{"id":"https://openalex.org/W2940198144","doi":"https://doi.org/10.4274/mjima.2018.33","title":"Detection of Hepatitis B Virus Drug Resistance Mutations by Pyrosequencing Method","display_name":"Detection of Hepatitis B Virus Drug Resistance Mutations by Pyrosequencing Method","publication_year":2019,"publication_date":"2019-04-09","ids":{"openalex":"https://openalex.org/W2940198144","doi":"https://doi.org/10.4274/mjima.2018.33","mag":"2940198144"},"language":"en","primary_location":{"id":"doi:10.4274/mjima.2018.33","doi":"https://doi.org/10.4274/mjima.2018.33","is_oa":true,"landing_page_url":"https://doi.org/10.4274/mjima.2018.33","pdf_url":"https://doi.org/10.4274/mjima.2018.33","source":{"id":"https://openalex.org/S4210224486","display_name":"Mediterranean Journal of Infection Microbes and Antimicrobials","issn_l":"2147-673X","issn":["2147-673X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Infection Microbes and Antimicrobials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4274/mjima.2018.33","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002089320","display_name":"Mehmet \u00c7imentepe","orcid":"https://orcid.org/0000-0002-3563-2468","observed_orcids":["https://orcid.org/0000-0002-3563-2468"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mehmet \u00c7\u0130MENTEPE","raw_affiliation_strings":["Department of Medical Microbiology, Adana, Turkey","\u00c7ukurova University Faculty of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Adana, Turkey","institution_ids":[]},{"raw_affiliation_string":"\u00c7ukurova University Faculty of Medicine,","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Deniz YILDIRIM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Deniz YILDIRIM","raw_affiliation_strings":["\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047793522","display_name":"S\u00fcheyla K\u00f6m\u00fcr","orcid":"https://orcid.org/0000-0003-2414-559X","observed_orcids":["https://orcid.org/0000-0003-2414-559X"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S\u00fcheyla K\u00d6M\u00dcR","raw_affiliation_strings":["\u00c7ukurova University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Adana, Turkey","\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00c7ukurova University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Adana, Turkey","institution_ids":["https://openalex.org/I55931168"]},{"raw_affiliation_string":"\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018685015","display_name":"Buket \u015eeflek","orcid":"https://orcid.org/0000-0002-0923-4407","observed_orcids":["https://orcid.org/0000-0002-0923-4407"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Buket \u015eEFLEK","raw_affiliation_strings":["\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067051995","display_name":"Deniz \u00d6ZDO\u011eRU SA\u011eDI\u00c7","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Deniz \u00d6ZDO\u011eRU SA\u011eDI\u00c7","raw_affiliation_strings":["\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076298248","display_name":"F\u00fcgen Yark\u0131n","orcid":"https://orcid.org/0000-0002-6012-2320","observed_orcids":["https://orcid.org/0000-0002-6012-2320"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"F\u00fcgen YARKIN","raw_affiliation_strings":["\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00c7ukurova University Faculty of Medicine, Department of Medical Microbiology, Adana, Turkey","institution_ids":["https://openalex.org/I55931168"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002089320"],"corresponding_institution_ids":["https://openalex.org/I55931168"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9229999780654907},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nucleos-t-ide-analogues","display_name":"nucleos(t)ide analogues","score":0.8410000205039978},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.8389999866485596},{"id":"https://openalex.org/keywords/lamivudine","display_name":"lamivudine","score":0.7480000257492065},{"id":"https://openalex.org/keywords/adefovir","display_name":"adefovir","score":0.9829999804496765},{"id":"https://openalex.org/keywords/telbivudine","display_name":"telbivudine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/entecavir","display_name":"entecavir","score":0.996999979019165},{"id":"https://openalex.org/keywords/tenofovir","display_name":"tenofovir","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rtm204i","display_name":"rtM204I","score":0.847000002861023},{"id":"https://openalex.org/keywords/rtl180m","display_name":"rtL180M","score":0.9390000104904175},{"id":"https://openalex.org/keywords/rtm204v","display_name":"rtM204V","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C125009961","wikidata":"https://www.wikidata.org/wiki/Q2342248","display_name":"Pyrosequencing","level":3,"score":0.838568389415741},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7324885129928589},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6384587287902832},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6008760929107666},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4744321405887604},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44186514616012573},{"id":"https://openalex.org/C3020804797","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Hepatitis virus","level":3,"score":0.4342949390411377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3727656304836273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32952362298965454},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2811574935913086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25302302837371826},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11464455723762512}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4274/mjima.2018.33","doi":"https://doi.org/10.4274/mjima.2018.33","is_oa":true,"landing_page_url":"https://doi.org/10.4274/mjima.2018.33","pdf_url":"https://doi.org/10.4274/mjima.2018.33","source":{"id":"https://openalex.org/S4210224486","display_name":"Mediterranean Journal of Infection Microbes and Antimicrobials","issn_l":"2147-673X","issn":["2147-673X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Infection Microbes and Antimicrobials","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7eeb121898b14af3b5a79d071bc2c43f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7eeb121898b14af3b5a79d071bc2c43f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 7 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4274/mjima.2018.33","doi":"https://doi.org/10.4274/mjima.2018.33","is_oa":true,"landing_page_url":"https://doi.org/10.4274/mjima.2018.33","pdf_url":"https://doi.org/10.4274/mjima.2018.33","source":{"id":"https://openalex.org/S4210224486","display_name":"Mediterranean Journal of Infection Microbes and Antimicrobials","issn_l":"2147-673X","issn":["2147-673X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Infection Microbes and Antimicrobials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2940198144.pdf","grobid_xml":"https://content.openalex.org/works/W2940198144.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W124116101","https://openalex.org/W1964291476","https://openalex.org/W1965855598","https://openalex.org/W1972454408","https://openalex.org/W2000618086","https://openalex.org/W2008241184","https://openalex.org/W2015062943","https://openalex.org/W2029143120","https://openalex.org/W2046089461","https://openalex.org/W2057475158","https://openalex.org/W2062964506","https://openalex.org/W2067848371","https://openalex.org/W2079707422","https://openalex.org/W2095299548","https://openalex.org/W2095444472","https://openalex.org/W2099690830","https://openalex.org/W2100167647","https://openalex.org/W2106401899","https://openalex.org/W2107683172","https://openalex.org/W2113010048","https://openalex.org/W2124316479","https://openalex.org/W2164762627","https://openalex.org/W2259746315","https://openalex.org/W2285163512","https://openalex.org/W2300241505","https://openalex.org/W2327539594","https://openalex.org/W2395276098","https://openalex.org/W2395331476","https://openalex.org/W2409117115","https://openalex.org/W2511294564","https://openalex.org/W2527570568","https://openalex.org/W2658017343","https://openalex.org/W2762342436","https://openalex.org/W2762718636","https://openalex.org/W4239389360"],"related_works":["https://openalex.org/W2391825088","https://openalex.org/W7110531650","https://openalex.org/W2372921589","https://openalex.org/W2467908276","https://openalex.org/W2215007428","https://openalex.org/W3032469517","https://openalex.org/W2375100033","https://openalex.org/W2300241505","https://openalex.org/W2494233367","https://openalex.org/W2128218670"],"abstract_inverted_index":{"Giri\u015f:":[0],"Kronik":[1],"hepatit":[2,28,52],"B":[3,29,53,178],"vir\u00fcs":[4],"(HBV)":[5,180],"enfeksiyonun":[6],"uzun":[7],"s\u00fcreli":[8],"tedavisi":[9],"s\u0131ras\u0131nda":[10],"n\u00fckleoz(t)id":[11],"analoglar\u0131na":[12],"kar\u015f\u0131":[13,129],"ila\u00e7":[14,34,82,125],"direnci":[15,35,126],"mutasyonlar\u0131n\u0131n":[16,37,84],"geli\u015fmesi":[17],"tedavi":[18,57,62],"ba\u015far\u0131s\u0131zl\u0131\u011f\u0131na":[19],"yol":[20],"a\u00e7abilen":[21],"\u00f6nemli":[22],"bir":[23,115,137,157],"sorundur.Bu":[24],"\u00e7al\u0131\u015fman\u0131n":[25],"amac\u0131":[26],"kronik":[27,51],"enfeksiyonu":[30,54],"olan":[31,55,134,143],"hastalarda":[32],"HBV":[33,96,200,209,230,249,361],"gen":[36],"pyrosequencing":[38,93,212,247,351],"metodu":[39,94],"ile":[40,80,103,153],"ara\u015ft\u0131r\u0131lmas\u0131d\u0131r.Gere\u00e7":[41],"ve":[42,46,60,77,123,127],"Y\u00f6ntem:":[43],"Kas\u0131m":[44],"2013":[45,218],"May\u0131s":[47],"2014":[48],"tarihleri":[49],"aras\u0131nda,":[50],"89'u":[56],"almayan":[58,107],"(naif)":[59],"48'i":[61],"alan":[63],"toplam":[64],"137":[65,226],"hastaya":[66],"ait":[67],"serum":[68,222],"\u00f6rnekleri":[69],"lamivudin":[70],"(LAM),":[71,263],"adefovir,":[72,264],"telbivudin":[73],"(TEL),":[74,266],"entekavir":[75],"(ETV)":[76],"tenofovir":[78,270],"(TDF)":[79],"ili\u015fkili":[81],"diren\u00e7":[83],"tespiti":[85],"i\u00e7in":[86],"real-time":[87,240],"polimeraz":[88],"zincir":[89],"reaksiyonu":[90],"testi":[91],"sonras\u0131":[92],"(PyroStar":[95,248],"Drug":[97,250],"Resistance":[98,251],"Test,":[99,252],"Altona":[100,253],"Diagnostics,":[101,254],"Germany)":[102,255],"analiz":[104],"edilmi\u015ftir.Bulgular:":[105],"Tedavi":[106],"89":[108,274],"hastada,":[109,121],"TDF'ye":[110],"duyarl\u0131l\u0131\u011f\u0131":[111],"azaltan":[112],"rtA194T":[113,281],"mutasyonu":[114,136,152],"(%1,1)":[116],"olguda":[117,139],"bulunmu\u015ftur.Tedavi":[118],"edilen":[119],"48":[120,235,290],"LAM":[122],"TEL'e":[124],"ETV'ye":[128],"da":[130],"\u00e7apraz":[131],"dirence":[132],"sebep":[133],"rtM204I":[135,297],"(%2,1)":[138,158],"tespit":[140,160],"edilmi\u015ftir.Kompansatuvar":[141],"mutasyon":[142],"rtL180M":[144,311],"iki":[145],"(%4,2)":[146],"hastada":[147,159],"g\u00f6zlenmi\u015ftir.ETV":[148],"direncini":[149],"g\u00f6steren":[150],"rtT184S":[151,323],"birlikte":[154],"rtM204V'nin":[155],"varl\u0131\u011f\u0131":[156],"edilmi\u015ftir.":[161],"\u00d6zIntroduction:":[162],"The":[163],"development":[164],"of":[165,193,319,336,350,357,369],"drug":[166,201,257,301,337,370],"resistance":[167,202,258,302,327,338,371],"mutations":[168,204,259,339],"to":[169,189,197,287,303,308,365],"nucleos(t)ide":[170],"analogues":[171],"during":[172,355],"long-term":[173],"therapy":[174],"for":[175,256],"chronic":[176,208,229,360],"hepatitis":[177],"virus":[179],"infection":[181,210,362],"is":[182],"a":[183],"major":[184],"problem":[185],"that":[186],"may":[187],"lead":[188],"treatment":[190,356],"failure.The":[191],"aim":[192],"this":[194],"study":[195],"was":[196,312,328,340],"investigate":[198],"the":[199,273,280,289,296,366],"gene":[203],"in":[205,314,330,342,346],"patients":[206,227,316,358],"with":[207,228,239,261,284,300,322,359],"by":[211,246],"method.Materials":[213],"and":[214,219,234,269,306,344,354],"Methods:":[215],"Between":[216],"December":[217],"May":[220],"2014,":[221],"samples":[223],"collected":[224],"from":[225],"infection,":[231],"(89":[232],"treatment-naive":[233,275,347],"treatment-experienced),":[236],"were":[237],"analyzed":[238],"polymerase":[241],"chain":[242],"reaction":[243],"analysis":[244],"followed":[245],"associated":[260,283,299],"lamivudine":[262],"telbivudine":[265],"entecavir":[267],"(ETV),":[268],"(TDF).Results:":[271],"Of":[272],"patients,":[276,292],"one":[277,293,331],"(1.1%)":[278],"had":[279,295],"mutation,":[282,298],"reduced":[285],"susceptibility":[286],"TDF.Of":[288],"treatment-experienced":[291,343],"(2.1%)":[294],"LAM,":[304],"TEL,":[305],"cross-resistance":[307],"ETV.Compensatory":[309],"mutation":[310,324],"observed":[313],"two":[315],"(4.2%).The":[317],"presence":[318],"rtM204V":[320],"combined":[321],"indicating":[325],"ETV":[326],"detected":[329],"patient":[332],"(2.1%).":[333],"Conclusion:The":[334],"incidence":[335],"8.3%":[341],"1.1%":[345],"patients.The":[348],"use":[349],"technology":[352],"before":[353],"would":[363],"contribute":[364],"rapid":[367],"detection":[368],"mutations.":[372]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-04-25T00:00:00"}