{"id":"https://openalex.org/W2942287205","doi":"https://doi.org/10.1093/neuonc/noz036.130","title":"IMMU-09. LOCALLY ADMINISTERED CAR T CELLS DEMONSTRATE MOST FAVORABLE ROUTE OF ADMINISTRATION IN A MODEL OF ATRT","display_name":"IMMU-09. LOCALLY ADMINISTERED CAR T CELLS DEMONSTRATE MOST FAVORABLE ROUTE OF ADMINISTRATION IN A MODEL OF ATRT","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2942287205","doi":"https://doi.org/10.1093/neuonc/noz036.130","mag":"2942287205"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noz036.130","doi":"https://doi.org/10.1093/neuonc/noz036.130","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz036.130","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii94/28442757/noz036.130.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii94/28442757/noz036.130.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019108027","display_name":"Johanna Lena Theruvath","orcid":"https://orcid.org/0000-0003-4470-9727","observed_orcids":["https://orcid.org/0000-0003-4470-9727"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johanna Theruvath","raw_affiliation_strings":["Stanford University, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031028113","display_name":"Claus Moritz Graef","orcid":"https://orcid.org/0000-0001-8573-3235","observed_orcids":["https://orcid.org/0000-0001-8573-3235"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claus Moritz Graef","raw_affiliation_strings":["Stanford University, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068982698","display_name":"Sabine Heitzeneder","orcid":"https://orcid.org/0000-0001-8770-2192","observed_orcids":["https://orcid.org/0000-0001-8770-2192"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabine Heitzeneder","raw_affiliation_strings":["Stanford University, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033972749","display_name":"Robbie G. Majzner","orcid":"https://orcid.org/0000-0001-6969-8011","observed_orcids":["https://orcid.org/0000-0001-6969-8011"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robbie Majzner","raw_affiliation_strings":["Stanford University, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080476711","display_name":"Louai Labanieh","orcid":"https://orcid.org/0000-0003-3998-7415","observed_orcids":["https://orcid.org/0000-0003-3998-7415"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louai Labanieh","raw_affiliation_strings":["Stanford University, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087779758","display_name":"Crystal Lee Mackall","orcid":"https://orcid.org/0000-0003-0359-9023","observed_orcids":["https://orcid.org/0000-0003-0359-9023","https://orcid.org/0000-0001-6323-4304"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Mackall","raw_affiliation_strings":["Stanford University, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.1025,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46342437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"Supplement_2","first_page":"ii94","last_page":"ii95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/atypical-teratoid-rhabdoid-tumor","display_name":"atypical teratoid/rhabdoid tumor","score":0.953000009059906},{"id":"https://openalex.org/keywords/route-of-administration","display_name":"route of administration","score":0.9210000038146973},{"id":"https://openalex.org/keywords/intratumoral-administration","display_name":"intratumoral administration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.9369999766349792},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.6460000276565552},{"id":"https://openalex.org/keywords/car-t-cell-trafficking","display_name":"CAR T cell trafficking","score":0.8679999709129333},{"id":"https://openalex.org/keywords/car-t-cell-persistence","display_name":"CAR T cell persistence","score":0.9390000104904175},{"id":"https://openalex.org/keywords/car-t-cell-toxicity","display_name":"CAR T-cell toxicity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6930000185966492},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cns-malignancies","display_name":"CNS malignancies","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6788141131401062},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.6185293197631836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.585710346698761},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5530998706817627},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5059911608695984},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4906877279281616},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4635801315307617},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.459468811750412},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4185606837272644},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35036367177963257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28622400760650635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24928143620491028},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noz036.130","doi":"https://doi.org/10.1093/neuonc/noz036.130","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz036.130","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii94/28442757/noz036.130.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6477526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6477526","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noz036.130","doi":"https://doi.org/10.1093/neuonc/noz036.130","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz036.130","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii94/28442757/noz036.130.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942287205.pdf","grobid_xml":"https://content.openalex.org/works/W2942287205.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2809533705","https://openalex.org/W4206357951","https://openalex.org/W4283768141","https://openalex.org/W4247899587","https://openalex.org/W4313426357","https://openalex.org/W4394595641","https://openalex.org/W4398191044","https://openalex.org/W4392560879","https://openalex.org/W7171504781","https://openalex.org/W4416450825"],"abstract_inverted_index":{"Efficient":[0],"trafficking":[1,258],"and":[2,49,56,98,102,115,176,231,238,244,259,289],"infiltration":[3],"of":[4,15,22,71,106,130,137,140,146,165,178,210,221,224,256,269],"CAR":[5,91],"T":[6],"cells":[7,26,61,81,132,142,171,227],"to":[8,78,89,93,121,126,207],"brain":[9,230],"tumors":[10],"is":[11,30],"an":[12],"important":[13],"determinant":[14],"treatment":[16,112,138,161,200],"success.":[17],"Data":[18],"comparing":[19],"the":[20,63,90,123,144,179,182,195,198,222,267],"route":[21,223,268],"delivery":[23,250],"for":[24,34,277,282,287],"CAR-T":[25,44,60,80,99,131,141,170,189,226,283],"in":[27,43,51,67,82,174,188,194,229,254],"CNS":[28,291],"malignancies":[29],"limited,":[31],"but":[32,152],"crucial":[33],"successful":[35],"clinical":[36,279],"trial":[37,280],"design.":[38],"We":[39,233],"therefore":[40],"investigated":[41],"differences":[42,187],"cell":[45,100,190,284],"efficacy,":[46,107,257],"trafficking,":[47],"toxicity":[48],"persistence":[50,262],"intratumoral":[52],"(IT),":[53],"intracerebroventricular":[54],"(ICV)":[55],"intravenous":[57,204],"(IV)":[58],"administered":[59,167],"targeting":[62],"immune":[64],"checkpoint":[65],"B7-H3":[66],"a":[68,86,117,162,278],"xenograft":[69],"model":[70],"Atypical":[72],"teratoid/rhabdoid":[73],"tumor":[74,96,145],"(ATRT).":[75],"In":[76,104,247],"order":[77],"detect":[79],"vivo":[83],"we":[84,108],"fused":[85],"nano-luciferase":[87],"protein":[88],"construct":[92],"simultaneously":[94],"track":[95],"growth":[97],"expansion":[101,139],"location.":[103],"terms":[105,255],"found":[109,173,193],"that":[110],"systemic":[111,154],"took":[113],"longer":[114],"required":[116],"tenfold":[118],"higher":[119],"dose":[120],"cure":[122],"mice":[124,151,237],"compared":[125],"locoregional":[127,147],"treatment.":[128],"Tracking":[129],"revealed":[133],"after":[134,160],"5":[135],"days":[136,159],"within":[143],"(IT,":[148,168],"ICV)":[149,169],"treated":[150,155,236],"not":[153,264],"mice.":[156],"Furthermore,":[157],"13":[158],"significant":[163,186],"fraction":[164],"locally":[166],"were":[172,192,215],"spleen":[175],"liver":[177],"mice,":[180],"demonstrating":[181],"migratory":[183],"potential.":[184],"No":[185],"numbers":[191],"spleens":[196],"between":[197],"different":[199],"groups.":[201],"Regarding":[202],"toxicity,":[203,260],"administration":[205,225],"led":[206],"high":[208],"levels":[209],"circulating":[211],"inflammatory":[212],"cytokines":[213],"which":[214],"undetectable":[216],"following":[217],"local":[218,249],"administration.":[219],"Independent":[220],"persisted":[228],"spleen.":[232],"re-challenged":[234],"previously":[235],"all":[239],"groups":[240],"effectively":[241],"rejected":[242],"flank":[243],"orthotopic":[245],"tumors.":[246],"summary,":[248],"might":[251],"be":[252],"favorable":[253],"whereas":[261],"may":[263],"depend":[265],"on":[266],"delivery.":[270],"These":[271],"findings":[272],"have":[273],"direct":[274],"valuable":[275],"implications":[276],"design":[281],"based":[285],"immunotherapies":[286],"ATRT":[288],"other":[290],"malignancies.":[292]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-03T00:00:00"}