{"id":"https://openalex.org/W2940367348","doi":"https://doi.org/10.2217/pgs-2018-0172","title":"Association between ABCB1 C3435T Polymorphism and Methotrexate Treatment Outcomes in Rheumatoid Arthritis Patients: A Meta-Analysis","display_name":"Association between ABCB1 C3435T Polymorphism and Methotrexate Treatment Outcomes in Rheumatoid Arthritis Patients: A Meta-Analysis","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2940367348","doi":"https://doi.org/10.2217/pgs-2018-0172","mag":"2940367348","pmid":"https://pubmed.ncbi.nlm.nih.gov/30983549"},"language":"en","primary_location":{"id":"doi:10.2217/pgs-2018-0172","doi":"https://doi.org/10.2217/pgs-2018-0172","is_oa":false,"landing_page_url":"https://doi.org/10.2217/pgs-2018-0172","pdf_url":null,"source":{"id":"https://openalex.org/S190377370","display_name":"Pharmacogenomics","issn_l":"1462-2416","issn":["1462-2416","1744-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2940367348"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082230871","display_name":"Xiao He","orcid":"https://orcid.org/0000-0002-0308-0910","observed_orcids":["https://orcid.org/0000-0002-0308-0910"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao He","raw_affiliation_strings":["Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","First Department, State Key Laboratory of Trauma, Burn & Combined Injury, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, PR China First Department, State Key Laboratory of Trauma, Burn & Combined Injury, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]},{"raw_affiliation_string":"First Department, State Key Laboratory of Trauma, Burn & Combined Injury, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]},{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, PR China First Department, State Key Laboratory of Trauma, Burn & Combined Injury, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, PR China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101065223","display_name":"Mingfang Sun","orcid":"https://orcid.org/0009-0003-1260-6798","observed_orcids":["https://orcid.org/0009-0003-1260-6798"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingfang Sun","raw_affiliation_strings":["Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110478069","display_name":"Shen\u2010ju Liang","orcid":"https://orcid.org/0000-0001-7635-9114","observed_orcids":["https://orcid.org/0000-0001-7635-9114"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenju Liang","raw_affiliation_strings":["Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039571697","display_name":"Mengshan Li","orcid":"https://orcid.org/0000-0003-4175-088X","observed_orcids":["https://orcid.org/0000-0003-4175-088X"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengshan Li","raw_affiliation_strings":["Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739411","display_name":"Liangliang Li","orcid":"https://orcid.org/0000-0002-0078-6280","observed_orcids":["https://orcid.org/0000-0002-0078-6280"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangliang Li","raw_affiliation_strings":["Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101461349","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0003-4372-3324","observed_orcids":["https://orcid.org/0000-0003-4372-3324"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210092099","display_name":"Daping Hospital","ror":"https://ror.org/00fthae95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092099"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yang","raw_affiliation_strings":["Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology & Clinical Immunology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing400042, PRChina","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210092099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2589,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.21807466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"5","first_page":"381","last_page":"392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.12759999930858612,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9330000281333923},{"id":"https://openalex.org/keywords/c3435t-polymorphism","display_name":"C3435T polymorphism","score":0.9599999785423279},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7519999742507935},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8461562395095825},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.750918984413147},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.7193774580955505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7032516002655029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6813947558403015},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.48304206132888794},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.39030584692955017},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34745410084724426},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/pgs-2018-0172","doi":"https://doi.org/10.2217/pgs-2018-0172","is_oa":false,"landing_page_url":"https://doi.org/10.2217/pgs-2018-0172","pdf_url":null,"source":{"id":"https://openalex.org/S190377370","display_name":"Pharmacogenomics","issn_l":"1462-2416","issn":["1462-2416","1744-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics","raw_type":"journal-article"},{"id":"pmid:30983549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30983549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W184114367","https://openalex.org/W610722440","https://openalex.org/W915180818","https://openalex.org/W1600159535","https://openalex.org/W1975678556","https://openalex.org/W1976068756","https://openalex.org/W1981501248","https://openalex.org/W1992378231","https://openalex.org/W1995019701","https://openalex.org/W2007872832","https://openalex.org/W2011669229","https://openalex.org/W2024530015","https://openalex.org/W2043235490","https://openalex.org/W2046130515","https://openalex.org/W2051185856","https://openalex.org/W2080638211","https://openalex.org/W2081407149","https://openalex.org/W2120332428","https://openalex.org/W2125435699","https://openalex.org/W2135230337","https://openalex.org/W2138285200","https://openalex.org/W2157823046","https://openalex.org/W2269601004","https://openalex.org/W2312539884","https://openalex.org/W2315713549","https://openalex.org/W2318063446","https://openalex.org/W2391662661","https://openalex.org/W2547564737","https://openalex.org/W2566891769","https://openalex.org/W2592808921","https://openalex.org/W2597600087","https://openalex.org/W2727494708","https://openalex.org/W2794104948","https://openalex.org/W2805776603","https://openalex.org/W2888811024","https://openalex.org/W2895310562","https://openalex.org/W2895832894","https://openalex.org/W2980857560","https://openalex.org/W4211033044","https://openalex.org/W4211111012","https://openalex.org/W4323053507"],"related_works":["https://openalex.org/W4320888124","https://openalex.org/W4206389424","https://openalex.org/W915180818","https://openalex.org/W184114367","https://openalex.org/W2391662661","https://openalex.org/W2963267583","https://openalex.org/W2597600087","https://openalex.org/W3096641984","https://openalex.org/W1995019701","https://openalex.org/W4414307059"],"abstract_inverted_index":{"Aim:":[0],"This":[1],"study":[2],"was":[3,71],"conducted":[4],"to":[5,47,75,119,134],"investigate":[6],"the":[7,68,76,79,107,137],"relationship":[8],"between":[9],"ABCB1":[10,108],"gene":[11,109],"C3435T":[12,110],"polymorphism":[13,111],"and":[14,42,89,128],"methotrexate":[15,120],"treatment":[16],"outcomes":[17],"in":[18,121],"rheumatoid":[19,122],"arthritis":[20,123],"patients.":[21,124],"Methods:":[22],"Seven":[23],"electronic":[24],"databases":[25],"(PubMed,":[26],"EMBASE,":[27],"Web":[28],"of":[29,57,67,78,117,139],"Science,":[30],"Cochrane,":[31],"OVID,":[32],"Chinese":[33],"biomedical":[34],"literature":[35],"[CBM],":[36],"China":[37],"National":[38],"Knowledge":[39],"Infrastructure":[40],"[CNKI]":[41],"Wanfang":[43],"databases)":[44],"were":[45,60,83,100],"searched":[46],"select":[48],"eligible":[49],"publications":[50],"until":[51],"18":[52],"July":[53],"2018.":[54],"The":[55,64],"references":[56],"relevant":[58],"articles":[59,96],"also":[61],"manually":[62],"searched.":[63],"quality":[65],"evaluation":[66],"included":[69],"studies":[70,131],"carried":[72],"out":[73],"according":[74],"guidelines":[77],"Newcastle\u2013Ottawa":[80],"Scale.":[81],"Data":[82],"analyzed":[84],"with":[85],"Review":[86],"Manager":[87],"5.3":[88],"Stata":[90],"13.0":[91],"software.":[92],"In":[93],"total,":[94],"12":[95],"involving":[97],"2014":[98],"patients":[99],"included.":[101],"Conclusion:":[102],"Our":[103],"results":[104],"demonstrated":[105],"that":[106],"might":[112],"be":[113],"a":[114],"reliable":[115],"predictor":[116],"response":[118],"However,":[125],"well-designed,":[126],"multicenter":[127],"large-scale":[129],"prospective":[130],"are":[132],"required":[133],"further":[135],"confirm":[136],"validity":[138],"our":[140],"results.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-04-25T00:00:00"}
