{"id":"https://openalex.org/W2940635116","doi":null,"title":"The development of cancer model system on metabolism and tumor suppressor effect analysis using systems biology approach","display_name":"The development of cancer model system on metabolism and tumor suppressor effect analysis using systems biology approach","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2940635116","mag":"2940635116"},"language":"en","primary_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/136102","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/136102","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/136102","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/136102","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"\uae40\uc601\uc120","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\uae40\uc601\uc120","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.7099999785423279},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6970000267028809},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.5649999976158142},{"id":"https://openalex.org/keywords/androgen-metabolism","display_name":"androgen metabolism","score":0.5669999718666077},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.9739999771118164},{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":0.7020000219345093},{"id":"https://openalex.org/keywords/thyroid-cancer-risk-factors","display_name":"thyroid cancer risk factors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/2-hydroxyestradiol","display_name":"2-hydroxyestradiol","score":0.8349999785423279},{"id":"https://openalex.org/keywords/2-methoxyestradiol","display_name":"2-methoxyestradiol","score":0.8980000019073486},{"id":"https://openalex.org/keywords/2-methoxyestrone","display_name":"2-methoxyestrone","score":0.7379999756813049},{"id":"https://openalex.org/keywords/2-hydroxyestrone","display_name":"2-hydroxyestrone","score":0.925000011920929},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.6349999904632568},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5716773867607117},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4754088521003723},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4598153233528137},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43510791659355164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41328752040863037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37805384397506714},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.350125789642334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18227294087409973}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/136102","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/136102","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/136102","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2940635116","doi":null,"is_oa":false,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/136102/1/TA01067.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/136102","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/136102","pdf_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/136102","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2940635116.pdf","grobid_xml":"https://content.openalex.org/works/W2940635116.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W121553317","https://openalex.org/W563366010","https://openalex.org/W1501449907","https://openalex.org/W1597819674","https://openalex.org/W1878492789","https://openalex.org/W1971663401","https://openalex.org/W1976379544","https://openalex.org/W1980350538","https://openalex.org/W1983887183","https://openalex.org/W1985098050","https://openalex.org/W1997917263","https://openalex.org/W1998371568","https://openalex.org/W1999101738","https://openalex.org/W2000983461","https://openalex.org/W2001707407","https://openalex.org/W2012894263","https://openalex.org/W2016184664","https://openalex.org/W2034543587","https://openalex.org/W2044421224","https://openalex.org/W2044530971","https://openalex.org/W2048771025","https://openalex.org/W2056308835","https://openalex.org/W2057132693","https://openalex.org/W2058473747","https://openalex.org/W2077495367","https://openalex.org/W2080758266","https://openalex.org/W2092870550","https://openalex.org/W2100486049","https://openalex.org/W2100988461","https://openalex.org/W2110019144","https://openalex.org/W2113429507","https://openalex.org/W2123347329","https://openalex.org/W2125055259","https://openalex.org/W2134923619","https://openalex.org/W2139533668","https://openalex.org/W2140000393","https://openalex.org/W2140947685","https://openalex.org/W2153925975","https://openalex.org/W2157795344","https://openalex.org/W2163424852","https://openalex.org/W2165674132","https://openalex.org/W2171428093","https://openalex.org/W2187029350","https://openalex.org/W2795740701","https://openalex.org/W2798056406","https://openalex.org/W3037638241","https://openalex.org/W3085162807","https://openalex.org/W4322699306"],"related_works":["https://openalex.org/W6982346854","https://openalex.org/W2151282072","https://openalex.org/W4253863294","https://openalex.org/W2995309388","https://openalex.org/W7036686348","https://openalex.org/W2212921172","https://openalex.org/W7127543192","https://openalex.org/W2031292997","https://openalex.org/W2411164767","https://openalex.org/W2568213545"],"abstract_inverted_index":{"[\ud55c\uae00]Systems":[0],"Biology\ub780":[1],"\uc0dd\ubb3c":[2],"\uc138\ud3ec\ub0b4\uc5d0\uc11c":[3,36],"\uc77c\uc5b4\ub098\ub294":[4],"\ubb3c\uc9c8\ub300\uc0ac,":[5],"\uc720\uc804\uc790":[6],"\uc870\uc808\uacfc\uc815,":[7],"\uc2e0\ud638\uc804\ub2ec":[8],"\uccb4\uacc4":[9],"\uacfc\uc815\uc744":[10],"\uc2dc\uc2a4\ud15c\uc801":[11,20,42],"\uc811\uadfc\uc744":[12],"\ud1b5\ud574":[13],"\ubaa8\ud615\ud654":[14,44],"\ud558\uace0":[15,45],"\ud574\uc11d\ud558\ub294":[16],"\uac83\uc744":[17,33],"\ubaa9\uc801\uc73c\ub85c":[18],"\ud55c\ub2e4.":[19],"\uc811\uadfc\uc774\ub780":[21],"\uc0c1\ud638\uc791\uc6a9\uc73c\ub85c":[22],"\uad6c\uc131\ub41c":[23],"\uacbd\ub85c":[24,56],"\uad6c\uc870":[25],"\uc790\ub8cc\ub97c":[26],"\uae30\ubc18\uc73c\ub85c":[27],"\ud558\uc5ec":[28],"\uc5ec\ub7ec":[29],"\uc5f0\uad6c":[30,144,149,171,197,214],"\uac00\uc124\ub4e4\uc744":[31],"\ud574\uacb0\ud558\ub294":[32],"\uc758\ubbf8\ud55c\ub2e4.":[34],"\ub530\ub77c\uc11c":[35,233],"\ub098\ud0c0\ub098\ub294":[37],"\ub2e4\uc591\ud55c":[38],"\ud604\uc0c1\ub4e4\uc5d0":[39],"\ub300\ud55c":[40,87],"\uac00\uc124\uc744":[41],"\uc811\uadfc\uc73c\ub85c":[43],"\ucd94\ub860\ud560":[46],"\uc218":[47,166,192,241],"\uc788\ub2e4.":[48],"\ubcf8":[49],"\uc5f0\uad6c\uc5d0\uc11c\ub294":[50,82,99,116,129],"\ubb3c\uc9c8\ub300\uc0ac":[51,85],"\uacbd\ub85c,":[52,54],"\uc138\ud3ec\uc2e0\ud638":[53],"\uc9c8\ubcd1":[55],"\ub4f1\uc744":[57],"\uc774\uc6a9\ud558\uc5ec":[58,161],"\uc554":[59,183],"\ubc1c\ubcd1":[60],"\uacfc\uc815\uc5d0\uc11c\uc758":[61,107],"\uc704\ud5d8\uc778\uc790\uc778":[62],"\ubb3c\uc9c8\ub300\uc0ac\uc640":[63,204],"\uc720\uc804\uc790\ub4e4\uc744":[64],"\uc5f0\uad6c\ud558\uc600\ub2e4.":[65,95,112,125],"\uccb4\uacc4\uc801":[66],"\uc5f0\uad6c\ub97c":[67,77],"\uc704\ud558\uc5ec":[68],"\uacbd\ub85c\ub97c":[69],"\uad6c\uc131\ud558\ub294":[70],"\uae30\ubcf8":[71],"\uc694\uc18c\uc778":[72],"\ud569\uc131\ubb3c\uacfc":[73],"\ud6a8\uc18c\ub85c":[74],"\ub098\ub204\uc5b4":[75],"\uc0ac\ub840\ubcc4\ub85c":[76],"\ud558\uc600\ub2e4.":[78,145],"\uccab":[79,146],"\ubc88\uc9f8":[80,97,114,127,147,169,195,212],"\uc0ac\ub840":[81,98,115,128,148,170,196,213],"\uc548\ub4dc\ub85c\uac90":[83,157],"\uc5d0\uc2a4\ud2b8\ub85c\uac90":[84,158],"\uacbd\ub85c\uc5d0":[86,136],"\ud638\ub974\ubaac":[88],"\ud504\ub85c\ud544\uc744":[89,160],"\uce21\uc815\ud558\uc5ec":[90],"\uac11\uc0c1\uc120":[91,151,162],"\uc9c8\ud658\uacfc":[92],"\uc5f0\uad00\uc131\uc774":[93,119,208],"\uc874\uc7ac\ud558\ub294\uc9c0":[94],"\ub450":[96,168],"\uac11\uc0c1\uc120\uc554":[100],"\ubc1c\ubcd1\uc2dc":[101,118,184],"\uc704\ud5d8\uc778\uc790\uac00":[102],"\ub418\ub294":[103],"\ud638\ub974\ubaac\ub4e4\uc744":[104],"\ucd94\uc815\ud558\uace0":[105],"\uc554\ubc1c\ubcd1":[106],"\uc704\ud5d8\uc778\uc790":[108,180],"\ud638\ub974\ubaac\ub4e4\uc758":[109],"\ud328\ud134\uc5d0":[110],"\ub300\ud574":[111,124,143],"\uc138":[113,194],"\ub300\uc7a5\uc554":[117],"\uc874\uc7ac\ud558\ub294":[120],"\ubb3c\uc9c8\ub300\uc0ac\ub97c":[121],"\ucc3e\uc544\ub0b4\ub294":[122],"\uacfc\uc815\uc5d0":[123],"\ub124":[126,211],"\uc720\ubc29\uc554":[130],"\uc885\uc591\ud0c4\uc555\uc790\uc778":[131,216],"BRCA1":[132,217,427,560],"\uc720\uc804\uc790\uac00":[133],"\uc138\ud3ec":[134],"\uc2e0\ud638":[135],"\uc788\ub294":[137],"\uc720\uc804\uc790\ub4e4\uc5d0":[138],"\ubbf8\uce58\ub294":[139],"\uc601\ud5a5\ub825\uc758":[140,234],"\uc815\ub3c4\uc640":[141,235],"\uc21c\uc11c\uc5d0":[142],"\uacb0\uacfc":[150,172,198,215],"\uc9c8\ud658":[152],"\uc758\uc0ac":[153],"\uacb0\uc815":[154],"\uc2dc\uc2a4\ud15c\uc744":[155],"\uac1c\ubc1c\ud558\uc600\uc73c\uba70":[156],"\ubb3c\uc9c8\ub300\uc0ac\uc758":[159],"\ud658\uc790\ub4e4\uc744":[163],"\ud310\ubcc4\ud574":[164],"\ub0bc":[165],"\uc788\uc5c8\ub2e4.":[167,193],"2-hydroxyestrone,":[173,481],"2-hydroxyestradiol,":[174,482],"2-methoxyestrone,":[175,483],"2-methoxyestradiol,":[176],"2-methoxyestradiol-3-methylether":[177,486],"\ub4f1\uc774":[178],"\uac11\uc0c1\uc120\uc554\uc758":[179],"\ud638\ub974\ubaac\uc73c\ub85c":[181],"\ucd94\uc815\ub418\uc5b4\uc84c\uc73c\uba70":[182],"\uc99d\uac00":[185],"\ucd94\uc138\uc758":[186],"\ube48\ub3c4":[187],"\ud328\ud134\uc744":[188],"\ub098\ud0c0\ub0b4\uace0":[189],"\uc788\uc74c\uc744":[190],"\ubcfc":[191,240],"\uc0dd\uccb4":[199],"\uc774\ubb3c":[200],"\ubb3c\uc9c8\ub300\uc0ac\uc5d0":[201],"\uc18d\ud55c":[202,223,227,231],"Dichlorobenzene":[203],"Styrene":[205],"\ubb3c\uc9c8\ub300\uc0ac\uac00":[206],"\ub300\uc7a5\uc554\uacfc":[207],"\uc788\ub2e4\uace0":[209],"\ucd94\uc815\ub418\uc5b4\uc84c\ub2e4.":[210],"\uc720\uc804\uc790\ub294":[218],"DNA":[219],"regulatory":[220,572],"complex\uc778":[221],"SWI/SNF\uc5d0":[222],"\uc720\uc804\uc790\uc640":[224],"checkpoint":[225,574],"arrest\uc5d0":[226],"\uc720\uc804\uc790,":[228],"transcription":[229,577],"factor\uc5d0":[230],"\uc720\uc804\uc790\uc5d0":[232],"\uc21c\uc11c\ub4e4":[236],"\uac04\uc5d0":[237],"\ucc28\uc774\uac00":[238],"\uc874\uc7ac\ud568\uc744":[239],"\uc788\uc5c8\ub2e4.\\n\\n[\uc601\ubb38]Systems":[242],"Biology":[243],"is":[244,269],"interpreted":[245],"as":[246,280,489],"systematic":[247,302,349],"modeling":[248,297],"the":[249,252,257,263,274,287,292,307,314,355,364,376,390,397,405,421,438,446,467,475,478,503,513,540,543,552,559,567],"metabolism":[250,310,523,526,529],"in":[251,291,313,396,437,527,539,551,558,569],"cells":[253,293],"of":[254,259,278,336,357,392,407,425,445,469,477,493,499,505,542,556],"an":[255,330,497],"organism,":[256],"process":[258,317,406],"gene":[260],"regulation":[261],"and":[262,298,311,324,329,341,369,387,423,456,471,485,496,524,554,576],"signal":[264],"transduction":[265],"system.":[266],"Systematic":[267],"approach":[268],"solving":[270],"problems":[271],"by":[272,300,318,343,345,362],"using":[273,319,466],"pathway":[275,323,338],"made":[276],"up":[277],"interactions":[279],"a":[281,284,301,337,348,380,412,429,443,531,549,562],"base.":[282],"Therefore,":[283],"hypothesis":[285],"on":[286,435,566],"various":[288],"phenomena":[289],"seen":[290,538],"has":[294,434],"to":[295,463],"be":[296,464,508],"inferred":[299],"approach.":[303],"This":[304],"study":[305],"researched":[306],"risk":[308,381,393,490],"factor":[309,382,394,491],"genes":[312,436,568],"cancer":[315,385,398,431,495,506],"development":[316,399,504],"metabolic":[320],"pathway,":[321],"signaling":[322,440],"disease":[325,361,451,459],"pathway.":[326,441],"A":[327],"compound":[328],"enzyme":[331],"which":[332],"are":[333],"basic":[334],"elements":[335],"were":[339,461,487],"divided":[340],"studied":[342,354,388,404,420],"case":[344,346,353,374,403,419,515,545],"for":[347],"study.":[350],"The":[351,372,401,417,510],"first":[352,447],"existence":[356],"correlation":[358,413,532],"with":[359,414,533],"thyroid":[360,384,449,457,494],"measuring":[363],"hormone":[365],"profile":[366,468],"regarding":[367],"androgen":[368,470],"estrogen":[370,472],"pathways.":[371],"second":[373,479],"estimated":[375,488,520],"hormones":[377,395,492],"that":[378,410,517,521,546],"become":[379],"when":[383],"develops":[386],"about":[389],"pattern":[391,501],"process.":[400],"third":[402,514],"finding":[408],"metabolisms":[409],"have":[411,530],"colon":[415,534],"cancer.":[416,535],"fourth":[418,544],"degree":[422,553],"order":[424,555],"influence":[426,557],"gene,":[428,561],"breast":[430],"tumor":[432,563],"suppressor,":[433,564],"cell":[439],"As":[442],"result":[444],"case,":[448,480],"gland":[450,458],"decision-making":[452],"system":[453],"was":[454,519,537,548],"developed":[455],"patients":[460],"able":[462],"distinguishedby":[465],"metabolisms.":[473],"In":[474],"results":[476,511,541],"2-methoxyestradiol":[484],"increase":[498],"frequency":[500],"during":[502],"could":[507],"seen.":[509],"from":[512],"showed":[516],"it":[518],"dichlorobenzene":[522],"styrene":[525],"xenobiotics":[528],"It":[536],"there":[547],"difference":[550],"depending":[565],"SWI/SNF":[570],"(DNA":[571],"complex),":[573],"arrest":[575],"factor.":[578]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-05-03T00:00:00"}
