{"id":"https://openalex.org/W2940317890","doi":"https://doi.org/10.21037/atm.2019.03.40","title":"Inhibition of pyroptosis attenuates Staphylococcus aureus-induced bone injury in traumatic osteomyelitis","display_name":"Inhibition of pyroptosis attenuates Staphylococcus aureus-induced bone injury in traumatic osteomyelitis","publication_year":2019,"publication_date":"2019-04-01","ids":{"openalex":"https://openalex.org/W2940317890","doi":"https://doi.org/10.21037/atm.2019.03.40","mag":"2940317890","pmid":"https://pubmed.ncbi.nlm.nih.gov/31168451","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6526268"},"language":"en","primary_location":{"id":"doi:10.21037/atm.2019.03.40","doi":"https://doi.org/10.21037/atm.2019.03.40","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm.2019.03.40","pdf_url":"https://atm.amegroups.com/article/viewFile/25113/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://atm.amegroups.com/article/viewFile/25113/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023863758","display_name":"Xiaobo Zhu","orcid":"https://orcid.org/0000-0002-9914-990X","observed_orcids":["https://orcid.org/0000-0002-9914-990X"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Zhu","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023426353","display_name":"Kaijia Zhang","orcid":"https://orcid.org/0000-0002-3526-8862","observed_orcids":["https://orcid.org/0000-0002-3526-8862"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaijia Zhang","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023213007","display_name":"Ke Lu","orcid":"https://orcid.org/0000-0003-0650-4210","observed_orcids":["https://orcid.org/0000-0003-0650-4210"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Lu","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101584912","display_name":"Tianshu Shi","orcid":"https://orcid.org/0000-0002-7147-4305","observed_orcids":["https://orcid.org/0000-0002-7147-4305"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianshu Shi","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045316597","display_name":"Siyu Shen","orcid":"https://orcid.org/0000-0002-9932-4210","observed_orcids":["https://orcid.org/0000-0002-9932-4210"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyu Shen","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068873274","display_name":"Xingren Chen","orcid":"https://orcid.org/0009-0007-5751-2313","observed_orcids":["https://orcid.org/0009-0007-5751-2313"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingren Chen","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070333917","display_name":"Jian Ping Dong","orcid":"https://orcid.org/0000-0001-6333-3724","observed_orcids":["https://orcid.org/0000-0001-6333-3724"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Dong","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101562296","display_name":"Wang Gong","orcid":"https://orcid.org/0000-0003-4920-5894","observed_orcids":["https://orcid.org/0000-0003-4920-5894"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Gong","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075071588","display_name":"Zhengyuan Bao","orcid":"https://orcid.org/0000-0002-3748-5975","observed_orcids":["https://orcid.org/0000-0002-3748-5975","https://orcid.org/0009-0002-1761-2487"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengyuan Bao","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021773001","display_name":"Yong Shi","orcid":"https://orcid.org/0000-0001-5256-1633","observed_orcids":["https://orcid.org/0000-0001-5256-1633"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Shi","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103208636","display_name":"Yuze Ma","orcid":"https://orcid.org/0000-0003-0668-5752","observed_orcids":["https://orcid.org/0000-0003-0668-5752"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuze Ma","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003673377","display_name":"Huajian Teng","orcid":"https://orcid.org/0000-0002-6441-2739","observed_orcids":["https://orcid.org/0000-0002-6441-2739"]},"institutions":[{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huajian Teng","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049981926","display_name":"Qing Yan Jiang","orcid":"https://orcid.org/0000-0002-2552-9686","observed_orcids":["https://orcid.org/0000-0002-2552-9686","https://orcid.org/0009-0005-6068-1332"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I4210130538","display_name":"Model Animal Research Center","ror":"https://ror.org/03h4e4c54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210130538"]},{"id":"https://openalex.org/I4391768045","display_name":"State Key Laboratory of Pharmaceutical Biotechnology","ror":"https://ror.org/043ea4m21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768045","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Jiang","raw_affiliation_strings":["Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210093, China","institution_ids":["https://openalex.org/I4210130538","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4391768045","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003673377","https://openalex.org/A5049981926"],"corresponding_institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I4210130538","https://openalex.org/I4391768045","https://openalex.org/I881766915"],"apc_list":null,"apc_paid":null,"fwci":2.1242,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.88375842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"8","first_page":"170","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.07739999890327454,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9279999732971191},{"id":"https://openalex.org/keywords/traumatic-osteomyelitis","display_name":"traumatic osteomyelitis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9319999814033508},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.972000002861023},{"id":"https://openalex.org/keywords/bone-destruction","display_name":"bone destruction","score":0.9309999942779541},{"id":"https://openalex.org/keywords/osteoclast-activation","display_name":"osteoclast activation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/bone-infection","display_name":"bone infection","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.9886177182197571},{"id":"https://openalex.org/C2780551157","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Osteomyelitis","level":2,"score":0.8493189811706543},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5628913640975952},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.4324919283390045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4145182967185974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36061131954193115},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.3582318425178528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32327577471733093},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2782539129257202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2421833872795105},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07717996835708618},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/atm.2019.03.40","doi":"https://doi.org/10.21037/atm.2019.03.40","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm.2019.03.40","pdf_url":"https://atm.amegroups.com/article/viewFile/25113/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5528568","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6526268","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31168451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31168451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6526268","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6526268/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21037/atm.2019.03.40","doi":"https://doi.org/10.21037/atm.2019.03.40","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm.2019.03.40","pdf_url":"https://atm.amegroups.com/article/viewFile/25113/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2971088638","display_name":null,"funder_award_id":"81622033","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4783550424","display_name":null,"funder_award_id":"81420108021","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7076703508","display_name":"\u7f13\u91ca\u5c0f\u5206\u5b50\u5316\u5408\u7269Kartogenin\u6c34\u51dd\u80f6\u91cd\u5efa\u8f6f\u9aa8\u53ca\u8f6f\u9aa8\u4e0b\u9aa8\u7f3a\u635f\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81730067","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327778","display_name":"Jiangsu Provincial Medical Youth Talent","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2940317890.pdf","grobid_xml":"https://content.openalex.org/works/W2940317890.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W180346897","https://openalex.org/W1969578149","https://openalex.org/W1986596391","https://openalex.org/W1999389285","https://openalex.org/W2003457351","https://openalex.org/W2013907285","https://openalex.org/W2068619092","https://openalex.org/W2092649207","https://openalex.org/W2120742034","https://openalex.org/W2133772449","https://openalex.org/W2140637559","https://openalex.org/W2304527713","https://openalex.org/W2345602998","https://openalex.org/W2462773201","https://openalex.org/W2560541542","https://openalex.org/W2566836667","https://openalex.org/W2604924798","https://openalex.org/W2610420640","https://openalex.org/W2750300401","https://openalex.org/W2761292242","https://openalex.org/W2780492013","https://openalex.org/W2786339835","https://openalex.org/W2788115780","https://openalex.org/W2805325131","https://openalex.org/W2807924733","https://openalex.org/W2885005743","https://openalex.org/W2913483701"],"related_works":["https://openalex.org/W2938794452","https://openalex.org/W7160432107","https://openalex.org/W4413947766","https://openalex.org/W1999389285","https://openalex.org/W4409647585","https://openalex.org/W2094958156","https://openalex.org/W2161886493","https://openalex.org/W5340292","https://openalex.org/W3171393412","https://openalex.org/W7096873171"],"abstract_inverted_index":{"Background:":[0],"Osteomyelitis":[1],"is":[2,18],"a":[3,19,218,239],"severe":[4],"bone":[5,12,97,145,195,208,234],"infection":[6],"and":[7,15,35,58,71,87,94,184,206,223],"typically":[8],"leads":[9],"to":[10,43,243],"progressive":[11],"resorption,":[13],"destruction":[14,103,235],"dysfunction.":[16],"Pyroptosis":[17],"form":[20],"of":[21,33,53,61,77,112,125,140,166,174,191,202,228],"programmed":[22],"cell":[23],"death":[24],"involved":[25],"in":[26,40,56,69,72,92,143,158,182,185,204,210,221,236],"various":[27],"infectious":[28,96,144],"diseases.":[29],"However,":[30],"the":[31,36,51,59,172,189,194,199,226],"identification":[32],"pyroptosis":[34,63,180,192,216,229],"role":[37],"it":[38],"plays":[39],"osteomyelitis":[41,57,67,150,162,222],"remains":[42],"be":[44],"clarified.":[45],"In":[46],"this":[47],"study,":[48],"we":[49],"investigated":[50],"expression":[52,76,124,139,165],"pyroptosis-associated":[54,78,126,141,167,175],"proteins":[55,142,168,176],"effects":[60],"inhibiting":[62],"on":[64],"S.":[65,159,178,232],"aureus-induced":[66,160,179,233],"both":[68,181],"vitro":[70,205],"vivo.":[73,211],"Methods:":[74],"The":[75,110,123,138],"protein\u2014NLRP3":[79],"(NLR":[80],"Family":[81],"Pyrin":[82],"Domain":[83],"Containing":[84],"3),":[85],"Caspase1":[86],"GSDMD":[88],"(GasderminD)":[89],"were":[90],"examined":[91],"murine":[93,161],"human":[95],"fragments":[98,146],"by":[99,106,117,130],"western":[100],"blot.":[101],"Bone":[102],"was":[104,115,128,151,169],"evaluated":[105],"microcomputed":[107],"tomography":[108],"(\u00b5CT).":[109],"concentration":[111],"inflammatory":[113],"factors":[114],"tested":[116],"Enzyme":[118],"linked":[119],"Immunosorbent":[120],"Assay":[121],"(ELISA).":[122],"gene":[127],"detected":[129],"real-time":[131],"quantitative":[132],"polymerase":[133],"chain":[134],"reaction":[135],"(RT-qPCR).":[136],"Results:":[137],"from":[147],"patients":[148],"with":[149],"significantly":[152],"higher":[153,164],"than":[154],"uninfected":[155],"bone.":[156],"Additionally,":[157],"model,":[163],"noticed.":[170],"Furthermore,":[171],"inhibitors":[173],"alleviated":[177],"vivo":[183],"vitro.":[186],"More":[187],"importantly,":[188],"inhibition":[190,227],"restored":[193],"formative":[196],"property,":[197],"attenuated":[198],"aberrant":[200],"activation":[201],"osteoclast":[203],"reversed":[207],"injury":[209],"Conclusions:":[212],"Our":[213],"study":[214],"identified":[215],"as":[217],"key":[219],"pathway":[220],"elaborated":[224],"that":[225],"could":[230],"attenuate":[231],"osteomyelitis,":[237],"providing":[238],"potential":[240],"treatment":[241],"target":[242],"osteomyelitis.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-04-25T00:00:00"}