{"id":"https://openalex.org/W2940888331","doi":"https://doi.org/10.1038/s41467-019-09654-4","title":"Ceramides bind VDAC2 to trigger mitochondrial apoptosis","display_name":"Ceramides bind VDAC2 to trigger mitochondrial apoptosis","publication_year":2019,"publication_date":"2019-04-23","ids":{"openalex":"https://openalex.org/W2940888331","doi":"https://doi.org/10.1038/s41467-019-09654-4","mag":"2940888331","pmid":"https://pubmed.ncbi.nlm.nih.gov/31015432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6478893"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-019-09654-4","doi":"https://doi.org/10.1038/s41467-019-09654-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-09654-4","pdf_url":"https://www.nature.com/articles/s41467-019-09654-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-019-09654-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016717537","display_name":"Shashank Dadsena","orcid":"https://orcid.org/0000-0002-0227-5900","observed_orcids":["https://orcid.org/0000-0002-0227-5900"]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shashank Dadsena","raw_affiliation_strings":["Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033552024","display_name":"Svenja Bockelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Svenja Bockelmann","raw_affiliation_strings":["Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084341381","display_name":"John G. Mina","orcid":"https://orcid.org/0000-0003-0429-1370","observed_orcids":["https://orcid.org/0000-0003-0429-1370"]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]},{"id":"https://openalex.org/I874055015","display_name":"Teesside University","ror":"https://ror.org/03z28gk75","country_code":"GB","type":"education","lineage":["https://openalex.org/I874055015"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"John G. M. Mina","raw_affiliation_strings":["Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany. j.mina@tees.ac.uk","School of Science, Engineering and Design, Teesside University, Middlesbrough, TS1 3BX, UK. j.mina@tees.ac.uk","Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0429-1370","affiliations":[{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany. j.mina@tees.ac.uk","institution_ids":["https://openalex.org/I170658231"]},{"raw_affiliation_string":"School of Science, Engineering and Design, Teesside University, Middlesbrough, TS1 3BX, UK. j.mina@tees.ac.uk","institution_ids":["https://openalex.org/I874055015"]},{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070546075","display_name":"Dina Hassan","orcid":"https://orcid.org/0000-0002-2754-015X","observed_orcids":["https://orcid.org/0000-0002-2754-015X"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE","EG"],"is_corresponding":false,"raw_author_name":"Dina G. Hassan","raw_affiliation_strings":["Institute of Environmental Studies and Research, Ain Shams University, Cairo, Egypt","Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Environmental Studies and Research, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058167233","display_name":"Sergei M. Korneev","orcid":"https://orcid.org/0000-0002-1273-5819","observed_orcids":["https://orcid.org/0000-0002-1273-5819"]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sergei Korneev","raw_affiliation_strings":["Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089654211","display_name":"Guilherme Razzera","orcid":"https://orcid.org/0000-0002-1448-3037","observed_orcids":["https://orcid.org/0000-0002-1448-3037"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]},{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["BR","PT"],"is_corresponding":false,"raw_author_name":"Guilherme Razzera","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Florian\u00f3polis, Brazil","Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Centro de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Santa Catarina, Florian\u00f3polis, Brazil","institution_ids":["https://openalex.org/I4104125"]},{"raw_affiliation_string":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157, Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001215236","display_name":"Helene Jahn","orcid":"https://orcid.org/0000-0002-1393-3323","observed_orcids":["https://orcid.org/0000-0002-1393-3323"]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helene Jahn","raw_affiliation_strings":["Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017569839","display_name":"Patrick Niekamp","orcid":"https://orcid.org/0000-0001-5485-6232","observed_orcids":["https://orcid.org/0000-0001-5485-6232"]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Niekamp","raw_affiliation_strings":["Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dagmar M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar M\u00fcller","raw_affiliation_strings":["Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048351044","display_name":"Markus Schneider","orcid":"https://orcid.org/0000-0002-8169-6577","observed_orcids":["https://orcid.org/0000-0002-8169-6577"]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Schneider","raw_affiliation_strings":["Center for Cellular Nanoanalytics, Osnabr\u00fcck University, Artilleriestra\u00dfe 77, 49076, Osnabr\u00fcck, Germany","Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","Plant Physiology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Nanoanalytics, Osnabr\u00fcck University, Artilleriestra\u00dfe 77, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]},{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]},{"raw_affiliation_string":"Plant Physiology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023003905","display_name":"Fikadu Tafesse","orcid":"https://orcid.org/0000-0002-8575-4164","observed_orcids":["https://orcid.org/0000-0002-8575-4164"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fikadu G. Tafesse","raw_affiliation_strings":["Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062095380","display_name":"\u202aSiewert J. Marrink","orcid":"https://orcid.org/0000-0001-8423-5277","observed_orcids":["https://orcid.org/0000-0001-8423-5277"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4405280116","display_name":"Zernike Institute for Advanced Materials","ror":"https://ror.org/02fc7pq83","country_code":"NL","type":"facility","lineage":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Siewert J. Marrink","raw_affiliation_strings":["Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028135857","display_name":"Manuel N. Melo","orcid":"https://orcid.org/0000-0001-6567-0513","observed_orcids":["https://orcid.org/0000-0001-6567-0513"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4405278324","display_name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier","ror":"https://ror.org/05qd25g49","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"id":"https://openalex.org/I4405280116","display_name":"Zernike Institute for Advanced Materials","ror":"https://ror.org/02fc7pq83","country_code":"NL","type":"facility","lineage":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["NL","PT"],"is_corresponding":true,"raw_author_name":"Manuel N. Melo","raw_affiliation_strings":["Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands. m.n.melo@itqb.unl.pt","Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157, Oeiras, Portugal. m.n.melo@itqb.unl.pt","Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157, Oeiras, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-6567-0513","affiliations":[{"raw_affiliation_string":"Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands. m.n.melo@itqb.unl.pt","institution_ids":["https://openalex.org/I169381384","https://openalex.org/I4405280116"]},{"raw_affiliation_string":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157, Oeiras, Portugal. m.n.melo@itqb.unl.pt","institution_ids":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]},{"raw_affiliation_string":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157, Oeiras, Portugal","institution_ids":["https://openalex.org/I4405278324","https://openalex.org/I83558840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004434143","display_name":"Joost C. M. Holthuis","orcid":"https://orcid.org/0000-0001-8912-1586","observed_orcids":["https://orcid.org/0000-0001-8912-1586"]},"institutions":[{"id":"https://openalex.org/I170658231","display_name":"Osnabr\u00fcck University","ror":"https://ror.org/04qmmjx98","country_code":"DE","type":"education","lineage":["https://openalex.org/I170658231"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["DE","NL"],"is_corresponding":true,"raw_author_name":"Joost C. M. Holthuis","raw_affiliation_strings":["Center for Cellular Nanoanalytics, Osnabr\u00fcck University, Artilleriestra\u00dfe 77, 49076, Osnabr\u00fcck, Germany. holthuis@uos.de","Membrane Biochemistry and Biophysics, Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH, Utrecht, The Netherlands. holthuis@uos.de","Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany. holthuis@uos.de","Center for Cellular Nanoanalytics, Osnabr\u00fcck University, Artilleriestra\u00dfe 77, 49076, Osnabr\u00fcck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cellular Nanoanalytics, Osnabr\u00fcck University, Artilleriestra\u00dfe 77, 49076, Osnabr\u00fcck, Germany. holthuis@uos.de","institution_ids":["https://openalex.org/I170658231"]},{"raw_affiliation_string":"Membrane Biochemistry and Biophysics, Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH, Utrecht, The Netherlands. holthuis@uos.de","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabr\u00fcck, 49076, Osnabr\u00fcck, Germany. holthuis@uos.de","institution_ids":["https://openalex.org/I170658231"]},{"raw_affiliation_string":"Center for Cellular Nanoanalytics, Osnabr\u00fcck University, Artilleriestra\u00dfe 77, 49076, Osnabr\u00fcck, Germany","institution_ids":["https://openalex.org/I170658231"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5004434143","https://openalex.org/A5028135857","https://openalex.org/A5084341381"],"corresponding_institution_ids":["https://openalex.org/I169381384","https://openalex.org/I170658231","https://openalex.org/I193662353","https://openalex.org/I4405278324","https://openalex.org/I4405280116","https://openalex.org/I83558840","https://openalex.org/I874055015"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":7.6912,"has_fulltext":true,"cited_by_count":247,"citation_normalized_percentile":{"value":0.98599996,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"1832","last_page":"1832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.06419999897480011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.8399999737739563},{"id":"https://openalex.org/keywords/vdac2","display_name":"VDAC2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vdac1","display_name":"VDAC1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/voltage-dependent-anion-channel","display_name":"voltage-dependent anion channel","score":0.8820000290870667},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/glutamate-residues","display_name":"glutamate residues","score":0.7630000114440918},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.699999988079071},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/mitochondrial-membrane","display_name":"mitochondrial membrane","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2779058106","wikidata":"https://www.wikidata.org/wiki/Q18032319","display_name":"VDAC1","level":5,"score":0.8725043535232544},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.8697624206542969},{"id":"https://openalex.org/C200784783","wikidata":"https://www.wikidata.org/wiki/Q7940725","display_name":"Voltage-dependent anion channel","level":5,"score":0.7579721808433533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6331119537353516},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5446687340736389},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.49155935645103455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4659826159477234},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4310286343097687},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42980024218559265},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.4238739311695099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3922252058982849},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36569690704345703},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.2800438106060028},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050995","descriptor_name":"Voltage-Dependent Anion Channel 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050995","descriptor_name":"Voltage-Dependent Anion Channel 1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D050995","descriptor_name":"Voltage-Dependent Anion Channel 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050995","descriptor_name":"Voltage-Dependent Anion Channel 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050996","descriptor_name":"Voltage-Dependent Anion Channel 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050996","descriptor_name":"Voltage-Dependent Anion Channel 2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D050996","descriptor_name":"Voltage-Dependent Anion Channel 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050996","descriptor_name":"Voltage-Dependent Anion Channel 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1038/s41467-019-09654-4","doi":"https://doi.org/10.1038/s41467-019-09654-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-09654-4","pdf_url":"https://www.nature.com/articles/s41467-019-09654-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5463910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6478893","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31015432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31015432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6478893","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6478893/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/57c0a6da-9993-4509-9cdc-c5cba8fe729e","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/57c0a6da-9993-4509-9cdc-c5cba8fe729e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dadsena, S, Bockelmann, S, Mina, J G M, Hassan, D G, Korneev, S, Razzera, G, Jahn, H, Niekamp, P, M\u00fcller, D, Schneider, M, Tafesse, F G, Marrink, S J, Melo, M N & Holthuis, J C M 2019, 'Ceramides bind VDAC2 to trigger mitochondrial apoptosis', Nature Communications, vol. 10, no. 1, 1832. https://doi.org/10.1038/s41467-019-09654-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:https://research.tees.ac.uk/ws/oai:openaire/fb3f4106-d803-4a6f-bef6-1e4ed211e25f","doi":null,"is_oa":true,"landing_page_url":"https://research.tees.ac.uk/en/publications/fb3f4106-d803-4a6f-bef6-1e4ed211e25f","pdf_url":"https://research.tees.ac.uk/ws/files/7155704/Ceramides_bind_VDAC2_to_trigger_mitochondrial_apoptosis.pdf","source":{"id":"https://openalex.org/S4306401198","display_name":"TeesRep (Teesside University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I874055015","host_organization_name":"Teesside University","host_organization_lineage":["https://openalex.org/I874055015"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dadsena, S, Bockelmann, S, Mina, J G M, Hassan, D G, Korneev, S, Razzera, G, Jahn, H, Niekamp, P, M\u00fcller, D, Schneider, M, Tafesse, F G, Marrink, S J, Melo, M N & Holthuis, J C M 2019, 'Ceramides bind VDAC2 to trigger mitochondrial apoptosis', Nature Communications, vol. 10, no. 1, 1832. https://doi.org/10.1038/s41467-019-09654-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:run.unl.pt:10362/92533","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/92533","pdf_url":"https://run.unl.pt/bitstreams/531842fd-cb9d-47b5-9183-87051c4a7c8a/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09654-4","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-019-09654-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0edaff2593084873947ef72e233d160e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0edaff2593084873947ef72e233d160e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:161032635f8246f6afb463a1fd58d74b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/161032635f8246f6afb463a1fd58d74b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)","raw_type":"article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/57c0a6da-9993-4509-9cdc-c5cba8fe729e","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/57c0a6da-9993-4509-9cdc-c5cba8fe729e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 10(1):1832. Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41467-019-09654-4","doi":"https://doi.org/10.1038/s41467-019-09654-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-019-09654-4","pdf_url":"https://www.nature.com/articles/s41467-019-09654-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G105728699","display_name":null,"funder_award_id":"LISBOA-01-0145-FEDER007660","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1516346500","display_name":null,"funder_award_id":"01-0145","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3749336523","display_name":null,"funder_award_id":"HO3539/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3870412118","display_name":"Sphingolipid homeostasis: from basic biology to applications","funder_award_id":"289278","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3891694003","display_name":null,"funder_award_id":"COMPETE_2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G449056522","display_name":null,"funder_award_id":"SFB\u2005944","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5468631136","display_name":null,"funder_award_id":"SFB944-P14","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5584939211","display_name":"Defining the role of host lipid repertoire in Mycobacterium tuberculosis infection","funder_award_id":"R21AI124225","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5647034220","display_name":null,"funder_award_id":"Project LISBOA-01-0145-FEDER-007660","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G9000857940","display_name":"Determining the role of sphingolipids in Mycobacterium tuberculosis infection","funder_award_id":"R01AI141549","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G946021960","display_name":null,"funder_award_id":"LISBOA-01-0145-FEDER","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321992","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","ror":"https://ror.org/050zdnc69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2940888331.pdf","grobid_xml":"https://content.openalex.org/works/W2940888331.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1072390356","https://openalex.org/W1581414531","https://openalex.org/W1820519065","https://openalex.org/W1917834902","https://openalex.org/W1964564102","https://openalex.org/W1966078827","https://openalex.org/W1974563432","https://openalex.org/W1976150259","https://openalex.org/W1980804643","https://openalex.org/W1984785146","https://openalex.org/W1986477156","https://openalex.org/W2000696450","https://openalex.org/W2024991781","https://openalex.org/W2027151723","https://openalex.org/W2029667189","https://openalex.org/W2029682546","https://openalex.org/W2044119772","https://openalex.org/W2048689532","https://openalex.org/W2049807952","https://openalex.org/W2054645758","https://openalex.org/W2063362926","https://openalex.org/W2068444709","https://openalex.org/W2069412624","https://openalex.org/W2071695311","https://openalex.org/W2071733232","https://openalex.org/W2073115843","https://openalex.org/W2073647995","https://openalex.org/W2088883749","https://openalex.org/W2091540921","https://openalex.org/W2093805100","https://openalex.org/W2093999644","https://openalex.org/W2104511328","https://openalex.org/W2107578201","https://openalex.org/W2112237647","https://openalex.org/W2119267663","https://openalex.org/W2128171794","https://openalex.org/W2134810505","https://openalex.org/W2137777926","https://openalex.org/W2140140535","https://openalex.org/W2142532813","https://openalex.org/W2146292423","https://openalex.org/W2156943914","https://openalex.org/W2157965986","https://openalex.org/W2162033191","https://openalex.org/W2163630562","https://openalex.org/W2165792071","https://openalex.org/W2170711116","https://openalex.org/W2192335738","https://openalex.org/W2242849497","https://openalex.org/W2258932259","https://openalex.org/W2259902722","https://openalex.org/W2314292783","https://openalex.org/W2327174080","https://openalex.org/W2510475640","https://openalex.org/W2519919846","https://openalex.org/W2556455626","https://openalex.org/W2580964123","https://openalex.org/W2607236711","https://openalex.org/W2613860781","https://openalex.org/W2768617092","https://openalex.org/W2769383666","https://openalex.org/W2776683791","https://openalex.org/W2783587949","https://openalex.org/W2800545681","https://openalex.org/W2901323432","https://openalex.org/W2910786346","https://openalex.org/W3155828254"],"related_works":["https://openalex.org/W7159866879","https://openalex.org/W7172515054","https://openalex.org/W7036295954","https://openalex.org/W2000561621","https://openalex.org/W7096681214","https://openalex.org/W2086350569","https://openalex.org/W4414350454","https://openalex.org/W2009060943","https://openalex.org/W2335464458","https://openalex.org/W3082415549"],"abstract_inverted_index":{"Ceramides":[0],"draw":[1],"wide":[2],"attention":[3],"as":[4,43,130],"tumor":[5],"suppressor":[6],"lipids":[7],"that":[8,53,74],"act":[9],"directly":[10],"on":[11,61],"mitochondria":[12],"to":[13,119],"trigger":[14],"apoptotic":[15],"cell":[16,135],"death.":[17],"However,":[18],"molecular":[19,49,139],"details":[20],"of":[21,64,87,92,103,128,133],"the":[22,36,65,79,96],"underlying":[23],"mechanism":[24],"are":[25],"largely":[26,117],"unknown.":[27],"Using":[28],"a":[29,57,71,126,138],"photoactivatable":[30],"ceramide":[31,45,58,80,97],"probe,":[32],"we":[33],"here":[34],"identify":[35],"voltage-dependent":[37],"anion":[38],"channels":[39,55,94],"VDAC1":[40,100],"and":[41],"VDAC2":[42,104,129],"mitochondrial":[44],"binding":[46,59],"proteins.":[47],"Coarse-grain":[48],"dynamics":[50],"simulations":[51],"reveal":[52],"both":[54,93],"harbor":[56],"site":[60,69],"one":[62],"side":[63],"barrel":[66],"wall.":[67],"This":[68],"includes":[70],"membrane-buried":[72],"glutamate":[73,109],"mediates":[75],"direct":[76,131],"contact":[77],"with":[78,95,110],"head":[81],"group.":[82],"Substitution":[83],"or":[84,105],"chemical":[85],"modification":[86],"this":[88],"residue":[89],"abolishes":[90],"photolabeling":[91],"probe.":[98],"Unlike":[99],"removal,":[101],"loss":[102],"replacing":[106],"its":[107],"membrane-facing":[108],"glutamine":[111],"renders":[112],"human":[113],"colon":[114],"cancer":[115],"cells":[116],"resistant":[118],"ceramide-induced":[120],"apoptosis.":[121],"Collectively,":[122],"our":[123],"data":[124],"support":[125],"role":[127],"effector":[132],"ceramide-mediated":[134],"death,":[136],"providing":[137],"framework":[140],"for":[141],"how":[142],"ceramides":[143],"exert":[144],"their":[145],"anti-neoplastic":[146],"activity.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":40},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":9}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2019-05-03T00:00:00"}