{"id":"https://openalex.org/W2942228202","doi":"https://doi.org/10.1016/j.molcel.2019.03.031","title":"ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2\u03b1 Axis","display_name":"ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2\u03b1 Axis","publication_year":2019,"publication_date":"2019-04-22","ids":{"openalex":"https://openalex.org/W2942228202","doi":"https://doi.org/10.1016/j.molcel.2019.03.031","mag":"2942228202","pmid":"https://pubmed.ncbi.nlm.nih.gov/31023583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555668"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcel.2019.03.031","doi":"https://doi.org/10.1016/j.molcel.2019.03.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.03.031","pdf_url":"http://www.cell.com/article/S1097276519302357/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1097276519302357/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044727261","display_name":"Eduardo Balsa","orcid":"https://orcid.org/0000-0002-6836-7023","observed_orcids":["https://orcid.org/0000-0002-6836-7023"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Balsa","raw_affiliation_strings":["Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082550681","display_name":"Meghan S. Soustek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan S. Soustek","raw_affiliation_strings":["Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033410175","display_name":"Ajith J. Thomas","orcid":"https://orcid.org/0000-0003-4412-3152","observed_orcids":["https://orcid.org/0000-0003-4412-3152"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajith Thomas","raw_affiliation_strings":["Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020864801","display_name":"Sara Cogliati","orcid":"https://orcid.org/0000-0002-0374-3489","observed_orcids":["https://orcid.org/0000-0002-0374-3489"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sara Cogliati","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009499216","display_name":"Carolina Garc\u00eda\u2010Poyatos","orcid":"https://orcid.org/0000-0003-0918-5403","observed_orcids":["https://orcid.org/0000-0003-0918-5403"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carolina Garc\u00eda-Poyatos","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elena Mart\u00edn-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Mart\u00edn-Garc\u00eda","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041955512","display_name":"Mark P. Jedrychowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Jedrychowski","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079793809","display_name":"Steven P. Gygi","orcid":"https://orcid.org/0000-0001-7626-0034","observed_orcids":["https://orcid.org/0000-0001-7626-0034"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve P. Gygi","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008918795","display_name":"Jos\u00e9 Antonio Enr\u0131\u0301quez","orcid":"https://orcid.org/0000-0002-3671-2961","observed_orcids":["https://orcid.org/0000-0002-3671-2961"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210149569","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","ror":"https://ror.org/04j0sev46","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Antonio Enriquez","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain; CIBERFES, Institute of Health Carlos III, Madrid 28029, Spain","CIBERFES, Institute of Health Carlos III, Madrid 28029, Spain","Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain; CIBERFES, Institute of Health Carlos III, Madrid 28029, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4210149569"]},{"raw_affiliation_string":"CIBERFES, Institute of Health Carlos III, Madrid 28029, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210149569"]},{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070153869","display_name":"Pere Puigserver","orcid":"https://orcid.org/0000-0002-0884-2718","observed_orcids":["https://orcid.org/0000-0002-0884-2718"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pere Puigserver","raw_affiliation_strings":["Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pere_puigserver@dfci.harvard.edu","Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pere_puigserver@dfci.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5070153869"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":17.8656,"has_fulltext":false,"cited_by_count":326,"citation_normalized_percentile":{"value":0.99873024,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"74","issue":"5","first_page":"877","last_page":"890.e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nutrient-stress","display_name":"nutritional stress","score":0.8930000066757202},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/respiratory-chain-supercomplexes","display_name":"respiratory chain supercomplexes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.9210000038146973},{"id":"https://openalex.org/keywords/eif2alpha","display_name":"eIF2\u03b1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8339999914169312},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.953000009059906},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/er-mitochondria-crosstalk","display_name":"ER-mitochondria crosstalk","score":0.8420000076293945},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7756565809249878},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.7401224374771118},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7361404299736023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6576535105705261},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6554954051971436},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5831509828567505},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48966673016548157},{"id":"https://openalex.org/C2777479484","wikidata":"https://www.wikidata.org/wiki/Q5323131","display_name":"EIF-2 kinase","level":5,"score":0.4451279044151306},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.42852532863616943},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4188224971294403},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.378702312707901},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24219459295272827},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.06733173131942749}],"mesh":[{"descriptor_ui":"D000068103","descriptor_name":"Serine-Arginine Splicing Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042967","descriptor_name":"Electron Transport Complex I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042967","descriptor_name":"Electron Transport Complex I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.molcel.2019.03.031","doi":"https://doi.org/10.1016/j.molcel.2019.03.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.03.031","pdf_url":"http://www.cell.com/article/S1097276519302357/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},{"id":"pmid:31023583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31023583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6555668","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6555668","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.molcel.2019.03.031","doi":"https://doi.org/10.1016/j.molcel.2019.03.031","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2019.03.031","pdf_url":"http://www.cell.com/article/S1097276519302357/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2412647930","display_name":"Energy Expenditure and Metabolic Effects through Brown/Beige Adipose Clk2 Kinase","funder_award_id":"R01DK089883","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3776643712","display_name":"Metabolic and epigenetic dependencies in melanomas during metastasis and targeted-drug resistance","funder_award_id":"R01CA181217","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5017718449","display_name":"Metabolic and Bioenergetic Control in Mitochondrial Diseases","funder_award_id":"R01GM121452","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5649279042","display_name":null,"funder_award_id":"F32 DK105679-03","funder_id":"https://openalex.org/F4320307844","funder_display_name":"European Molecular Biology Organization"},{"id":"https://openalex.org/G8513814855","display_name":"YY1-mediated transcriptional control of thermogenic-secreted factors in brown fat","funder_award_id":"F32DK105679","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320307844","display_name":"European Molecular Biology Organization","ror":"https://ror.org/04wfr2810"},{"id":"https://openalex.org/F4320308605","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59"},{"id":"https://openalex.org/F4320321673","display_name":"EMBO","ror":"https://ror.org/04wfr2810"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942228202.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1558780103","https://openalex.org/W1965285497","https://openalex.org/W1977111750","https://openalex.org/W1977603207","https://openalex.org/W1986248905","https://openalex.org/W1987695736","https://openalex.org/W2003338675","https://openalex.org/W2013091489","https://openalex.org/W2015808639","https://openalex.org/W2016752484","https://openalex.org/W2019263782","https://openalex.org/W2019455536","https://openalex.org/W2023374667","https://openalex.org/W2023699381","https://openalex.org/W2031211461","https://openalex.org/W2046307510","https://openalex.org/W2066379425","https://openalex.org/W2070923004","https://openalex.org/W2097259163","https://openalex.org/W2104696999","https://openalex.org/W2120521980","https://openalex.org/W2121077787","https://openalex.org/W2121198137","https://openalex.org/W2127049578","https://openalex.org/W2130758099","https://openalex.org/W2154507552","https://openalex.org/W2167470355","https://openalex.org/W2169368410","https://openalex.org/W2169501919","https://openalex.org/W2269880005","https://openalex.org/W2304223963","https://openalex.org/W2439976878","https://openalex.org/W2518855060","https://openalex.org/W2521735958","https://openalex.org/W2532753205","https://openalex.org/W2558143992","https://openalex.org/W2604606314","https://openalex.org/W2626395293","https://openalex.org/W2740717097","https://openalex.org/W2769589482","https://openalex.org/W2789667300","https://openalex.org/W2793262607","https://openalex.org/W2886733571"],"related_works":["https://openalex.org/W2969842628","https://openalex.org/W2942504926","https://openalex.org/W2003338675","https://openalex.org/W4224927216","https://openalex.org/W4313379958","https://openalex.org/W2793262607","https://openalex.org/W2912429826","https://openalex.org/W3176935432","https://openalex.org/W4210994296","https://openalex.org/W2803821303"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":39},{"year":2024,"cited_by_count":59},{"year":2023,"cited_by_count":57},{"year":2022,"cited_by_count":42},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":40},{"year":2019,"cited_by_count":14}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-03T00:00:00"}
