{"id":"https://openalex.org/W2940070494","doi":"https://doi.org/10.21608/aps.2019.20210","title":"Antifungal resistance and predominance of virulence determinants among Candida albicans isolated from various clinical specimens","display_name":"Antifungal resistance and predominance of virulence determinants among Candida albicans isolated from various clinical specimens","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2940070494","doi":"https://doi.org/10.21608/aps.2019.20210","mag":"2940070494"},"language":"en","primary_location":{"id":"doi:10.21608/aps.2019.20210","doi":"https://doi.org/10.21608/aps.2019.20210","is_oa":true,"landing_page_url":"https://doi.org/10.21608/aps.2019.20210","pdf_url":"https://aps.journals.ekb.eg/article_29012_982ad8aa1b3253a5968a8d371ecce5e0.pdf","source":{"id":"https://openalex.org/S4210205377","display_name":"Archives of Pharmaceutical Sciences Ain Shams University","issn_l":"2356-8380","issn":["2356-8380","2356-8399"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pharmaceutical Sciences Ain Shams University","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aps.journals.ekb.eg/article_29012_982ad8aa1b3253a5968a8d371ecce5e0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066198160","display_name":"Houdaii H. El-Houssaini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3130228804","display_name":"Heliopolis University","ror":"https://ror.org/02tme6r37","country_code":"EG","type":"education","lineage":["https://openalex.org/I3130228804"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Houdaii El-Houssaini","raw_affiliation_strings":["Department of Microbiology and Public Health, Faculty of Pharmacy, Heliopolis University for Sustainable Development, 3 Cairo-Belbeis Road, El Horreya P.O 11788, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Public Health, Faculty of Pharmacy, Heliopolis University for Sustainable Development, 3 Cairo-Belbeis Road, El Horreya P.O 11788, Cairo, Egypt","institution_ids":["https://openalex.org/I3130228804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049020987","display_name":"Walid Faisal Elkhatib","orcid":"https://orcid.org/0000-0001-5815-3200","observed_orcids":["https://orcid.org/0000-0001-5815-3200"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Walid Elkhatib","raw_affiliation_strings":["Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, African Union Organization St., Abbassia 11566, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, African Union Organization St., Abbassia 11566, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091760500","display_name":"Omnia M. Elnabawy","orcid":"https://orcid.org/0000-0001-7060-6196","observed_orcids":["https://orcid.org/0000-0001-7060-6196"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Omnia Elnabawy","raw_affiliation_strings":["Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Abbassia square, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Abbassia square, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060368111","display_name":"Hebatallah Ahmed Nasser","orcid":"https://orcid.org/0000-0002-2801-4506","observed_orcids":["https://orcid.org/0000-0002-2801-4506"]},"institutions":[{"id":"https://openalex.org/I3130228804","display_name":"Heliopolis University","ror":"https://ror.org/02tme6r37","country_code":"EG","type":"education","lineage":["https://openalex.org/I3130228804"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hebatallah Nasser","raw_affiliation_strings":["Department of Microbiology and Public Health, Faculty of Pharmacy, Heliopolis University for Sustainable Development, 3 Cairo-Belbeis Road, El Horreya P.O 11788, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Public Health, Faculty of Pharmacy, Heliopolis University for Sustainable Development, 3 Cairo-Belbeis Road, El Horreya P.O 11788, Cairo, Egypt","institution_ids":["https://openalex.org/I3130228804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049020987"],"corresponding_institution_ids":["https://openalex.org/I107720978"],"apc_list":{"value":50,"currency":"USD","value_usd":50},"apc_paid":{"value":50,"currency":"USD","value_usd":50},"fwci":0.1918,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.50523131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"3","issue":"1","first_page":"11","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.9700000286102295},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/extracellular-hydrolytic-enzymes","display_name":"extracellular hydrolytic enzymes","score":0.8539999723434448},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cell-surface-hydrophobicity","display_name":"cell surface hydrophobicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phospholipase","display_name":"phospholipase","score":0.7839999794960022},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hemolysin","display_name":"hemolysin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fluconazole-resistance","display_name":"fluconazole resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/voriconazole-resistance","display_name":"voriconazole resistance","score":0.9179999828338623},{"id":"https://openalex.org/keywords/clotrimazole-resistance","display_name":"clotrimazole resistance","score":0.878000020980835},{"id":"https://openalex.org/keywords/amphotericin-b-susceptibility","display_name":"amphotericin B susceptibility","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nystatin","display_name":"nystatin","score":0.890999972820282},{"id":"https://openalex.org/keywords/micafungin","display_name":"micafungin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.895509660243988},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8474471569061279},{"id":"https://openalex.org/C2779020398","wikidata":"https://www.wikidata.org/wiki/Q6827850","display_name":"Micafungin","level":4,"score":0.7161436080932617},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6585094928741455},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.6479772329330444},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.5716648101806641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5646340250968933},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.5555421113967896},{"id":"https://openalex.org/C2777762789","wikidata":"https://www.wikidata.org/wiki/Q251005","display_name":"Nystatin","level":3,"score":0.49030473828315735},{"id":"https://openalex.org/C136139683","wikidata":"https://www.wikidata.org/wiki/Q2746278","display_name":"Hemolysin","level":4,"score":0.47317057847976685},{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.45384636521339417},{"id":"https://openalex.org/C2780628323","wikidata":"https://www.wikidata.org/wiki/Q413546","display_name":"Clotrimazole","level":3,"score":0.43316149711608887},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.42302900552749634},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.41121962666511536},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23078718781471252},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.21772807836532593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06605347990989685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21608/aps.2019.20210","doi":"https://doi.org/10.21608/aps.2019.20210","is_oa":true,"landing_page_url":"https://doi.org/10.21608/aps.2019.20210","pdf_url":"https://aps.journals.ekb.eg/article_29012_982ad8aa1b3253a5968a8d371ecce5e0.pdf","source":{"id":"https://openalex.org/S4210205377","display_name":"Archives of Pharmaceutical Sciences Ain Shams University","issn_l":"2356-8380","issn":["2356-8380","2356-8399"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pharmaceutical Sciences Ain Shams University","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0e7d3b56cf5342288d67e47a2f043727","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0e7d3b56cf5342288d67e47a2f043727","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Pharmaceutical Sciences Ain Shams University, Vol 3, Iss 1, Pp 11-20 (2019)","raw_type":"article"},{"id":"doi:10.60692/1qer3-z1019","doi":"https://doi.org/10.60692/1qer3-z1019","is_oa":true,"landing_page_url":"https://doi.org/10.60692/1qer3-z1019","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/tj6be-08455","doi":"https://doi.org/10.60692/tj6be-08455","is_oa":true,"landing_page_url":"https://doi.org/10.60692/tj6be-08455","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.21608/aps.2019.20210","doi":"https://doi.org/10.21608/aps.2019.20210","is_oa":true,"landing_page_url":"https://doi.org/10.21608/aps.2019.20210","pdf_url":"https://aps.journals.ekb.eg/article_29012_982ad8aa1b3253a5968a8d371ecce5e0.pdf","source":{"id":"https://openalex.org/S4210205377","display_name":"Archives of Pharmaceutical Sciences Ain Shams University","issn_l":"2356-8380","issn":["2356-8380","2356-8399"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pharmaceutical Sciences Ain Shams University","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321119","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2940070494.pdf","grobid_xml":"https://content.openalex.org/works/W2940070494.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W218643715","https://openalex.org/W615254675","https://openalex.org/W1524526489","https://openalex.org/W1917218555","https://openalex.org/W1940720973","https://openalex.org/W1968758930","https://openalex.org/W1975092522","https://openalex.org/W2012936067","https://openalex.org/W2022531352","https://openalex.org/W2028042667","https://openalex.org/W2039886457","https://openalex.org/W2051853225","https://openalex.org/W2051876017","https://openalex.org/W2079885014","https://openalex.org/W2107855398","https://openalex.org/W2108388947","https://openalex.org/W2129541275","https://openalex.org/W2139772374","https://openalex.org/W2140106791","https://openalex.org/W2141174747","https://openalex.org/W2144035662","https://openalex.org/W2156260604","https://openalex.org/W2159475709","https://openalex.org/W2166370309","https://openalex.org/W2185920964","https://openalex.org/W2314322923","https://openalex.org/W2383272022","https://openalex.org/W2905036259","https://openalex.org/W4292333032","https://openalex.org/W6712115856"],"related_works":["https://openalex.org/W2905036259","https://openalex.org/W4365512516","https://openalex.org/W7052410573","https://openalex.org/W4286876228","https://openalex.org/W3005403654","https://openalex.org/W4403117115","https://openalex.org/W2966115731","https://openalex.org/W2979737259","https://openalex.org/W2766273849","https://openalex.org/W2945453790"],"abstract_inverted_index":{"Candida":[0],"albicans":[1,39,49],"remains":[2],"the":[3,24,35,62,102,112,147],"most":[4],"common":[5],"cause":[6],"of":[7,61,101,114,146,167,192],"hospital-acquired":[8],"fungal":[9],"infections":[10],"due":[11,29],"to":[12,17,30,107],"its":[13],"virulence":[14,40,96,207],"determinants.":[15],"Resistance":[16],"antifungal":[18,67],"therapy":[19],"has":[20],"increased":[21],"dramatically,":[22],"narrowing":[23],"few":[25],"available":[26],"therapeutic":[27],"options":[28],"their":[31,72,108],"potential":[32,109],"toxicity.":[33],"However,":[34],"association":[36,110],"between":[37,95],"C.":[38,48],"determinants":[41,80,97],"and":[42,71,87,98,125,133,144,153,158,165,187,206],"resistance":[43,99,205],"profiles":[44,100],"needs":[45],"further":[46],"investigation.":[47],"(n=":[50],"25)":[51],"isolated":[52],"from":[53],"various":[54],"clinical":[55,115,193],"samples":[56],"were":[57,77,92,117,121,130,139],"identified.":[58],"Antibiogram":[59],"analysis":[60],"tested":[63,148],"isolates":[64,120,149,194],"against":[65],"different":[66],"agents":[68],"was":[69,161],"performed":[70],"minimum":[73],"inhibitory":[74],"concentrations":[75],"(MICs)":[76],"verified.":[78],"Virulence":[79],"including":[81],"extracellular":[82],"hydrolytic":[83,137],"enzymes,":[84],"biofilm":[85,159],"formation,":[86],"cell":[88],"surface":[89],"hydrophobicity":[90],"(CSH)":[91],"investigated.":[93],"Correlations":[94],"experimented":[103],"isolates,":[104,168],"in":[105,141,163],"addition":[106],"with":[111,184],"source":[113],"specimens,":[116],"analyzed.":[118],"All":[119],"amphotericin":[122,185],"B,":[123],"nystatin":[124],"micafungin":[126],"sensitive,":[127],"while":[128,156],"100%":[129,145],"clotrimazole,":[131],"fluconazole":[132,188],"voriconazole":[134],"resistant.":[135],"Extracellular":[136],"activities":[138],"detected":[140],"52,":[142],"68":[143],"for":[150],"phospholipase,":[151],"protease,":[152],"hemolysin,":[154],"respectively,":[155],"CSH":[157,170],"production":[160],"shown":[162],"24":[164],"20%":[166],"respectively.":[169,190],"had":[171],"significant":[172,196],"(p":[173,197],"<":[174,176,198,200],"/em>":[175,199],"0.05)":[177,201],"positive":[178],"as":[179,181],"well":[180],"negative":[182],"associations":[183],"B":[186],"MICs,":[189],"Source":[191],"showed":[195],"influence":[202],"on":[203],"some":[204],"patterns.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-04-25T00:00:00"}
