{"id":"https://openalex.org/W2940052886","doi":"https://doi.org/10.1002/ijc.32320","title":"Non\u2010V600E BRAF mutations and EGFR signaling pathway in colorectal cancer","display_name":"Non\u2010V600E BRAF mutations and EGFR signaling pathway in colorectal cancer","publication_year":2019,"publication_date":"2019-04-09","ids":{"openalex":"https://openalex.org/W2940052886","doi":"https://doi.org/10.1002/ijc.32320","mag":"2940052886","pmid":"https://pubmed.ncbi.nlm.nih.gov/30963570"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.32320","doi":"https://doi.org/10.1002/ijc.32320","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.32320","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32320","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32320","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064316490","display_name":"Hiroki Osumi","orcid":"https://orcid.org/0000-0002-4742-0446","observed_orcids":["https://orcid.org/0000-0002-4742-0446"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Osumi","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":"https://orcid.org/0000-0002-4742-0446","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069216523","display_name":"Eiji Shinozaki","orcid":"https://orcid.org/0000-0002-7448-5894","observed_orcids":["https://orcid.org/0000-0002-7448-5894","https://orcid.org/0000-0003-1831-0536"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Eiji Shinozaki","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066658797","display_name":"Takeru Wakatsuki","orcid":"https://orcid.org/0000-0002-1463-3859","observed_orcids":["https://orcid.org/0000-0002-1463-3859"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeru Wakatsuki","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":"https://orcid.org/0000-0002-1463-3859","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078320729","display_name":"Mitsukuni Suenaga","orcid":"https://orcid.org/0000-0002-6634-2893","observed_orcids":["https://orcid.org/0000-0002-6634-2893","https://orcid.org/0000-0003-1787-3716"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsukuni Suenaga","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014800720","display_name":"Takashi Ichimura","orcid":"https://orcid.org/0000-0003-0231-6511","observed_orcids":["https://orcid.org/0000-0003-0231-6511"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Ichimura","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077085235","display_name":"Mariko Ogura","orcid":"https://orcid.org/0000-0002-1004-8425","observed_orcids":["https://orcid.org/0000-0002-1004-8425"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Ogura","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070643359","display_name":"Daisuke Takahari","orcid":"https://orcid.org/0000-0002-2492-6014","observed_orcids":["https://orcid.org/0000-0002-2492-6014"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Takahari","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012297126","display_name":"Akira Ooki","orcid":"https://orcid.org/0000-0001-7618-5775","observed_orcids":["https://orcid.org/0000-0001-7618-5775"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Ooki","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101660596","display_name":"Takeshi Suzuki","orcid":"https://orcid.org/0000-0002-2206-1096","observed_orcids":["https://orcid.org/0000-0002-2206-1096"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Suzuki","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667324","display_name":"Yumiko Ota","orcid":"https://orcid.org/0000-0001-6497-3264","observed_orcids":["https://orcid.org/0000-0001-6497-3264"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Ota","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047876211","display_name":"Izuma Nakayama","orcid":"https://orcid.org/0000-0003-4987-1934","observed_orcids":["https://orcid.org/0000-0003-4987-1934"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Izuma Nakayama","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103234751","display_name":"Keisho Ch\u00ecn","orcid":"https://orcid.org/0000-0002-2015-8185","observed_orcids":["https://orcid.org/0000-0002-2015-8185"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisho Chin","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091623593","display_name":"Yoshio Miki","orcid":"https://orcid.org/0000-0003-0114-392X","observed_orcids":["https://orcid.org/0000-0003-0114-392X"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Miki","raw_affiliation_strings":["Department of Genetic Diagnosis Cancer Institute, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Diagnosis Cancer Institute, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091701897","display_name":"Kensei Yamaguchi","orcid":"https://orcid.org/0000-0001-6887-5709","observed_orcids":["https://orcid.org/0000-0001-6887-5709"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kensei Yamaguchi","raw_affiliation_strings":["Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069216523"],"corresponding_institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":1.1233,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.7824856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"145","issue":"9","first_page":"2488","last_page":"2495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.35600000619888306},{"id":"https://openalex.org/keywords/histological-differentiation","display_name":"histological differentiation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.7739999890327454},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.781000018119812},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.5830000042915344},{"id":"https://openalex.org/keywords/multiplex-genotyping","display_name":"multiplex genotyping","score":0.6019999980926514},{"id":"https://openalex.org/keywords/luminex-assay","display_name":"Luminex multiplex assay","score":0.7440000176429749},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8795289397239685},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.8514584898948669},{"id":"https://openalex.org/C2776470698","wikidata":"https://www.wikidata.org/wiki/Q21851559","display_name":"V600E","level":4,"score":0.7848409414291382},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7349030375480652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6939752697944641},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5180314183235168},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4906417429447174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48718494176864624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4701400399208069},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.4161979854106903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24503299593925476},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.23938044905662537},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.18783527612686157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07404983043670654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.32320","doi":"https://doi.org/10.1002/ijc.32320","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.32320","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32320","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:30963570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30963570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.32320","doi":"https://doi.org/10.1002/ijc.32320","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.32320","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32320","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2940052886.pdf","grobid_xml":"https://content.openalex.org/works/W2940052886.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W310635454","https://openalex.org/W1764134105","https://openalex.org/W1892665108","https://openalex.org/W1975946874","https://openalex.org/W1976053063","https://openalex.org/W1981064496","https://openalex.org/W1985035689","https://openalex.org/W1989773675","https://openalex.org/W2005348280","https://openalex.org/W2072599380","https://openalex.org/W2077428590","https://openalex.org/W2129998117","https://openalex.org/W2134142320","https://openalex.org/W2143501159","https://openalex.org/W2151441865","https://openalex.org/W2158943617","https://openalex.org/W2159064822","https://openalex.org/W2160304102","https://openalex.org/W2334157638","https://openalex.org/W2470575266","https://openalex.org/W2517626693","https://openalex.org/W2526760325","https://openalex.org/W2580868502","https://openalex.org/W2613375073","https://openalex.org/W2712978371","https://openalex.org/W2739964468","https://openalex.org/W2744203203","https://openalex.org/W2763245454","https://openalex.org/W2787981425","https://openalex.org/W2810934513","https://openalex.org/W6644173963","https://openalex.org/W6646987944"],"related_works":["https://openalex.org/W2588508072","https://openalex.org/W4389279887","https://openalex.org/W2954009009","https://openalex.org/W2072599380","https://openalex.org/W2900293586","https://openalex.org/W2946982563","https://openalex.org/W2951619489","https://openalex.org/W3135902243","https://openalex.org/W2140279101","https://openalex.org/W2891553143"],"abstract_inverted_index":{"The":[0,168,187],"Raf":[1],"murine":[2],"sarcoma":[3],"viral":[4],"oncogene":[5],"homolog":[6],"B":[7],"(BRAFV600E)":[8],"mutation":[9],"(MT)":[10],"in":[11,58,68,79,122],"metastatic":[12],"colorectal":[13],"cancer":[14],"(CRC)":[15],"is":[16],"a":[17,22,94,202,225],"well\u2010known":[18],"prognostic":[19],"indicator":[20],"and":[21,37,102,118,139,177,184,210,230,238],"negative":[23],"predictive":[24],"biomarker":[25],"for":[26,97],"antiepidermal":[27],"growth":[28],"factor":[29],"receptor":[30],"(EGFR)":[31],"treatment.":[32],"However,":[33],"the":[34,47,59,85,113,192,217,244],"clinical":[35,48,116],"characteristics":[36,49,188,218,241],"significance":[38],"of":[39,50,55,84,146,170,189,198,219],"BRAFnon\u2010V600E":[40,51,222,233],"MTs":[41,52,57,179,223,234],"remain":[42],"unclear.":[43],"Here,":[44],"we":[45],"evaluated":[46],"vs.":[53],"those":[54],"other":[56],"EGFR":[60,86],"signaling":[61],"pathway,":[62],"including":[63],"BRAFV600E.":[64],"Consecutive":[65],"CRC":[66,132],"patients":[67,143,190,220],"our":[69,80],"institute":[70],"from":[71,135],"June":[72],"2012":[73],"to":[74,243,251],"November":[75],"2013":[76],"were":[77,127,144,180,195,224,235],"enrolled":[78],"study.":[81],"Multiplex":[82],"genotyping":[83],"pathway":[87],"was":[88],"performed":[89,128],"with":[90,191,221],"archival":[91],"samples":[92,133],"using":[93,129],"Luminex":[95],"Assay":[96],"BRAFV600E/BRAFnon\u2010V600E,":[98,171],"KRAS/NRAS":[99],"exons":[100,174],"2\u20134,":[101],"phosphatidylinositol\u20104,5\u2010bisphosphate":[103],"3\u2010kinase,":[104],"catalytic":[105],"subunit":[106],"alpha":[107],"(PIK3CA).":[108],"We":[109],"analyzed":[110],"correlations":[111],"among":[112],"MT":[114,194],"profiles,":[115],"data":[117],"primary":[119,204,227],"tumor":[120,205,228],"locations":[121],"CRC.":[123],"All":[124],"statistical":[125],"analyses":[126],"R":[130],"software.":[131],"(824)":[134],"374":[136],"(45.4%)":[137],"male":[138],"450":[140],"(54.6%)":[141],"female":[142],"analyzed,":[145],"which":[147],"154":[148],"(18.7%),":[149],"202":[150],"(24.5%),":[151],"270":[152],"(32.8%)":[153],"or":[154,162,164],"198":[155],"(24.0%)":[156],"had":[157],"Stages":[158],"I,":[159],"II,":[160],"III":[161],"IV":[163],"recurrent":[165],"CRC,":[166],"respectively.":[167,186],"frequencies":[169],"KRAS":[172],"(including":[173],"2\u20134),":[175],"NRAS":[176],"PIK3CA":[178],"5.3/1.7,":[181],"41.4,":[182],"3.3":[183],"9.6%,":[185],"BRAFV600E":[193,245],"an":[196,211],"age":[197],"\u226565":[199],"years":[200],"old,":[201],"right\u2010sided":[203],"location,":[206],"poorly":[207],"differentiated":[208],"histology":[209],"advanced":[212],"disease":[213],"stage.":[214],"In":[215],"contrast,":[216],"left\u2010sided":[226],"location":[229],"well\u2010differentiated":[231],"histology.":[232],"relatively":[236],"rare":[237],"showed":[239],"different":[240],"compared":[242],"MT.":[246],"These":[247],"results":[248],"may":[249],"contribute":[250],"future":[252],"precision":[253],"medicine.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-04-25T00:00:00"}
