{"id":"https://openalex.org/W2940239018","doi":"https://doi.org/10.1016/j.bbrc.2019.04.014","title":"Inhibition of cyclin-dependent kinases by AT7519 is effective to overcome chemoresistance in colon and cervical cancer","display_name":"Inhibition of cyclin-dependent kinases by AT7519 is effective to overcome chemoresistance in colon and cervical cancer","publication_year":2019,"publication_date":"2019-04-10","ids":{"openalex":"https://openalex.org/W2940239018","doi":"https://doi.org/10.1016/j.bbrc.2019.04.014","mag":"2940239018","pmid":"https://pubmed.ncbi.nlm.nih.gov/30979499"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2019.04.014","doi":"https://doi.org/10.1016/j.bbrc.2019.04.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2019.04.014","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079527746","display_name":"Changlei Xi","orcid":"https://orcid.org/0000-0002-3545-9263","observed_orcids":["https://orcid.org/0000-0002-3545-9263"]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]},{"id":"https://openalex.org/I4210148362","display_name":"Jingzhou Central Hospital","ror":"https://ror.org/04gnkpp77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148362"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changlei Xi","raw_affiliation_strings":["Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China","institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418073","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0003-3220-6065","observed_orcids":["https://orcid.org/0000-0003-3220-6065"]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]},{"id":"https://openalex.org/I4210148362","display_name":"Jingzhou Central Hospital","ror":"https://ror.org/04gnkpp77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148362"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China","institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006770280","display_name":"Jie Yu","orcid":"https://orcid.org/0000-0002-7401-7580","observed_orcids":["https://orcid.org/0000-0002-7401-7580"]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]},{"id":"https://openalex.org/I4210148362","display_name":"Jingzhou Central Hospital","ror":"https://ror.org/04gnkpp77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148362"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Yu","raw_affiliation_strings":["Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China","institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101450434","display_name":"Hui Ye","orcid":"https://orcid.org/0000-0001-7607-627X","observed_orcids":["https://orcid.org/0000-0001-7607-627X","https://orcid.org/0009-0000-4595-3399"]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]},{"id":"https://openalex.org/I4210148362","display_name":"Jingzhou Central Hospital","ror":"https://ror.org/04gnkpp77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148362"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Ye","raw_affiliation_strings":["Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China","institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064112966","display_name":"Longlei Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]},{"id":"https://openalex.org/I4210148362","display_name":"Jingzhou Central Hospital","ror":"https://ror.org/04gnkpp77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148362"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longlei Cao","raw_affiliation_strings":["Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China","institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101705442","display_name":"Zhilin Gong","orcid":"https://orcid.org/0000-0001-9717-5226","observed_orcids":["https://orcid.org/0000-0001-9717-5226"]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]},{"id":"https://openalex.org/I4210148362","display_name":"Jingzhou Central Hospital","ror":"https://ror.org/04gnkpp77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148362"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhilin Gong","raw_affiliation_strings":["Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China. Electronic address: Doctor_gong434020@163.com","Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China. Electronic address: Doctor_gong434020@163.com","institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"]},{"raw_affiliation_string":"Department of Anorectal Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China","institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101705442"],"corresponding_institution_ids":["https://openalex.org/I177739611","https://openalex.org/I4210148362"],"apc_list":{"value":2450,"currency":"USD","value_usd":2450},"apc_paid":null,"fwci":3.2575,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.93805918,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"513","issue":"3","first_page":"589","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/at7519","display_name":"AT7519","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.972000002861023},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":1.0},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.9409999847412109},{"id":"https://openalex.org/keywords/5-fluorouracil-resistance","display_name":"5-fluorouracil resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":1.0},{"id":"https://openalex.org/keywords/rna-polymerase-ii-phosphorylation","display_name":"RNA polymerase II phosphorylation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.953000009059906},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5720000267028809},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.7984129190444946},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6515231132507324},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6287754774093628},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6001993417739868},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5994501113891602},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.5736002922058105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5447205305099487},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5293563008308411},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.46851468086242676},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4300863444805145},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.320105642080307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3155619204044342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23452526330947876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07207825779914856}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2019.04.014","doi":"https://doi.org/10.1016/j.bbrc.2019.04.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2019.04.014","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:30979499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30979499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1975186639","https://openalex.org/W1985139403","https://openalex.org/W2080278485","https://openalex.org/W2106480783","https://openalex.org/W2106603430","https://openalex.org/W2121288523","https://openalex.org/W2143238584","https://openalex.org/W2149658883","https://openalex.org/W2153389501","https://openalex.org/W2160656155","https://openalex.org/W2161882832","https://openalex.org/W2163012126","https://openalex.org/W2414600312","https://openalex.org/W2462715093","https://openalex.org/W2473912994","https://openalex.org/W2583136106","https://openalex.org/W2763578259","https://openalex.org/W2805101561","https://openalex.org/W2811225034","https://openalex.org/W2902263717","https://openalex.org/W6751896567"],"related_works":["https://openalex.org/W2153389501","https://openalex.org/W3015777401","https://openalex.org/W2274089490","https://openalex.org/W3173533075","https://openalex.org/W2805101561","https://openalex.org/W4380224657","https://openalex.org/W2892095406","https://openalex.org/W2535220274","https://openalex.org/W3106736553","https://openalex.org/W1964764225"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-04-25T00:00:00"}
