{"id":"https://openalex.org/W2941493755","doi":null,"title":"CXCR4 expressed in somatotrophs mediates GH production and cell proliferation","display_name":"CXCR4 expressed in somatotrophs mediates GH production and cell proliferation","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2941493755","mag":"2941493755"},"language":"en","primary_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/124274","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/124274","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/124274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"\uc774\uc6a9\ud638","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\uc774\uc6a9\ud638","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/somatotrophs","display_name":"somatotrophs","score":0.953000009059906},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.906000018119812},{"id":"https://openalex.org/keywords/chemokine-receptor-signaling","display_name":"chemokine receptor signaling","score":0.5950000286102295},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C94984642","wikidata":"https://www.wikidata.org/wiki/Q3015605","display_name":"Somatotropic cell","level":4,"score":0.7909200191497803},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.5880234837532043},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.5289794206619263},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4891231656074524},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48594462871551514},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.40200507640838623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3895719349384308},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27851641178131104},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.19998139142990112},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.193514883518219},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15255451202392578},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.10380962491035461},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.07064366340637207},{"id":"https://openalex.org/C175444787","wikidata":"https://www.wikidata.org/wiki/Q39072","display_name":"Microeconomics","level":1,"score":0.06757983565330505}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/124274","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/124274","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2941493755","doi":null,"is_oa":false,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/124274/1/T010465.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/124274","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/124274","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W188824656","https://openalex.org/W1857372604","https://openalex.org/W1964083898","https://openalex.org/W1967263422","https://openalex.org/W1973192097","https://openalex.org/W1973432232","https://openalex.org/W1973473416","https://openalex.org/W1974132609","https://openalex.org/W1980790180","https://openalex.org/W2001526641","https://openalex.org/W2009350817","https://openalex.org/W2010638326","https://openalex.org/W2018186473","https://openalex.org/W2042418839","https://openalex.org/W2054989216","https://openalex.org/W2060686995","https://openalex.org/W2064079390","https://openalex.org/W2071013566","https://openalex.org/W2071648206","https://openalex.org/W2075140861","https://openalex.org/W2086065874","https://openalex.org/W2091595850","https://openalex.org/W2097640935","https://openalex.org/W2098509726","https://openalex.org/W2099376832","https://openalex.org/W2102934360","https://openalex.org/W2107088471","https://openalex.org/W2111421930","https://openalex.org/W2113012529","https://openalex.org/W2113941252","https://openalex.org/W2130782339","https://openalex.org/W2131721978","https://openalex.org/W2146877635","https://openalex.org/W2162053493","https://openalex.org/W2162854474","https://openalex.org/W2569957976"],"related_works":["https://openalex.org/W7099448032","https://openalex.org/W2141954093","https://openalex.org/W2056097884","https://openalex.org/W7220714294","https://openalex.org/W6990432400","https://openalex.org/W2409134897","https://openalex.org/W2089861070","https://openalex.org/W66243824","https://openalex.org/W3099411243","https://openalex.org/W7009628137"],"abstract_inverted_index":{"[\ud55c\uae00]\\n\\n\ud654\ud559\uc8fc\uc131\uc778\uc790":[0],"stromal":[1,198],"cell-derived":[2,199],"factor-1":[3,200],"(SDF1)":[4,201],"\uacfc":[5,38,53],"\uadf8":[6,42],"\ubc30\uc704\uc790\uc5d0":[7],"\ub300\ud55c":[8],"\uc218\uc6a9\uccb4\uc778":[9],"CXCR4":[10,63,87,205,253,273,283],"\uac04\uc758":[11],"\uc0c1\ud638\uc791\uc6a9\uc740":[12],"\ub1cc\ud558\uc218\uccb4":[13,27,59,95,114,182],"\uc804\uc5fd\uc758":[14],"\uae30\ub2a5\uc744":[15],"\uc870\uc808\ud558\ub294":[16],"\ub370":[17],"\uc911\uc694\ud55c":[18,193],"\uc5ed\ud560\uc744":[19,171,194],"\ud558\ub294":[20],"\uac83\uc73c\ub85c":[21,196],"\uc0dd\uac01\ub418\uace0":[22],"\uc788\ub2e4.":[23],"\ubcf8":[24],"\uc5f0\uad6c\uc5d0\uc11c\ub294":[25],"\ubc31\uc11c\uc758":[26,58,82,89,94,113],"\uc804\uc5fd":[28],"\uc138\ud3ec\uc640":[29,76,98,117],"\uc131\uc7a5":[30,77,122,127,187],"\ud638\ub974\ubaac":[31,123,188],"\ubd84\ube44":[32,189],"\uc554":[33],"\uc138\ud3ec\uc8fc\uc778":[34],"GH3":[35,61,102,136,165,243,262,300,359,391],"\uc138\ud3ec\uc8fc\uc5d0\uc11c\uc758":[36],"SDF1":[37,227,308,314,335,356],"CXCR4\uc758":[39],"\ubc1c\ud604":[40,101],"\ubc0f":[41,126,190],"\uc5ed\ud560\uc5d0":[43],"\ub300\ud558\uc5ec":[44,110],"\uc54c\uc544\ubcf4\uace0\uc790":[45],"\ud558\uc600\ub2e4.":[46],"\uc5ed\uc804\uc0ac":[47],"\ud6a8\uc18c-\uc911\ud569":[48],"\ud6a8\uc18c":[49],"\uc5f0\uc1c4":[50],"\ubc18\uc751":[51],"\ubd84\uc11d":[52,71],"\uba74\uc5ed":[54,68],"\uc870\uc9c1\ud654\ud559":[55],"\ubd84\uc11d\uc744":[56,150],"\ud1b5\ud574":[57,146,151,162],"\uc804\uc5fd\uacfc":[60],"\uc138\ud3ec\uc8fc\uc5d0\uc11c":[62],"\uc218\uc6a9\uccb4\uac00":[64,88],"\ubc1c\ud604\ub428\uc744":[65,92],"\ud655\uc778\ud558\uc600\ub2e4.":[66],"\uc774\uc911":[67],"\ud615\uad11":[69],"\uc5fc\uc0c9":[70],"\uacb0\uacfc\uc5d0":[72],"\ub530\ub974\uba74":[73],"CXCR4\ub97c":[74],"\ubc1c\ud604\ud558\ub294":[75],"\ud638\ub974\ubaac\uc744":[78],"\ubd84\ube44\ud558\ub294":[79],"\uc138\ud3ec\uc758":[80],"\ubd84\ud3ec\ub294":[81],"\ub1cc\ud558\uc218\uccb4\uc5d0\uc11c":[83],"\uc77c\uce58\ud558\uace0":[84],"\uc788\uc73c\uba70,":[85],"\uc774\ub294":[86,159],"\uc131\uc7a5\uc790\uadf9\uc138\ud3ec\uc5d0\uc11c":[90],"\ud55c\uc815\uc801\uc73c\ub85c":[91],"\uc2dc\uc0ac\ud55c\ub2e4.":[93],"\uc77c\ucc28":[96,115],"\ubc30\uc591":[97,116],"\uc131\uc7a5\ud638\ub974\ubaac\ubd84\ube44\ud638\ub974\ubaac":[99],"\uc218\uc6a9\uccb4":[100],"\uc138\ud3ec":[103,133,166,183,191],"(GH3-hGHRHR)\ub97c":[104],"\uc774\uc6a9\ud558\uc5ec":[105],"SDF1\uacfc":[106],"\uc131\uc7a5\ud638\ub974\ubaac\ubd84\ube44\ud638\ub974\ubaac,":[107],"\uc18c\ub9c8\ud1a0\uc2a4\ud0c0\ud2f4\uc758":[108],"\uae30\ub2a5\uc5d0":[109],"\uc870\uc0ac\ud558\uc600\ub2e4.":[111],"SDF1\uc740":[112],"GH3-hGHRHR":[118,327],"\uc138\ud3ec\uc5d0\uc11c":[119],"\uc131\uc7a5\ud638\ub974\ubaac\ubd84\ube44\ud638\ub974\ubaac\uacfc":[120],"\ub9c8\ucc2c\uac00\uc9c0\ub85c":[121],"\uc720\uc804\uc790\uc758":[124],"\uc804\uc0ac":[125],"\ud638\ub974\ubaac\uc758":[128],"\ubd84\ube44\ub97c":[129],"\ucd09\uc9c4\uc2dc\ucf30\ub2e4.":[130],"SDF1\uc5d0":[131,152],"\uc758\ud55c":[132],"\uc99d\uc2dd":[134],"\uc720\ub3c4\ub294":[135],"\uc138\ud3ec\uc8fc\uc5d0":[137],"SDF1\ub97c":[138],"\ucca8\uac00\ud558\uc600\uc744":[139],"\ub54c":[140],"BrdU":[141,349],"incorporation":[142,350],"\uc774":[143],"\uc99d\uac00\ud558\ub294":[144],"\uacb0\uacfc\ub97c":[145],"\uc785\uc99d\ud558\uc600\ub2e4.":[147],"Western":[148,374],"blot":[149,375],"\uc758\uc874\uc801\uc73c\ub85c":[153],"ERK1/2\uc774":[154],"\uc778\uc0b0\ud654\ub428\uc744":[155],"\uc54c":[156],"\uc218":[157],"\uc788\uc5c8\uc73c\uba70,":[158],"\uc5ec\ub7ec":[160],"\uc5f0\uad6c\ub97c":[161],"\uc99d\uba85\ub41c":[163],"MAPK\uac00":[164],"\uc99d\uc2dd\uc5d0":[167,192],"\uc788\uc5b4":[168],"\uc138\ud3ec\ub0b4":[169],"\ub9e4\uac1c\uc790\uc758":[170],"\ud55c\ub2e4\ub294":[172],"\uc0ac\uc2e4\uc744":[173],"\uc7ac\ud655\uc778\ud558\uc600\ub2e4.":[174],"\ub530\ub77c\uc11c":[175],"\uc774\ub7ec\ud55c":[176],"\uacb0\uacfc\ub4e4\uc744":[177],"\ubc14\ud0d5\uc73c\ub85c":[178],"SDF1/CXCR4":[179,387,400],"\uc0c1\ud638\uc791\uc6a9\uc774":[180],"\uc815\uc0c1":[181],"\ub610\ub294":[184],"\uc131\uc7a5\uc790\uadf9\uc138\ud3ec":[185],"\uc554\uc885\uc5d0\uc11c":[186],"\ud560":[195],"\uc0dd\uac01\ub41c\ub2e4.\\n\\n\\n\\n\\n\\n[\uc601\ubb38]\\n\\nChemokine":[197],"and":[202,228,230,238,249,261,296,312,326,409,411,416],"its":[203],"receptor":[204],"interaction":[206,388,401],"may":[207],"play":[208],"an":[209,383,403],"important":[210,404],"role":[211,232,405],"in":[212,233,256,278,287,319,329,345,353,358,389,406],"the":[213,224,234,269,279,305,330,378,390,412],"regulation":[214],"of":[215,226,272,307,368,386,414],"anterior":[216,259,323],"pituitary":[217,237,260,293,324,343],"function.":[218],"In":[219,394],"this":[220],"study":[221],"we":[222,303],"investigated":[223],"expression":[225],"CXCR4,":[229],"their":[231],"normal":[235,257,415],"rat":[236,258,280,288,291,322,342],"growth":[239,275],"hormone":[240,276],"(GH)":[241,277],"producing":[242],"tumor":[244,263],"cell":[245,294,360,364,392],"line.":[246],"RT-PCR":[247],"analysis":[248],"immunohistochemistry":[250],"revealed":[251],"that":[252,380,399],"was":[254,351,370],"expressed":[255,286],"cells.":[264,419],"Double":[265],"immunofluorescent":[266],"staining":[267],"showed":[268],"complete":[270],"colocalization":[271],"with":[274,310,333],"pituitary,":[281],"indicating":[282,362],"is":[284,382],"exclusively":[285],"somatotrophs.":[289],"Using":[290],"primary":[292,321,341],"cultures,":[295],"GHRH-receptor":[297],"expressing":[298],"stable":[299],"(GH3-GHRHR)":[301],"cells,":[302,325],"evaluated":[304],"function":[306],"comparing":[309],"GHRH":[311],"somatostatin.":[313],"stimulated":[315],"GH":[316,338,407],"gene":[317],"activation":[318],"both":[320],"cells":[328,344],"same":[331],"manner":[332],"GHRH.":[334],"also":[336,371],"stimulate":[337],"secretion":[339],"from":[340],"dose":[346],"dependant":[347],"manner.":[348],"increased":[352],"response":[354],"to":[355],"addition":[357],"culture,":[361],"SDF1-induced":[363],"proliferation.":[365,393],"SDF1-dependent":[366],"phosphorylation":[367],"ERK1/2":[369],"confirmed":[372],"by":[373],"analysis,":[376],"supporting":[377],"evidence":[379],"MAPK":[381],"intracellular":[384],"mediator":[385],"conclusion,":[395],"these":[396],"results":[397],"indicate":[398],"plays":[402],"production":[408],"secretion,":[410],"proliferation":[413],"tumorous":[417],"somatotrophs":[418]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-05-03T00:00:00"}