{"id":"https://openalex.org/W2941849009","doi":"https://doi.org/10.1371/journal.ppat.1007742","title":"DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA","display_name":"DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA","publication_year":2019,"publication_date":"2019-04-26","ids":{"openalex":"https://openalex.org/W2941849009","doi":"https://doi.org/10.1371/journal.ppat.1007742","mag":"2941849009","pmid":"https://pubmed.ncbi.nlm.nih.gov/31026293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6505960"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1007742","doi":"https://doi.org/10.1371/journal.ppat.1007742","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007742","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007742&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007742&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046413696","display_name":"Liudi Tang","orcid":"https://orcid.org/0000-0001-8303-3614","observed_orcids":["https://orcid.org/0000-0001-8303-3614"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liudi Tang","raw_affiliation_strings":["Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, PA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, PA, United States of America","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049057313","display_name":"Muhammad Abdullah Sheraz","orcid":"https://orcid.org/0000-0003-4780-6581","observed_orcids":["https://orcid.org/0000-0003-4780-6581"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Sheraz","raw_affiliation_strings":["Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, PA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, PA, United States of America","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael McGrane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael McGrane","raw_affiliation_strings":["FlowMetric Diagnostics, Doylestown, PA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FlowMetric Diagnostics, Doylestown, PA, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023737081","display_name":"Jinhong Chang","orcid":"https://orcid.org/0000-0002-6723-494X","observed_orcids":["https://orcid.org/0000-0002-6723-494X"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhong Chang","raw_affiliation_strings":["Baruch S. Blumberg Institute, Doylestown, PA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, Doylestown, PA, United States of America","institution_ids":["https://openalex.org/I4210157427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076597546","display_name":"Ju\u2010Tao Guo","orcid":"https://orcid.org/0000-0001-5335-2788","observed_orcids":["https://orcid.org/0000-0001-5335-2788"]},"institutions":[{"id":"https://openalex.org/I4210157427","display_name":"Baruch S. Blumberg Institute","ror":"https://ror.org/05evayb02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210157427"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ju-Tao Guo","raw_affiliation_strings":["Baruch S. Blumberg Institute, Doylestown, PA, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5335-2788","affiliations":[{"raw_affiliation_string":"Baruch S. Blumberg Institute, Doylestown, PA, United States of America","institution_ids":["https://openalex.org/I4210157427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076597546"],"corresponding_institution_ids":["https://openalex.org/I4210157427"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2350,"currency":"USD","value_usd":2350},"fwci":10.0869,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.98856701,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"15","issue":"4","first_page":"e1007742","last_page":"e1007742"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-alpha","display_name":"DNA polymerase alpha","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9829999804496765},{"id":"https://openalex.org/keywords/covalently-closed-circular-dna","display_name":"covalently closed circular DNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/relaxed-circular-dna","display_name":"relaxed circular DNA","score":0.8679999709129333},{"id":"https://openalex.org/keywords/persistent-hbv-infection","display_name":"persistent HBV infection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/aphidicolin","display_name":"aphidicolin","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cd437","display_name":"CD437","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C189490182","wikidata":"https://www.wikidata.org/wiki/Q1052153","display_name":"cccDNA","level":5,"score":0.9679157733917236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.701999843120575},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.6858471035957336},{"id":"https://openalex.org/C2776253266","wikidata":"https://www.wikidata.org/wiki/Q414000","display_name":"Aphidicolin","level":4,"score":0.5536431670188904},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.533108115196228},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.521162748336792},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.48660099506378174},{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.46301907300949097},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.44514885544776917},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41932839155197144},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3433713912963867},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3415224552154541},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30936652421951294},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.22541412711143494},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D004256","descriptor_name":"DNA Polymerase I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.ppat.1007742","doi":"https://doi.org/10.1371/journal.ppat.1007742","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007742","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007742&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6505960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6505960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:31026293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31026293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cd51b72780654ee6aa66c4868869bc6b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cd51b72780654ee6aa66c4868869bc6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 15, Iss 4, p e1007742 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8049533","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/DNA_Polymerase_alpha_is_essential_for_intracellular_amplification_of_hepatitis_B_virus_covalently_closed_circular_DNA/8049533","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1007742","doi":"https://doi.org/10.1371/journal.ppat.1007742","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1007742","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007742&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G36680115","display_name":"Evaluation of therapeutic benefits of HBV nucleocapsid assembly inhibitors","funder_award_id":"R01AI113267","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5238554148","display_name":null,"funder_award_id":"AI113267","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2941849009.pdf","grobid_xml":"https://content.openalex.org/works/W2941849009.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W186771457","https://openalex.org/W1676377504","https://openalex.org/W1772122236","https://openalex.org/W1797768250","https://openalex.org/W1819459887","https://openalex.org/W1844576826","https://openalex.org/W1918954877","https://openalex.org/W1962079617","https://openalex.org/W1964229627","https://openalex.org/W1971403557","https://openalex.org/W1972992218","https://openalex.org/W1974755980","https://openalex.org/W1984472078","https://openalex.org/W1988615815","https://openalex.org/W1996849931","https://openalex.org/W1997270466","https://openalex.org/W1998671948","https://openalex.org/W2006303534","https://openalex.org/W2007902841","https://openalex.org/W2010338556","https://openalex.org/W2031579836","https://openalex.org/W2036477200","https://openalex.org/W2042445786","https://openalex.org/W2043722115","https://openalex.org/W2043861742","https://openalex.org/W2047820533","https://openalex.org/W2048109276","https://openalex.org/W2050571266","https://openalex.org/W2051173965","https://openalex.org/W2056399135","https://openalex.org/W2062891613","https://openalex.org/W2067109440","https://openalex.org/W2089108066","https://openalex.org/W2090438862","https://openalex.org/W2095369054","https://openalex.org/W2096001011","https://openalex.org/W2098458274","https://openalex.org/W2099665776","https://openalex.org/W2109893427","https://openalex.org/W2117181252","https://openalex.org/W2143233396","https://openalex.org/W2143780877","https://openalex.org/W2185296599","https://openalex.org/W2255917706","https://openalex.org/W2325608780","https://openalex.org/W2406287421","https://openalex.org/W2412655055","https://openalex.org/W2541628542","https://openalex.org/W2546292426","https://openalex.org/W2549733770","https://openalex.org/W2618110836","https://openalex.org/W2670135441","https://openalex.org/W2735440128","https://openalex.org/W2742497340","https://openalex.org/W2752218796","https://openalex.org/W2759319254","https://openalex.org/W2760560147","https://openalex.org/W2778928474","https://openalex.org/W2785277519","https://openalex.org/W2808018867","https://openalex.org/W2809177606","https://openalex.org/W2883789961","https://openalex.org/W2885378257","https://openalex.org/W2888073022","https://openalex.org/W2888111730","https://openalex.org/W2888601619","https://openalex.org/W2889370079","https://openalex.org/W2902898030","https://openalex.org/W2911063796","https://openalex.org/W2921849048","https://openalex.org/W4285719527","https://openalex.org/W6756020134"],"related_works":["https://openalex.org/W4206274728","https://openalex.org/W2541628542","https://openalex.org/W1990662760","https://openalex.org/W2911063796","https://openalex.org/W2002563557","https://openalex.org/W4311582291","https://openalex.org/W2067206332","https://openalex.org/W1819459887","https://openalex.org/W2404840196","https://openalex.org/W3133715818"],"abstract_inverted_index":{"Persistent":[0],"hepatitis":[1],"B":[2],"virus":[3],"(HBV)":[4],"infection":[5],"relies":[6],"on":[7,157],"the":[8,30,42,52,59,69,153,182,198,201,214,225],"establishment":[9],"and":[10,179,245],"maintenance":[11],"of":[12,32,45,64,111,125,134,143,155,184,200,227],"covalently":[13,187],"closed":[14,188],"circular":[15,49,189],"(ccc)":[16],"DNA,":[17,51],"a":[18,25,78,96,102,144],"3.2":[19],"kb":[20],"episome":[21],"that":[22,39,84,100,161,192,213,235],"serves":[23],"as":[24,66,68,121,123],"viral":[26,239],"transcription":[27],"template,":[28],"in":[29,57,61,106,137,197,206],"nucleus":[31],"an":[33],"infected":[34,107],"hepatocyte.":[35],"Although":[36],"evidence":[37],"suggests":[38],"cccDNA":[40,93,104,135,158,169,207,228],"is":[41,90,174,195],"repair":[43,199],"product":[44],"nucleocapsid":[46],"associated":[47],"relaxed":[48],"(rc)":[50],"cellular":[53],"DNA":[54,85,204,217],"polymerases":[55,218],"involving":[56],"repairing":[58],"discontinuity":[60],"both":[62],"strands":[63],"rcDNA":[65,178],"well":[67,122],"underlying":[70],"mechanism":[71],"remain":[72],"to":[73,132,167,176,223,234],"be":[74],"fully":[75],"understood.":[76],"Taking":[77],"chemical":[79],"genetics":[80],"approach,":[81],"we":[82],"found":[83],"polymerase":[86],"alpha":[87],"(Pol":[88],"\u03b1)":[89],"essential":[91],"for":[92,181],"intracellular":[94,230],"amplification,":[95],"genome":[97],"recycling":[98],"pathway":[99,232],"maintains":[101],"stable":[103],"pool":[105],"hepatocytes.":[108],"Specifically,":[109],"inhibition":[110],"Pol":[112,126,148,165,172,193,243,246],"\u03b1":[113,127,149,166,173,194],"by":[114,129,221],"small":[115],"molecule":[116],"inhibitors":[117],"aphidicolin":[118],"or":[119],"CD437":[120,156,162],"silencing":[124],"expression":[128],"siRNA":[130],"led":[131],"suppression":[133],"amplification":[136,231],"human":[138],"hepatoma":[139],"cells.":[140],"CRISPR-Cas9":[141],"knock-in":[142],"CD437-resistant":[145],"mutation":[146],"into":[147],"genes":[150],"completely":[151],"abolished":[152],"effect":[154],"formation,":[159],"indicating":[160],"directly":[163],"targets":[164],"disrupt":[168],"biosynthesis.":[170],"Mechanistically,":[171],"recruited":[175],"HBV":[177,222],"required":[180],"generation":[183],"minus":[185,202],"strand":[186,203],"rcDNA,":[190],"suggesting":[191],"involved":[196],"nick":[205],"synthesis.":[208],"Our":[209],"study":[210],"thus":[211],"reveals":[212],"distinct":[215],"host":[216],"are":[219],"hijacked":[220],"support":[224],"biosynthesis":[226],"from":[229,236],"compared":[233],"de":[237],"novo":[238],"infection,":[240],"which":[241],"requires":[242],"\u03ba":[244],"\u03bb.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-05-03T00:00:00"}