{"id":"https://openalex.org/W2941778486","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.2011","title":"Banoxantrone (AQ4N), tissue CYP 450 targeted prodrug: The results of a phase I study using an accelerated dose escalation","display_name":"Banoxantrone (AQ4N), tissue CYP 450 targeted prodrug: The results of a phase I study using an accelerated dose escalation","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W2941778486","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.2011","mag":"2941778486"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.2011","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.2011","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057503413","display_name":"John Sarantopoulos","orcid":"https://orcid.org/0009-0002-4395-136X","observed_orcids":["https://orcid.org/0009-0002-4395-136X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Sarantopoulos","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060992997","display_name":"Anthony W. Tolcher","orcid":"https://orcid.org/0000-0002-6322-9721","observed_orcids":["https://orcid.org/0000-0002-6322-9721"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. W. Tolcher","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Wong","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029455802","display_name":"Sanjay Goel","orcid":"https://orcid.org/0000-0002-2798-7568","observed_orcids":["https://orcid.org/0000-0002-2798-7568"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Goel","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012209573","display_name":"Muralidhar Beeram","orcid":"https://orcid.org/0009-0002-6603-3780","observed_orcids":["https://orcid.org/0009-0002-6603-3780"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Beeram","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110415857","display_name":"Gilbert N. Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Lam","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084712974","display_name":"Keyur Desai","orcid":"https://orcid.org/0009-0007-5423-4039","observed_orcids":["https://orcid.org/0009-0007-5423-4039"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Desai","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Woody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Woody","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054253771","display_name":"Sridhar Mani","orcid":"https://orcid.org/0000-0003-4132-6157","observed_orcids":["https://orcid.org/0000-0003-4132-6157"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Mani","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022467575","display_name":"Kyriakos P. Papadopoulos","orcid":"https://orcid.org/0000-0002-0667-2620","observed_orcids":["https://orcid.org/0000-0002-0667-2620"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. P. Papadopoulos","raw_affiliation_strings":["Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Drug Development CTRC UTHSCSA, San Antonio, TX; Novacea, Inc, South San Francisco, CA; Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY; University of Texas Health Science Center, San Antonio, TX; MicroConstants, San Diego, CA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I165951966","https://openalex.org/I4390039242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"2011","last_page":"2011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aq4n","display_name":"AQ4N","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.7089999914169312},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7540000081062317},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.5669999718666077},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.5979999899864197},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.460999995470047},{"id":"https://openalex.org/keywords/accelerated-titration","display_name":"accelerated titration","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8600192070007324},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6763788461685181},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6158405542373657},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5948068499565125},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5511448383331299},{"id":"https://openalex.org/C2777482430","wikidata":"https://www.wikidata.org/wiki/Q7168709","display_name":"Peripheral edema","level":3,"score":0.5441360473632812},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5073475241661072},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5070197582244873},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4989607334136963},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4913126528263092},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4687856435775757},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45940130949020386}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.2011","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.2011","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2576256214","https://openalex.org/W2129518684","https://openalex.org/W2137134600","https://openalex.org/W2753466426","https://openalex.org/W2613104194","https://openalex.org/W2242760435","https://openalex.org/W1483282931","https://openalex.org/W2228652421","https://openalex.org/W2558491929","https://openalex.org/W7053977150"],"abstract_inverted_index":{"2011":[0],"Background:":[1],"AQ4N":[2,27,54,62,266,303,313,330],"was":[3,63,95,100,116,133,234,253,268,274,281],"rationally":[4],"designed":[5],"to":[6,16,136],"have":[7],"anti-tumor":[8],"activity":[9,318],"following":[10,78],"bioreduction":[11],"by":[12,102,121],"tissue":[13,193],"cytochrome":[14],"P450":[15],"AQ4,":[17],"an":[18],"active":[19],"DNA":[20],"topoisomerase":[21],"II":[22],"inhibitor.":[23],"Preclinical":[24],"studies":[25],"demonstrated":[26],"selectively":[28],"targets":[29],"lymphoid":[30],"tissues":[31],"and":[32,46,70,88,97,153,170,195,217,231,279,292,298,332,337],"hypoxic":[33],"tumor":[34],"tissues.":[35],"This":[36],"study":[37],"assessed":[38,117],"the":[39,77,98,167,179,185,263],"maximum":[40],"tolerated":[41,306],"dose":[42,79,111,173],"(MTD),":[43],"pharmacokinetic":[44],"(PK),":[45],"pharmacodynamic":[47],"(PD)":[48],"of":[49,53,72,105,143,159,190,229],"repeated":[50],"weekly":[51,311,325],"dosing":[52,326],"in":[55,76,178,296,319],"patients":[56],"(pts)":[57],"with":[58,108,240,324,335],"advanced":[59],"cancers.":[60],"Methods:":[61],"administered":[64,308],"IV":[65],"on":[66,309],"Days":[67],"1,":[68],"8,":[69],"15":[71],"a":[73,109,147,310],"28-day":[74],"cycle":[75],"cohorts":[80],"12,":[81],"24,":[82],"48,":[83],"96,":[84],"192,":[85],"384,":[86],"768,":[87],"1200":[89,140,180],"mg/m2.":[90,138,329],"Accelerated":[91],"titration":[92],"design":[93],"2B":[94],"employed":[96],"MTD":[99],"defined":[101],"\u2264":[103],"33%":[104],"6":[106,220],"pts":[107,125,145,161,221],"drug-related":[110],"limiting":[112],"toxicity":[113,165],"(DLT).":[114],"Response":[115],"every":[118],"8":[119,223],"weeks":[120],"RECIST.":[122],"Results:":[123],"16":[124],"were":[126,162,205,300],"enrolled.":[127],"A":[128,157,289],"single":[129],"pt":[130,177,237],"per":[131],"cohort":[132,182],"treated":[134,163],"up":[135],"384":[137],"At":[139,259],"mg/m2,":[141,169],"2":[142],"5":[144,150,160],"experienced":[146,222],"DLT":[148],"(Grade":[149],"respiratory":[151,196],"distress":[152],"Grade":[154],"3":[155],"fatigue).":[156],"total":[158],"without":[164],"at":[166,327],"768":[168,260,328],"established":[171],"this":[172],"as":[174],"MTD.":[175],"One":[176,236],"mg/m2":[181,261],"died":[183],"during":[184],"trial":[186],"from":[187],"acute":[188],"complications":[189],"metastatic":[191],"soft":[192],"sarcoma":[194],"distress.":[197],"The":[198,251],"most":[199],"common":[200],"adverse":[201],"events":[202],"(AE)":[203],"observed":[204],"fatigue":[206],"(63%),":[207],"anorexia":[208],"(38%),":[209,211,213],"nausea":[210],"vomiting":[212],"peripheral":[214],"edema":[215],"(25%),":[216],"diarrhea":[218],"(25%).":[219],"serious":[224],"AEs.":[225],"Anticipated":[226],"blue":[227],"coloration":[228],"skin":[230],"body":[232],"fluids":[233],"observed.":[235,301],"(48":[238],"mg/m2)":[239],"renal":[241],"cancer":[242],"has":[243],"had":[244],"stable":[245],"disease":[246],"for":[247,316],">":[248],"12":[249],"months.":[250],"PK":[252],"linear":[254],"over":[255],"all":[256],"doses":[257],"studied.":[258],"(n=4),":[262],"Day":[264],"1":[265],"Cmax":[267],"99.8":[269],"\u00b1":[270,276,283],"27.0":[271],"\u03bcg/mL,":[272],"AUC0-\u221e":[273],"259.5":[275],"67.8":[277],"\u03bcg\u00b7h/mL,":[278],"T1/2":[280],"3.9":[282],"0.7":[284],"h":[285],"(range":[286],"3.1\u20134.8":[287],"h).":[288],"predictable":[290],"dose-related":[291],"exposure":[293],"related":[294],"decrease":[295],"lymphocytes":[297],"neutrophils":[299],"Conclusions:":[302],"is":[304],"well":[305],"when":[307],"schedule.":[312],"levels":[314],"sufficient":[315],"anti-neoplastic":[317],"pre-clinical":[320],"models":[321],"are":[322,340],"achieved":[323],"monotherapy":[331],"combination":[333],"trials":[334],"chemo-":[336],"radiation":[338],"therapy":[339],"planned.":[341],"[Table:":[342],"see":[343],"text]":[344]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-05-03T00:00:00"}
