{"id":"https://openalex.org/W2940201673","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p204","title":"Abstract P204: Gender-specific Relationships Between Plasma Levels of Endocannabinoids and Vagal and Sympathetic Control of Heart Rate in Normotensive Obese Older Adults","display_name":"Abstract P204: Gender-specific Relationships Between Plasma Levels of Endocannabinoids and Vagal and Sympathetic Control of Heart Rate in Normotensive Obese Older Adults","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W2940201673","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p204","mag":"2940201673"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.70.suppl_1.p204","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p204","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.70.suppl_1.p204","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071860862","display_name":"Christopher L. Schaich","orcid":"https://orcid.org/0000-0002-5302-0828","observed_orcids":["https://orcid.org/0000-0002-5302-0828"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris L Schaich","raw_affiliation_strings":["Wake Forest Univ Sch Medicine, Winston-Salem, NC","Chris L Schaich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Univ Sch Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Chris L Schaich","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015929279","display_name":"Hossam A. Shaltout","orcid":"https://orcid.org/0000-0001-7948-3815","observed_orcids":["https://orcid.org/0000-0001-7948-3815"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hossam A Shaltout","raw_affiliation_strings":["Wake Forest Univ Sch Medicine, Winston-Salem, NC","Hossam A Shaltout"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Univ Sch Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Hossam A Shaltout","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065855620","display_name":"Alexander L. Kovach","orcid":"https://orcid.org/0000-0002-8254-3492","observed_orcids":["https://orcid.org/0000-0002-8254-3492"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Kovach","raw_affiliation_strings":["RTI International, Rsch Triangle Park, NC","Alex Kovach"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI International, Rsch Triangle Park, NC","institution_ids":["https://openalex.org/I180297670"]},{"raw_affiliation_string":"Alex Kovach","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029665394","display_name":"Megan Grabenauer","orcid":"https://orcid.org/0000-0003-3706-3083","observed_orcids":["https://orcid.org/0000-0003-3706-3083"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Grabenauer","raw_affiliation_strings":["RTI International, Rsch Triangle Park, NC","Megan Grabenauer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI International, Rsch Triangle Park, NC","institution_ids":["https://openalex.org/I180297670"]},{"raw_affiliation_string":"Megan Grabenauer","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102889704","display_name":"Brian F. Thomas","orcid":"https://orcid.org/0000-0002-0097-4804","observed_orcids":["https://orcid.org/0000-0002-0097-4804"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian F Thomas","raw_affiliation_strings":["RTI International, Rsch Triangle Park, NC","Brian F Thomas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RTI International, Rsch Triangle Park, NC","institution_ids":["https://openalex.org/I180297670"]},{"raw_affiliation_string":"Brian F Thomas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004493967","display_name":"Tina E. Brinkley","orcid":"https://orcid.org/0000-0002-1905-758X","observed_orcids":["https://orcid.org/0000-0002-1905-758X"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina E Brinkley","raw_affiliation_strings":["Wake Forest Univ Sch Medicine, Winston-Salem, NC","Tina E Brinkley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Univ Sch Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Tina E Brinkley","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057209268","display_name":"Barbara J. Nicklas","orcid":"https://orcid.org/0000-0002-7726-6670","observed_orcids":["https://orcid.org/0000-0002-7726-6670"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J Nicklas","raw_affiliation_strings":["Wake Forest Univ Sch Medicine, Winston-Salem, NC","Barbara J Nicklas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Univ Sch Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Barbara J Nicklas","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034603627","display_name":"Debra I. Diz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra I Diz","raw_affiliation_strings":["Wake Forest Univ Sch Medicine, Winston-Salem, NC","Debra I Diz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Univ Sch Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Debra I Diz","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.4332999885082245,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocannabinoids","display_name":"endocannabinoids","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anandamide","display_name":"anandamide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/2-arachidonoylglycerol","display_name":"2-arachidonoylglycerol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.906000018119812},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7639999985694885},{"id":"https://openalex.org/keywords/autonomic-control-of-heart-rate","display_name":"autonomic control of heart rate","score":0.7459999918937683},{"id":"https://openalex.org/keywords/baroreflex-sensitivity","display_name":"baroreflex sensitivity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.9570000171661377},{"id":"https://openalex.org/keywords/vagal-tone","display_name":"vagal tone","score":0.7789999842643738},{"id":"https://openalex.org/keywords/sympathetic-tone","display_name":"sympathetic tone","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hypertension-risk","display_name":"hypertension risk","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8143867254257202},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.691344141960144},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.6576142311096191},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.650904655456543},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.6373151540756226},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6321024894714355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5490926504135132},{"id":"https://openalex.org/C10928738","wikidata":"https://www.wikidata.org/wiki/Q1195426","display_name":"Vagal tone","level":5,"score":0.5290499925613403},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.52411949634552},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.5084606409072876},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.4355723261833191},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3290787637233734},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08802840113639832}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.70.suppl_1.p204","doi":"https://doi.org/10.1161/hyp.70.suppl_1.p204","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.70.suppl_1.p204","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981538767","https://openalex.org/W2222938274","https://openalex.org/W2415030877","https://openalex.org/W1094797422","https://openalex.org/W2800364420","https://openalex.org/W1993146478","https://openalex.org/W2165207625","https://openalex.org/W2991511700","https://openalex.org/W2086229307","https://openalex.org/W4403227270"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"in":[2,15,37,223,234,237,293],"obese":[3,44],"individuals":[4],"indicate":[5],"higher":[6],"circulating":[7],"endocannabinoids":[8,23,53],"anandamide":[9],"(AEA)":[10],"and":[11,24,30,55,61,94,97,101,124,133,143,167,189,216,249,264,266,299,302],"2-arachidonoylglycerol":[12],"(2-AG)":[13],"than":[14],"lean":[16],"counterparts.":[17],"However,":[18,236],"the":[19,52,176,194,217,283,291],"association":[20],"between":[21,185,213,247],"plasma":[22,49,186,214],"autonomic":[25,288],"control":[26,78,289],"of":[27,42,51,67,84,129,150,160,170,193,253,290],"blood":[28,125],"pressure":[29,86,126],"heart":[31,76,120],"rate":[32,77,121],"has":[33],"not":[34,233,240],"been":[35],"assessed":[36],"obesity.":[38],"In":[39,111],"a":[40,147,155,181,209,280],"sample":[41,139],"normotensive,":[43],"older":[45],"adults":[46],"we":[47,179,242],"analyzed":[48],"content":[50,188],"AEA":[54,248,265],"total":[56],"AG":[57,187,215],"using":[58],"mass":[59,158],"spectrometry":[60],"examined":[62],"correlations":[63],"with":[64,146,279],"various":[65],"indices":[66,128],"spontaneous":[68,197,219,255],"sympathovagal":[69],"activity.":[70],"Spontaneous":[71],"baroreflex":[72],"sensitivity":[73],"(BRS)":[74],"for":[75,282,297],"was":[79,116],"calculated":[80],"by":[81],"spectral":[82],"analysis":[83,115],"arterial":[85],"(AP)":[87],"time":[88,113],"(Sequence":[89],"[Seq]":[90],"Up,":[91],"Seq":[92,95],"Down":[93],"All)":[96],"frequency":[98],"(low-frequency":[99],"[LF]":[100],"high-frequency":[102],"[HF]":[103],"\u03b1)":[104],"domains":[105],"from":[106],"continuous":[107],"resting":[108],"AP":[109,169],"recordings.":[110],"addition,":[112],"domain":[114],"used":[117],"to":[118,286,309],"calculate":[119],"variability":[122],"(HRV)":[123],"variability,":[127],"cardiac":[130],"vagal":[131,218],"tone":[132],"vascular":[134],"sympathetic":[135,254],"tone,":[136],"respectively.":[137],"The":[138],"included":[140],"8":[141],"males":[142,224,241],"17":[144],"females":[145,238],"mean":[148,156,168],"age":[149],"68.4":[151],"\u00b1":[152,162,172],"0.6":[153],"years,":[154],"body":[157],"index":[159,192,252],"35.0":[161],"0.8":[163],"kg/m":[164],"2":[165],",":[166],"101.0":[171],"2.2":[173],"mmHg.":[174],"Across":[175],"complete":[177],"sample,":[178],"report":[180,208],"significant":[182,210,244],"inverse":[183,211],"correlation":[184,212],"HF\u03b1,":[190],"an":[191,251],"vagally-mediated":[195],"parasympathetic":[196],"BRS":[198,220,256],"(":[199,225,257,268],"r":[200,226,258,269],"=":[201,227,259,270],"-0.50,":[202],"P":[203,229,261,272],"<":[204,230,262,273],"0.05).":[205,274],"We":[206],"further":[207],"(Seq":[221],"Up)":[222],"-0.87,":[228],"0.01)":[231],"but":[232,239],"females.":[235],"found":[243],"positive":[245],"relationships":[246],"LF\u03b1,":[250],"0.49,":[260],"0.05),":[263],"HRV":[267],"0.50,":[271],"These":[275],"results":[276],"are":[277],"consistent":[278],"role":[281],"endocannabinoid":[284],"system":[285],"modulate":[287],"circulation":[292],"populations":[294],"at":[295],"risk":[296],"hypertension":[298],"cardiovascular":[300],"disease,":[301],"suggest":[303],"gender":[304],"differences":[305],"that":[306],"have":[307],"yet":[308],"be":[310],"elucidated.":[311]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-04-25T00:00:00"}