{"id":"https://openalex.org/W2940705170","doi":"https://doi.org/10.1099/acmi.ac2019.po0017","title":"Mathematical modelling to characterise the in vivo dynamics of Salmonella in the na\u00efve and immunised host","display_name":"Mathematical modelling to characterise the in vivo dynamics of Salmonella in the na\u00efve and immunised host","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2940705170","doi":"https://doi.org/10.1099/acmi.ac2019.po0017","mag":"2940705170"},"language":"en","primary_location":{"id":"doi:10.1099/acmi.ac2019.po0017","doi":"https://doi.org/10.1099/acmi.ac2019.po0017","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.ac2019.po0017","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1099/acmi.ac2019.po0017","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005929532","display_name":"Myrto Vlazaki","orcid":"https://orcid.org/0000-0001-9659-9254","observed_orcids":["https://orcid.org/0000-0001-9659-9254"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Myrto Vlazaki","raw_affiliation_strings":["University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079287007","display_name":"Olivier Restif","orcid":"https://orcid.org/0000-0001-9158-853X","observed_orcids":["https://orcid.org/0000-0001-9158-853X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olivier Restif","raw_affiliation_strings":["University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":700,"currency":"GBP","value_usd":858},"apc_paid":{"value":700,"currency":"GBP","value_usd":858},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1A","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.23469999432563782,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella","display_name":"Salmonella","score":0.9729999899864197},{"id":"https://openalex.org/keywords/within-host-dynamics","display_name":"within-host dynamics","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/salmonella-vaccines","display_name":"Salmonella vaccines","score":0.3499999940395355},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.949999988079071},{"id":"https://openalex.org/keywords/killed-whole-cell-vaccine","display_name":"killed whole-cell vaccine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bacterial-migration","display_name":"bacterial migration","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bacterial-replication","display_name":"bacterial replication","score":0.7680000066757202},{"id":"https://openalex.org/keywords/bacterial-killing","display_name":"bacterial killing","score":0.718999981880188},{"id":"https://openalex.org/keywords/compartmental-model","display_name":"compartmental model","score":0.718999981880188},{"id":"https://openalex.org/keywords/typhoid-fever","display_name":"typhoid fever","score":0.7080000042915344},{"id":"https://openalex.org/keywords/paratyphoid-fever","display_name":"paratyphoid fever","score":0.9100000262260437},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.6320000290870667},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9750000238418579},{"id":"https://openalex.org/keywords/blood","display_name":"blood","score":0.7310000061988831},{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.5109999775886536},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.7766458988189697},{"id":"https://openalex.org/C520601542","wikidata":"https://www.wikidata.org/wiki/Q83319","display_name":"Typhoid fever","level":2,"score":0.7322546243667603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5883457660675049},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.510564923286438},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4590325653553009},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4086507558822632},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39241823554039},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.37252771854400635},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24511149525642395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20450878143310547},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08575963973999023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0825861394405365},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07375538349151611}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1099/acmi.ac2019.po0017","doi":"https://doi.org/10.1099/acmi.ac2019.po0017","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.ac2019.po0017","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1099/acmi.ac2019.po0017","doi":"https://doi.org/10.1099/acmi.ac2019.po0017","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.ac2019.po0017","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3165774909","https://openalex.org/W2013882084","https://openalex.org/W2015077069","https://openalex.org/W7100182142","https://openalex.org/W2150732753","https://openalex.org/W2080033753","https://openalex.org/W3044942949","https://openalex.org/W1964002643","https://openalex.org/W2972635973","https://openalex.org/W2029765376"],"abstract_inverted_index":{"Systemic":[0],"salmonellosis":[1],"encompasses":[2],"typhoid":[3],"and":[4,7,14,18,49,65,70,109,125,140,148,191,208],"paratyphoid":[5],"fever,":[6],"invasive":[8],"non-typhoidal":[9],"salmonellosis,":[10],"with":[11,34,94,172],"high":[12],"mortality":[13],"morbidity":[15],"amongst":[16],"children":[17],"the":[19,29,42,47,54,75,82,86,100,103,132,137,143,149,154,158,163,201,205,215],"immunocompromised":[20],"in":[21,46,67,77,81,142,153,157,183],"low-resource":[22],"settings.":[23],"Immunisation":[24],"efforts":[25],"remain":[26],"hampered":[27],"by":[28,56],"unavailability":[30],"of":[31,41,85,105,146,204,212,218],"safe":[32],"vaccines":[33],"cross-protectivity":[35],"against":[36],"causative":[37],"Salmonella":[38,44,151,188],"strains.":[39],"Characterisation":[40],"within-host":[43],"dynamics":[45,152],"na\u00efve":[48,159],"immunised":[50,171],"host":[51,87],"can":[52,91],"elucidate":[53],"mechanisms":[55],"which":[57],"different":[58,83,89],"vaccine":[59,68,179],"types":[60],"exert":[61],"their":[62,182],"protective":[63],"effect,":[64],"help":[66],"selection":[69],"design.":[71],"Experimental":[72],"data":[73,168],"tracking":[74],"changes":[76],"bacterial":[78,106,133,219],"population":[79],"composition":[80],"tissues":[84],"at":[88],"timepoints":[90],"be":[92],"coupled":[93],"mechanistic":[95,123],"mathematical":[96,206],"models":[97],"to":[98,129,166,180,199],"estimate":[99],"parameters":[101,213],"governing":[102,214],"processes":[104,135,217],"replication,":[107],"killing":[108],"inter-organ":[110],"migration.":[111],"Using":[112],"a":[113,121,174],"recently":[114],"described":[115],"minimisation-divergence":[116],"estimation":[117],"approach,":[118],"we":[119,194],"extend":[120],"three-compartmental":[122],"model":[124,165,207],"re-analyse":[126],"existing":[127],"datasets":[128],"better":[130,210],"characterise":[131],"migratory":[134],"between":[136],"blood,":[138],"liver":[139],"spleen":[141],"early":[144],"stages":[145],"infection,":[147],"overall":[150],"later":[155],"phases":[156],"host.":[160],"We":[161],"apply":[162],"same":[164],"published":[167],"from":[169],"mice":[170],"either":[173],"live-attenuated":[175],"or":[176],"killed":[177],"whole-cell":[178],"identify":[181,195],"vivo":[184],"differential":[185],"impacts":[186],"on":[187],"migration,":[189],"replication":[190],"death.":[192],"Finally,":[193],"alternative":[196],"experimental":[197],"designs":[198],"improve":[200],"statistical":[202],"qualities":[203],"allow":[209],"inference":[211],"unobserved":[216],"dynamics.":[220]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2019-05-03T00:00:00"}