{"id":"https://openalex.org/W2942380324","doi":null,"title":"Modifying and Measuring the Stiffness of a Regenerative Cardiac Scaffold In Vitro","display_name":"Modifying and Measuring the Stiffness of a Regenerative Cardiac Scaffold In Vitro","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2942380324","mag":"2942380324"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wpi.edu:etd-theses-2097","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/etd-theses/1098","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2097&context=etd-theses","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses (All Theses, All Years)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2097&context=etd-theses","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084124045","display_name":"Daniel Filipe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Filipe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084124045"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scaffold-stiffness","display_name":"scaffold stiffness","score":0.8949999809265137},{"id":"https://openalex.org/keywords/surgical-ventricular-restoration","display_name":"surgical ventricular restoration","score":0.7390000224113464},{"id":"https://openalex.org/keywords/urinary-bladder-matrix","display_name":"urinary bladder matrix","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dacron","display_name":"Dacron","score":0.972000002861023},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.9679999947547913},{"id":"https://openalex.org/keywords/fibroblast-culture","display_name":"fibroblast culture","score":0.621999979019165},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8840000033378601},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9319999814033508},{"id":"https://openalex.org/keywords/scaffold-degradation","display_name":"scaffold degradation","score":0.328000009059906},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.5590000152587891},{"id":"https://openalex.org/keywords/in-vitro-mechanical-testing","display_name":"in vitro mechanical testing","score":0.5860000252723694},{"id":"https://openalex.org/keywords/cell-surface-interactions","display_name":"cell-surface interactions","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.6785321235656738},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48992985486984253},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.46955612301826477},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42163509130477905},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.40208759903907776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35354045033454895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2714323401451111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26484864950180054},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21307191252708435},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09212785959243774}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wpi.edu:etd-theses-2097","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/etd-theses/1098","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2097&context=etd-theses","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses (All Theses, All Years)","raw_type":"text"},{"id":"mag:2942380324","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wpi.edu/etd-theses/1098/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wpi.edu:etd-theses-2097","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wpi.edu/etd-theses/1098","pdf_url":"https://digitalcommons.wpi.edu/cgi/viewcontent.cgi?article=2097&context=etd-theses","source":{"id":"https://openalex.org/S4377196141","display_name":"Digital WPI","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses (All Theses, All Years)","raw_type":"text"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942380324.pdf","grobid_xml":"https://content.openalex.org/works/W2942380324.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W23584388","https://openalex.org/W1594006630","https://openalex.org/W1601381175","https://openalex.org/W1796236068","https://openalex.org/W1851592922","https://openalex.org/W1935621924","https://openalex.org/W1964604682","https://openalex.org/W1967873955","https://openalex.org/W1968476132","https://openalex.org/W1969390542","https://openalex.org/W1971173752","https://openalex.org/W1985398384","https://openalex.org/W1986174586","https://openalex.org/W1991248456","https://openalex.org/W1992079370","https://openalex.org/W1993654937","https://openalex.org/W1994502600","https://openalex.org/W1994976809","https://openalex.org/W1999186101","https://openalex.org/W1999427702","https://openalex.org/W2003105934","https://openalex.org/W2003422631","https://openalex.org/W2005331253","https://openalex.org/W2009721592","https://openalex.org/W2012524269","https://openalex.org/W2014051267","https://openalex.org/W2018630085","https://openalex.org/W2020688767","https://openalex.org/W2022318591","https://openalex.org/W2022422907","https://openalex.org/W2029277031","https://openalex.org/W2031335327","https://openalex.org/W2032691932","https://openalex.org/W2037617291","https://openalex.org/W2039067945","https://openalex.org/W2041207612","https://openalex.org/W2054635074","https://openalex.org/W2060462183","https://openalex.org/W2061086747","https://openalex.org/W2061142495","https://openalex.org/W2068614684","https://openalex.org/W2074749249","https://openalex.org/W2077204544","https://openalex.org/W2079153315","https://openalex.org/W2081910534","https://openalex.org/W2084360725","https://openalex.org/W2086971394","https://openalex.org/W2088770941","https://openalex.org/W2093453395","https://openalex.org/W2093987869","https://openalex.org/W2112710263","https://openalex.org/W2113070583","https://openalex.org/W2115942217","https://openalex.org/W2118546684","https://openalex.org/W2122183924","https://openalex.org/W2125138738","https://openalex.org/W2126617987","https://openalex.org/W2128090530","https://openalex.org/W2128281971","https://openalex.org/W2128404501","https://openalex.org/W2129350159","https://openalex.org/W2131918640","https://openalex.org/W2134139753","https://openalex.org/W2134159326","https://openalex.org/W2144749699","https://openalex.org/W2149757185","https://openalex.org/W2152671357","https://openalex.org/W2159469901","https://openalex.org/W2166608755","https://openalex.org/W2168321841","https://openalex.org/W2168324813","https://openalex.org/W2171503266","https://openalex.org/W2181350280","https://openalex.org/W2249335696","https://openalex.org/W2334062080","https://openalex.org/W3131591919"],"related_works":["https://openalex.org/W2171206582","https://openalex.org/W3089730712","https://openalex.org/W4393031599","https://openalex.org/W3134614557","https://openalex.org/W6940492396","https://openalex.org/W2056239011","https://openalex.org/W2976692043","https://openalex.org/W2070161918","https://openalex.org/W3089751192","https://openalex.org/W3216147739"],"abstract_inverted_index":{"\"The":[0],"stiffness":[1,27,66,107,144,183,212,426,443],"of":[2,22,28,34,52,67,86,89,95,108,190,209,221,295,308,318,339,348,379,398,415,436,441,444],"scaffolds":[3,101,135,272,286,366,446],"used":[4,204],"in":[5,14,39,58,75,82,103,119,142,158,163,175,181,198,225,230,234,278,288,301,315,320,354,357,370,376],"surgical":[6],"ventricular":[7],"restoration":[8],"may":[9],"play":[10],"an":[11,74,276,313],"important":[12],"role":[13,423],"the":[15,29,32,48,65,92,146,207,235,271,292,306,316,321,343,351,377,421,434,442],"degree":[16],"to":[17,46,56,61,193,205,215,305,336,342,345,365,433,454,461],"which":[18,36,97,195,409,424],"they":[19],"facilitate":[20,462],"regeneration":[21,429],"functional":[23],"cardiac":[24,399,438],"tissue.":[25],"The":[26,50,105,299],"scaffold":[30,69,110,185,211],"influences":[31],"phenotype":[33],"cells":[35],"are":[37,458],"present":[38],"it":[40,98],"as":[41,43],"well":[42],"their":[44],"ability":[45],"deform":[47],"scaffold.":[49],"goal":[51],"this":[53,83],"study":[54,84],"was":[55,80,203,297,310],"evaluate":[57],"vitro":[59,76,176],"methods":[60,153],"characterize":[62],"and":[63,91,115,121,129,259,373,450],"alter":[64],"new":[68],"materials.":[70],"Membrane":[71,200],"inflation":[72,124,170,201,449],"testing,":[73,139],"mechanical":[77],"testing":[78,171,202],"method,":[79],"evaluated":[81],"because":[85],"its":[87,239],"ease":[88],"use":[90],"similar":[93,140,192],"mode":[94],"loading":[96],"shares":[99],"with":[100,187,333,368,394],"implanted":[102],"vivo.":[104,199],"structural":[106,143,182],"two":[109,147],"materials,":[111],"urinary":[112],"bladder":[113],"matrix":[114],"Dacron,":[116],"were":[117,149,268],"determined":[118],"vivo":[120],"using":[122,137],"membrane":[123,138,169,224,448],"testing.":[125],"Despite":[126],"higher":[127],"tensions":[128],"lower":[130],"area":[131],"stretch":[132],"ratios":[133],"for":[134,151,178,273,291],"tested":[136],"changes":[141,180],"between":[145,184],"materials":[148,186],"found":[150],"both":[152],"(5.6":[154],"\u00b1":[155,161,243,250,256,263,282,324,330,361,384,391],"3.3":[156,392],"fold":[157],"vivo,":[159],"5.0":[160],"1.0":[162],"vitro).":[164],"This":[165],"finding":[166],"demonstrated":[167],"that":[168,194],"is":[172,196,405,410],"a":[173,188,222,231,355,374,402,406,413],"useful":[174],"method":[177],"measuring":[179],"level":[189],"sensitivity":[191],"measured":[197],"assess":[206],"effectiveness":[208],"altering":[210],"through":[213,452],"exposure":[214,453],"various":[216],"cell":[217,226,455],"culture":[218,227,289,456],"conditions.":[219],"Incubation":[220],"biological":[223],"media":[228,290,344,372],"resulted":[229,353],"drastic":[232],"decrease":[233,356,375],"elastic":[236,279,302,358],"modulus":[237,280,303,359],"from":[238],"initial":[240],"value":[241],"(3.55":[242],"0.52":[244],"MPa)":[245,284,363],"after":[246,401],"2":[247],"weeks":[248,254,261,275],"(1.79":[249],"0.30":[251],"MPa),":[252,258],"4":[253],"(1.04":[255],"0.09":[257],"10":[260,274],"(0.014":[262],"0.01":[264,362],"MPa).":[265],"When":[266],"fibroblasts":[267,309,352,369],"cultured":[269,367],"on":[270,428],"increase":[277,300,314,346],"(0.134":[281],"0.05":[283],"over":[285],"incubated":[287],"same":[293],"amount":[294,378],"time":[296],"observed.":[298],"due":[304],"presence":[307],"accompanied":[311],"by":[312,350,412,447],"percentage":[317],"collagen":[319,349,382],"samples":[322],"(54.1":[323],"5.1":[325,331],"%":[326,332,386,393],"without":[327,387],"fibroblasts,":[328],"83.2":[329],"fibroblasts).":[334],"Contrary":[335],"expectation,":[337],"addition":[338],"ascorbic":[340,388,395],"acid":[341],"production":[347],"(0.030":[360],"compared":[364],"standard":[371],"enzymatically":[380],"degraded":[381],"(40.8":[383],"4.7":[385],"acid,":[389],"21.1":[390],"acid).":[396],"Regeneration":[397],"tissue":[400],"myocardial":[403],"infarction":[404],"complicated":[407],"process":[408],"influenced":[411],"myriad":[414],"different":[416],"factors.":[417],"Future":[418],"studies":[419],"investigating":[420],"exact":[422],"substrate":[425],"has":[427],"will":[430],"be":[431],"essential":[432],"development":[435],"improved":[437],"scaffolds.":[439],"Characterization":[440],"these":[445],"manipulation":[451],"conditions":[457],"powerful":[459],"approaches":[460],"future":[463],"studies.\"":[464]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2019-05-03T00:00:00"}