{"id":"https://openalex.org/W2942293736","doi":null,"title":"Formulation and evaluation of ciprofloxacin-cockle shells derived calcium carbonate aragonite nanoparticles physicochemical properties mediated in vitro bactericidal activity in Salmonella Typhimurium","display_name":"Formulation and evaluation of ciprofloxacin-cockle shells derived calcium carbonate aragonite nanoparticles physicochemical properties mediated in vitro bactericidal activity in Salmonella Typhimurium","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2942293736","mag":"2942293736"},"language":"en","primary_location":{"id":"pmh:oai:psasir.upm.edu.my:61912","doi":null,"is_oa":true,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/61912/1/Formulation%20and%20evaluation%20of%20ciprofloxacin-cockle%20shells%20.pdf","pdf_url":"http://psasir.upm.edu.my/id/eprint/61912/1/Formulation%20and%20evaluation%20of%20ciprofloxacin-cockle%20shells%20.pdf","source":{"id":"https://openalex.org/S4377196260","display_name":"Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130343225","host_organization_name":"Universiti Putra Malaysia","host_organization_lineage":["https://openalex.org/I130343225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://psasir.upm.edu.my/id/eprint/61912/1/Formulation%20and%20evaluation%20of%20ciprofloxacin-cockle%20shells%20.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082345019","display_name":"Tijani Isa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tijani Isa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034868140","display_name":"Sani Ibn Yakubu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sani Ibn Yakubu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077922146","display_name":"Yaya Rukayadi","orcid":"https://orcid.org/0000-0001-7807-4462","observed_orcids":["https://orcid.org/0000-0001-7807-4462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaya Rukayadi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7807-4462","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049524431","display_name":"Alhaji Zubair Jaji","orcid":"https://orcid.org/0000-0001-9721-2920","observed_orcids":["https://orcid.org/0000-0001-9721-2920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alhaji Zubair Jaji","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9721-2920","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.41429999470710754,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.41429999470710754,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3862000107765198,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.10930000245571136,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cockle-shell","display_name":"cockle shell","score":0.7889999747276306},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.8980000019073486},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9190000295639038},{"id":"https://openalex.org/keywords/drug-nanoparticle-interaction","display_name":"drug-nanoparticle interaction","score":0.6759999990463257},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8539999723434448},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5260000228881836},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2779866092","wikidata":"https://www.wikidata.org/wiki/Q23775","display_name":"Aragonite","level":3,"score":0.7481649518013},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.7261512875556946},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6698988080024719},{"id":"https://openalex.org/C2778039128","wikidata":"https://www.wikidata.org/wiki/Q23767","display_name":"Calcium carbonate","level":2,"score":0.6494003534317017},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6444591283798218},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.5766565203666687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5626416802406311},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.47279518842697144},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.44867679476737976},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4292842745780945},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.36191868782043457},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3172132968902588},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2668262720108032},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.23146778345108032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1791839301586151},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12360581755638123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09064331650733948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:psasir.upm.edu.my:61912","doi":null,"is_oa":true,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/61912/1/Formulation%20and%20evaluation%20of%20ciprofloxacin-cockle%20shells%20.pdf","pdf_url":"http://psasir.upm.edu.my/id/eprint/61912/1/Formulation%20and%20evaluation%20of%20ciprofloxacin-cockle%20shells%20.pdf","source":{"id":"https://openalex.org/S4377196260","display_name":"Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130343225","host_organization_name":"Universiti Putra Malaysia","host_organization_lineage":["https://openalex.org/I130343225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:2942293736","doi":null,"is_oa":false,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/61912/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:psasir.upm.edu.my:61912","doi":null,"is_oa":true,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/61912/1/Formulation%20and%20evaluation%20of%20ciprofloxacin-cockle%20shells%20.pdf","pdf_url":"http://psasir.upm.edu.my/id/eprint/61912/1/Formulation%20and%20evaluation%20of%20ciprofloxacin-cockle%20shells%20.pdf","source":{"id":"https://openalex.org/S4377196260","display_name":"Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130343225","host_organization_name":"Universiti Putra Malaysia","host_organization_lineage":["https://openalex.org/I130343225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2942293736.pdf"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W147777729","https://openalex.org/W611976593","https://openalex.org/W1963926939","https://openalex.org/W1965519310","https://openalex.org/W1969200326","https://openalex.org/W1976600818","https://openalex.org/W1986118562","https://openalex.org/W1986701384","https://openalex.org/W1997670407","https://openalex.org/W1999866520","https://openalex.org/W2000924336","https://openalex.org/W2009809742","https://openalex.org/W2013980860","https://openalex.org/W2018504340","https://openalex.org/W2022595058","https://openalex.org/W2024033907","https://openalex.org/W2033725454","https://openalex.org/W2046422196","https://openalex.org/W2047905490","https://openalex.org/W2056217507","https://openalex.org/W2063790803","https://openalex.org/W2067255881","https://openalex.org/W2067994654","https://openalex.org/W2069415463","https://openalex.org/W2074420216","https://openalex.org/W2076233570","https://openalex.org/W2089140120","https://openalex.org/W2092665512","https://openalex.org/W2094340050","https://openalex.org/W2111032304","https://openalex.org/W2119567467","https://openalex.org/W2123037483","https://openalex.org/W2140799056","https://openalex.org/W2185763548","https://openalex.org/W2972418483"],"related_works":["https://openalex.org/W6999942887","https://openalex.org/W2404870875","https://openalex.org/W4235232343","https://openalex.org/W2325862592","https://openalex.org/W2324781907","https://openalex.org/W7213079213","https://openalex.org/W7221507146","https://openalex.org/W7170154134","https://openalex.org/W4407611813","https://openalex.org/W3046811749"],"abstract_inverted_index":{"Since":[0],"the":[1,7,23,35,67,72,97,107,112,127,130,158,186],"use":[2],"of":[3,9,32,37,66,74,104,129,175,179,189],"classical":[4],"antibiotics":[5],"in":[6,61,71,95,118],"management":[8],"resistant":[10],"bacterial":[11],"infections":[12],"requires":[13],"high":[14],"dosage":[15],"and":[16,43,76,79,109,115,125,135],"regular":[17],"administration":[18],"for":[19],"a":[20,151],"lengthy":[21],"duration,":[22],"enhanced":[24,177],"delivery":[25],"system":[26],"that":[27,172],"will":[28],"ensure":[29],"sustained":[30,152],"release":[31,154],"antibiotic":[33],"to":[34,124,143],"Site":[36],"action":[38],"is":[39],"important.":[40],"We":[41],"synthesized":[42],"formulated":[44,68],"ciprofloxacin-cockle":[45],"shell":[46],"derived":[47],"calcium":[48],"carbonate":[49],"aragonite":[50],"nanoparticles":[51,69,110,144],"(C-CSCCAN),":[52],"appropriately":[53],"analysed":[54],"its":[55],"physicochemical":[56,173],"properties":[57,174],"mediated":[58],"antibacterial":[59,164],"activity":[60,165],"Salmonella":[62,180],"Typhimurium.":[63],"The":[64],"size":[65],"were":[70,139],"range":[73],"13.94":[75],"23.95":[77],"nm":[78],"Zeta":[80],"potential":[81],"was":[82,121,155,170],"optimally":[83],"negative.":[84],"Diffraction":[85],"pattern":[86],"by":[87],"X-ray":[88],"powder":[89],"diffraction":[90],"(XRD)":[91],"revealed":[92],"strong":[93],"crystallizations":[94],"all":[96],"formulations.":[98],"Fourier-transform":[99],"(FT-IR)":[100],"spectra":[101],"displayed":[102],"evidence":[103],"interactions":[105],"between":[106],"drug":[108,153],"at":[111,141],"molecular":[113],"level":[114],"no":[116],"change":[117],"peaks":[119],"position":[120],"observed":[122,156],"prior":[123],"after":[126],"synthesis":[128],"nanoparticles.":[131],"Higher":[132],"encapsulation":[133],"(99.5)":[134],"loading":[136],"capacity":[137],"(5.9%)":[138],"attained":[140],"ciprofloxacin":[142],"ratio":[145],"1:17.":[146],"No":[147],"burst":[148],"effect":[149],"but":[150],"from":[157],"formulation.":[159],"C-CSCCAN":[160],"suspension":[161],"exhibited":[162],"higher":[163],"than":[166],"free":[167],"ciprofloxacin.":[168,190],"It":[169],"concluded":[171],"CSCCAN":[176],"susceptibility":[178],"Typhimurium,":[181],"which":[182],"could":[183],"potentially":[184],"improve":[185],"clinical":[187],"efficacy":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-03T00:00:00"}