{"id":"https://openalex.org/W29421995","doi":null,"title":"von Willebrand disease: a laboratory approach.","display_name":"von Willebrand disease: a laboratory approach.","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W29421995","mag":"29421995","pmid":"https://pubmed.ncbi.nlm.nih.gov/15981443"},"language":"en","primary_location":{"id":"pmid:15981443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15981443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The National medical journal of India","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024264745","display_name":"Sucheta Trasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sucheta Trasi","raw_affiliation_strings":["Institute of Haematology (ICMR), 7th floor, Multistoreyed Building, K.E.M. Hospital, Parel, Mumbai 400008, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Haematology (ICMR), 7th floor, Multistoreyed Building, K.E.M. Hospital, Parel, Mumbai 400008, Maharashtra, India","institution_ids":["https://openalex.org/I37048141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031782697","display_name":"Kanjaksha Ghosh","orcid":"https://orcid.org/0000-0002-0645-6565","observed_orcids":["https://orcid.org/0000-0002-0645-6565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanjaksha Ghosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080193162","display_name":"Shrimati Shetty","orcid":"https://orcid.org/0000-0002-1582-9562","observed_orcids":["https://orcid.org/0000-0002-1582-9562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shrimati Shetty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107843222","display_name":"Dipika Mohanty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dipika Mohanty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00216099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"2","first_page":"78","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-willebrand-disease","display_name":"von Willebrand disease","score":1.0},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8450000286102295},{"id":"https://openalex.org/keywords/inherited-bleeding-disorders","display_name":"inherited bleeding disorders","score":0.7670000195503235},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.37599998712539673},{"id":"https://openalex.org/keywords/vwf-multimer-analysis","display_name":"VWF multimer analysis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ristocetin-cofactor-assay","display_name":"ristocetin cofactor assay","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ristocetin-induced-platelet-aggregation","display_name":"ristocetin-induced platelet aggregation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/factor-viii-c","display_name":"factor VIII:C","score":0.6539999842643738},{"id":"https://openalex.org/keywords/factor-viii-related-antigen","display_name":"factor VIII-related antigen","score":0.6489999890327454},{"id":"https://openalex.org/keywords/acquired-von-willebrand-syndrome","display_name":"acquired von Willebrand syndrome","score":0.8450000286102295},{"id":"https://openalex.org/keywords/platelet-function-analyzer","display_name":"platelet function analyzer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/thromboelastography","display_name":"thromboelastography","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C2778780528","wikidata":"https://www.wikidata.org/wiki/Q709360","display_name":"Von Willebrand disease","level":4,"score":0.8577299118041992},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.7814956307411194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6611037254333496},{"id":"https://openalex.org/C2776057759","wikidata":"https://www.wikidata.org/wiki/Q904599","display_name":"Ristocetin","level":4,"score":0.5609738230705261},{"id":"https://openalex.org/C2776217217","wikidata":"https://www.wikidata.org/wiki/Q611571","display_name":"Bleeding diathesis","level":3,"score":0.5538642406463623},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5472043752670288},{"id":"https://openalex.org/C2777664302","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thromboelastography","level":3,"score":0.5214171409606934},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.5197641253471375},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.46110469102859497},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43633002042770386},{"id":"https://openalex.org/C2779216453","wikidata":"https://www.wikidata.org/wiki/Q489957","display_name":"Bleeding time","level":4,"score":0.42804357409477234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3254026770591736},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.2126893699169159}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15981443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15981443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The National medical journal of India","raw_type":"Journal Article"},{"id":"mag:29421995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15981443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":184,"referenced_works":["https://openalex.org/W28685297","https://openalex.org/W114168622","https://openalex.org/W160258599","https://openalex.org/W172098433","https://openalex.org/W190408506","https://openalex.org/W236459808","https://openalex.org/W251715931","https://openalex.org/W1504674459","https://openalex.org/W1518079854","https://openalex.org/W1534508763","https://openalex.org/W1535522835","https://openalex.org/W1576493459","https://openalex.org/W1618588028","https://openalex.org/W1717199198","https://openalex.org/W1791724134","https://openalex.org/W1838133438","https://openalex.org/W1840869316","https://openalex.org/W1854830079","https://openalex.org/W1872237323","https://openalex.org/W1877699882","https://openalex.org/W1880636970","https://openalex.org/W1899124983","https://openalex.org/W1916695978","https://openalex.org/W1922676200","https://openalex.org/W1929000169","https://openalex.org/W1936073859","https://openalex.org/W1956605984","https://openalex.org/W1978562226","https://openalex.org/W1978734517","https://openalex.org/W1979091103","https://openalex.org/W1979770196","https://openalex.org/W1980086781","https://openalex.org/W1980914901","https://openalex.org/W1981417002","https://openalex.org/W1982015481","https://openalex.org/W1983015203","https://openalex.org/W1985895863","https://openalex.org/W1987483445","https://openalex.org/W1987504329","https://openalex.org/W1988042693","https://openalex.org/W1989174616","https://openalex.org/W1989584416","https://openalex.org/W1991852898","https://openalex.org/W1992115777","https://openalex.org/W1994087300","https://openalex.org/W1996588278","https://openalex.org/W2000478146","https://openalex.org/W2004567083","https://openalex.org/W2011553051","https://openalex.org/W2018008610","https://openalex.org/W2018318070","https://openalex.org/W2022627833","https://openalex.org/W2025071568","https://openalex.org/W2025896576","https://openalex.org/W2026616037","https://openalex.org/W2027949435","https://openalex.org/W2028211858","https://openalex.org/W2029399343","https://openalex.org/W2030470655","https://openalex.org/W2032833833","https://openalex.org/W2035782659","https://openalex.org/W2037680600","https://openalex.org/W2039765797","https://openalex.org/W2041234387","https://openalex.org/W2041972892","https://openalex.org/W2042679209","https://openalex.org/W2043517024","https://openalex.org/W2045874762","https://openalex.org/W2047774204","https://openalex.org/W2048874206","https://openalex.org/W2049604140","https://openalex.org/W2051069436","https://openalex.org/W2052266937","https://openalex.org/W2055997119","https://openalex.org/W2056845211","https://openalex.org/W2057857083","https://openalex.org/W2059197944","https://openalex.org/W2059483134","https://openalex.org/W2060372234","https://openalex.org/W2060665196","https://openalex.org/W2062002285","https://openalex.org/W2065501812","https://openalex.org/W2067349432","https://openalex.org/W2068027702","https://openalex.org/W2070373506","https://openalex.org/W2075998623","https://openalex.org/W2076648678","https://openalex.org/W2077924260","https://openalex.org/W2077947016","https://openalex.org/W2078629931","https://openalex.org/W2083669780","https://openalex.org/W2084694908","https://openalex.org/W2085517358","https://openalex.org/W2088394137","https://openalex.org/W2089812396","https://openalex.org/W2092266379","https://openalex.org/W2095395921","https://openalex.org/W2096465437","https://openalex.org/W2097195075","https://openalex.org/W2099079408","https://openalex.org/W2099880703","https://openalex.org/W2101485714","https://openalex.org/W2103380294","https://openalex.org/W2105923599","https://openalex.org/W2106319447","https://openalex.org/W2107011819","https://openalex.org/W2107879735","https://openalex.org/W2112229901","https://openalex.org/W2112889922","https://openalex.org/W2118452945","https://openalex.org/W2124586765","https://openalex.org/W2125645759","https://openalex.org/W2127994875","https://openalex.org/W2128153803","https://openalex.org/W2128940917","https://openalex.org/W2130661187","https://openalex.org/W2130775876","https://openalex.org/W2131364104","https://openalex.org/W2133770419","https://openalex.org/W2134915108","https://openalex.org/W2136124268","https://openalex.org/W2140319297","https://openalex.org/W2143112776","https://openalex.org/W2144756146","https://openalex.org/W2145237733","https://openalex.org/W2145988292","https://openalex.org/W2147944062","https://openalex.org/W2148038451","https://openalex.org/W2149483660","https://openalex.org/W2150562642","https://openalex.org/W2152420062","https://openalex.org/W2153853866","https://openalex.org/W2155624681","https://openalex.org/W2156082602","https://openalex.org/W2156128583","https://openalex.org/W2157046471","https://openalex.org/W2157680326","https://openalex.org/W2158364013","https://openalex.org/W2158862125","https://openalex.org/W2160630948","https://openalex.org/W2160634133","https://openalex.org/W2161370807","https://openalex.org/W2161607998","https://openalex.org/W2161681967","https://openalex.org/W2162213422","https://openalex.org/W2164197618","https://openalex.org/W2166019792","https://openalex.org/W2166049758","https://openalex.org/W2167308940","https://openalex.org/W2205715766","https://openalex.org/W2210270565","https://openalex.org/W2253353716","https://openalex.org/W2274562896","https://openalex.org/W2276516681","https://openalex.org/W2278696749","https://openalex.org/W2296993345","https://openalex.org/W2300195782","https://openalex.org/W2316772631","https://openalex.org/W2329065056","https://openalex.org/W2340923921","https://openalex.org/W2341828371","https://openalex.org/W2346212100","https://openalex.org/W2399725806","https://openalex.org/W2400480246","https://openalex.org/W2403875573","https://openalex.org/W2408618239","https://openalex.org/W2411316627","https://openalex.org/W2476674920","https://openalex.org/W2510865896","https://openalex.org/W2520438147","https://openalex.org/W2540776065","https://openalex.org/W2562898120","https://openalex.org/W2563965256","https://openalex.org/W2592714610","https://openalex.org/W2604253534","https://openalex.org/W2609733517","https://openalex.org/W2620451926","https://openalex.org/W2621526153","https://openalex.org/W2728458404","https://openalex.org/W2740127513","https://openalex.org/W2751121827","https://openalex.org/W2752405730","https://openalex.org/W4212841357","https://openalex.org/W4324263265"],"related_works":["https://openalex.org/W2318730393","https://openalex.org/W2012811918","https://openalex.org/W2994577528","https://openalex.org/W2262937537","https://openalex.org/W1512169776","https://openalex.org/W2211141672","https://openalex.org/W1513405397","https://openalex.org/W1971378946","https://openalex.org/W2074498944","https://openalex.org/W3214269423"],"abstract_inverted_index":{"von":[0,70],"Willebrand":[1,71],"disease":[2,94],"(VWD)":[3],"is":[4,16,29,78],"a":[5,99,107,202,227,239,258],"common":[6],"inherited":[7],"bleeding":[8,263],"disorder.":[9],"Accurate":[10],"diagnosis":[11,109,229,240],"and":[12,33,45,53,63,95,142,160,185,208],"classification":[13],"of":[14,27,85,89,92,101,126,170,174,230,241,249,262,268],"VWD":[15,251],"crucial":[17],"for":[18,238],"clinical":[19,23],"management.":[20],"A":[21,31],"detailed":[22],"history,":[24],"including":[25],"that":[26],"bleeding,":[28],"required.":[30],"family":[32],"drug":[34],"history":[35,261],"are":[36,191],"also":[37,56,67,163],"important.":[38],"Genetic":[39],"factors":[40,47],"such":[41,48,177],"as":[42,49,178,201],"blood":[43],"group,":[44],"environmental":[46],"stress,":[50],"trauma,":[51],"pregnancy":[52],"inflammation":[54],"should":[55,103,252],"be":[57,104,111,253],"considered.":[58],"The":[59,146,172],"age,":[60],"ethnic":[61],"group":[62],"hormonal":[64],"status":[65],"could":[66],"affect":[68],"the":[69,90,93,115,196,210,217,234,247,266],"factor":[72,119,155],"(VWF)":[73],"levels.":[74],"No":[75],"single":[76],"test":[77],"robust":[79],"enough":[80],"to":[81,193,225],"detect":[82],"all":[83,215,221],"variants":[84],"VWD.":[86,171,231,242],"In":[87],"view":[88],"heterogeneity":[91],"limitations":[96],"in":[97,165,255,265],"assays,":[98,134],"battery":[100],"tests":[102,224],"performed":[105],"before":[106],"final":[108,228],"can":[110,219],"reached.":[112],"These":[113],"include":[114],"screening":[116],"coagulation":[117],"tests,":[118],"VIII:C":[120],"assay,":[121,124,138],"VWF":[122,128,131,135,143,152],"antigen":[123],"assessment":[125],"functional":[127],"which":[129,190],"includes":[130],"ristocetin":[132],"cofactor":[133],"collagen":[136],"binding":[137,153],"ristocetin-induced":[139],"platelet":[140,179,198],"aggregation":[141],"multimer":[144],"analysis.":[145],"newer":[147],"ELISA":[148],"techniques":[149],"based":[150],"on":[151],"with":[154,257],"VIII":[156],"glycoprotein":[157],"(Gp)":[158],"1b":[159],"cerebrosides":[161],"have":[162,206],"helped":[164],"determining":[166],"certain":[167],"unusual":[168],"forms":[169],"advent":[173],"new":[175],"systems":[176],"function":[180,199],"analysers":[181,188],"(PFA),":[182],"thromboelastography":[183],"(TEG)":[184],"clot":[186],"signature":[187],"(CSA),":[189],"designed":[192],"assess":[194],"either":[195],"primary":[197],"or":[200,264],"global":[203],"haemostasis":[204],"screen,":[205],"facilitated":[207],"simplified":[209],"diagnosis.":[211],"However,":[212],"few":[213],"centres":[214],"over":[216],"world":[218],"perform":[220],"these":[222],"expensive":[223],"provide":[226],"We":[232],"reviewed":[233],"laboratory":[235],"investigations":[236],"required":[237],"Apart":[243],"from":[244],"congenital":[245],"VWD,":[246],"possibility":[248],"acquired":[250],"considered":[254],"those":[256],"negative":[259],"past":[260],"presence":[267],"an":[269],"underlying":[270],"disease.":[271]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
