{"id":"https://openalex.org/W2941999002","doi":"https://doi.org/10.1093/neuonc/noz036.011","title":"ATRT-12. BINIMETINIB SUPPRESSES THE GROWTH OF ATYPICAL TERATOID/RHABDOID TUMOR CELLS AND INDUCES APOPOTOSIS","display_name":"ATRT-12. BINIMETINIB SUPPRESSES THE GROWTH OF ATYPICAL TERATOID/RHABDOID TUMOR CELLS AND INDUCES APOPOTOSIS","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2941999002","doi":"https://doi.org/10.1093/neuonc/noz036.011","mag":"2941999002"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noz036.011","doi":"https://doi.org/10.1093/neuonc/noz036.011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz036.011","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii65/28443080/noz036.011.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii65/28443080/noz036.011.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008383242","display_name":"Shubin Shahab","orcid":"https://orcid.org/0000-0003-2323-5892","observed_orcids":["https://orcid.org/0000-0003-2323-5892"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubin Shahab","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054848389","display_name":"Jeffrey A. Rubens","orcid":"https://orcid.org/0000-0002-8111-6114","observed_orcids":["https://orcid.org/0000-0002-8111-6114"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Rubens","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019028542","display_name":"Charles G. Eberhart","orcid":"https://orcid.org/0000-0002-2910-9427","observed_orcids":["https://orcid.org/0000-0002-2910-9427"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Eberhart","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049721824","display_name":"Eric H. Raabe","orcid":"https://orcid.org/0000-0002-9368-7037","observed_orcids":["https://orcid.org/0000-0002-9368-7037"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Raabe","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"Supplement_2","first_page":"ii65","last_page":"ii65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-teratoid-rhabdoid-tumor","display_name":"atypical teratoid/rhabdoid tumor","score":0.968999981880188},{"id":"https://openalex.org/keywords/binimetinib","display_name":"binimetinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.871999979019165},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.7929999828338623},{"id":"https://openalex.org/keywords/selumetinib","display_name":"selumetinib","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mek162","display_name":"MEK162","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cleaved-caspase-3","display_name":"cleaved caspase-3","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cleaved-parp","display_name":"cleaved PARP","score":0.9449999928474426}],"concepts":[{"id":"https://openalex.org/C2776087337","wikidata":"https://www.wikidata.org/wiki/Q7448840","display_name":"Selumetinib","level":5,"score":0.7872103452682495},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7174254059791565},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.5667984485626221},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5437111258506775},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.535633385181427},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5200069546699524},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.47562482953071594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4590841829776764},{"id":"https://openalex.org/C2778467961","wikidata":"https://www.wikidata.org/wiki/Q631904","display_name":"Atypical teratoid rhabdoid tumor","level":3,"score":0.4491186738014221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3390420079231262},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2884759306907654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07722964882850647},{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noz036.011","doi":"https://doi.org/10.1093/neuonc/noz036.011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz036.011","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii65/28443080/noz036.011.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6477334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6477334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noz036.011","doi":"https://doi.org/10.1093/neuonc/noz036.011","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noz036.011","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_2/ii65/28443080/noz036.011.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2941999002.pdf","grobid_xml":"https://content.openalex.org/works/W2941999002.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4240089338","https://openalex.org/W3031228908","https://openalex.org/W4393089654","https://openalex.org/W4399787513","https://openalex.org/W7141736832","https://openalex.org/W2809342647","https://openalex.org/W4298233967","https://openalex.org/W2618549083","https://openalex.org/W2970350868","https://openalex.org/W4380361593"],"abstract_inverted_index":{"Atypical":[0],"teratoid/rhabdoid":[1],"(AT/RT)":[2],"tumors":[3,10,36],"are":[4],"a":[5,31,66,171],"class":[6],"of":[7,34,48,52,56,96,107,135,144,153],"malignant":[8],"CNS":[9],"disproportionately":[11],"affecting":[12],"children":[13],"with":[14,93],"limited":[15],"therapeutic":[16],"options.":[17],"Our":[18],"group":[19],"has":[20,82],"previously":[21],"demonstrated":[22],"that":[23,81],"the":[24,38,53],"MAP":[25],"kinase":[26],"pathway":[27],"is":[28,58,65],"altered":[29],"in":[30,71,163],"large":[32],"proportion":[33],"these":[35,176],"and":[37,45,114,121,129,146],"MEK":[39,68],"inhibitor":[40,69],"selumetinib":[41,57],"decreases":[42,126],"cell":[43,127,165],"growth":[44,89],"promotes":[46],"apoptosis":[47,131],"AT/RT":[49,88,164],"cells.":[50],"One":[51],"major":[54],"drawbacks":[55],"its":[59],"poor":[60],"blood-brain":[61],"barrier":[62],"penetration.":[63,85],"Binimetinib":[64,86,124],"novel":[67],"currently":[70],"pediatric":[72],"phase":[73],"II":[74],"clinical":[75],"trials":[76],"for":[77,117,139,148,174],"low":[78],"grade":[79],"glioma":[80],"improved":[83],"brain":[84],"inhibits":[87],"at":[90,141,147,150],"nanomolar":[91],"concentrations,":[92],"IC25":[94],"values":[95,106],"66.9":[97],"nM,":[98,100,102,109,111],"36.68":[99],"69.75":[101],"622.7":[103],"nM.and":[104],"IC50":[105],"101.06":[108],"107.69":[110],"691.485":[112],"nM":[113,116,143,152],"1429.9":[115],"CHLA266,":[118],"CHLA06,":[119],"BT37":[120,149],"BT12":[122],"respectively.":[123],"successfully":[125],"proliferation[ER1]":[128],"induces":[130],"(2\u20133":[132],"fold":[133],"induction":[134],"cleaved":[136,156],"PARP;":[137],"p<0.005":[138],"CHLA06":[140],"250":[142],"MEK162":[145,154],"1000":[151],"by":[155],"caspase":[157],"3":[158],"positive":[159],"cells":[160],"on":[161],"immunofluorescence)":[162],"lines,":[166],"suggesting":[167],"binimetinib":[168],"could":[169],"offer":[170],"potential":[172],"avenue":[173],"treating":[175],"deadly":[177],"tumors.":[178]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-05-03T00:00:00"}
