W2613703036","https://openalex.org/W2735224236","https://openalex.org/W2791839134","https://openalex.org/W2900701906","https://openalex.org/W2917698825","https://openalex.org/W4210702584","https://openalex.org/W4234797890"],"related_works":["https://openalex.org/W2017145164","https://openalex.org/W2791839134","https://openalex.org/W4281814463","https://openalex.org/W7071771770","https://openalex.org/W3046694445","https://openalex.org/W7166491674","https://openalex.org/W2902457027","https://openalex.org/W2917698825","https://openalex.org/W2561376062","https://openalex.org/W4223522757"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1,122,139,143,215,235],"possesses":[2],"an":[3],"unusually":[4],"large":[5],"representation":[6],"of":[7,25,55,67,92,119,136,174,180,190,220,230],"type":[8],"II":[9],"toxin\u2013antitoxin":[10],"(TA)":[11],"systems,":[12,37],"whose":[13],"functions":[14],"and":[15,29,41,48,77,109,125,187],"targets":[16],"are":[17,85,131,206],"mostly":[18],"unknown.":[19],"To":[20],"better":[21],"understand":[22],"the":[23,56,65,80,98,116,120,134,137,181,191,218,227],"basis":[24,66],"their":[26,44],"unique":[27],"expansion":[28],"to":[30,87],"probe":[31],"putative":[32,81,166,182],"functional":[33,75,95],"similarities":[34],"among":[35,133],"these":[36,93],"here":[38,225],"we":[39,73,114,162,176],"computationally":[40],"experimentally":[42],"investigated":[43],"sequence":[45,69],"relationships.":[46],"Bioinformatic":[47],"phylogenetic":[49],"investigations":[50],"revealed":[51],"that":[52,84,127,149,178,188,203],"51":[53],"sequences":[54,205,212],"VapBC":[57],"toxin":[58,204],"family":[59],"group":[60],"into":[61],"paralogous":[62],"sub-clusters.":[63],"On":[64],"conserved":[68],"fingerprints":[70],"within":[71],"paralogues,":[72],"predicted":[74],"residues":[76,78,96],"at":[79],"TA":[82,89,123,129,159,167,222,231],"interface":[83],"useful":[86],"evaluate":[88],"interactions.":[90],"Substitution":[91],"likely":[94],"abolished":[97],"toxin's":[99],"growth-inhibitory":[100],"activity.":[101],"Furthermore,":[102,217],"conducting":[103],"similarity":[104],"searches":[105],"in":[106,144,169,213,233],"101":[107],"mycobacterial":[108],"\u223c4500":[110],"other":[111],"prokaryotic":[112],"genomes,":[113],"assessed":[115],"relative":[117],"conservation":[118],"M.":[121,138,170,214,234],"systems":[124,223,232],"found":[126,148],"most":[128],"orthologues":[130],"well-conserved":[132],"members":[135],"complex,":[140],"which":[141],"cause":[142],"animal":[145],"hosts.":[146],"We":[147],"soil-inhabiting,":[150],"free-living":[151],"Actinobacteria":[152],"also":[153],"harbor":[154],"as":[155,157],"many":[156],"12":[158],"pairs.":[160],"Finally,":[161],"identified":[163],"five":[164],"novel":[165],"modules":[168],"tuberculosis.":[171],"For":[172],"one":[173],"them,":[175],"demonstrate":[177],"overexpression":[179],"toxin,":[183],"Rv2514c,":[184],"induces":[185],"bacteriostasis":[186],"co-expression":[189],"cognate":[192],"antitoxin":[193,211],"Rv2515c":[194],"restores":[195],"bacterial":[196],"growth.":[197],"Taken":[198],"together,":[199],"our":[200],"findings":[201],"reveal":[202],"more":[207],"closely":[208],"related":[209],"than":[210],".":[216,236],"identification":[219],"additional":[221],"reported":[224],"expands":[226],"known":[228],"repertoire":[229]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2019-05-03T00:00:00"}