{"id":"https://openalex.org/W2940174652","doi":"https://doi.org/10.1016/j.arteri.2019.01.005","title":"Tratamiento de la hipercolesterolemia familiar con iPCSK9 en un paciente diagnosticado de distrofia muscular cong\u00e9nita con contraindicaci\u00f3n para la toma de estatinas","display_name":"Tratamiento de la hipercolesterolemia familiar con iPCSK9 en un paciente diagnosticado de distrofia muscular cong\u00e9nita con contraindicaci\u00f3n para la toma de estatinas","publication_year":2019,"publication_date":"2019-04-09","ids":{"openalex":"https://openalex.org/W2940174652","doi":"https://doi.org/10.1016/j.arteri.2019.01.005","mag":"2940174652","pmid":"https://pubmed.ncbi.nlm.nih.gov/30979437"},"language":"es","primary_location":{"id":"doi:10.1016/j.arteri.2019.01.005","doi":"https://doi.org/10.1016/j.arteri.2019.01.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.arteri.2019.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S2898450218","display_name":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis","issn_l":"0214-9168","issn":["0214-9168","1578-1879","1695-4661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066041444","display_name":"Sergio Arnedo Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Sergio Arnedo Hern\u00e1ndez","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a. Electronic address: sarnedo@riojasalud.es","Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a. Electronic address: sarnedo@riojasalud.es","institution_ids":["https://openalex.org/I4210138511"]},{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017879778","display_name":"Jos\u00e9 Daniel Mosquera Lozano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Daniel Mosquera Lozano","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086172339","display_name":"Iratxe Mart\u00ednez de Narvajas Urra","orcid":"https://orcid.org/0000-0002-8372-9563","observed_orcids":["https://orcid.org/0000-0002-8372-9563"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Iratxe Mart\u00ednez de Narvajas Urra","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089368321","display_name":"Estela Menendez Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Estela Men\u00e9ndez Fern\u00e1ndez","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077643101","display_name":"Elisa Rabad\u00e1n Pejenaute","orcid":"https://orcid.org/0000-0002-5942-0611","observed_orcids":["https://orcid.org/0000-0002-5942-0611"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elisa Rabad\u00e1n Pejenaute","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043329043","display_name":"Ram\u00f3n Baeza\u2010Trinidad","orcid":"https://orcid.org/0000-0002-7854-3115","observed_orcids":["https://orcid.org/0000-0002-7854-3115"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ram\u00f3n Baeza Trinidad","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068203249","display_name":"Marta Casa\u00f1as","orcid":"https://orcid.org/0000-0001-8694-3904","observed_orcids":["https://orcid.org/0000-0001-8694-3904"]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Casa\u00f1as Mart\u00ednez","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103845781","display_name":"\u00c1ngel Brea Hernando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138511","display_name":"Hospital San Pedro","ror":"https://ror.org/031va0421","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210138511"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angel Brea Hernando","raw_affiliation_strings":["Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de L\u00edpidos, Servicio de Medicina Interna, Hospital San Pedro, Logro\u00f1o, La Rioja, Espa\u00f1a","institution_ids":["https://openalex.org/I4210138511"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066041444"],"corresponding_institution_ids":["https://openalex.org/I4210138511"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07179266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"6","first_page":"278","last_page":"281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/alirocumab","display_name":"alirocumab","score":0.9620000123977661},{"id":"https://openalex.org/keywords/congenital-muscular-dystrophy","display_name":"congenital muscular dystrophy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lipoprotein-apheresis","display_name":"lipoprotein apheresis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7080000042915344},{"id":"https://openalex.org/keywords/heterozygous-familial-hypercholesterolemia","display_name":"heterozygous familial hypercholesterolemia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/myopathy","display_name":"myopathy","score":0.3140000104904175},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8578160405158997},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.6474747657775879},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.5722911953926086},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.5575997233390808},{"id":"https://openalex.org/C2779981540","wikidata":"https://www.wikidata.org/wiki/Q1399182","display_name":"Facioscapulohumeral muscular dystrophy","level":3,"score":0.4734627604484558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32760846614837646},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32160770893096924},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.32095038890838623},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.19758397340774536}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091362","descriptor_name":"PCSK9 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009136","descriptor_name":"Muscular Dystrophies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.arteri.2019.01.005","doi":"https://doi.org/10.1016/j.arteri.2019.01.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.arteri.2019.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S2898450218","display_name":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis","issn_l":"0214-9168","issn":["0214-9168","1578-1879","1695-4661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis","raw_type":"journal-article"},{"id":"pmid:30979437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30979437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1962272706","https://openalex.org/W2473359164","https://openalex.org/W2512572393","https://openalex.org/W2564712078","https://openalex.org/W2608926410","https://openalex.org/W6640798808"],"related_works":["https://openalex.org/W2990302522","https://openalex.org/W2730804398","https://openalex.org/W2977838949","https://openalex.org/W2913360617","https://openalex.org/W4214937995","https://openalex.org/W2914084461","https://openalex.org/W2922127210","https://openalex.org/W3068292693","https://openalex.org/W3047528811","https://openalex.org/W7125509468"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-04-25T00:00:00"}